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Basic Biomedical and Translational Science Discovery: Early-Stage Investigator (ESI) Pilot Awards is sponsored by California HIV/AIDS Research Program (CHRP). This initiative seeks to fund HIV-related basic biomedical and translational pilot studies proposed by early career stage investigators, ultimately working toward the discovery and development of new tools to better prevent, treat, and cure HIV.
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About | Contact | Support Us Basic Biomedical Sciences Research For Early Stage Investigators (ESI) Community-Centered Research Collaboratives to Address Local HIV-Related Syndemics Across California Economic Justice for HIV Care Long Acting Injectable PrEP Implementation Low Barrier Technology Interventions Measuring the Impact of Racism on HIV Social and Behavioral Intervention Pilots Mentored Training Supplements For previously funded projects, search the RGPO Funded Research Database Since 1983, CHRP has invested over $418 million to support investigator-initiated HIV research projects, to train early-career scientists, and to establish collaboratives which coordinate and implement HIV research across California.
Economic Justice Interventions to Address HIV and HIV Syndemic Factors in California (2025): CHRP awarded approximately $2,000,000 to three investigators testing the impact of interventions that support economic security on HIV outcomes.
The studies will each focus on distinct, marginalized groups of people living with HIV including those who have experience with the criminal justice system, transgender women, and people who are experiencing homelessness.
Low Barrier Technology Interventions for HIV Prevention and Care (2025): CHRP invested over $1,000,000 in eleven innovative projects that will explore the feasibility of developing and/or implementing technology-based interventions to improve equitable access to HIV prevention and care.
The studies will reach highly marginalized populations and health care deserts in Riverside, San Diego, Orange, Humboldt, Lake and Mendocino Counties and beyond with interventions including public health vending machines, mobile health and improved service delivery using novel approaches including artificial intelligence, and large language modeling.
HIV Policy Research Centers (2025): CHRP invested over $2,000,000 to support the continued work of the California HIV Policy Research Centers. This will allow dedicated time for the Policy Research Centers to focus on analysis and dissemination of work that connects outcomes to California policy changes that support Californians living with or impacted by HIV.
In addition, a portion of this award will be dedicated to support capacity building to strengthen the skills and expertise within community organizations to conduct policy research.
Measuring the Impact of Racism on the HIV Epidemic in California (2024) : CHRP awarded more than $900,000 to three investigators who will develop methods of measuring the impact of racism on HIV-STI related outcomes among communities in California that are highly impacted by HIV.
The three studies will each focus on sexual and gender minority (SGM) persons of color; each of the study teams have lived experience in the communities they will work in; and one awardee is an early career stage investigator.
Community-Centered Demonstration Projects to Support Implementation of Long-Acting Injectable PrEP Adoption Across California (2024) : CHRP has invested more than $9,000,000 in five outstanding projects that will each increase equity in provision of LAI PrEP across California.
They will reach many distinct California geographies and priority populations, such as Fresno, Riverside and Kern Counties, persons with substance use disorders, and cis- and transgender women receiving syphilis treatment; and will employ non-traditional service delivery models including community pharmacists as PrEP providers.
The “learning collaborative” model, community-based recruitment techniques, and acting upon policy research conducted by CHRP’s HIV Policy Research Centers are centerpieces of many of the new projects.
Social and Behavioral Intervention Pilot Studies to Support HIV Prevention and Care (2024) : Methamphetamine use is a key driver of the HIV epidemic, with one in three HIV seroconversions among sexual and gender minority individuals reporting persistent use.
CHRP is proud to sponsor an open-label pilot clinical trial to evaluate the feasibility, safety, and preliminary efficacy of ketamine-assisted psychotherapy to treat methamphetamineuse disorders among persons seeking treatment, and treatment and examining it’s impact on HIV-transmission risk behaviors. The PI is an early career stage investigator.
Basic Biomedical and Translational Science Discovery Initiative (2024) : Applications for these biannual awards were newly restricted to early career stage investigators (ESI) with named mentors, and the quality of the applications received was exceptionally high.
CHRP is investing $1,900,000 in seven ESIs who will forge new paths toward an HIV cure and improved HIV treatment via epigenetic modulation, chimeric antigen receptor engineering, probing new compartments of the HIV reservoir, and the interaction of HIV RNA with human DNA. Many will utilize emerging single-cell sequencing technologies, and three will leverage the Last Gift cohort, a unique California resource.
Community-Centered Research Collaboratives (2023): CHRP funded five community-centered collaborative research teams who will work to identify HIV-related syndemic outcomes that are important to that community, jointly create a research agenda to improve those outcomes, implement research projects to serve that agenda, and disseminate research results with and for that community.
Basic Biomedical Discovery Initiative (2022) : We awarded seven grants to fund early-stage laboratory exploration aimed at understanding mechanisms of HIV prevention, treatment, or cure at the cellular or subcellular level. Learn more about these projects by clicking here ( Basic Biomedical Sciences Research Awards ).
Implementation Science (2021) : CHRP awarded four grants to support HIV implementation science that have the potential to be scalable for sustained impact on the HIV epidemic in California. Policy Research Centers (2021) : We awarded three grants to fund statewide HIV Policy Research Centers.
These multi-disciplinary, academic teams work in partnership with providers, consumers, advocates, and policymakers to conduct timely and impactful HIV policy research. The Centers are working to strengthen local, state and national capacity to enact HIV-relevant policies informed by objective and rigorous research.
According to the current listing, eligibility includes: Early-career stage investigators in California. Confirm the full requirements in the official notice before applying.
Basic Biomedical and Translational Science Discovery: Early-Stage Investigator (ESI) Pilot Awards is funded by California HIV/AIDS Research Program (CHRP). Verify program details on the funder's official page before applying.
This opportunity targets applicants in California. If your organization operates elsewhere, check the official notice for location requirements.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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