Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) is a grant from NIGMS that funds additional costs within the scope of currently active NIH research grants. Current recipients of specific NIH research grants may apply for supplemental funding to meet increased, unforeseen costs that fall within their peer-reviewed and approved project scope.

Applications are considered prior approval requests and are routed directly to the Grants Management Officer of the parent award. Eligible applicants include nonprofits, universities, and state and local governments that already hold qualifying NIH grants. Participating institutes span nearly all major NIH components, including NEI, NHLBI, NHGRI, NIAID, NCI, NIMH, and many others.

Award amounts vary by institute and available funding, with the program open through December 1, 2028.

PA-26-001: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations NATIONAL INSTITUTES OF HEALTH ( NIH ) National Eye Institute ( NEI ) National Heart, Lung, and Blood Institute ( NHLBI ) National Human Genome Research Institute ( NHGRI ) National Institute on Alcohol Abuse and Alcoholism ( NIAAA ) National Institute of Allergy and Infectious Diseases ( NIAID ) National Institute of Arthritis and Musculoskeletal and Skin Diseases ( NIAMS ) National Institute of Biomedical Imaging and Bioengineering ( NIBIB ) National Institute on Deafness and Other Communication Disorders ( NIDCD ) National Institute of Dental and Craniofacial Research ( NIDCR ) National Institute of Diabetes and Digestive and Kidney Diseases ( NIDDK ) National Institute on Drug Abuse ( NIDA ) National Institute of Environmental Health Sciences ( NIEHS ) National Institute of General Medical Sciences ( NIGMS ) National Institute of Mental Health ( NIMH ) National Institute of Neurological Disorders and National Institute of Nursing Research ( NINR ) National Institute on Minority Health and Health Disparities ( NIMHD ) National Library of Medicine ( NLM ) Fogarty International Center ( FIC ) National Center for Complementary and Integrative Health ( NCCIH ) National Center for Advancing Translational Sciences ( NCATS ) Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs ( ORIP ) Office of Strategic Coordination ( Common Fund ) National Cancer Institute ( NCI ) Office of The Director, National Institutes of Health ( OD ) All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers.

The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention ( ODP ) Office of Behavioral and Social Sciences Research ( OBSSR ) Office of Dietary Supplements ( ODS ) Office of Research on Women's Health ( ORWH ) Funding Opportunity Title Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) Check for any recent Notices of NIH Policy Changes that may impact application requirements.

Funding Opportunity Number (FON) Companion Funding Opportunity See Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s) 93. 310, 93. 866, 93.

839, 93. 273, 93. 855, 93.

846, 93. 286, 93. 847, 93.

113, 93. 142, 93. 143, 93.

350, 93. 989, 93. 393, 93.

394, 93. 395, 93. 396, 93.

399, 93. 867, 93. 172, 93.

233, 93. 837, 93. 838, 93.

859, 93. 242, 93. 307, 93.

853, 93. 361, 93. 879, 93.

351, 93. 313, 93. 173, 93.

213, 93. 372, 93. 840, 93.

279, 93. 121 Funding Opportunity Purpose Current recipients of specific types of NIH research grants may apply for administrative supplements, using this Notice of Funding Opportunity (NOFO), to provide additional funding to a currently funded grant to meet increased costs that are within the scope of the peer-reviewed and approved project, but that were unforeseen when the new or competing renewal application was awarded.

Applications for administrative supplements are considered prior approval requests (as described in Section 8. 1. 2.

11 of the NIH Grants Policy Statement ) and will be routed directly to the Grants Management Officer of the parent award. There is no guarantee that funds are available from the awarding IC or for any specific grant. Therefore, prior to submission, applicants must discuss potential requests with the awarding ICO grants and program officials.

Funding Opportunity Goal(s) NIH’s mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. See the NIH Mission Statement and the NIH Director’s Statement of Priorities , entitled “Advancing NIH’s Mission Through a Unified Strategy.

