Biomedical Technology Service Centers (P30 Centers)

Biomedical Technology Service Centers (P30 Centers) is sponsored by National Institute of Biomedical Imaging and Bioengineering (NIBIB). NIBIB will establish Biomedical Technology Service Centers (P30 Centers) that support infrastructure and resources needed by diverse groups of funded NIH researchers but are not widely available.

Expired PAR-13-249: NIBIB Biomedical Technology Service Centers (P30) This notice has expired. Check the NIH Guide for active opportunities and notices. of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) of Participating Organizations National Institute of Biomedical Imaging and Funding Opportunity Title NIBIB Biomedical Technology Service March 5, 2014 - This PAR has been reissued as PAR-14-145.

Funding Opportunity Announcement (FOA) Number Companion Funding Opportunity Individual applicants may not submit more than one NIBIB P30 Center application. However, there is no limit on the number of applications an institution may submit provided that each application is scientifically distinct. See Section III.

3. Additional Information on Eligibility . Catalog of Federal Domestic Assistance (CFDA) Number(s) Funding Opportunity Purpose NIBIB will establish Biomedical Technology Service Centers (P30 Centers) that support infrastructure and resources that are needed by a diverse group of funded NIH researchers, but are not widely available.

Consistent with this function NIBIB P30 Centers should engage in dissemination activities and may engage in training activities. Infrastructure and resources in an NIBIB P30 Center could range from shared biomedical instrumentation to open bioinformatics systems. Letter of Intent Due Date(s) Six weeks before the application due date.

AIDS Application Due Date(s) Required Application Instructions It is critical that applicants follow the instructions in Application Guide except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced.

While some links are provided, applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Looking ahead : NIH is committed to transitioning all grant programs to electronic submission using the SF424 Research and Related (R&R) format and is currently investigating solutions that will accommodate NIH’s multi-project programs. NIH will announce plans to transition the remaining programs in the NIH Guide to Grants and Contracts and on NIH’s Applying Electronically website . Part 1.

Overview Information Part 2. Full Text of Announcement Section I. Funding Opportunity Description Section II.

Award Information Section III. Eligibility Information Section IV. Application and Submission Section V.

Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII.

Other Information Full Text of Announcement Section I. Funding Opportunity Description NIBIB-supported Biomedical Technology Service Centers (NIBIB P30 Centers) ensure that independently-funded NIH investigators working in a targeted area will have access to biomedical technologies and expertise that are not widely available.

NIBIB P30 Centers must serve investigators from multiple institutions outside the applicant institution and are expected to be regional or national in scope. typical NIBIB P30 Center could include, but are not limited to, specialized shared instrumentation, customized algorithms, novel tissue/organ engineering platforms or open bioinformatics systems.

NIBIB P30 Centers will not support independent scientific research or unfunded pilot studies, except for limited development of novel technologies that support the NIBIB P30 Center service mission (see "Technology Service Cores" section). NIBIB will not support P30 Centers that focus on a specific disease, and will not support P30 Centers that involve clinical trials or patient services.

NIBIB will not support P30 Centers that overlap with pre-existing facilities at the host institution. function to help the community gain access to these resources, NIBIB P30 Centers should engage in dissemination activities. If appropriate, NIBIB P30 Centers may also engage in training activities.

NIBIB P30 Centers shall consist of one Administrative Core and one or more Technology Service Cores. coordinates the different components and activities of the NIBIB P30 Center including training and dissemination, etc. Technology Service Cores are shared facilities that provide a needed service to investigators outside of the NIBIB P30 Center, enabling them to conduct their funded individual research projects more effectively.

Each Technology Service Core shall have an associated Research Base component consisting of projects that will utilize the Technology Service Core. Investigators using the Technology Service Cores (i.e., the "Research Base") are expected to have highly-regarded existing biomedical research programs funded by NIH Institutes or Centers, other Federal Agencies, or other nationally or internationally-recognized funding sources.

