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Find similar grantsBiomedical Technology Optimization and Dissemination (BTOD) Centers is sponsored by National Institute of General Medical Sciences (NIGMS), NIH. This program provides resources for late-stage technology development with driving biomedical projects and community engagement. It replaces the Biomedical Technology Research Resource (P41) program.
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Biomedical Technology Optimization and Dissemination (BTOD) Centers (RM1) | National Institute of General Medical Sciences The NIGMS Biomedical Technology Optimization and Dissemination (BTOD) Program has two goals: Optimize state-of-the-art, NIGMS mission-relevant , late-stage technologies Broadly disseminate these technologies for biomedical research use by both experts and non-experts NIGMS encourages investigators to propose BTOD Centers that focus on technology research areas within the NIGMS mission.
Technologies of interest include but are not limited to analytical biochemistry, chemical biology, computational methods, high throughput biochemistry methods, molecular modeling, modeling of biological systems, data science, spectroscopy, microscopy, imaging, structural biology, molecular biology, and cell manipulation.
The BTOD Notice of Funding Opportunity (NOFO), an update of the Biomedical Technology Development and Dissemination (BTDD) program, is PAR-23-110 . Potential applicants are strongly advised to contact NIGMS staff at least 10 weeks prior to the application due date to discuss the suitability of a proposed project for the program.
Projects requiring significant technology development fall outside this program's scope, but may be appropriate for NIGMS Technology Development Program (R21 or R01) . Prospective applicants with mature technologies ready to serve as a user resource may consider applying for the NIGMS National and Regional Resources (R24) or the NIGMS Mature Synchrotron Resources (P30) .
RPPR Guidance for Funded Centers Carolina Salvador Morales, Ph. D. and Alvin Yeh, Ph.
D. Division of Biophysics, Biomedical Technology, and Computational Biosciences National Institute of General Medical Sciences National Institutes of Health Center on Macromolecular Dynamics by NMR Spectroscopy (COMD/NMR) New York Structural Biology Center BTDD Grant Number: RM1-GM145397 Principal Investigator: Arthur G. Palmer, Ph.
D. The COMD/NMR Center develops advanced methods in NMR spectroscopy for studying conformation and dynamics of protein and nucleic acid during biological processes and makes these sophisticated methods accessible to a wider research community to facilitate applications to biomedical questions. This Center was previously supported by the BTRR Program (P41GM118302).
Center on Probes for Molecular Mechanotechnology (CPMM) BTDD Grant Number: RM1-GM145394 Principal Investigator: Khalid Salaita, Ph. D. CPMM optimizes and disseminates advanced technologies to measure forces at the surface of cells.
The CPMM team will develop probes for light microscopy, flow cytometry, and plate readers. These probes will enable studies of mechanobiology and mechanotransduction pathways in cells. The GCE4All Center: Unleashing the Potential of Genetic Code Expansion for Biomedical Research BTDD Grant Number: RM1-GM144227 Principal Investigator: Ryan A.
Mehl, Ph. D. Genetic Code Expansion (GCE) technology – the engineering of cellular translation to express proteins containing non-canonical amino acids – provides unprecedented ways to probe and manipulate macromolecular structure and function, analyze protein malfunctions in disease, engineer bioanalytical tools, and create precision biotherapeutics.
The GCE4All Center's mission is to optimize and extend existing GCE technologies to enable facile use by non-specialists and broadly disseminate them via widespread education, effective training, and sustainable access so that powerful GCE approaches become standard widely-used biomedical research tools.
MicroED Imaging Center at UCLA University of California Los Angeles BTOD Grant Number: RM1-GM158451-01 Principal Investigator: Tamir Gonen, Ph. D. The emergence of microcrystal electron diffraction (MicroED) facilitates the determination of new protein structures at atomic resolution from vanishingly small crystals.
MicroED exploits the strong interaction between electrons and nano-scale three-dimensional crystals and takes advantage of emerging cryo-EM instrumentation to established crystallographic methods. It enables determination of previously unknown protein structures at atomic resolution from crystals smaller than the wavelength of visible light.