” Open Date (Earliest Submission Date) Due dates may vary by awarding IC. See Administrative Supplements on the NIH Grants & Funding site for IC-specific information including any special due dates. Applicants may also contact their respective awarding IC.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. AIDS Application Due Date(s) Earliest start dates vary by awarding IC.

Required Application Instructions It is critical that applicants follow the instructions in the How to Apply - Application Guide , as appropriate except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide , follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Use Grants. gov Workspace to prepare and submit your application and eRA Commons to track your application.

Part 1. Overview Information Part 2. Full Text of Announcement Section I.

Notice of Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV.

Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII.

Agency Contacts Section VIII. Other Information Part 2. Full Text of Announcement Section I.

Notice of Funding Opportunity Description Definition: An administrative supplement (Type 3) is a request for additional funds during a current project period to provide for an increase in costs due to unforeseen circumstances. All additional costs must be within the current scope of the peer reviewed and approved project and the activities must not extend beyond the term of the current award.

Administrative supplements do not require peer review. Potential indicators of a change of scope include but are not limited to: Change in the specific aims approved at the time of award Change from non-human subject research to research involving human subjects Shift of the research emphasis from one disease area to another Administrative supplements are used for a variety of unforeseen circumstances.

See Administrative Supplements on the NIH Grants & Funding site for a list of acceptable potential uses. See Section VIII. Other Information for award authorities and regulations.

Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs. Section II. Award Information The funding instrument will be the same as the Parent Award.

Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement. Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities.

See Section VI. 2 for additional information about the substantial involvement for this NOFO. Application Types Allowed Non-competing Administrative Supplements.

Optional: Accepting applications that either propose or do not propose clinical trial(s) Administrative supplement applications may not propose changes to the overall human subjects or clinical trial designation of the award. Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Application budgets are limited to no more than the amount of the current parent award and must reflect the actual needs of the proposed project.

The funding mechanism being used to support this program, administrative supplements, can be used to provide for an increase in costs due to unforeseen circumstances. All costs must be within the current scope of the peer reviewed and approved project, and may not extend beyond the term of the current award. The project and budget periods must be within the currently approved project period for the existing parent award.

Administrative supplements are not permitted during a no-cost extension and will be considered only in rare situations (e.g., public health emergency declaration, or natural disaster). NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this Notice of Funding Opportunity (NOFO). Section III.

Eligibility Information All organizations administering an eligible parent award may apply for a supplement under this NOFO.

Higher Education Institutions - Includes all types Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Non-domestic (non-U.S.) Entities (Organizations) REMINDER: This funding opportunity is for supplements to existing projects.

To be eligible, the parent award must be active, and the research proposed in the supplement must be accomplished within the competitive segment. The proposed supplement must be to provide for an increase in costs due to unforeseen circumstances. All additional costs must be within the scope of the peer reviewed and approved project.

IMPORTANT: The research proposed by the NIH recipient in the supplement application must be within the original scope of the NIH-supported grant project. Foreign Organizations/International Collaborations Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement , are allowed. All activities with foreign institutions must align with existing parent award. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts.

All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025. Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding.

This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components , funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible.

Failure to complete registration in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement 2. 3. 9.

2 Electronically Submitted Applications for additional information. System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration.

SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.

gov registration process. The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.

gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants.

gov – Applicants must have an active SAM registration in order to complete the Grants. gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide .

Individual(s) must be a PD(s)/PI(s) on an active grant or cooperative agreement, and the research proposed in the supplement must be accomplished within the competitive segment of the active award. Individuals are encouraged to work with their organizations to develop applications for support.

For supplements to parent awards that include multiple PDs/PIs, the supplement may be submitted by the recipient organization of the parent award on behalf of any or all of the PDs/PIs (in accordance with the existing leadership plan). Do not use this administrative supplement application to add, delete, or change the PDs/PIs listed on the parent award.

Visit the Multiple Program Director/Principal Investigator Policy in the How to Apply - Application Guide for more information. This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1. 2 Definition of Terms .

