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Biological Technologies BAA -- HR001126S0003 is sponsored by Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO). This Broad Agency Announcement seeks transformative research leveraging biological properties and processes to enhance warfighter protection and performance.
It is particularly interested in groundbreaking applications of artificial intelligence (AI), machine learning (ML), biotechnology, and bio-inspired engineering that can fundamentally improve military readiness and response capabilities.
Specific areas of interest include AI and ML for Biology (accelerating biological simulations, developing biological foundation models, and building AI-enabled decision-making tools) and Human Performance (advances in cognition, fatigue mitigation, neural processing, and resilience under extreme stress).
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DARPA - Biological Technologies Office Document Type:Grants Notice Funding Opportunity Number:HR001126S0003 Funding Opportunity Title:Biological Technologies Opportunity Category:Discretionary Opportunity Category Explanation: Funding Instrument Type:Cooperative Agreement Other Procurement Contract Category of Funding Activity:Science and Technology and other Research and Development Expected Number of Awards: Assistance Listings:12.
910 -- Research and Technology Development Cost Sharing or Matching Requirement:No Last Updated Date:Oct 01, 2025 Original Closing Date for Applications:Sep 30, 2026 See Full Announcement for details. Current Closing Date for Applications:Sep 30, 2026 See Full Announcement for details.
Archive Date:Oct 30, 2026 Estimated Total Program Funding: Eligible Applicants:Others (see text field entitled "Additional Information on Eligibility" for clarification) Additional Information on Eligibility:All responsible sources capable of satisfying the Government's needs may submit a proposal that shall be considered by DARPA. See the Eligibility Information section of the BAA for more information.
## Additional Information Agency Name:DARPA - Biological Technologies Office Description:The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) is soliciting proposals that leverage biological properties and processes to revolutionize our ability to protect the nation’s warfighters. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.
Link to Additional Information:SAM. gov Contract Opportunities Grantor Contact Information:If you have difficulty accessing the full announcement electronically, please contact: ## Similar Opportunities (identified by AI)
According to the current listing, eligibility includes: All responsible sources capable of satisfying the Government's needs may submit a proposal. Historically Black Colleges and Universities, Small Businesses, Small Disadvantaged Businesses and Minority Institutions are encouraged to submit proposals. Confirm the full requirements in the official notice before applying.
Biological Technologies BAA -- HR001126S0003 is funded by Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
On June 3, 2026, four DARPA Biological Technologies Office SBIR topics close simultaneously — SWiFT, BARK, EXPOSITION, and Medical Swarm Robotics. Combined Phase I plus Phase II potential exceeds $6 million per company, and together they sketch a coherent strategy of distributed, autonomous, dual-species combat casualty care that depends on small businesses, not primes, to actually build.
Read articleDARPA pre-released Release 6 of its FY26 SBIR BAA on September 2, 2026. Five of the seven SBIR topics belong to the Biological Technologies Office, and four of those describe one continuous problem: keeping a casualty alive with no surgeon, no imaging, and no evacuation. Here are the award sizes, the Direct-to-Phase-II gates, and the sequencing DARPA is buying.
Read articleDARPA BTO pre-released four FY26 SBIR/STTR topics on April 30, 2026, with proposals due June 3. Two topics — SWiFT and EXPOSITION — offer Direct-to-Phase-II awards up to $1.5M, bypassing the standard Phase I gate. Here is what each topic is actually solving, why the DP2 structure matters, and how small biotech, surgical robotics, and battlefield-medicine teams should decide whether to compete.
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