AI in Bioprocessing and Sustainability Research Grants (MilliporeSigma)

Biotech routes for valorisation of residual biomass is sponsored by European Commission — Horizon Europe. Expected Outcome: Successful proposals will contribute to the implementation of the EU initiative on Biotechnology and Biomanufacturing and the EU Life Sciences Strategy as well as the updated EU Bioeconomy Strategy, the Clean Industrial Deal, the European Chemical Industry Action Plan, the upcoming EU Biotechnology and Circular Economy Acts. Projects results are expected to contribute to the following expected outcomes: Increased added value of residual biomass for biorefinery applications. Availability of a wider portfolio of sustainable bio-based products via industrial biotech. Robust, scalable and efficient biotech process(es) applicable to residual biomass. Scope: Diversifying biomass feedstock resources for bio-based products is key to contribute to resilience and strategic autonomy of bio-based operations. Industrial biotechnologies have showcased that they can play a key role to address residual biomass into valuable bio-based products. However, scaling up from research to demo scale requires addressing systemic and technical challenges. This entails the integration of adequate pretreatment and conversion processes, tailored to the targeted residual biomass and its composition variability, in order to achieve high yield, titre and selectivity. At the same time, it requires that these processes are scalable and sustainable. Moreover, effective logistics are needed to mobilise the residual biomass, requiring cooperation with primary producers, waste management operators and other biomass providers. Proposals under this topic should: Demonstrate (at least TRL 6) efficient biotechnology based processes to convert residual biomass streams into bio-based chemicals, intermediates, polymers, materials, ingredients [1] and/or enzymes. The topic focuses on processes in which biotechnology is the key enabling technology; the integration of supporting unit operations based on technologies other than biotechnology is in scope. Optimisation of selected cells, enzymes and/or microorganisms, including microbiomes, is also in scope. The feedstock in scope includes: Forestry and agricultural residues and/or side streams from the processing of forestry and agricultural biomass (including livestock-based ones such as manure and animal byproducts), residues from aquatic biomass, including from fisheries, micro/macro algae production and aquaculture, urban and/or industrial bio-based waste and side-streams (including food industry waste and side-streams, cellulose from post-consumer and post-industrial waste, urban biowaste and sewage sludge, and other bio-based waste/side-streams from industrial operations including wood and pulp and paper industry), mixed streams from the above. Integrate optimised biomass pretreatment/fractionation processes tailored to selected residual biomass and optimise (energy)-efficient separation and/or purification process step(s) across the value chain. The valorisation of by-products and side streams across the value chain via the cascading approach is in scope. Validate (at TRL 5 and above) conversion (or use) of biorefinery product(s) into end-products proving to fulfil market requirements for selected applications sectors. Address resource efficiency and circularity. When pursuing circular models, ensure that neither pathogens nor contaminants are injected back in the loop, to avoid negative effects on human health and the environment. In addition to the specific requirements applicable for the type of action, as described in section 2.2.3.1 of the CBE JU Annual Work Programme 2026 [2] , proposals under this topic should: Under the multi-actor approach (MAA), ensure the sufficient involvement of feedstock producers/managers for residual feedstock supply. Optimise logistic models (including sourcing, storage and transport) of residual feedstock, minimising distances and costs. Ensure seamless integration with biomass providers, while promoting win-win business models. Perform a risk assessment on impacts, p Programme areas: Global Challenges and European Industrial Competitiveness, Food, Bioeconomy Natural Resources, Agriculture and Environment, Bio-based Innovation Systems in the EU Bioeconomy, Horizon Europe (HORIZON) Keywords: Applied and industrial chemistry, Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation, Industrial bioengineering, Industrial biotechnology, bio-based chemicals, bio-based ingredients, bio-based materials, bio-based polymers, bio-based products, bio-conversions, biotechnology, STEP-Biotech

