AHRQ Patient-Centered Outcomes Research (PCOR) Mentored Research Scientist Career Development Award (K01)

AHRQ Patient-Centered Outcomes Research (PCOR) Mentored Research Scientist Career Development Award (K01) is sponsored by Agency for Health Care Research and Quality. Provides support for qualified individuals for an intensive, mentored research career development experience in comparative effectiveness research methods applied to patient-centered outcomes research.

Expired PA-22-049: AHRQ Patient-Centered Outcomes Research (PCOR) Mentored Research Scientist Career Development Award (K01) This notice has expired. For NIH, in limited situations, applications may be accepted on a case-by-case basis for a short period after expiration to accommodate NIH late or continuous submission policies . Contact the eRA Service Desk for any submission issues.

Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1. Overview Information Participating Organization(s) Agency for Healthcare Research and Quality ( AHRQ ) NOTE: The policies, guidelines, terms, and conditions stated in this announcement may differ from those used by the NIH.

Where this Notice of Funding Opportunity (NOFO) provides specific written guidance that may differ from the general guidance provided in the grant application form, please follow the instructions given in this NOFO. Also note that AHRQ has different page limits than NIH for the application Research Strategy, which can be found within each individual NOFO.

Components of Participating Agency for Healthcare Research and Quality ( AHRQ ) Notice of Funding Opportunity Title AHRQ Patient-Centered Outcomes Research (PCOR) Mentored Research Scientist Career Development Award (K01) Research Scientist Development Award - Research & Training March 31, 2025 - This funding opportunity was updated to align with agency priorities.

Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. January 21, 2025 - Notice to Extend Expiration dates for AHRQ PA-22-049 and PA-22-050. See Notice April 04, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.

See Notice NOT-OD-24-084 December 16, 2024 - Special Emphasis Notice: AHRQ Announces Interest in Research to Improve Treatment and Management of Menopause symptoms. See Notice NOT-HS-25-009 . May 13, 2024 - Special Emphasis Notice: AHRQ Announces Interest in Health Services Research to Improve Care Delivery, Access, Quality, Equity, and Health Outcomes for Older Adults.

See Notice NOT-HS-24-013 November 16, 2023 - Special Emphasis Notice: AHRQ Announces Interest in Health Services Research to Improve Healthcare for Persons Living with Disabilities. See Notice NOT-HS-24-004 January 11, 2023 - AHRQ Announces Interest in Research on Climate Change and Healthcare.

See Notice NOT-HS-23-006 NOT-OD-23-012 Reminder: FORMS-H Grant Application Forms and Instructions Must be Used for Due Dates On or After January 25, 2023 - New Grant Application Instructions Now Available NOT-OD-22-190 - Adjustments to NIH and AHRQ Grant Application Due Dates Between September 22 and September 30, 2022 October 28, 2021 - Reminder: FORMS-G Grant Application Forms & Instructions Must be Used for Due Dates On or After January 25, 2022 - New Grant Application Instructions Now Available.

See Notice NOT-OD-22-018 . August 5, 2021 - New NIH "FORMS-G" Grant Application Forms and Instructions Coming for Due Dates on or after January 25, 2022. See Notice NOT-OD-21-169 .

August 5, 2021 - Update: Notification of Upcoming Change in Federal-wide Unique Entity Identifier Requirements. See Notice NOT-OD-21-170 . April 20, 2021 - Expanding Requirement for eRA Commons IDs to All Senior/Key Personnel.

See Notice NOT-OD-21-109 .

