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STREAM - Systems for Tracking and Resilience in Efficient Agricultural-input Management - is an ARPA-H program sitting at the intersection of agriculture, environmental monitoring, and human health. It funds the discovery of safer herbicide alternatives, the tracking of how herbicides spread through soil and water, and methods to remove or degrade herbicide residues from the environment.
Artificial intelligence and machine learning are central to the discovery half of the program: ARPA-H is explicitly seeking AI/ML approaches to identify novel chemical compounds, biologically derived herbicides, and advanced biological treatments that target weeds while minimising ecosystem impact - a generative and predictive chemistry problem closely analogous to AI-driven drug discovery, applied to agricultural inputs rather than therapeutics.
The health framing matters for positioning a proposal: ARPA-H's interest is in the downstream human health consequences of agricultural chemical exposure, so proposals need to connect the agricultural or environmental technology to a health outcome rather than to yield or cost alone.
STREAM is solicited through the Scalable Solutions Office Innovative Solutions Opening, ARPA-H-SOL-24-105, on a rolling basis: applicants submit a Solution Summary first and receive feedback before full proposals are invited. The stated deadline is 14 September 2026 at 11:59pm ET.
Award amounts are not fixed and are negotiated as Other Transaction agreements; the range given here is indicative of ARPA-H mission office awards generally, not a published STREAM ceiling.
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Or search similar grants →According to the current listing, eligibility includes: ARPA-H mission office Innovative Solutions Openings are generally open to a broad range of applicants including universities, nonprofit research organizations, for-profit companies of any size, national laboratories, and teams combining these. Specific eligibility terms are set out in the full solicitation on SAM.gov under ARPA-H-SOL-24-105 (Scalable Solutions Office). The process is two-step and rolling: submit a Solution Summary first, receive ARPA-H feedback, and submit a full proposal only if invited. Proposals should connect agricultural-input technology to human health outcomes, consistent with ARPA-H's mission scope. The stated deadline is 14 September 2026 at 11:59pm ET. Confirm the full requirements in the official notice before applying.
The current listing shows ARPA-H does not publish a fixed award ceiling for STREAM; awards are made as Other Transaction agreements through the Scalable Solutions Office Innovative Solutions Opening (ARPA-H-SOL-24-105) and are scoped to the proposed work. ARPA-H program awards under mission office ISOs have historically ranged from roughly $2,000,000 to $50,000,000 depending on scope and phase. Applicants should confirm budget expectations in the solicitation on SAM.gov before proposing. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for ARPA-H STREAM Systems for Tracking and Resilience in Efficient Agricultural-input Management for AI-Driven Herbicide Discovery and Environmental Monitoring are due September 14, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
ARPA-H STREAM Systems for Tracking and Resilience in Efficient Agricultural-input Management for AI-Driven Herbicide Discovery and Environmental Monitoring is funded by Advanced Research Projects Agency for Health (ARPA-H), Scalable Solutions Office. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
The FY2026 Department of Defense Multidisciplinary University Research Initiative (MURI) program supports basic research in science and engineering at U.S. institutions of higher education, with emphasis on multidisciplinary research where more than one traditional discipline interacts. The Army, Navy, and Air Force basic research offices are seeking applications across 22 topic areas including artificial intelligence and autonomy, information sensing and processing, and systems manipulation. MURI grants typically provide $1.25 million to $1.5 million per year for three years with option to extend two additional years. Approximately $170 million in total funding is available annually across all topics. The program is administered through the Office of Naval Research (ONR), Army Research Office (ARO), and Air Force Office of Scientific Research (AFOSR).
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