AI Grants (Open Philanthropy)

AI Grants (Open Philanthropy) is sponsored by Open Philanthropy. Supports a range of AI-related work including building civic infrastructure, expanding AI literacy, advancing AI/ML research, and supporting guardrails against generative AI risks.

We’re a philanthropic funder that partners with leading donors to multiply their impact. Coefficient has directed over $5 billion in grants since 2014. Our mission is to help others as much as we can with the resources available to us.

Accelerating growth and scientific progress Improving health through cleaner air Biosecurity & Pandemic Preparedness Building resilience against biological risk Effective Giving & Careers Empowering people to maximize their impact Improving the lives of farmed animals Improving how critical decisions are made Encouraging generous and cost-effective aid Global Catastrophic Risks Opportunities Countering threats to civilization Supporting growth to reduce global poverty Global Health & Wellbeing Opportunities Improving health and wellbeing for all people Lead Exposure Action Fund Accelerating progress toward a lead-free world Navigating Transformative AI Ensuring AI is safe and well-governed Science and Global Health R&D Supporting lifesaving ideas and discoveries Accelerating development of Strep A vaccines Strategic Cause Selection We believe the most important decision a philanthropist makes is choosing which causes to support.

We conduct in-depth research to identify the areas where our funding can help others the most. Coefficient Giving directed over $1 billion in 2025, the most in our history. This significant milestone is the result of extraordinary dedication from our funders, staff, and grantees, who share the conviction that effective philanthropy can be a powerful lever for making the world a much better place.

Open Philanthropy Is Now Coefficient Giving Our new name marks our next chapter as we double down on our longstanding goal of helping more funders increase their impact. We believe philanthropy can be a far more vital force for progress than it is today. Announcing the Strep A Vaccine Fund Strep A causes over 600,000 deaths per year — a toll comparable to HIV/AIDS and malaria — but attracts a tiny fraction of the research funding.

Today, we're launching the Strep A Vaccine Fund: a multi-donor initiative to accelerate the development of Strep A vaccines. Science and Global Health R&D Using AI to create more effective vaccines Professors David Baker and Neil King use advanced protein modeling software and nanoparticle technology to develop better vaccines.

Their approach has already led to an approved COVID-19 vaccine and more effective flu vaccine that has completed Phase I trials. David Baker won the Nobel Prize in Chemistry in 2024. Effective Giving & Careers Helping people find high-impact careers Four professionals share how our career advising grantees — Probably Good, High Impact Medicine, and High Impact Professionals — helped them find paths to greater impact.

Science and Global Health R&D Transforming tuberculosis testing through a low-cost device Saad Bhamla is a key figure in the frugal innovation movement, which seeks to build cheaper versions of existing scientific tools. His latest innovation, a portable device to test tuberculosis and other diseases, could well be another consequential contribution to global public health.

Eliminating lead paint, one country at a time In dozens of low- and middle-income countries, much of the paint supply contains dangerous amounts of lead. The Lead Exposure Elimination Project is working to end this public health crisis, which has received little attention from the global health community relative to its devastating effects.

Freeing hundreds of millions of chickens from cages The Open Wing Alliance (OWA), a coalition of advocacy groups, has persuaded more than 3,000 food companies worldwide to shift to using cage-free eggs, through a mix of negotiation and public campaigns. Thanks to OWA and other advocates, over 250 million hens have been spared from confinement.