BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24)

BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24) is sponsored by National Institutes of Health (NIH). Supports dissemination of resources for integration into neuroscience research practice.

RFA-NS-27-001: BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed) Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations National Institute of Neurological Disorders and National Eye Institute ( NEI ) National Institute on Alcohol Abuse and Alcoholism ( NIAAA ) National Institute of Biomedical Imaging and Bioengineering ( NIBIB ) Eunice Kennedy Shriver National Institute of Child Health and Human Development ( NICHD ) National Institute on Deafness and Other Communication Disorders ( NIDCD ) National Institute on Drug Abuse ( NIDA ) National Institute of Mental Health ( NIMH ) National Center for Complementary and Integrative Health ( NCCIH ) All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers.

The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Office of Behavioral and Social Sciences Research ( OBSSR ) Funding Opportunity Title BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed) U24 Resource-Related Research Projects – Cooperative Agreements Check for any recent Notices of NIH Policy Changes that may impact application requirements.

Funding Opportunity Number (FON) Companion Funding Opportunity See Section III. 3. Additional Information on Eligibility .

Assistance Listing Number(s) 93. 372, 93. 853, 93.

173, 93. 279, 93. 286, 93.

866, 93. 273, 93. 213, 93.

242, 93. 865, 93. 867 Funding Opportunity Purpose This notice of funding opportunity (NOFO) supports efforts to disseminate resources for integration into neuroscience research practice.

The resource(s) should be relevant to the goals of the BRAIN Initiative as outlined in the " BRAIN 2025: A Scientific Vision " and " The BRAIN Initiative 2. 0: From Cells to Circuits, Toward Cures " and shared broadly to the neuroscience community. The resource(s) should address compelling needs of neuroscience researchers that are otherwise unavailable or impractical in their current form.

Activities must include dissemination of an existing resource, and may include one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and/or specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community.

Funding Opportunity Goal(s) To provide extramural research support for the Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative’s aim of revolutionizing our understanding of the brain and its function in unprecedented detail.

The NIH BRAIN Initiative’s focus is foundational development of new technologies and tools to map, monitor, and modulate brain circuits in model systems and humans – toward the ultimate goal of treating and curing human brain disorders. BRAIN Initiative research adheres to open, and ethical science – and requires diverse expertise across all technical domains.

Open Date (Earliest Submission Date) Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed All applications are due by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Required Application Instructions It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide , follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Use Grants. gov Workspace to prepare and submit your application and eRA Commons to track your application.

Part 1. Overview Information Part 2. Full Text of Announcement Section I.

Notice of Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV.

Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII.

Agency Contacts Section VIII. Other Information Part 2. Full Text of Announcement Section I.

Notice of Funding Opportunity Description Since 2014, the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative has aimed to accelerate the development and application of innovative neurotechnologies, enabling researchers to produce a new dynamic picture of the brain that reveals how individual cells and complex neural circuits interact in both time and space.

It is expected that these advances will ultimately lead to new ways to treat and prevent brain disorders. The NIH BRAIN Initiative recognizes innovative ideas require creativity, scientific expertise, and experience.

There are many benefits that flow from a scientific workforce with team participation including: fostering scientific innovation, enhancing global competitiveness, contributing to robust learning environments, improving the quality of the research, and enhancing public trust The NIH also encourages businesses to participate in the BRAIN Initiative.

It is possible for companies to submit applications directly to BRAIN Initiative program announcements or to collaborate with academic researchers in joint submissions. Small businesses should consider applying to one of the BRAIN Initiative small business NOFOs The BRAIN Initiative requires a high level of coordination and sharing between investigators.

It is expected that BRAIN Initiative recipients will cooperate and coordinate their activities after awards are made by participating in Program Director/Principal Investigator (PD/PI) meetings and in other activities such as the BRAIN Initiative Conference. The data sharing expectations for BRAIN Initiative awards can be found at NOT-MH-19-010 .

This NOFO is related to the recommendations in the BRAIN 2025 (Section III, Part 8b) and the BRAIN Initiative 2. 0: From Cells to Circuits, Toward Cures (Priority Area 8, Section III) Reports. Specifically, this NOFO solicits applications that will address the recommendations on "Dissemination and training in new technologies" As noted in the BRAIN 2.

0 report “new tools and new knowledge should be shared broadly to maximize the value of the BRAIN Initiative and to seed new paths of inquiry”. The overall goal of this NOFO is to accelerate the scientific impact of the BRAIN Initiative through rapid dissemination of developed and validated technologies and resources broadly to the neuroscience research community.

Awards from this RFA will be made for no more than 5 years, with a possibility of one renewal.

