American Cancer Society RFA: ACS‑Flatiron Real‑World Data Impact Award

American Cancer Society RFA: ACS-Flatiron Real-World Data Impact Award is a grant from the American Cancer Society that funds cancer research leveraging real-world clinical data to generate evidence with direct impact on cancer patient outcomes. The award supports independent investigators at U.S. academic institutions or nonprofits conducting research that uses real-world oncology data to address critical gaps in cancer care.

Eligible applicants are individual independent investigators at U.S. academic institutions or nonprofits. Awards total $100,000 for one year plus 10 percent indirect costs.

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As the nation's largest private, not-for-profit source of funds for scientists studying cancer, the American Cancer Society (ACS) remains committed to funding basic, translational, clinical, and cancer control research now and in the future - as much as we are able given our available financial resources. The ACS grant process is managed by the Extramural Discovery Science (EDS) team.

Guidance and Information for Applications All applications are submitted and reviewed through ProposalCentral. Applications become available on ProposalCentral about 3 months before the deadline. The links below give you details about focusing your topic, what to include, and how to format your application.

Application Cycles and Deadlines Research Grants for Independent Investigators Applications are available on ProposalCentral approximately 3 months before the deadline. Discovery Boost Grants (DBG) RFA: Arizona Discovery Boost RFA: ACS-Fanconi Discovery Boost Who Can Apply: Independent investigators at any career stage.

Purpose: To fund exploratory research to develop research methodologies, establish feasibility, or pilot test high-risk/high-reward research across the research continuum. RFAs: In addition to the standard DBG, applicants may consider submitting an application in response to an RFA. See the RFA webpage for the scope and intent of the RFA.

Funding: 2 years with $135K a year direct costs, plus 10% allowable indirect costs Deadlines: June 1* and Dec. 1* Mission Boost Grants (MBG) Who Can Apply: Independent investigators at any career stage. Purpose: Enables transition of patient-focused research to accelerate clinical impact Funding, Stage I: 2 years with $135K a year direct costs, plus 10% allowable indirect costs Funding, Stage II: 1.

5 years with $545K total direct costs, plus 10% allowable indirect costs Deadlines: June 1* and Dec. 1* Research Scholar Grants (RSG) What's Updated: Applicant eligibility has changed. The cutoff is now 8 years from initial independent research appointment.

Who Can Apply: Investigators within the first 8 years of an initial independent research career or full-time faculty appointment may submit a new application. Resubmissions from investigators beyond the 8-year cutoff require Program Office approval. Funding: Up to 4 years with $215K a year direct costs, plus 10% allowable indirect costs Deadlines: June 1* and Dec.

1* Applications are available on ProposalCentral approximately 3 months before the deadline. Postdoctoral Fellowships (PF) What's Updated: Applicant eligibility has changed. Who Can Apply: Investigators who are US citizens or non-citizens holding an appropriate visa when the application is submitted and who have completed 3 or fewer years of postdoctoral research training.

Funding: Progressive stipends of $66K, $68K, and $70K for up to 3 years, plus an annual $4K fellowship allowance and $1,500 travel allowance in the final year Application Deadlines: June 1* and Dec.

1* Clinician Scientist Development Grant (CSDG) Who Can Apply: Full-time faculty who have clinical responsibilities, do not lead an independent research program, and want to be mentored and participate in research training to become an independent clinician scientist. Funding: 3 to 5 years with $135K direct costs a year, plus 8% allowable indirect costs Deadlines: June 1* and Dec.

1* The next ASTRO-CSDG deadline is Dec 1 Institutional Block Grants Applications are available on ProposalCentral approximately 3 months before the deadline. Institutional Research Grants (IRG) Who Can Apply: Awarded to institutions as block grants to provide seed money for newly independent investigators to initiate cancer research projects. The principal investigator of the grant should be an associate or full professor.

Funding: New IRGs are for 4 years, up to $120K per year. IRG renewals are for 4 years, up to $100K per year. All IRG applications will be due June 1 each year Requests for Applications (RFA) Who Can Apply: Independent investigators, meeting the ACS Research Scholar Grant (RSG) eligibility requirements.