NIBIB P30 Centers have an External Advisory Committee (EAC) that advises the Program Director/Principal Investigator on current operating procedures and future directions for the NIBIB P30 Center. Because extensive planning is required in preparing NIBIB P30 applications, prospective new applicants are encouraged to discuss their plans with the relevant NIBIB Program Directors (refer to http://www. nibib.

nih. gov/Research/ProgramAreas ) well before the application is prepared. The NIBIB intends to reissue this FOA, pending availability of funds, after the transition to electronic grant submission http://grants.

nih. gov/grants/guide/notice-files/NOT-OD-12-161. html .

Section II. Award Information Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. Application Types Allowed Glossary and the PHS 398 Application Guide provide details on these application Funds Available and Anticipated Number of Awards The number of awards will depend on NIH appropriations and the submission of a sufficient number of meritorious applications.

On average, NIBIB anticipates funding approximately one new application every Application budgets are not limited but it is strongly recommended that applicants not request a budget of more than $600,000 in direct costs per year. In addition, up to $500,000 can be requested for equipment over the five-year duration of the grant. Support may be requested for up to five years.

described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education: Black Colleges and Universities (HBCUs) Controlled Colleges and Universities (TCCUs) Native and Native Hawaiian Serving Institutions American Native American Pacific Islander Serving Institutions (AANAPISIs) Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Nonprofits without 501(c)(3) IRS Status (Other than Institutions For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Non-domestic (non-U.S.) Entities (Foreign Institutions) are Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to Foreign components, as defined in the NIH Grants Policy Statement , are not allowed.

Applicant organizations must complete the following registrations as described in the PHS 398 Application Guide to be eligible to apply for or receive an award. Applicants must have a valid Dun and Bradstreet Universal Numbering System (DUNS) number in order to begin each of the following Award Management (SAM) must maintain an active entity registration (formerly CCR registration), to be renewed at least annually. Use the Sam.

gov Manage Entity function to manage your entity registrations. See the Grants Registration User Guide at SAM. gov for additional information.

All Program Directors/Principal Investigators (PD(s)/PI(s)) must also work with their institutional officials to register with the eRA Commons or ensure their existing eRA Commons account is affiliated with the eRA Commons account of the applicant organization. All registrations must be completed by the application due date.

Applicant organizations are strongly encouraged to start the registration process at least6 weeks prior to the application due date. Eligible Individuals (Program Director/Principal Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Multiple PDs/PIs are not allowed. Only one PD/PI may be designated on the application.

The PD/PI may not submit more than one NIBIB P30 Center This FOA does not require cost sharing as defined in the NIH Grants Policy Statement . 3. Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

NIH will not accept any application that is essentially the same as one already reviewed within the past thirty-seven months (as described Grants Policy Statement ), except for submission: To an RFA of an application that was submitted previously as an investigator-initiated application but not paid; Of an investigator-initiated application that was originally submitted to an RFA but not paid; or Of an application with a changed grant activity code.

and Submission Information Applicants are required to prepare applications according to the current PHS 398 application forms in accordance with the PHS 398 2. Content and Form of Application Submission It is critical that applicants follow the instructions in Application Guide , except where instructed in this funding opportunity announcement to do otherwise.

Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and By the date listed in Part 1.

Overview Information , prospective applicants are asked to submit a letter of intent that includes the following information: Descriptive title of proposed activity Name(s), address(es), and telephone number(s) of the PD(s)/PI(s) Names of other key personnel Participating institution(s) Number and title of this funding opportunity The letter of intent should be sent to: Christina H Liu, Ph. D. P.

E. Division of Applied Science and Technology National Institute of Biomedical Imaging and Bioengineering 6707 Democracy Boulevard, Suite 200 Bethesda, MD 20892 (20817 for courier service) Telephone: (301) 451-7638 Applications must be prepared using the PHS 398 research grant application forms and instructions for preparing a research grant application.