NOT-OD-22-018 Reminder: FORMS-G Grant Application Forms & Instructions Must be Used for Due Dates On or After January 25, 2022 - New Grant Application Instructions Now Available NOT-OD-21-170- Update: Notification of Upcoming Change in Federal-wide Unique Entity Identifier Requirements NOT-OD-21-109 - Expanding Requirement for eRA Commons IDs to All Senior/Key Personnel Changes to the Biographical Sketch and Other Support Format Page for Due Dates on or after May 25, 2021 of Updated AHRQ Policy for Late Application Submission for Active Peer Review or National Advisory Council Service Policy on the Inclusion of Priority Populations in Research Emphasis Notice (SEN): AHRQ Announces Interest in Health Services Research to Limitation on AHRQ FY2021 Grants, Cooperative Agreements, and Contracts Guide Notice on Exception to the Use of the Single IRB Review Requirements During the Coronavirus Disease 2019 (COVID-19) Public Health Emergency Changes to the Biographical Sketch and Other Support Format Page for Due Dates on or after May 25, 2021 NOT-OD-21-095 - Extending the Special Exception to the NIH/AHRQ/NIOSH Post-Submission Material Policy During the COVID-19 Pandemic: January 2022 Council to the HHS Notice of Award (NoA) Beginning October 1, 2020 Agency for Healthcare Research and Quality Data Management Plan Policy NOT-OD-20-077 - Reminder: FORMS-F Grant Application Forms & Instructions Must be Used for Due Dates On or After May 25, 2020 New Grant Application Instructions Now Available Guide Notice on Implementation of the Use of a Single Institutional Review Board (IRB) for Cooperative Research at 45 CFR 46.

114 (b) Announces Change in Grant Recipient Purchasing of Identifiable CMS Data, Multiple Program Director/Principal Investigator Policy Notice of Funding Opportunity (NOFO) Number Companion Funding Opportunity Additional Information on Eligibility .

Assistance Listing Number(s) Funding Opportunity Purpose The primary purpose of the AHRQ Patient-Centered Outcomes Research (PCOR) Mentored Research Scientist Career Development Award (K01) program is to provide support for qualified individuals for an intensive, mentored research career development experience in comparative effectiveness research (CER) methods as applied to patient-centered outcomes research (PCOR).

Open Date (Earliest Submission Date) Letter of Intent Due Date(s) The first standard due date for this NOFO is February 12, 2022. All applications are due by 5:00 PM local time of applicant organization. Applications are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

AIDS Application Due Date(s) Generally, four months after the receipt date. Generally, four months after the merit review. New Date March 13, 2026 per issuance of NOT-HS-25-013 .

(Original Expiration Date: March 13, 2025) It is critical that applicants follow the Career Development (K) Instructions in the SF424 (R&R) Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from the Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV and follow the AHRQ Grants Policy and Guidance found on the AHRQ website at http://www. ahrq. gov/funding/policies/nofoguidance/index.

html . the NOFO-specific instructions deviate from those in the Application Guide, follow the NOFO-specific instructions . Applications that do not comply with these instructions may be delayed or not accepted for review.

Part 1. Overview Information Part 2. Full Text of the Announcement I.

Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV.

Application and Submission Section V. Application Review Information Section VI. Award Administration Information Section VII.

Agency Contacts Section VIII. Other Information Part 2. Full Text of Announcement Section I.

Funding Opportunity The overall goal of the AHRQ Research Career Development program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's health services research needs.

In addition to this opportunity, AHRQ supports other career development programs designed to foster research methodological skills development and progression towards research independence.

More information about AHRQ career development programs may be found at the AHRQ Training The objective of the AHRQ Patient-Centered Outcomes Research (PCOR) Mentored Research Scientist Career Development Award (K01) is to provide salary and research support for a sustained period of protected time (3-5 years) for intensive research career development, under the guidance of an experienced mentor in patient-centered outcomes research.

The expectation is that, through this sustained period of research career development, recipients will launch independent research careers and become competitive for new research project grant (e.g., R01) funding.

PCOR is defined as the conduct and synthesis of research comparing the benefits and harms of different interventions and strategies to prevent, diagnose, treat and monitor health conditions, as well as the delivery of health care in real world settings.

The purpose of this research is to improve health outcomes by developing and disseminating evidence-based information to patients, clinicians, and other decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. The award may be used by candidates with different levels of prior research training and at different stages in their career development.

For example, a candidate with limited experience in health services research may use an award to support a career development experience that includes a designated period of didactic training followed by a period of closely supervised research experience.

A candidate with previous health services research experience and training may not require extensive additional didactic preparation and may use an award to support a career development experience that focuses on an intensive, supervised research experience. The training of research scientists will focus on the generation and translation of new scientific evidence and analytic tools.

In particular, the emphasis is on developing and enhancing the research and methodological capacities for conducting patient-centered outcomes research and for the integration of evidence into practice and decision-making in the healthcare system.