Purpose: Sustain the research of early-stage investigators with high-scoring, but unfunded research projects recently submitted to either the ACS-RSG or the NCI-R01 grant funding mechanisms. Funding: $150,000 for a 1-year project period; no indirect costs allowed.

Deadline: January 5, 2026 RFA: ACS IMPACT - Expanding Prostate Cancer Clinical Trials in the Community Who Can Apply: Local oncology practices and hospitals with direct patient interaction and the capability to participate in clinical trials.

Purpose: To build the infrastructure needed to increase participation of Black men with prostate cancer in clinical trials through the use of Trial Library and involvement with the Prostate Cancer Clinical Trial Consortium. Funding: $200,000 direct costs per year for 2 years.

LOI Deadline: September 30, 2024* RFA: Biology to Prevention Award This grant is a collaboration between the American Cancer Society (ACS) and Cancer Research UK (CRUK) Who Can Apply: Independent investigators at any career stage. Proposals must include one US PI and one UK PI. Purpose: Supports a team research project that aligns with the CRUK Biology to Prevention funding scheme..

Funding: Projects can be up to 5 years. The US PI can request up to a total of $860,000 direct costs, plus 10% allowable indirect costs for a 5-year project period. US PI budget due to ACS June 11, 2026.

Full application due to CRUK June 18, 2026. Cancer Health Research Centers (CHERCs) Who Can Apply: Independent investigators at eligible US academic institutions or nonprofits. Applicants from underrepresented groups and Minority-Serving Institutions (MSIs) are encouraged to apply.

Funding: 4-year award with $1. 65M ($1. 5M direct cost plus 10% indirect cost).

Awards are renewable; see RFA for more information. Letter of Intent: Required for new applications Application deadlines: June 1 and December 1 Watch the informational webinar RFA: EDS Accelerator Award Who Can Apply: Independent investigators at any career stage. Purpose: Support the commercialization of an ongoing cancer research project and to validate and de-risk technologies.

Funding: $75,000 direct costs for a 1 year project period. No indirect costs allowed. Application Deadline: Rolling starting in March 2024 RFA: Leukemia Exploration and Prevention Grant Program (LEAP) Who Can Apply: Independent investigators at all career ranks Purpose: To enable the discovery of cancer interception or prevention therapies for RUNX1- FPD hematologic malignancies.

Funding: Awards are for up to 4 years. $215,000 per year direct costs plus 10% IDC for RSG award; $430,000 per year direct costs plus 10% IDC for Team award. Application Deadline: Anticipated June 1, 2026* RFA: ACS - Flatiron Real-World Data Impact Award (RWIA) Who Can Apply: Independent investigators at eligible US academic institutions or nonprofits.

Purpose: Advance the use of real-world evidence (RWE) to address clinically relevant questions. Funding: $100,000 direct costs for a 1-year award period plus 10% indirect costs.

Pre-LOI Deadline: April 1, 2026 LOI Deadline: April 15, 2026 Application Deadline: July 1, 2026 Spring 2025 TheoryLab Collaborative (TLC) Grant Announcement Who Can Apply: Members of the ACS research ecosystem (grantees, intramural scientists) who are independent investigators at any career stage.

Purpose: Initiate new, interdisciplinary collaborations within the ACS research ecosystem Funding: $61,200 total for a 1-year project, no indirect costs Application Deadline: June 2, 2025 Applications are available on ProposalCentral approximately 3 months before the deadline. Curious About ACS Professor Awardees? See the list of all current and previous ACS Professors .

Who Can Apply: Applicants must have obtained the rank of full professor for more than 5 years and no more than 20 years. Funding: $80,000 direct costs per year for 5-years; renewable Letter of Intent (LOI) Deadline: Between June 1 and September 1 for new Professor submissions only.

Application Deadline: December 1* for new and renewal applications * If the grant application deadline falls on a weekend or holiday, applications will be accepted the following business day. Have Questions About Research Grants? Application & Peer Review Process All you need to know, from how to select a grant to when you'll get an award announcement.

Find answers you need. Can I make a case for eligibility? Are there tips about resubmitting?

See All ACS Grant Mechanisms Easy-to-scan info about eligibility, funding, and more. Link to any funding opportunity for details. Extramural Grants Department (EDS) Contacts See your EDS Research Program contacts to get your questions answered.

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