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Biological Technologies is sponsored by Defense Advanced Research Projects Agency (DARPA), Biological Technologies Office (BTO). Supports revolutionary research leveraging biological properties/processes to advance national security and protect warfighters; excludes incremental improvements.
Key focus areas include advanced machine learning and AI for biological data and systems, combat casualty care, human performance optimization, bio-inspired materials, sensors, manufacturing, agricultural, ecological, and environmental security, biosafety, biosecurity, next-generation surveillance, and biomedical and biodefense technologies.
Foreign companies may be eligible as DARPA aims for international collaboration for national security.
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gov Maintenance Calendar View similar opportunities DARPA - Biological Technologies Office Document Type:Grants Notice Funding Opportunity Number:HR001126S0003 Funding Opportunity Title:Biological Technologies Opportunity Category:Discretionary Opportunity Category Explanation: Funding Instrument Type:Cooperative Agreement Other Procurement Contract Category of Funding Activity:Science and Technology and other Research and Development Expected Number of Awards: Assistance Listings:12.
910 -- Research and Technology Development Cost Sharing or Matching Requirement:No Last Updated Date:Oct 01, 2025 Original Closing Date for Applications:Sep 30, 2026 See Full Announcement for details. Current Closing Date for Applications:Sep 30, 2026 See Full Announcement for details.
Archive Date:Oct 30, 2026 Estimated Total Program Funding: Eligible Applicants:Others (see text field entitled "Additional Information on Eligibility" for clarification) Additional Information on Eligibility:All responsible sources capable of satisfying the Government's needs may submit a proposal that shall be considered by DARPA. See the Eligibility Information section of the BAA for more information.
## Additional Information Agency Name:DARPA - Biological Technologies Office Description:The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) is soliciting proposals that leverage biological properties and processes to revolutionize our ability to protect the nation’s warfighters. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.
Link to Additional Information:SAM. gov Contract Opportunities Grantor Contact Information:If you have difficulty accessing the full announcement electronically, please contact: [](mailto:BTOBAA2026@darpa. mil) ## Similar Opportunities (identified by AI) NOAA-OAR-CPO-2012-2003041 #### Health & Human Services * Frequently Asked Questions ## Your session will expire in 3 minutes.
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According to the current listing, eligibility includes: Open to a wide range of organizations, including foreign entities, as long as the research aligns with national security interests. Abstract submission and DARPA invitation are required before full proposal submission. Confirm the full requirements in the official notice before applying.
Applications for Biological Technologies are due September 30, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Biological Technologies is funded by Defense Advanced Research Projects Agency (DARPA), Biological Technologies Office (BTO). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
DARPA's Biological Technologies Office (BTO) Office-Wide Broad Agency Announcement (HR001126S003) seeks abstracts and proposals that leverage biological properties and processes to revolutionize the ability to protect warfighters, with an explicit emphasis on applying artificial intelligence and machine learning across biological science. Priority research areas include machine learning and AI applications, combat casualty care, human performance optimization, materials/sensors/processing, agricultural and environmental solutions, security and surveillance, and biomedical and biodefense initiatives. Abstracts are accepted on a rolling basis until September 30, 2026.
DARPA's Biological Technologies Office (BTO) office-wide Broad Agency Announcement (BAA HR001126S0003) funds research that leverages artificial intelligence and machine learning to advance the biological sciences for national security. Priority interest areas include warfighter health, biodefense, diagnostic systems for chemical and biological threat detection, medical countermeasures, materials and sensors, agricultural and environmental applications, security and surveillance, and novel approaches to tactical care and performance recovery. Abstracts are accepted on a rolling basis through September 30, 2026, with award sizes varying by the scope of the proposed effort.
On June 3, 2026, four DARPA Biological Technologies Office SBIR topics close simultaneously — SWiFT, BARK, EXPOSITION, and Medical Swarm Robotics. Combined Phase I plus Phase II potential exceeds $6 million per company, and together they sketch a coherent strategy of distributed, autonomous, dual-species combat casualty care that depends on small businesses, not primes, to actually build.
Read articleDARPA pre-released Release 6 of its FY26 SBIR BAA on September 2, 2026. Five of the seven SBIR topics belong to the Biological Technologies Office, and four of those describe one continuous problem: keeping a casualty alive with no surgeon, no imaging, and no evacuation. Here are the award sizes, the Direct-to-Phase-II gates, and the sequencing DARPA is buying.
Read articleDARPA BTO pre-released four FY26 SBIR/STTR topics on April 30, 2026, with proposals due June 3. Two topics — SWiFT and EXPOSITION — offer Direct-to-Phase-II awards up to $1.5M, bypassing the standard Phase I gate. Here is what each topic is actually solving, why the DP2 structure matters, and how small biotech, surgical robotics, and battlefield-medicine teams should decide whether to compete.
Read article