The training program will incorporate the recommendations of the Patient-Centered Outcomes Research Institute (PCORI) Methodology Committee to guide the development of CER methodological skills in candidates, who will then apply these skills to PCOR.

Of central importance will be the inclusion of stakeholders (patients, providers, administrators, policy makers) in the selection of research questions, execution of the research, and dissemination/implementation of research findings. The Patient-Centered Outcomes Research Institute Methodology Committee was established to develop and improve the science and methods of comparative clinical effectiveness research.

The Committee’s recommended methodology standards and subsequent updates can be found at www. pcori. org.

Candidates must focus their research and career enhancement/development plans in one or both of the following areas: 1. The reduction of disparities in healthcare outcomes and quality among racial and ethnic minority populations and underserved equity is an important societal goal. AHRQ intends that research funded by the agency contribute to this goal by addressing equity.

Candidates are encouraged to propose projects addressing any healthcare delivery-related topic with demonstrated health inequities, including but not limited to: Maternal Healthcare Delivery Prevention of Diagnostic Errors Care Delivery for Persons with Multiple Chronic Conditions Digital Healthcare Tools /Methods Integration of SDOH and Social Needs Care within Healthcare Nursing Home Care Delivery Behavior and Mental Healthcare Delivery (including substance Healthcare Policies (including changes in health insurance access, coverage and payment) 2.

Evaluating and comparing healthcare delivery system designs; developing and evaluating system redesigns; or implementing and disseminating effective, evidence-based design practices.

Candidates may focus their research on areas from a wide range of issues within delivery system The organization and management of healthcare delivery (e.g., primary care medical home, the development of accountable care organizations, other forms of bundling care); Strategies for increasing providers compliance with evidence-based guidelines; Transition support for patients with complex healthcare needs, including ways to reduce unnecessary re-hospitalization; Care delivery and coordination for chronic care patients; and Payment and reporting strategies for improving access, quality, and/or the value and administration of health care and its delivery.

Candidates are strongly encouraged to emphasize and address Novel approaches for engaging stakeholder groups (e.g., clinicians, patients, consumers, policymakers, insurers, buyers, and administrators) in the development of research questions, measurement of outcomes, the design of projects, and as appropriate and feasible, participation in the research; Specific Plans for disseminating the findings and incorporating them into healthcare delivery at the onset of developing a research project.

Pursuant to its authorizing legislation, see 42 U.S.C. 299(c), AHRQ conducts and supports research for AHRQ priority populations (see Section IV. 7 for a list of priority populations).

AHRQ is interested in research that includes a focus on priority populations such that meaningful subgroup analysis can be conducted and results can be produced that are stratified by priority population.

Recipients of awards under this NOFO must provide annual and final reports of performance in achieving the NOFO objective to build capacity of early career research scientists in comparative effectiveness research methods, applied to patient-centered outcomes. (see Section VI. 3.

Reporting ). Career Training Objectives Section 937(e) of the Public Health Service Act, 42 U.S.C. 299b-37(e), authorizes AHRQ to build capacity for comparative effectiveness research by establishing grant programs that provide training for researchers in methods used to conduct such research.

[At] a minimum, such training shall be in methods that meet the methodological standards adopted [by As noted above, this NOFO solicits applications which apply CER methods to PCOR. The purpose of this focus is to improve health outcomes by developing and disseminating evidence-based information to patients, clinicians, and other decision-makers, responding to their expressed effective for which patients under specific circumstances.

Research career training objectives and candidates must focus the content on healthcare delivery within the United States.

Each proposed career development plan must: (1) have intrinsic research importance in the area of PCOR; (2) serve as a suitable vehicle for learning the methodology, theories, and concepts needed for a well-trained PCOR researcher; (3) ensure high research productivity; and (4) sufficiently prepare the candidate for PCOR research using CER methodology that is responsive to and involves stakeholders in the development of the research and/or in the dissemination and implementation of research findings.

