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Bill and Melinda Gates Foundation Grand Challenges Investigations is a grant from the Bill and Melinda Gates Foundation that funds high-impact, exploratory research addressing critical global health and development challenges. Grand Challenges grants support bold, innovative ideas in areas such as global health, agricultural development, inclusive financial systems, and water and sanitation.
The foundation works with partners in over 130 countries and focuses on reducing poverty, disease, and inequity worldwide. Awards range from $100,000 to $1,000,000. Eligibility is open to U.S. 501(c)(3) organizations and other qualifying nonprofits, as well as universities and research institutions globally.
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Learn about our origins, how we work, committed grants, careers, and our role in fighting inequities. * Diversity, equity, and inclusion 2026 Gates Foundation Annual Letter: The road to 2045 With 20 years to go, Gates Foundation CEO Mark Suzman lays out a roadmap for progress. Learn how our seven divisions collaborate with partners in over 130 countries to address the issues we care about and drive change.
* Agricultural Development * Inclusive Financial Systems * Water, Sanitation & Hygiene Read the latest stories, research, interviews, and news from across the Gates Foundation. * Partners of Human Potential * Maternal and child health Partners of Human Potential Learn more about the stories of our amazing partners and their game-changing work.
* Our commitment to grantees * Our commitment to grantees The foundation awards the majority of its grants to U.S. 501(c)(3) organizations and other tax-exempt organizations identified by our staff. (Tax status definitions) (Glossary of terms) **Request for proposals (RFP):** * Grand Challenges grant opportunities Our commitment to grantees We are a nonprofit fighting poverty, disease, and inequity around the world. [](https://twitter.
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According to the current listing, eligibility includes: Universities and research institutions globally. Confirm the full requirements in the official notice before applying.
The current listing shows $100,000 - $1,000,000. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Bill & Melinda Gates Foundation Grand Challenges Investigations is funded by Bill & Melinda Gates Foundation. Verify program details on the funder's official page before applying.
This listing is flagged as international in scope. Check the official notice for country-specific restrictions before applying.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
MacKenzie Scott's Yield Giving has moved more than $26 billion — including roughly $7 billion in 2025, over a third of all U.S. megagifts — through unrestricted, trust-based grants with no application. Melinda French Gates's Pivotal Ventures has committed $2 billion to women's health and economic power. The Bezos philanthropies have moved billions more. As the Buffett–Gates era winds down, this new class of megadonor is rewriting the rules of major giving. Here is what changes for nonprofits, and how to become the kind of organization this money finds.
Read articleThe Gates Foundation committed at least $1 billion over two years to equitable AI alongside its 10th Goalkeepers Report — 40% education, 40% health, 10% agriculture, 10% digital infrastructure. Five days later, 60 organizations signed a five-year goal to reach 3.4 billion speakers of underrepresented languages. Here is how implementing nonprofits should read both.
Read articleGates committed $540.2 million over a decade to the Institute for Health Metrics and Evaluation — the largest gift in University of Washington history — while IHME's federal grant income falls from $7.3 million to a projected $4.8 million. The gift is a case study in the anchor-funder model: what it can do that federal money cannot, and the concentration risk it quietly underwrites.
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