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Find similar grantsBiological Technologies Office (BTO) AI BTO Solicitation is sponsored by Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO). This solicitation seeks proposals for technologies at the intersection of artificial intelligence and biotechnology to catalyze future research projects.
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Department of War organization. Biological Technologies Office The Biological Technologies Office (BTO) leverages biological properties and processes to revolutionize our ability to protect the nation’s warfighters. BTO harnesses advances in artificial intelligence (AI) and machine learning (ML) to create new opportunities for transformative science across the biological spectrum.
Warfighter health and well-being are critical to mission success. BTO develops diagnostic and assessment systems to identify chemical and biological threats, medical countermeasures, and novel approaches to tactical care and warfighter performance and recovery on and off the battlefield.
BTO also leverages biological processes, technologies, and manufacturing opportunities to create resilient infrastructures and supply chains, protective solutions, and innovative sensors to ensure mission success in any location.
We develop foundational technologies to simulate and predict biological systems and outcomes (simulation, foundation models, data generation): Generate: Vastly improving the quality and quantity of biological data while reducing costs; increasing speed and automation of cloud labs. Understand: Exploring the state of the art and enlisting stakeholders to construct necessary research portfolio.
Simulate: Enabling sequence to function and function to sequence that underpins whole cell modeling and cell-cell interactions. We explore solutions for warfighter readiness, health, and recovery, including medical countermeasures, diagnostics, health IT, and medical devices: Optimize: Ensuring peak warfighter performance, both physical and cognitive, throughout all phases of a mission.
Prevent: Protecting warfighters from any threat and advancing capabilities on the battlefield for immediate injury treatment. Restore: Creating biotechnological approaches to provide tactical care and restore function to injured warfighters.
We develop solutions to support mission success, including, for example, fibers for garments and distributed forward manufacturing: Do: Creating solutions that increase operational resilience and logistic security. Make: Utilizing the advantages of biology to enable point-of-need production or strengthen existing supply chain for critical commodities.
Strengthen: Providing technologies that harden operations against disruption and expand capabilities in the field. Innovation in Biotechnology RSS feed for Opportunities Transforming battlefield casualty care: Critical steps of tactical combat casualty care that bridge the gap between injury on the battlefield and arrival at surgical care.
| Learn more DARPA Triage Challenge: Transforming how medical responders triage in mass casualty incidents. | Learn more BTO leadership is responsible for guiding and overseeing the research and development activities within specific technical areas. Opportunities to engage include R&D programs and efforts, challenge competitions, and technology transition efforts for the Biological Technologies Office.
| See all DARPA Opportunities | RSS feed for Opportunities Use these filters to narrow your results by research topic or date. Search by keyword to find your specific BTO opportunity. Pushing Technology's Limits Our BTO research programs are finite in duration, but the revolutionary advancements they drive create lasting change.
Learn more about recent and ongoing efforts across our key thrust areas. | See all DARPA programs Use these filters to narrow your results by research topic or status. Search by keyword to find your specific BTO program.
Brightest Minds in Science and Engineering Our BTO program managers are visionary leaders whose experience spans industry, government, and academia. They conceive, plan, and oversee the high-risk R&D efforts for which we are best known. | See all DARPA program managers Use these filters to narrow your results by research topic or date.
Search by keyword to find a specific BTO program manager or their research interests. Translate your bio-attribution research into national security impact Register for the DARPA Bio-Attribution Challenge to win a share of $180,000 in prizes. Upgrading biomass waste into strategic materials The Fleetwood program aims to produce critical chemicals from widely available domestic resources.
DART and MSAI triumph at DARPA Triage Challenge In Challenge Event 2, teams drive mass casualty tool advancements, facilitate robot-medic teaming demonstrations.
According to the current listing, eligibility includes: All responsible sources capable of satisfying the Government's needs may submit a proposal. Confirm the full requirements in the official notice before applying.
The current listing shows not specified (past Pitch Day awards ranged from $100,000 to $300,000 with a total of $4.5 million available). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for Biological Technologies Office (BTO) AI BTO Solicitation are due September 30, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Biological Technologies Office (BTO) AI BTO Solicitation is funded by Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO). Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
On June 3, 2026, four DARPA Biological Technologies Office SBIR topics close simultaneously — SWiFT, BARK, EXPOSITION, and Medical Swarm Robotics. Combined Phase I plus Phase II potential exceeds $6 million per company, and together they sketch a coherent strategy of distributed, autonomous, dual-species combat casualty care that depends on small businesses, not primes, to actually build.
Read articleDARPA pre-released Release 6 of its FY26 SBIR BAA on September 2, 2026. Five of the seven SBIR topics belong to the Biological Technologies Office, and four of those describe one continuous problem: keeping a casualty alive with no surgeon, no imaging, and no evacuation. Here are the award sizes, the Direct-to-Phase-II gates, and the sequencing DARPA is buying.
Read articleDARPA BTO pre-released four FY26 SBIR/STTR topics on April 30, 2026, with proposals due June 3. Two topics — SWiFT and EXPOSITION — offer Direct-to-Phase-II awards up to $1.5M, bypassing the standard Phase I gate. Here is what each topic is actually solving, why the DP2 structure matters, and how small biotech, surgical robotics, and battlefield-medicine teams should decide whether to compete.
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