Research projects conducted must be designed to provide a strong foundation for of CER methodological emphasis could include, but are not limited to: Prospective, longitudinal cohort studies of the effectiveness/comparative effectiveness of healthcare diagnoses, treatment, and services including pharmaceuticals, devices and other types of interventions or combination of interventions; Cluster-randomized, randomized, or practical clinical trials of the effectiveness/comparative effectiveness of new or existing healthcare technologies, involving wide inclusion of patients and health systems that adequately reflect healthcare provision for the general population; Innovative approaches (clinical, methodological, and statistical) in the design as well as analysis of studies that more adequately identify and account for clinical heterogeneity of treatment effects; Integration of quantitative and qualitative analytical frameworks and techniques in the screening, synthesis, appraisal, and dissemination/implementation of evidence; The identification, role, and assessment of observational studies in the systematic review and synthesis of evidence on comparative Meta-analysis and systematic review methodology; Decision science modeling and analysis; The design, analytical tools, and statistical techniques for reducing, confounding and mitigating the impacts of potential bias inherent in the observational studies of comparative effectiveness; The communication of risk and benefit and contextual information that enhances the use of evidence in decision-making, as well as the comparative effectiveness of different approaches and technologies in accomplishing such objective; Implementation science methodology, within a comparative Training in use of registries, combining large-scale longitudinal data sets, and data mining techniques (as applied to comparative effectiveness The ability to conduct subgroup analyses to determine which treatments and interventions work best for specific populations, such as underserved and underrepresented groups with the intent to focus on reduction of components include, but are not limited to: Utilization of a translational framework to provide theoretical underpinnings and organizing structure to help identify appropriate analytical designs and methods most suitable for addressing specific PCOR research As necessary, utilization of any translational tool adopted by PCORI to assist with the dynamic implementation of the translational framework; Engagement of stakeholders (e.g., providers, consumers, community groups, payers, purchasers, policymakers, administrators) in the formulation of their research (in the development of research questions, measurement of outcomes, the design of projects, and as necessary, participation in the research), and to the extent necessary, the implementation and dissemination of Demonstrated ability to collaborate with institutions and networks well-versed in systematic review methodologies or with research centers capable of performing accelerated clinical effectiveness and outcomes research and the translation, dissemination and uptake of evidentiary information for healthcare practice and decision-making; Assessment of the benefits and harms of preventive, diagnostic, therapeutic, palliative, or health delivery system interventions to inform decision making, highlighting comparisons and outcomes that matter to people; Inclusion of an individual’s preferences, autonomy and needs, focusing on outcomes that people notice and care about such as survival, function, symptoms, and health related quality of life.

Special Note: To ensure that applications are responsive to AHRQ priorities as well as NOFO requirements, consultation with AHRQ staff prior to application submission is encouraged. See Section VIII. Other Information for award authorities and regulations.

Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed Applicants may propose to gain experience in a clinical trial led by a mentor/co-mentor as part of their research career development.

Funds Available and Anticipated Number of Awards The number of awards is contingent upon budget appropriations and the submission of a sufficient number of meritorious applications. Future year funding is contingent upon the availability of funds for each year of Award budgets are composed of salary and other program-related expenses, as described below. The total project period may not exceed 5 years.

Other Award Budget Information AHRQ will contribute up to $ 90,000 direct costs per year toward the salary of the career award recipient. Further guidance on budgeting for career development salaries is provided in the SF424 (R&R) The total salary requested must be based on a full-time staff appointment.

The salary must be consistent both with the established salary structure at the institution and with salaries actually provided by the institution from its own funds to other staff members of equivalent qualifications, rank, and responsibilities in the department concerned.

For effort directly committed to the K award, the sponsoring institution may supplement the AHRQ salary contribution up to a level that is consistent with the institution's salary scale. However, supplementation may not be from Federal funds unless specifically authorized by the Federal program from which such funds are derived.

Institutional supplementation of salary must not require extra duties or responsibilities that would interfere with the purpose of the career award.

Fringe benefits will be provided at the institution's federally negotiated fringe benefit rate or, if a federally negotiated fringe benefit rate does not exist, at the actual fringe benefit rate in effect at For effort not directly committed to the K award, the candidate may derive additional compensation for effort associated with other Federal sources or awards provided the total salary derived from all Federal sources does not exceed the maximum legislated salary rate and the total percent effort does not exceed 100%.

Further guidance on budgeting for career development salaries is provided in the SF424 (R&R) Application Guide. See also NOT-OD-17-094 .

Other Program-Related Expenses AHRQ will contribute up to $ 25,000 direct costs per year toward the research development costs of the candidate, which must be justified and consistent with the stage of development of the candidate and the proportion of time to be spent in research or career development activities.