3. Additional Information on Eligibility Applicant organizations may submit more than one application, if each is sufficiently distinct from any other administrative supplement currently under consideration by the awarding NIH Institute or Center. Administrative supplements do not count against six applications allowed from individual PD/PIs.

Since applications to this NOFO will only receive administrative review by the awarding Institute or Center, and will not receive a peer review, the NIH policy on resubmissions will not apply.

However, applications not accepted by the Institute or Center for review, or not funded by the Institute or Center, should not be submitted again without either responding to any written concerns or contacting the awarding Institute or Center for instructions. Section IV. Application and Submission Information 1.

Requesting an Application Package Applicants must prepare applications using current forms in accordance with the How to Apply - Application Guide . The application forms package specific to this opportunity must be accessed through ASSIST , Grants. gov Workspace or an institutional system-to-system solution.

Links to apply using ASSIST or Grants. gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution.

2. Content and Form of Application Submission All forms must be completed for the supplemental activities only and must not reflect funding or activities for the previously awarded parent award. It is critical that applicants follow the instructions for their submission option and the How to Apply - Application Guide , as appropriate.

except where instructed in this NOFO to do otherwise (in this NOFO, in a policy notice , or other notice from NIH Guide for Grants and Contracts ). Conformance to documented requirements is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

All page limitations applicable to the parent award as described in the Application Guide and the How to Apply - Application Guide for the activity code of the parent award must be followed. Instructions for Application Submission Administrative supplement requests must be submitted through Grants. gov using electronic submission processes.

Use the submission options in Part I of this NOFO to access the application forms package posted at Grants. gov. If presented with more than one form package, use the Competition ID and Competition Titles provided to determine the most appropriate application forms package for your situation.

Administrative supplement requests for multi-project activity codes must be submitted electronically using a single-project application form package. Prepare applications using the SF424 (R&R) forms associated with the chosen package. Please note that some forms marked optional in the application package are required for submission of applications for this NOFO.

Follow all instructions in the How to Apply - Application Guide to ensure you complete all appropriate required and optional forms, with the following additional guidance: Select “Revision” in the “Type of Application” field. The "Descriptive Title of the Applicant's Project" must match the title of the currently funded grant.

The “EIN” field must include the 12-digit Payment Management System (PMS) Entity Identification Number (EIN) associated with the currently funded grant.

SF424 (R&R) Other Project Information form: If applicable, attach PDF documents in the “Other Attachments” field indicating that the proposed research experience was approved by the Institutional Animal Care and Use Committee (IACUC) or human subjects Institutional Review Board (IRB) at the recipient institution. Name the documents “IACUC Documentation. pdf” and/or “IRB Documentation.

pdf”. Adherence to the NIH Inclusion Policies for Human Subjects must be ensured, if additional human subjects involvement is planned for the supplement. For NRSA Institutional Training Grants requesting additional childcare costs: Ruth L.

Kirschstein National Research Service Award (NRSA) Institutional Training Awards supporting full-time pre- and post-doctoral trainees (i.e. T32, TL1, TU2, and T90, as detailed at https://researchtraining. nih. gov/programs/training-grants ), will be provided funds to support childcare costs for 25% of the full-time predoctoral or post-doctoral NRSA training appointment slots, in accordance with NOT-OD-25-100 .

If recipients need to request childcare cost support for more than 25% of the full-time predoctoral or post-doctoral NRSA training appointment slots, the recipient must upload a PDF named “Childcare_Costs. pdf” (without quotation marks). The attachment must specify the number of additional trainee slots for which childcare cost support is being requested.

Recipients are not required to submit supporting documentation. Recipients must maintain all supporting documentation (e.g., proof provider is licensed). NIH reserves the right to request proof at any time.

FAQs are available at: https://grants. nih. gov/faqs#/funding_programs_childcare_costs.

htm . SF424 (R&R) Project/Performance Site Location(s) form: Include the primary site where the proposed supplement activities will be performed. If a portion of the proposed supplement activities will be performed at any other site(s), identify the locations in the fields provided.