Submit a signed, typewritten original of the application, including the checklist, and three signed photocopies in one package to: Center for Scientific Review National Institutes of Health 6701 Rockledge Drive, Room 1040, MSC 7710 Bethesda, MD 20892-7710 (U.S. Postal Service Express or regular mail) Bethesda, MD 20817 (for express/courier service; non-USPS service) At the time of submission, two additional paper copies of the application and all copies of the Appendix files must be sent to: Director, Office of Scientific Review National Institute of Biomedical Imaging and Bioengineering Bethesda, MD 20892-5469 (20817 for courier service) Telephone: (301) 496-8633 All page limitations described in the PHS 398 Application Page Limits must be followed, in addition to the following page limitations to the Research Strategy section of each component of the application.

Administrative Core: 6 pages Technology Service Core (s): 12 pages each Dissemination Core: 6 pages Instructions for the Submission of Multi-Component Applications The following section supplements the instructions found in the PHS398 Application Guide, and should be used for preparing a multi-component application.

The application should consist of the following components: Technology Service Core (s) All instructions in the PHS398 Application Guide must be followed, with the following additional instructions, as noted.

All instructions in the PHS 398 Application Guide Description, Project/Performance Sites, Senior/Key Personnel, Other Significant Contributors, Human Embryonic All instructions in the PHS 398 Application Guide Table of Contents (Overall) All instructions in the PHS 398 Application Guide must be followed. The Table of Contents for the Overall Component should include all Components in this application.

Detailed Budget for Initial Budget All instructions in the PHS 398 Application Guide must be followed with the following additional instructions: Estimated Initial Budgets for all Components should be included in the estimated Initial Overall Budget for Entire Proposed Period of All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Estimated Entire Budgets for all Components should be included in the estimated Entire Overall Funds may be requested for professional personnel, technical and support personnel, equipment, supplies, travel, consultants and web site development.

Allowable items for each category are given below: Personnel: Salaries for Key personnel. The PD/PI is expected to devote at least 3 calendar months of his/her efforts to the P30 Center, with a minimum of 1. 2 calendar months being devoted to the Administrative Core.

The P30 Center can cover salaries for individual Technology Service Core Component Directors to the extent that they provide an essential P30 Center function. No overlap of time or effort between the P30 Center and other funded and Support Personnel: Salaries for technical or support positions in the P30 Center. No overlap of time or effort between the P30 Center and other funded grants is permitted.

Equipment: Major equipment requests should be justified. Price quotes should be included for equipment costing more than $25,000. General purpose equipment requests should be included only when necessary to support visiting P30 Center Supplies: Consumable supplies related to the operation of the P30 Center (including office materials and scientific supplies).

Travel: Domestic and foreign travel for P30 Center personnel, if the travel is directly related to the activities of the P30 Center. Consultants: Consultants (including External Advisory Committee members) and any associated Site: Development and maintenance of a web site. Contracts: Service Contracts for major equipment items.

agreements: Funds may be requested for domestic subcontracts. In general, funds may not be requested for foreign subcontracts. Foreign subcontracts may be allowed if a written waiver is provided by the NIBIB Note: Funds may not be requested to support courses given for academic or other types of credit.

Individuals benefiting from the training programs may not be paid a stipend. Note: Funds may not be requested for alteration and renovation, rental space, staff retreats, direct support for individual research projects, or direct support for pilot studies. Biographical Sketch (Overall) All instructions in the PHS 398 Application Guide must be followed.

Start with a Biographical Sketch of the PD/PI, followed by Biographical Sketches of other investigators arranged in alphabetical order. This section should contain all relevant Biographical Sketches for the entire application. All instructions in the PHS 398 Application Guide must be followed.

Describe the institutional commitment to the P30 Center (e.g., laboratory/office space, facilities, research funds). All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Introduction: For Resubmission Applications provide an Introduction addressing the previous peer review critique. Aims: State concisely the goals of the proposed P30 Center.

Strategy: NIBIB P30 Centers shall consist of one Administrative Core and one or more Technology Service Cores. Describe the overall objectives of the P30 Center, and discuss what makes this particular P30 Center unique. Give a brief overview of the Technology Service Cores, and evaluate the regional and national need for the Technology Service Describe the qualifications of the PD/PI.