The MEDIC-MicroED Imaging Center at UCLA will continue to optimize and refine a powerful method of microcrystal electron diffraction (MicroED) that is critical to the advancement of structural biology, pharmaceutical research and the broader biomedical sciences. This center was previously supported by the BTRR Program (P41GM136508).
National Center for Translational and Developmental Proteomics (NCTDP) BTOD Grant Number: RM1-GM156535-01 Principal Investigators: Neil L. Kelleher, Ph. D.
The National Center for Translational and Developmental Proteomics (NCTDP) optimizes and disseminates technologies for the discovery and targeted measurement of the diverse molecular forms of proteins (proteoforms) using top-down mass spectrometry.
These efforts advance robust and accessible approaches for characterizing the proteoforms that underlie cellular function, health, and disease, while bridging top-down proteomics with other -omics platforms and emerging single-molecule protein sequencing methods. By strengthening and integrating these technologies, the Center aims to accelerate the adoption of proteoform-level analysis across the biomedical research community.
NCTDP disseminates its tools and methods broadly through publications, presentations, user training, commercialization, and implementation in shared resource facilities. This Center was previously supported by the BTRR Program (P41GM108569). National Resource for Advanced NMR Technology Florida State University and University of Florida BTDD Grant Number: RM1-GM148766 Principal Investigators: Robert W.
Schurko, Ph. D. ; William W.
Brey, Ph. D. ; Joanna R.
Long, Ph. D. The National Resource for Advanced NMR Technology leverages recent breakthroughs in materials science and instrumentation to develop technologies that advance the sensitivity and spectral resolution of biomolecular NMR spectroscopy.
These advances will lead to new tools that are needed to provide novel insights into biological processes and structures that are at the forefront of biomedical research, including enzyme mechanisms, metabolic flux, structure-function relationships, mechanisms of intrinsically disordered proteins, and cell wall structures.
This Resource aims to disseminate their technologies and advances to a broad user community through educational lectures and training activities, peer-reviewed publications and conference presentations, annual workshops, and a dedicated website with Resource materials and postings. This Resource was previously supported by the BTRR Program (P41GM122698).
Native Mass Spectrometry Guided Structural Biology Center (nMS->SB) Georgia Institute of Technology BTDD Grant Number: RM1-GM149374 Principal Investigator: Vicki Wysocki, Ph. D.
The nMS-> SB Center empowers specialist and non-specialist biomedical researchers to use native MS workflows and instrumentation that permit rapid, accurate, and highly sensitive structural biology characterization of mass, subunit stoichiometry, connectivity and topology, conformational diversity/stability/flexibility, heterogeneity, hierarchy in assembly, and relative subunit binding strengths of macromolecular complexes.
Interdigitation of Center components with other structural biology tools will advance structural biology initiatives worldwide with integrated suites of nMS-based tools translated to users. This Center was previously supported by the BTRR Program (P41GM128577).
UTSW-UNC Center for Cell Signaling Analysis UT Southwestern Medical Center and the University of North Carolina Chapel Hill BTDD Grant Number: RM1-GM145399 Principal Investigators: Kevin M. Dean, Ph. D.
; Klaus M. Hahn, Ph. D.
The Center for Cell Signaling Analysis optimizes and disseminates advanced technologies for visualization and quantitative analysis of molecular events in living cells and tissues.
User-friendly and integrated technologies of the Center combine biosensors, optogenetics and chemogenetics; modular, high-speed, and high resolution light-sheet microscopes; and image analysis and computational modeling to derive signaling circuits, including the inference of causality and kinetics of connections.
Technologies are disseminated through existing infrastructure including imaging facilities throughout the U.S., the FIJI software ecosystem, and commercial and non-profit companies. This page last updated on
According to the current listing, eligibility includes: See official notice (Typically for institutions and organizations with established biomedical technology development programs). Confirm the full requirements in the official notice before applying.
The current listing shows maximum recurring budget $850,000 direct costs per year; additional support for equipment. Up to 5-year project periods, renewable up to a maximum of 15 years. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Biomedical Technology Optimization and Dissemination (BTOD) Centers is funded by National Institute of General Medical Sciences (NIGMS), NIH. Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
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