SF424 (R&R) Sr/Key Person Profile (Expanded) form: List the PD/PI as the first person (regardless of their role on the supplement activities). List any other Senior/Key Personnel who are being added through this supplement, or for whom additional funds are being requested through this supplement; include a biographical sketch for each.

Budget forms (e.g., R&R Budget, PHS 398 Training Budget): Only include funds requested for the additional supplement activities. For NRSA Institutional Training Grants requesting additional childcare costs: If the supplement request is only for additional childcare cost support, you are not required to include the PHS 398 Training Budget form; refer to the instructions for Other Attachments above.

Research Plan form (i.e., PHS 398 Research Plan form, PHS 398 Research Training Program Plan, PHS Fellowship Supplemental Form, and PHS 398 Career Development Award Supplemental Form): At a minimum, the Research Strategy or Program Plan section, as applicable, must be completed and must include a summary or abstract of the funded parent award or project.

Other sections should also be included if they are being changed by the proposed supplement activities. Other Plan(s): For awards subject to the 2023 Data Management & Sharing Policy, if an awarded supplement request would change the Data Management and Sharing (DMS) Plan, a revised DMS Plan must be requested via as a Prior Approval request on the Parent Award.

For NRSA and F99 Individual Fellows requesting childcare costs: Current fellows may request an administrative supplement to provide childcare costs on an existing award. Applicants must request the childcare costs in the Childcare Costs Section of the PHS Fellowship Supplemental Form as outlined in the How to Apply – Application Guide . PHS Human Subjects and Clinical Trials Information form: This form is optional.

Given that the proposed supplement should not change the scope of the awarded parent project, it will typically not be needed. If new recruitment or use of an additional existing dataset or resource is proposed in the supplement application, Section 2 should be revised and new Inclusion Enrollment Reports created, as well as other required sections, as appropriate for supplemental activities.

Foreign (non-U.S.) Organizations must follow policies described in the NIH Grants Policy Statement , and procedures for foreign organizations described throughout the How to Apply - Application Guide . 3. Unique Entity Identifier and System for Award Management (SAM) See Part 1.

Section III. 1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants. gov 4.

Submission Dates and Times Part I. Overview Information contains information about Key Dates and Times. Applicants are encouraged to submit electronic applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission.

When a submission date falls on a weekend or Federal holiday , the application deadline is automatically extended to the next business day. Applicants are responsible for viewing their electronic application before the due date in the eRA Commons to ensure accurate and successful submission.

For electronic application submission, information on the submission process and a definition of on-time submission are provided in the How to Apply - Application Guide . 5. Intergovernmental Review (E.

O. 12372) This initiative is not subject to intergovernmental review. All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement .

Pre-award costs are allowable only as described in the NIH Grants Policy Statement Section 7. 9. 1 Selected Items of Cost .

7. Other Submission Requirements and Information Applications must be submitted using the instructions specified above. Applicants must complete all required registrations prior to submission.

Section III. Eligibility Information contains information about registration. For assistance with your electronic application or for more information on the electronic submission process, visit How to Apply – Application Guide .

If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Dealing with System Issues guidance. For assistance with application submission contact the Application Submission Contacts in Section VII. Agency Contacts.

For applications submitted electronically on the SF424 (R&R) Application forms, all PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form. Failure to register in the eRA Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.

The applicant organization must ensure that the unique entity identifier provided on the application is the same identifier used in the organization’s profile in the eRA Commons and for the System for Award Management. Additional information may be found in the How to Apply - Application Guide .

Recipients or subrecipients must submit any information related to violations of federal criminal law involving fraud, bribery, or gratuity violations potentially affecting the federal award. See Mandatory Disclosures, 2 CFR 200. 113 and NIH Grants Policy Statement Section 4.

1. 35 . Send written disclosures to the NIH Chief Grants Management Officer listed on the Notice of Award for the IC that funded the award and to the HHS Office of Inspector Grant Self Disclosure Program at grantdisclosures@oig.

hhs. gov . Post Submission Materials Section V.