He/she should be a highly experienced and respected scientist with demonstrated administrative capabilities and a proven track record for obtaining NIH and/or other relevant funding, as well as a track record of providing technical service to the scientific community. Only one PD/PI may be designated for a P30 Center. For New Applications, describe the factors and events contributing to the decision to create the P30 Center.

For Renewal Applications, highlight major accomplishments from the previous funding period, and point out major changes from the original P30 Center design.

Sharing Plan : Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the PHS 398 Researchers are encouraged to share data obtained using the facilities of the P30 Center.

Scientific and technical staff are encouraged to share information on the technologies available at the P30 All instructions in the PHS398 Application Guide must be followed, with the following additional instructions, as noted. Face Page (Administrative Core) A Title page with the name of the Core and the Core Director should be generated in place of the Face Page.

Description, Project/Performance Sites, Senior/Key Personnel, Other Significant Contributors, Human Embryonic Stem Cells (Administrative Core) All instructions in the PHS 398 Application Guide Table of Contents (Administrative This section should contain the Table of Contents for the Administrative Core. The Table of Contents for the entire application should be presented in the Table of Contents section of the Overall Component.

Detailed Budget for Initial Budget Period (Administrative Core) This section should contain the Detailed Initial Budget for the Administrative Core. Budget for Entire Proposed Period of Support (Administrative Core) This section should contain the Entire Budget for the Biographical Sketch (Administrative All relevant Biographical Sketches should be presented in the Biographical Sketch section of the Overall Component.

Resources (Administrative Core) All instructions in the PHS 398 Application Guide Research Plan (Administrative Core) All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Introduction: For Resubmission Applications provide an Introduction addressing the previous peer review critique.

Aims: State concisely the goals of the proposed Administrative Strategy: The PD/PI of the P30 Center will be the Director of Describe the qualifications of other staff who will be involved in the Administrative Core. The External Advisory Committee is appointed by the PD/PI. External Advisory Committee members and the chair should be from outside the host institution, and should be rotated periodically.

Describe the role of the External Advisory Committee. The External Advisory Committee chair should be knowledgeable about the P30 Center technology and the science it serves, but should not be a member of the P30 Center staff or a major user of the P30 Center.

Other committee members should be balanced among scientists knowledgeable about the P30 Center technologies, experts in the application of P30 Center technologies to biomedical research problems, and users of the technology. For new P30 grant applications the External Advisory Committee should not be constituted prior to or during the review of the application, and potential candidates should not be approached or discussed.

For existing P30 Centers, list the current members of the External Advisory Committee, and briefly describe their qualifications. The External Advisory Committee should meet at least annually and prepare a written report, addressed to the PD/PI, of its recommendations.

This report must be supplied as part of the P30 Center Annual Describe the role of any local executive committees that are proposed as adjuncts to the External Advisory Committee. Describe the P30 Center organizational structure. Discuss the relationship of the P30 Center to the administrative structure of Describe the P30 Center operating procedures.

Discuss procedures to review requests for use of the equipment and facilities, Sharing Plan : Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the PHS Researchers are encouraged to share data obtained using the facilities of the P30 Center.

Scientific and technical staff are encouraged to share information on the technologies available at the P30 Technology Service Core(s) All instructions in the PHS398 Application Guide must be followed. NIBIB P30 Centers do not have a minimum number of Technology Service Cores.

However, if there is more than one Technology Service Core, each Technology Service Core should be considered as a separate Component and Face Page (Technology Service Core) A Title page with the name of the Core and the Core Director should be generated in place of the Face Page.

Description, Project/Performance Sites, Senior/Key Personnel, Other Significant Contributors, Human Embryonic Stem Cells (Technology Service Core) All instructions in the PHS 398 Application Guide Table of Contents (Technology Service This section should contain the Table of Contents for the Technology Service Core.

