Additional Ventures Foundation - Single Ventricle Research Fund (SVRF)

Additional Ventures Foundation - Single Ventricle Research Fund (SVRF) is sponsored by Additional Ventures Foundation. The SVRF offers annual grants to enhance research and care for individuals with single ventricle heart defects, encouraging innovative projects aligned with the Additional Ventures Research Roadmap.

Single Ventricle Research Fund (SVRF) – Additional Ventures Single Ventricle Research Fund (SVRF) Our flagship funding program — the Single Ventricle Research Fund (SVRF) — is an annual research award program that supports foundational studies aimed at improving outcomes for individuals with single ventricle heart disease.

By addressing the organ- and multi-organ-level complications and clinical sequelae that drive long-term morbidity and mortality, the SVRF seeks to close critical gaps in understanding and treatment, and accelerate progress toward better, more predictive, and preventative care. Applicants may apply for either the Independent Investigator or Career Development tracks.

The Independent Investigator Track is open to both tenure and non-tenure track independent investigators, including instructors, assistant professors, and tenured faculty. The Career Development Track is open to postdoctoral fellows or postdoc equivalents who hold mentored positions.

Independent Investigator Track applicants can apply for up to $600,000 in direct costs, and Career Development Track applicants may apply for up to $300,000 in direct costs, over 3 years. In its sixth cycle, the SVRF welcomes foundational research that is directly relevant to improving outcomes for individuals with single ventricle heart disease.

Proposed projects must be led by principal investigator(s) who hold doctoral degrees (e.g. PhD, MD, PsyD, or equivalent doctorates). Proposals are accepted for two program tracks: Independent Investigator and Career Development. Independent Investigator Track: Eligible investigators include independent investigators of all levels (including those with Instructor or Assistant Professor status).

Collaborative proposals (e.g., includes multiple lead investigators who make significant contributions) are encouraged. One principal investigator must be selected as the primary contact, with all other lead investigators listed as co-investigators. Up to five (5) co-investigators may be added to each project, and they must meet the same eligibility requirements as the principal investigator.

Career Development Track: Eligible investigators include postdoctoral fellows or equivalents holding a mentored position. Collaborative proposals will not be accepted through this track. The SVRF welcomes foundational research that is directly relevant to improving outcomes for individuals with single ventricle heart disease.

All proposals must clearly demonstrate how their aims — including any work on the origins or pathobiology of single ventricle heart disease — relate to the mechanisms driving long-term morbidity and mortality. Studies that examine cardiac development or the causes of single ventricle malformations without clear links to patient outcomes will not be considered.

Priority outcomes include preventing or reversing key organ-level complications such as lymphatic dysfunction, liver disease, impaired kidney and gut perfusion, heart failure, valve dysfunction, arrhythmia, and neurodevelopmental challenges.

While these priority areas reflect the most pressing outcome-related challenges in single ventricle heart disease, the SVRF remains open to bold, innovative outcome-related proposals that may emerge outside of these focus areas.

Applications that introduce novel concepts or unexpected avenues for improving outcomes are encouraged, provided they maintain clear relevance to the long-term health and quality of life of individuals with single ventricle heart defects. Deadlines are subject to change at the discretion of Additional Ventures in response to nationally or globally related events.

Historically, the SVRF has selected 14-17 proposals each year and has collectively awarded almost $48M to support SV research. View our list of funded studies for additional information on our SVRF awardees. Up to $600,000 in direct costs for the Independent Investigator Track awards.

The Career Development Track awards are eligible for up to $300,000 in direct costs. Awards under both tracks span over three (3) years. Indirect costs up to 10% will be provided in addition to the total funded amount.

Up to $600,000 in direct costs for Independent Investigator Track awards, up to $300,000 for Career Development Track awards, over three (3) years. Indirect costs up to 10% will be provided in addition to the total funded amount. Full proposal invitations: Full proposal due (invite only): Open the program of your choice under the Grant Opportunities tab.

Click “Apply Now” to begin your application. To revisit an existing application, click the Proposals tab. Submit your completed LOI and/or application.

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