Bio-based additives as alternatives to unlock and increase recyclability and/or biodegradability is sponsored by European Commission — Horizon Europe. Expected Outcome: Successful proposals will contribute to the implementation of the Zero Pollution Action Plan, the Circular Economy Action Plan, the Ecodesign for Sustainable Products Regulation, the Chemicals Strategy for Sustainability and the Chemical Industry Action Plan. They will provide solutions in line with the objectives of the EU legislation on waste but also the Horizon Europe Mission "Restore our Ocean and Waters by 2030" in particular to Objective 2: "Prevent and eliminate pollution of our oceans, Seas and waters” as well as the Horizon Europe Mission “A Soil Deal for Europe”, in particular objectives “Reduce soil pollution and enhance restoration”. Projects results are expected to contribute to the following expected outcomes: Wider availability of bio-based additives targeting high functional properties, stability and compatibility with polymers/matrices. Contribution to improved circularity of end products in relevant market sectors. Potential replicability into other industrial sectors to widen market opportunity. Reduction or avoidance of environmental impacts related to life cycle of additives and additive-containing materials and/or products. Scope: While additives are often necessary to confer specific properties to materials and/or products, their presence can hinder their circular EoL (including – depending on the application – recycling and/or biodegradation). Risks upon recycling and biodegradation encompass the release into the environment of harmful substances, e.g., release of persistent organic pollutants (POPs), volatile organic compounds (VOCs), toxic metals, microplastics. Proposals under this topic should: Demonstrate (at least at TRL 6) innovative processes for the synthesis of bio-based SSbD additives that: Enable a circular EoL for materials and/or products that are currently not recyclable and/or not biodegradable, or Improve circularity of materials and/or products, e.g., by requiring resources/energy efficient and safe conditions for recycling or facilitating biodegradation. In the context of this topic, circular EoL includes recycling and/or biodegradation. Justify the choice of the proposed solution(s) in addressing existing bottlenecks in the circular EoL of targeted materials and/or products including where embedded additives play a fundamental role in hindering circularity. Provide alternative solutions that prevent the release of harmful chemicals during the product life cycle (including from products produced from recyclates) of materials and/or products, while enabling the relevant EoL options. Application of the demonstrated bio-based additives could be relevant for bio-based, partly bio-based or non-bio-based end products. Demonstrate (at least at TRL 6) the compatibility and processability of SSbD bio-based additives within the formulation/manufacturing of materials and/or products. Validate the technical performances of materials/products incorporating the novel bio-based additive(s) and proving to fulfil market requirements for selected application sector(s). Target at least two distinct market sectors in cooperation with end-users. If targeting biodegradability of end-products, assess that the additives, as well as the end-product, biodegrade safely in different environments (soil and water) according to existing EU/International standards, methods and protocols. If targeting recyclability as the EoL, test and validate it, including assessing the effect of the additives on the waste management system (encompassing sorting, separation and recycling). Any recycling route is in scope: mechanical, chemical, organic, enzymatic (including their possible combination). In addition to the specific requirements applicable for the type of action, as described in section 2.2.3.1 of the CBE JU Annual Work Programme 2026 [1] , proposals under this topic should: As part of the multi-actor approach (MAA) approach, involve waste management, product manufacturers, brand owners and consumers Programme areas: Global Challenges and European Industrial Competitiveness, Food, Bioeconomy Natural Resources, Agriculture and Environment, Bio-based Innovation Systems in the EU Bioeconomy, Horizon Europe (HORIZON) Keywords: Applied and industrial chemistry, Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation, Industrial biotechnology, Polymers and plastics, bio-based additives, bio-based materials, bio-based products, bio-degradation, biotechnology, circularity, recycling, safe and sustainable by design, STEP-Biotech

Boosting biorefinery competitiveness through biotech is sponsored by European Commission — Horizon Europe. Expected Outcome: Successful proposals will contribute to the implementation of the EU initiative on Biotechnology and Biomanufacturing, the EU Life Sciences Strategy, the updated EU Bioeconomy Strategy, the EU Biotechnology Act, the Clean Industrial Deal, the European Chemical Industry Action Plan and the upcoming EU Circular Economy Act. Projects results are expected to contribute to the following expected outcomes: Full industrial scale biorefinery and related value chain(s) for the sustainable production of bio-based products using biotech as a key enabling technology. Availability of bio-based products meeting market and technical performance requirements as relevant for their respective application areas. Improvement of sustainability, circularity and resource efficiency compared to relevant benchmark(s). Contribution to increasing the EU’s strategic autonomy, resilience and competitiveness. Scope: Biorefineries integrating biotechnologies, underpinned by sustainably sourced bio-based feedstock, have a huge potential to transform the EU manufacturing landscape, spurring socio-economic growth, fostering job creation and contributing to defossilisation of the EU economy. Europe is strong in life sciences including industrial biotechnology. However, research results often struggle to be deployed to the market; in most cases, scale-up needs de-risking and requires overcoming challenges in large-scale process and reactor design, cell productivity, efficient use of feedstock, operative condition stability, reactor sterility and efficient integration of downstream operations among others. Proposals under this topic should: Demonstrate (at TRL 8) a sustainable and robust biomanufacturing route to obtain bio-based product(s). The proposal should focus on processes in which biotechnology is the key enabling technology; the integration of (upstream and/or downstream) supporting unit operations based on technologies other than biotechnology is in scope. Products in scope include chemicals, intermediates, polymers, ingredients and enzymes. Food and feed ingredients as main application are out of scope. Optimisation of selected cells, enzymes and/or microorganisms is also in scope provided that the starting TRL is at least 6. Demonstrate (at TRL 8) the further conversion or use of the obtained biorefinery product(s) into at least one end-product driving the business case; validate it (TRL 6 and above) in relevant market applications. Additional end-product(s) with high prospective market potential can be targeted, reaching at least TRL 6. In addition to the specific requirements applicable for the type of action, as described in section 2.2.3.1 of the CBE JU Annual Work Programme 2026 [1] , proposals under this topic should: As part of the multi-actor approach (MAA), ensure adequate involvement of all key actors in the value chains relevant for this topic and across the sustainable circular bio-based system, including feedstock providers, policymakers and end users. Address compliance with EU regulatory frameworks as relevant for targeted products and applications, identify potential gaps and provide recommendations to overcome them. Perform a risk assessment on impacts, potentially deriving from the use of biotechnology, on human and ecosystem safety and identify adequate mitigation measures. Assess the adequacy of policy and regulatory means to manage these risks and provide recommendations to overcome potential identified bottlenecks. Include a task to apply the SSbD framework, developed by the European Commission, for the assessment of the production process of targeted biorefinery product(s) as well as the chosen derived end product(s). For more information on the SSbD framework and criteria, refer to Safe and sustainable by design . Seek complementarities and avoid overlaps with past and ongoing R&I projects addressing similar challenges, including those funded by BBI JU/CBE JU and under Horizon 2020/Horizon Europe (under Cl Programme areas: Global Challenges and European Industrial Competitiveness, Food, Bioeconomy Natural Resources, Agriculture and Environment, Bio-based Innovation Systems in the EU Bioeconomy, Horizon Europe (HORIZON) Keywords: Applied and industrial chemistry, Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation, Industrial bioengineering, Industrial biotechnology, bio-based feedstock, bio-based products, bio-conversion, bioreactors, biorefineries, downstream technologies, safe and sustainable by design, STEP-Biotech