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PA-24-266 supports the development and implementation of digital healthcare solutions including AI/ML clinical decision support, generative AI for clinical workflows, smart point-of-care tools, and AI-based safety alerts that demonstrably improve healthcare quality, safety, and efficiency. The R21 phase funds early-stage feasibility and prototype work; the R33 phase funds translational scaling and clinical implementation.
Standard receipt dates are February 16, June 16, and October 16, with the next round closing June 16, 2026, and a final cycle August 1, 2026. Strong fit for clinical AI teams, health systems, and digital health innovators with concrete deployment plans.
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Or search similar grants →According to the current listing, eligibility includes: U.S. and foreign organizations including academic institutions, nonprofits, small businesses, government agencies, health systems, hospitals, and tribal organizations. Multiple PIs encouraged. Health systems and clinical sites required for R33 phase. Confirm the full requirements in the official notice before applying.
The current listing shows R21 phase: up to $275,000 direct costs over 2 years; R33 phase: up to $1,000,000 direct costs over 3 years. Combined R21/R33 total up to $1,275,000 direct costs across 5 years. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for AHRQ NIH Using Innovative Digital Healthcare Solutions to Improve Quality at the Point of Care R21 R33 PA-24-266 for AI Clinical Decision Support are due August 1, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
AHRQ NIH Using Innovative Digital Healthcare Solutions to Improve Quality at the Point of Care R21 R33 PA-24-266 for AI Clinical Decision Support is funded by Agency for Healthcare Research and Quality (AHRQ) and National Institutes of Health (NIH). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
AHRQ PA-24-261 funds research to determine (1) whether and how breakthrough uses of AI systems affect patient safety in real clinical environments and (2) how AI systems can be safely implemented and used in healthcare delivery. The R18 mechanism funds evaluation - this NOFO explicitly does not support development of new AI systems but rather the rigorous post-deployment evaluation of AI in live clinical settings, complementing AHRQ's broader digital healthcare portfolio. Topics include AI failure mode analysis, alert fatigue from clinical AI, AI-driven diagnostic safety, equity impacts of clinical AI, and human-AI team performance in care delivery. Strong fit for health services researchers, patient safety researchers, and health systems studying AI deployment outcomes.
NCI ITCR Advanced Development U24 (RFA-CA-27-020) funds the maturation, enhancement, validation, and dissemination of emerging informatics technologies for cancer research and clinical care. Awards support AI/ML platforms ready to move beyond prototype, including deep learning cancer imaging tools, AI clinical decision support systems, multimodal cancer foundation models, AI-driven genomics pipelines, and digital pathology AI. Up to $600K direct costs per year for up to 5 years allows substantial software engineering, validation, and community adoption activities. Strong fit for established cancer informatics teams with mature AI prototypes ready for production deployment.
NCI ITCR Sustained Support U24 (RFA-CA-27-021) sustains widely-adopted cancer informatics technologies in production use by the cancer research community. Funds operational support, user experience improvement, security and accessibility hardening, and continued community engagement for mature AI/ML tools. Examples include cBioPortal, AI cancer imaging platforms, genomic data commons tools, and clinical informatics platforms. Up to $600K direct costs per year for up to 5 years. Strong fit for teams maintaining open-source cancer AI infrastructure with broad user communities.
Despite NIH budget pressure, hundreds of millions in AI healthcare research grants remain active in 2026. Full breakdown of Bridge2AI, AHRQ patient safety, NSF/NIH Smart Health, BARDA, Gates Foundation, and Google.org — with eligibility, amounts, and current deadlines.
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