These funds may be used for the following expenses: (a) tuition and fees related to career development; (b) research-related expenses, such as supplies, equipment and technical personnel; (c) travel to research meetings or training; and (d) statistical services including personnel and Salary for mentors, secretarial and administrative assistants, etc. is not allowed.

Indirect Costs (also known as Facilities & Administrative [F&A] Costs) are reimbursed at 8% of modified total direct costs. 42 U.S.C. 299b-37 authorizes AHRQ to make these awards to support the training of researchers in the methods used to conduct comparative clinical effectiveness research.

All applications submitted and AHRQ grants made in response to this NOFO are subject to 45 CFR Part 75 (Uniform Administrative Requirements, Cost Principles and Audit Requirements for HHS Awards; http://www. ecfr. gov/cgi-bin/text-idx?

node=pt45. 1. 75 ), the HHS Grants Policy Statement (see http://www.

ahrq. gov/funding/policies/hhspolicy/index. html ), and the terms and conditions set forth in the Notice Section III.

Eligibility Information Higher Education Institutions Public/ or non-profit private institutions such as a: Community-based organization Unit of local or State government Indian/Native American Tribal Government (Federally recognized) Indian/Native American Tribal Government (Other than Federally Indian/Native American Tribally Designated Organization The following types of Higher Education Institutions are always encouraged to apply for AHRQ support as Public or Private Institutions of Higher Education: Hispanic-serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving AHRQ’s authorizing legislation does not allow for-profit organizations to be eligible to lead applications under this research mechanism.

For-profit organizations may participate in projects as members of consortia or as subcontractors only. Because the purpose of this program is to improve healthcare in the United States, foreign institutions may participate in projects as members of consortia or as subcontractors only. Applications submitted by for-profit organizations or foreign institutions will not be reviewed.

Organizations described in section 501(c) 4 of the Internal Revenue Code that engage in lobbying are not HHS grants policy requires that the grant recipient perform a substantive role in the conduct of the planned project or program activity and not merely serve as a conduit of funds to another party or parties.

If consortium/contractual activities represent a significant portion of the overall project, the applicant must justify why the applicant organization, rather than the party(s) performing this portion of the overall project, should be the grantee and what substantive role the applicant organization will play.

Justification can be provided in the Specific Aims or Research Strategy section of the PHS398 Research Plan Component sections of the SF424 (R&R) application. There is no budget allocation guideline for determining substantial involvement; determination of substantial involvement is based on a review of the primary project activities for which grant support is provided and the organization(s) that will be performing those activities.

Non-domestic (non-U.S.) Entities (Foreign Institutions) are Non-domestic (non-U.S.) components of U.S. Organizations are not eligible Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted.

Registration can take 6 weeks or more, so applicants should begin the registration process as soon as Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number. After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application.

Management (SAM) System for Award Management (SAM) Applicants must complete and maintain an active requires renewal at least annually . The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.

Commercial and Government Entity (NCAGE) Code NATO Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. eRA Commons - Applicants must have an active DUNS number to register in eRA Commons. Organizations can register with the eRA Commons as they are working through their SAM or Grants.

gov registration, but all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Applicants must have an active DUNS number and SAM registration in order to complete the Grants.

gov registration. Please note that a federal-wide transition from the DUN and Bradstreet (D&B) Data Universal Numbering System (DUNS) number to a new government-owned Unique Entity Identifier (UEI) is underway. By April 2022, the federal government will stop using the DUNS number to uniquely identify entities registered in the System for Award Management (SAM) .

SAM will become the central repository for the new UEI that will be incorporated into an institution’s SAM registration. See NOT-OD-21-170 ( https://grants. nih.

gov/grants/guide/notice-files/NOT-OD-21-170. html ) Director/Principal Investigators (PD/PI) The PD/PI must have an eRA Commons account. The PD/PI should work with his/her organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons.

If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks. Please note that for applications with due dates of January 25, 2022, and after, all individuals listed in the SF424 R&R Senior/Key Person Profile (Expanded) Form will be required to have an eRA Commons username (Commons ID).