The Table of Contents for the entire application should be presented in the Table of Contents section of the Overall Component. Detailed Budget for Initial Budget Period (Technology Service Core) This section should contain the Detailed Initial Budget for the Technology Service Core.

Budget for Entire Proposed Period of Support (Technology Service Core) This section should contain the Entire budget for the Biographical Sketch (Technology All relevant Biographical Sketches should be presented in the Biographical Sketch section of the Overall Component.

Resources (Technology Service Core) All instructions in the PHS 398 Application Guide should Research Plan (Technology Service All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Introduction: For Resubmission Applications provide an Introduction addressing the previous peer review critique.

Aims: State concisely the goals of the proposed Technology Strategy: Identify the Director of each Technology Service Core, and discuss his/her qualifications. Technology Service Core Directors should be acknowledged experts with independently-funded research programs that use the Technology Service Core services. The PD/PI of the P30 Center may be Director of one (or more) of the Technology Service Cores.

The Technology Service Cores may support technicians and engineers that have the appropriate scientific or engineering skills. Examples of appropriate skills could be: operation and maintenance of the specialized shared instrumentation, development of custom algorithms, development of tissue/organ bioengineering platforms and development of open bioinformatics systems.

Where appropriate, an established expert in the Technical Service Core activities could also be included as a consultant. Describe the hardware, software and other specialized facilities available to the Technology Service Core. Technology Service Cores are expected to implement and maintain appropriate commercial equipment and off-the-shelf software, and may also utilize specially-designed equipment and software.

Finally, limited developmental research is appropriate if it directly enhances the utility of the Technology Service Cores. Whenever possible, open-source software should be utilized. If an element of the support provided by the P30 Center involves software or algorithm development, it should be disseminated in open-source platforms.

Discuss the investigator usage of each Technology Service Core. The minimum requirement for establishing a Technology Service Core is significant usage by five or more investigators with independently-funded, peer-reviewed projects.

The resources in the Technology Service Cores should be equitably distributed: the maximum effort that a single Technology Service Core can spend on projects directed by a single investigator Projects using a particular Technology Service Core form a "Research Base" for that Technology Service Core. Each Research Base must be described in detail in the Appendix.

For New Applications, each Technology Service Core should include information on preliminary studies. For Renewal Applications, each Technology Service Core should include a Progress Report.

Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the PHS Researchers are encouraged to share data obtained using the facilities of the P30 Center.

Scientific and technical staff are encouraged to share information on the technologies available at the P30 All instructions in the PHS398 Application Guide must be followed, with the following additional instructions, as noted: Face Page (Dissemination Core) A Title page with the name of the Core and the Core Director should be generated in place of the Face Page.

Description, Project/Performance Sites, Senior/Key Personnel, Other Significant Contributors, Human Embryonic Stem Cells (Dissemination Core) All instructions in the PHS 398 Application Guide Table of Contents (Dissemination Core) This section should contain the Table of Contents for the Dissemination Core. The Table of Contents for the entire application should be presented in the Table of Contents section of the Overall Component.

Detailed Budget for Initial Budget Period (Dissemination Core) This section should contain the Detailed Initial Budget for the Dissemination Core. Budget for Entire Proposed Period of Support (Dissemination Core) This section should contain the Entire Budget for the Biographical Sketch (Dissemination Core) All relevant Biographical Sketches should be presented in the Biographical Sketch section of the Overall Component.

Resources (Dissemination Core) All instructions in the PHS 398 Application Guide Research Plan (Dissemination Core) All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Introduction: For Resubmission Applications provide an Introduction addressing the previous peer review critique.

Aims: State concisely the goals of the proposed Dissemination Strategy: A fundamental motivation for the NIBIB P30 Center program is to apply cutting-edge technology to important biomedical research problems. The realization of this goal depends on an effective Dissemination Describe the details of the Dissemination Program.

Dissemination activities should inform the scientific community about the technical capabilities of the P30 Center, and promote and enable a broader use A variety of approaches can be proposed to promote dissemination.