Application Review Information Administrative Supplements do not receive peer review. Instead, the administrative criteria described below will be considered in the administrative evaluation process. The staff of the NIH awarding component will evaluate requests for a supplement to determine its overall merit.

The following general criteria will be used: Budget and Period of Support NIH staff will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.

NIH staff will consider the ability of the proposed supplement activities to increase or preserve the parent award’s overall impact within the original scope of award: Will the administrative supplement increase or preserve the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved?

If applicable, will the administrative supplement increase or preserve the likelihood that the fellowship or career development will enhance the candidate's potential for, and commitment to, a productive, independent scientific research career in a health-related field? If applicable, will the administrative supplement increase or preserve the likelihood for the candidate to maintain a strong research program?

If applicable, will the administrative supplement increase or preserve the potential benefit of the instrument requested for the overall research community and its potential impact on NIH-funded research?

If applicable, will the administrative supplement increase or preserve the likelihood that the proposed training program will equip the trainees with the skills, knowledge and experiences necessary to transition to successful careers in the biomedical research workforce? In addition, each of the following criteria will be evaluated as applicable for the proposed supplement.

Protections for Human Subjects For research that involves human subjects but does not involve one of the categories of research that are exempt under 45 CFR Part 46, the committee will evaluate the justification for involvement of human subjects and the proposed protections from research risk relating to their participation according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained, and 5) data and safety monitoring for clinical trials.

For research that involves human subjects and meets the criteria for one or more of the categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. For additional information on review of the Human Subjects section, please refer to the Guidelines for the Review of Human Subjects .

Inclusion of Human Subjects Policies When the proposed project involves human subjects and/or NIH-defined clinical research, the committee will evaluate the proposed plans for inclusion. For additional information on review of the Inclusion section, please refer to the Guidelines for the Review of Inclusion in Clinical Research .

The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following three points: (1) a complete description of all proposed procedures including the species, strains, ages, sex, and total numbers of animals to be used; (2) justifications that the species is appropriate for the proposed research and why the research goals cannot be accomplished using an alternative non-animal model; and (3) interventions including analgesia, anesthesia, sedation, palliative care, and humane endpoints that will be used to limit any unavoidable discomfort, distress, pain and injury in the conduct of scientifically valuable research.

Methods of euthanasia and justification for selected methods, if NOT consistent with the American Veterinary Medicine Association (AVMA) Guidelines for the Euthanasia of Animals, is also required but is found in a separate section of the application. For additional information on review of the Vertebrate Animals Section, please refer to the Worksheet for Review of the Vertebrate Animals Section.

NIH staff will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed. 2. Review and Selection Process Administrative supplement requests will undergo an administrative evaluation by NIH staff, but not a full peer review.

Applications submitted for this funding opportunity will be assigned to the awarding component for the parent award and will be administratively evaluated using the criteria shown above. Prior to making an award, NIH reviews an applicant’s federal award history in SAM. gov to ensure sound business practices.

An applicant can review and comment on any information in the Responsibility/Qualification records available in SAM. gov. NIH will consider any comments by the applicant in the Responsibility/Qualification records in SAM. gov to ascertain the applicant’s integrity, business ethics, and performance record of managing Federal awards per 2 CFR Part 200.

206 “Federal awarding agency review of risk posed by applicants. ” This provision will apply to all NIH grants and cooperative agreements except fellowships. 3.

Anticipated Announcement and Award Dates Section VI. Award Administration Information A Notice of Award (NoA) is the official authorizing document notifying the applicant that an award has been made and that funds may be requested from the designated HHS payment system or office.

This may be as an NoA for the supplemental activities only; alternatively, it may be as either a revision to the current year NoA or included as part of a future year NoA. The NoA is signed by the Grants Management Officer and emailed to the recipient’s business official.

In accepting the award, the recipient agrees that any activities under the award are subject to all provisions currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions. Recipients must comply with any funding restrictions described in Section IV. 6.

Funding