Projects may accomplish this goal by engaging in one or more of the following types of activities: Production and distribution of reagents (e.g., antibodies, chemical probes, transgenic lines) using quality control manufacturing processes Services providing customized instrumentation based on end user needs Provision of state-of-art components, devices, or integrated systems (e.g., for assaying neural activity and/or connectivity) either distributed to end users or operated as specialized core facilities with user engagement Resources focused on enabling the translation of neurotechnologies for human use Maintenance, minor enhancements, and distribution of open-source computational models and software packages User facilities that enable scientists from outside institutions to utilize specialized tools or techniques Training in usage of the resource The following are examples of projects responsive to this NOFO.

These are representative, but not exhaustive, examples.

Consortium that provides screening services for voltage sensors and other probes for identifying changes in membrane potential or network modulatory states Resource that provides reliable multichannel microelectrodes to the neuroscience community that are compatible with other recording technologies, such as optical imaging and stimulation or MRI Imaging services for large-scale recording of neural activity from multiple brain areas or for large-scale sampling/manipulation of cellular activity with simultaneous whole-brain activity measurements Dissemination of novel miniaturized wireless imaging systems and serving as a core resource for researchers A resource that gathers, standardizes and streamlines the distribution of transgenic mouse models for neuroscience research This NOFO will support applications which address one or more of the specific goals of the BRAIN Initiative, as described in the planning document " BRAIN 2025: A Scientific Vision " and updated and enhanced in 2019 by " The BRAIN Initiative 2.

0: From Cells to Circuits, Toward Cures ". Applications are not limited to existing BRAIN Initiative investigators or to technologies previously developed using BRAIN Initiative or NIH funds, nor must the end user community be limited to investigators with BRAIN Initiative funding. End users may include those studying disease relevant mechanisms.

Projects should address compelling needs of broad communities of investigators or should justify the impact and unmet opportunity of providing the services at smaller scales. Proposed techniques, resources or approaches must be at a stage wherein the potential value for research is well established, through publications or other demonstration methods, and dissemination must occur by early in year 2.

Projects focused on developing novel and unproven technologies are not responsive to this NOFO. Applicants developing new technologies are encouraged to submit to one of the BRAIN technology development NOFOs . Applications to develop web-accessible data archives are strongly recommended to consider funding through RFA-MH-25-110 , “BRAIN Initiative: Data Archives for the BRAIN Initiative”.

Please see https://www. braininitiative. nih.

gov/funding/ for more details about these and other BRAIN Initiative programs. Integration of proven techniques to produce new experimental systems, or application of existing technologies to produce new reagents such as genetic lines or constructs with an existing technology, are appropriate, but need to be described clearly with timelines for completion of development and testing.

Clear value to the intended user group must be demonstrated in the application and dissemination must be planned by early year 2. For projects proposing the development of novel technologies/resources with commercial potential, potential applicants should consider funding through the Small Business Innovation Research (SBIR) program or the Small Business Technology Transfer (STTR) program. Please see: seed..

nih. gov/ for more details about these technology development programs. Resources are expected to be free from any patent or licensing constraints that would unduly restrict academic research use and impede achieving the goals of this funding program.

For resources requiring material from human subjects (e.g. DNA, fibroblasts, blood, tissue), broad sharing of the resource and any derivatives with academic and industry investigators is expected, consistent with achieving the goals of this program and consistent with applicable laws, regulations, and informed consents.

In cases where the disseminated resource involves patented materials across several institutions, it is expected that these institutions utilize standard or model agreements in order to reduce negotiation cost and time. Applicants are strongly encouraged to consult the Scientific/Research Contact listed below to discuss the alignment of their proposed work with the goals of this NOFO, and the BRAIN Initiative Program.

The success of the project will be facilitated by the adoption of clear, quantitative milestones with realistic and efficient timelines. Applications must include proposed milestones for each year of requested support, which will be evaluated as part of the review process. The milestones and timeline should include the timing and quantity of dissemination of the resource to the neuroscience community.

Applications that fail to include annual milestones will be considered incomplete and will be withdrawn before review. Final version of milestones will be agreed upon at the time of award. If justified, future year milestones may be revised based on data and information obtained in the current year.

Applications Not Responsive to this NOFO: Proposed research that is not responsive to this NOFO and will not be reviewed include the following: Projects focused on developing novel and unproven technologies Projects which lack clear indication that the resource is well established and validated, through publications or other demonstration methods. Projects where dissemination is not planned to occur by early year 2.

Projects that support clinical trials or provide patient services. Applicants considering such efforts are encouraged to explore alternative funding mechanisms. Projects proposing repositories of brain and related bio-specimens.

See Section VIII. Other Information for award authorities and regulations. Section II.

Award Information Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement. Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities. See Section VI.

2 for additional information about the substantial involvement for this NOFO. Application Types Allowed The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.

Not Allowed: Only accepting applications that do not propose clinical trials. Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards The NIH anticipates providing $10M per year to fund an estimated 10 to 20 awards.

