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Advancing Head & Neck Cancer Early Detection Research (AHEAD) is sponsored by National Institute of Dental and Craniofacial Research (NIDCR) and National Cancer Institute (NCI). This notice of funding opportunity (NOFO) invites applications focused on early detection of head and neck cancer by applying molecular, cellular, and multi-omics signatures to clinical studies.
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Advancing Head & Neck Cancer Early Detection Research (AHEAD) | NIDCR NIH Websites Are Changing Get the Latest Updates and FAQs Advancing Head & Neck Cancer Early Detection Research (AHEAD) Head and neck cancers are the sixth most common type of cancers worldwide, and more than 65,000 people are diagnosed each year in the United States.
Despite prevention efforts and improved treatment, the overall five-year survival rate for head and neck cancer patients remains around 40%-50%. The low survival rate and low quality of life for patients are often due to limited detection and interventions for early disease.
In response, NIDCR and the National Cancer Institute (NCI) issued the Advancing Head and Neck Cancer Early Detection Research (AHEAD) notice of funding opportunity , or NOFO (formerly known as a funding opportunity announcement).
The NOFO invited applications focused on early detection by applying molecular, cellular, and multi-omics signatures to clinical studies to distinguish benign from premalignant lesions and to identify prognostic signatures of the transformation from premalignant to malignant lesions.
The partnership between NIDCR and NCI enables AHEAD investigators to access valuable NIDCR and NCI resources to enhance their research capabilities, including NCI’s Early Detection Research Network, a national hub that provides infrastructure for discovery and validation of biomarkers for early cancer detection. In 2023, NIDCR, together with NCI, awarded seven grants totaling $4. 4 million for up to five years of support.
Award Number Principal Investigator(s) Institution Award Title *U01-CA290479 and NCI Ludmil B. Alexandrov University of California, San Diego Mapping Immuno-Genomic Drivers of the Head and Neck Precancer Invasive-Disease Transition U01-DE033324 Sara Isabel Pai Massachusetts General Hospital Early Detection and Risk of Head and Neck Cancer Through Immune Based Spatial Omics U01-DE033329 Anna R.
Giuliano Moffitt Cancer Center Biomarker Approach to Screening for the Early Detection of HPV-Related Oropharyngeal Cancer (BASH OPC) U01-DE033330 Yu Leo Lei University of Michigan, Ann Arbor Advancing On-Slide and Optical Biopsy Tools to Detect High-Risk Oral Premalignancy U01-DE033348 Laura Rozek Georgetown University Oral Dysplasias to Carcinomas: Multi-Omics Study of Progression U01-DE033351 Fatemeh Momen Heravi Columbia University Immune and Transcriptomic Biomarkers of Progressive Oral Premalignant Lesions R56-DE033344 Hua Li Washington University, St.
Louis Combined Imaging and RNA Analyses to Predict Head and Neck Cancer Recurrence
According to the current listing, eligibility includes: Investigators focused on early detection research for head and neck cancer. Confirm the full requirements in the official notice before applying.
Advancing Head & Neck Cancer Early Detection Research (AHEAD) is funded by National Institute of Dental and Craniofacial Research (NIDCR) and National Cancer Institute (NCI). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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