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Biological Technologies Broad Agency Announcement (HR001126S0003) is sponsored by Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO). DARPA BTO is soliciting proposals that leverage biological properties and processes to revolutionize the ability to protect the nation's warfighters.
This includes harnessing advances in artificial intelligence (AI) and machine learning (ML) to create new opportunities for transformative science across the biological spectrum.
Specific interests include discovering interventions that utilize biotechnology, biochemistry, molecular biology, microbiology, neuroscience, psychology, cognitive science, social and behavioral science, and related disciplines to assess and optimize human performance and teaming.
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DARPA - Biological Technologies Office Document Type:Grants Notice Funding Opportunity Number:HR001126S0003 Funding Opportunity Title:Biological Technologies Opportunity Category:Discretionary Opportunity Category Explanation: Funding Instrument Type:Cooperative Agreement Other Procurement Contract Category of Funding Activity:Science and Technology and other Research and Development Expected Number of Awards: Assistance Listings:12.
910 -- Research and Technology Development Cost Sharing or Matching Requirement:No Last Updated Date:Oct 01, 2025 Original Closing Date for Applications:Sep 30, 2026 See Full Announcement for details. Current Closing Date for Applications:Sep 30, 2026 See Full Announcement for details.
Archive Date:Oct 30, 2026 Estimated Total Program Funding: Eligible Applicants:Others (see text field entitled "Additional Information on Eligibility" for clarification) Additional Information on Eligibility:All responsible sources capable of satisfying the Government's needs may submit a proposal that shall be considered by DARPA. See the Eligibility Information section of the BAA for more information.
## Additional Information Agency Name:DARPA - Biological Technologies Office Description:The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) is soliciting proposals that leverage biological properties and processes to revolutionize our ability to protect the nation’s warfighters. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.
Link to Additional Information:SAM. gov Contract Opportunities Grantor Contact Information:If you have difficulty accessing the full announcement electronically, please contact: ## Similar Opportunities (identified by AI)
According to the current listing, eligibility includes: Universities, industry, and government laboratories. Confirm the full requirements in the official notice before applying.
Applications for Biological Technologies Broad Agency Announcement (HR001126S0003) are due September 30, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Biological Technologies Broad Agency Announcement (HR001126S0003) is funded by Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO). Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
On June 3, 2026, four DARPA Biological Technologies Office SBIR topics close simultaneously — SWiFT, BARK, EXPOSITION, and Medical Swarm Robotics. Combined Phase I plus Phase II potential exceeds $6 million per company, and together they sketch a coherent strategy of distributed, autonomous, dual-species combat casualty care that depends on small businesses, not primes, to actually build.
Read articleDARPA pre-released Release 6 of its FY26 SBIR BAA on September 2, 2026. Five of the seven SBIR topics belong to the Biological Technologies Office, and four of those describe one continuous problem: keeping a casualty alive with no surgeon, no imaging, and no evacuation. Here are the award sizes, the Direct-to-Phase-II gates, and the sequencing DARPA is buying.
Read articleDARPA BTO pre-released four FY26 SBIR/STTR topics on April 30, 2026, with proposals due June 3. Two topics — SWiFT and EXPOSITION — offer Direct-to-Phase-II awards up to $1.5M, bypassing the standard Phase I gate. Here is what each topic is actually solving, why the DP2 structure matters, and how small biotech, surgical robotics, and battlefield-medicine teams should decide whether to compete.
Read article