Advanced Molecular Detection (AMD) Program

Advanced Molecular Detection (AMD) Program is sponsored by Centers for Disease Control and Prevention (CDC). Integrates next-generation genomic sequencing technologies with bioinformatics and epidemiology expertise to enhance pathogen detection and public health response.

Stakeholders advocate funding for CDC Advanced Molecular Detection program | myadlm.

org Dear Chairs Capito and Aderholdt and Ranking Members Baldwin and DeLauro, We, the undersigned professional societies and associations, academic institutions and companies, representing a broad range of scientific, public health and clinical professionals, thank you for your continued support of the Advanced Molecular Detection (AMD) program at the Centers for Disease Control and Prevention (CDC).

Given the program’s growing importance to the nation’s public health and biosecurity infrastructure, we respectfully request that you provide $175 million for the CDC’s AMD program within the National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) for Fiscal Year (FY) 2027.

Established by Congress in FY 2014, the CDC’s AMD program enables the agency to integrate next-generation genomic sequencing and advanced data analytics into public health practice. Prior to the program’s inception, the U.S. experienced a widening technological gap, and the public health system was falling behind in pathogen genomics.

Today, the AMD serves as a cornerstone of modern biosurveillance, providing modern genomic sequencing and data analysis tools that allow state and local health departments to rapidly detect, characterize, and track infectious diseases.

Genomic data are also central in the development of vaccines, therapeutics, and diagnostics, demonstrating that the benefits of AMD extend beyond the immediate public health impact and into the healthcare industry. AMD technologies have also been instrumental in identifying and containing foodborne disease outbreaks.

Because the technology allows for a more precise identification of the pathogen and location of the contaminated food source, the health and economic impacts of an outbreak can be minimized and resolved more quickly.

CDC officials have additionally been able to use AMD to improve the public health response to both seasonal and emerging strains such as H5N1 avian influenza, by applying genetic sequencing methods to detect the emergence of novel influenza virus strains, information that is already used to improve yearly influenza vaccines.

The AMD program and its partners routinely make this genomic data publicly available, amplifying its value for researchers, public health officials, and industry. Further, the AMD program has supported the training of public health and clinical laboratory professionals in genomics and bioinformatics, enabling them to interpret genomic sequencing data and apply it to public health responses.

Deploying AMD through community-based methods, such as wastewater surveillance, has proven over the past few years to have enormous value in detecting the presence of notable threats, such as polio and antimicrobial resistant bacterial strains, as well as rare and serious conditions such as acute flaccid myelitis (AFM).

With supplemental funding provided over the last four years, the program has been able to integrate public health practice with academic research capabilities in five states (GA, WA, MN, VA, and MA) through the Pathogen Genomics Centers of Excellence.

These centers ensure that our broader public health system can continue to benefit from rapidly evolving, cutting-edge science and technology driven in partnership with research institutions. For example, the Northwest Center of Excellence in Washington State developed protocols to sequence H5N1 strains from infected poultry and humans, enabling public health officials to analyze transmission between species and assess population risk.

As these supplemental funds are projected to run out in FY2027, there is a significant risk to sustaining these capabilities without increased base funding. AMD is currently funded at $43 million. To fully realize the program’s potential and sustain the infrastructure and partnerships established in recent years, CDC estimates that up to $175 million in annual funding is needed.

This funding level aligns with the level proposed in the Tracking Pathogens Act, which was enacted without an authorization level as part of a year-end legislative package in 2022. Increased annual funding will ensure continuity of operations, preserve critical genomic surveillance capacity, and enable CDC and its partners to rapidly detect and respond to emerging infectious disease threats.

Without increased and sustained base funding, these capabilities will erode, weakening the nation’s ability to identify outbreaks early, respond effectively, and maintain global leadership in public health innovation.

American Society for Microbiology AAMC (Association of American Medical Colleges) American Clinical Laboratory Association American Institute of Biological Sciences American Medical Technologists American Medical Technologists Association American Society for Virology American Society of Tropical Medicine and Hygiene Association for Diagnostics & Laboratory Medicine Association for Molecular Pathology (AMP) Association for Professionals in Infection Control and Epidemiology (APIC) Association of Public Health Laboratories Association of State and Territorial Health Officials Big Cities Health Coalition College of American Pathologists Infectious Diseases Society of America Society for Public Health Education Trust for America's Health