These approaches include, but are not limited to: publishing book chapters, patents, newsletters, or annual reports; conducting workshops; distributing software products; transferring technologies to other laboratories; licensing technologies to industry; and building a robust web Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the PHS Researchers are encouraged to share data obtained using the facilities of the P30 Center.

Scientific and technical staff are encouraged to share information on the technologies available at the P30 All instructions in the PHS398 Application Guide must be followed, with the following additional instructions, as noted: Face Page (Training Core) A Title page with the name of the Core and the Core Director should be generated in place of the Face Page.

Description, Project/Performance Sites, Senior/Key Personnel, Other Significant Contributors, Human Embryonic Stem Cells (Training Core) All instructions in the PHS 398 Application Guide Table of Contents (Training Core) This section should contain the Table of Contents for the Training Core. The Table of Contents for the entire application should be presented in the Table of Contents section of the Overall Component.

Detailed Budget for Initial Budget This section should contain the Detailed Initial Budget for the Training Core. Budget for Entire Proposed Period of This section should contain the Entire Budget for the Biographical Sketch (Training Core) All relevant Biographical Sketches should be presented in the Biographical Sketch section of the Overall Component.

Resources (Training Core) All instructions in the PHS 398 Application Guide Research Plan (Training Core) All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Introduction: For Resubmission Applications provide an Introduction addressing the previous peer review critique. Aims: State concisely the goals of the proposed Training.

Strategy: The Training Program (if present and appropriate for the P30 Center) should create a cadre of biomedical researchers that are trained in the P30 Center technologies, and can effectively apply them to their own research.

The academic rank of the trainees should be appropriate to the technology being disseminated, and could range from advanced graduate students, who are using the technology in their thesis projects, to faculty members and practicing physicians, who are aiming to use the technology in their research and/or clinical practice.

Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the PHS Researchers are encouraged to share data obtained using the facilities of the P30 Center.

Scientific and technical staff are encouraged to share information on the technologies available at the P30 Appendix for the Entire Application Do not use the Appendix to circumvent page limits. Follow all instructions for the Appendix (please note all format requirements) as described in the PHS 398 Application Guide. For each Technology Service Core include a Research Base in the Appendix.

Describe up to 12 projects in each Research Base in detail (up to one page for each project). In addition, provide a Table that includes each project in the Research Base.

Each entry in the Table should include: Details of peer reviewed funding(s) Start and end dates for the project(s) Number of publications that have resulted from the project (for Renewal applications only) Utilization of human subjects or animals in the project (Yes/No) For Renewal applications, projects from the previous funding period that are not being continued should be listed in a separate Table.

For Renewal applications, the Appendix should also include the most recent External Advisory Committee Report. Part I. Overview Information contains information about Key Dates.

Information on the process of receipt and determining if your application is considered on-time is described in detail in the PHS 398 Applicants may track the status of the application in the eRA Commons , NIH’s electronic system for grants Intergovernmental Review (E. O.

12372) This initiative is not subject to intergovernmental All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Pre-award costs are allowable only as described in the NIH Grants Requirements and Information Applications must be postmarked on or before the due dates in Part I. Overview Information .

Upon receipt, applications will be evaluated for completeness by the Center for Scientific Review, NIH. Applications that are incomplete will not be reviewed.

Requests of $500,000 or more for direct costs in any Applicants requesting $500,000 or more in direct costs in any year (excluding consortium F&A) must contact NIBIB program staff at least 6 weeks before submitting the application and follow the Policy on the Acceptance for Review of Unsolicited Applications that Request $500,000 or More in Direct Costs as described in the PHS Application Guide.

This policy applies to all New, Renewal and Resubmission applications. Post-Submission Materials Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-10-115 . Section V.

Application Review Information Only the review criteria described below will be considered in the review process. As part of the NIH mission , all applications submitted to the NIH in support of biomedical and behavioral research are evaluated for scientific and technical merit through the NIH peer Reviewers will provide an overall