See NOT-OD-21-109 ( https://grants. nih. gov/grants/guide/notice-files/NOT-OD-21-109.

html ) The PD/PI must be registered with ORCID . The personal profile associated with the PD(s)/PI(s) eRA Commons account must be linked to a valid ORCID ID. For more information on linking an ORCID ID to an eRA Commons personal profile see the ORCID topic in our eRA Commons online help .

Eligible Individuals (Program Director/Principal Any candidate with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director/Principal Investigator (PD/PI) is invited to work with his/her mentor(s) and organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for AHRQ support. Multiple PDs/PIs are not allowed.

By the time of award, the individual must be a citizen or a non-citizen national of the United States or have been lawfully admitted for permanent residence (i.e., possess a currently valid Permanent Resident Card USCIS Form I-551, or other legal verification of such status). Candidates for the K01 award must have a research or health-professional doctoral degree. Such degrees include, but are not limited to, the Ph.

D. , Sc. D.

, Dr.P. H. This funding opportunity may support individuals who propose to train in a new field or individuals who have had a hiatus in their research career because of illness or pressing family circumstances.

Individuals who apply for the PCOR K01 award can also apply or possess an AHRQ or NIH Small Grant (R03) or Exploratory/Developmental Grant (R21) but may not receive salary support from that award if the K01 is Individuals are not eligible if they have simultaneously submitted or have an application which is pending peer review for any Federal or non-Federal research grant, contract, or cooperative agreement on which they are named PD/PI which exceeds $100,000 direct costs per year; or are the proposed subproject leader on Program Projects (P01) or Center Grants (P50) or cooperative agreements.

Lastly, individuals cannot have been or currently be a PD/PI on peer-reviewed Federal or non-Federal research grants, contracts or cooperative agreements over $100,000 direct costs per year; or be or have been a subproject leader on Program Projects (P01) or Center Grants (P50) or Individuals who have been or are currently a PD/PI on any other individual Federal mentored career development awards are not eligible to All candidates for AHRQ individual mentored career development grants are limited to a total of five years of mentored career development support.

If the candidate has been a scholar appointed to any Federally-funded institutional mentored career development program (from mechanisms including, but not limited to, the K12 and KL2), the time appointments on these grants count toward the total five year AHRQ time limitation.

For example, an individual who has been appointed to an AHRQ K12 or NIH KL2 institutional mentored career development grant for three years can request only two years of individual career development support on an AHRQ K01 grant. The minimum allowable time requested for all other applicants to AHRQ s individual mentored career development grants remains at three years per instructions in this announcement.

This NOFO does not require cost sharing. While there is no cost sharing requirement included in this NOFO, AHRQ welcomes applicant institutions, including any collaborating institutions, to devote resources to this effort. An indication of institutional support from the applicant and its collaborators indicates a greater potential of success and sustainability of the project.

Examples of institutional support would include donated equipment and space, institutional funded staff time and effort, or other resource investments. Applicant institutions should indicate institutional support by outlining the specific contributions to the project and providing assurances that their organization and any collaborators are committed to providing these funds and resources to the project.

This information can be included at the end of the budget justification section of the application, but institutional support dollars are not to be shown/included in the detailed budget request.

Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct, and each is from a The AHRQ will not accept duplicate or highly overlapping applications under review at the same time, per 2. 3. 7.

4 Submission of Resubmission Application . An individual may not have two or more competing AHRQ career development applications pending review concurrently.

In addition, AHRQ A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application. An application that has substantial overlap with another application pending appeal of initial peer review (see NOT-OD-18-197 ).

At the time of award, the candidate must have a full-time appointment at the applicant institution. A full-time appointment is generally considered to be 40 hours per week, unless otherwise specified and consistently-applied by the applicant institution. Candidates who have VA appointments may not consider part of the VA effort toward satisfying the full time requirement at the applicant institution.

Candidates with a full-time VA appointment are not eligible to apply. Candidates (with one exception noted below) must be able to commit a minimum of nine person-months (75% of full-time professional effort, or 30 hours per week) annually conducting research career development activities associated with this award for up to five years.

The remaining three months (25% effort) annual effort can be divided among other research, clinical, and teaching activities but only if these activities are consistent with the goals of the Award, i.e., the candidate’s development into an independent investigator. Applicants for the AHRQ individual mentored career development