Application budgets are not limited but need to reflect the actual needs of the proposed project. Support may be requested for up to 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III.

Eligibility Information Higher Education Institutions - Includes all types Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Applications Involving the NIH Intramural Research Program The requests by NIH intramural scientists will be limited to the incremental costs required for participation.

As such, these requests will not include any salary and related fringe benefits for career, career conditional or other Federal employees (civilian or uniformed service) with permanent appointments under existing position ceilings or any costs related to administrative or facilities support (equivalent to Facilities and Administrative or F&A costs).

These costs may include salary for staff to be specifically hired under a temporary appointment for the project, consultant costs, equipment, supplies, travel, and other items typically listed under Other Expenses. Applicants should indicate the number of person-months devoted to the project, even if no funds are requested for salary and fringe benefits. If selected, appropriate funding will be provided by the NIH Intramural Program.

Intellectual property will be managed in accord with established policy of NIH in compliance with Executive Order 10096, as amended, 45 CFR Part 7; patent rights for inventions developed in NIH facilities are NIH property unless NIH waives its rights. Should an extramural application include the collaboration with an intramural scientist, no funds for the support of the intramural scientist may be requested in the application.

The intramural scientist may submit a separate request for intramural funding as described above. Intramural scientist cannot be a multi-PI on an extramural award. Foreign Organizations/Foreign Collaborations Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts.

All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025. Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding.

This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components , funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible.

Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2. 3. 9.

2 Electronically Submitted Applications for additional information System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration.

SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.

gov registration process. The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.

gov registrations; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants.

gov – Applicants must have an active SAM registration in order to complete the Grants. gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide . This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement NIH Grants Policy Statement Section 1. 2 Definition of Terms.

3. Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct. The NIH will not accept duplicate or highly overlapping applications under review at the same time, per NIH Grants Policy Statement Section 2.

3. 7. 4 Submission of Resubmission Application .

This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2. 3. 9.

4 Similar, Essentially Identical, or Identical Applications ). Section IV. Application and Submission Information 1.

Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants. gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.

gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution. 2.

Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise (in this NOFO, in a policy notice , or other notice from NIH Guide for Grants and Contracts ).

Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review. All page limitations described in the How to Apply – Application Guide and the Table of Page Limits must be followed.

Instructions for Application Submission The following section supplements the instructions found in the How to Apply – Application Guide and should be used for preparing an application to this NOFO. All instructions in the How to Apply - Application Guide must be followed. SF424(R&R) Project/Performance Site Locations All instructions in the How to Apply - Application Guide must be followed.

SF424(R&R) Other Project Information All instructions in the How to Apply - Application Guide must be followed. Proposed Milestones and Timeline: – Applications that do not include this will be withdrawn and not reviewed. Milestones and timeline should be submitted as a separate attachment and must be no more than 2 pages in length.

Applications must describe quantitative milestones for each year of support, that will serve as reliable indicators for objective evaluation of progress over the course of the project.

The milestones should include realistic quantitative goals for resource usage and dissemination metrics (e.g. number of users, unique labs/institutions) which will be reported at the end of a given annual funding period, and clearly describe when dissemination of the resource will commence. Other common milestones may include user feedback, optimization and standardization, plans for sustainability, and outreach activities.

These should include quantifiable measures of success, specific outcomes , and rationale. NIH Program staff will use the project milestones for evaluation of the funded award, and to determine whether to modify or continue the award in subsequent budget years. Applicants should include a project timeline in the form of a Gantt chart (or similar) that includes all major tasks to be performed during the project.

The chart should also include estimated start and completion dates for those tasks. Applicants may consider this template in developing their milestone plan, focusing on key milestones consistent with achieving the goals of this program. Applicants should keep in mind continuation of funding will be dependent upon the recipient’s ability to show adequate progress towards milestone accomplishment.

Letters of Support : Letters of support from potential resource users are strongly advised. In their letters, users should describe their research plans with a level of detail sufficient for reviewers to assess the potential impact of the proposed resource. No more than 10 letters from planned or potential end users may be submitted.

It is encouraged that these letters demonstrate the applicant has considered how to engage participation from the end user community. Other letters of support from the institution, key personnel, and key contributors do not count towards these 10 letters of support from end users.

Applications may also include institutional letters which describe financial and collaborative arrangements, and/or agreements for payment for services, or letters which describe third party or strategic partners interest.

In cases where the disseminated resource involves patented materials from several institutions, it is expected that these institutions utilize standard or model agreements (e.g. Uniform Biological Material Transfer Agreement ) in order to reduce negotiation cost and time, and that these arrangements are described in the letters of support.

Such letters must acknowledge awareness by the collaborating institutions that broad sharing of the resource and any derivatives with academic and industry investigators is expected, consistent with achieving the goals of this program. The Letters of Support attachment of the application should include a cover page listing the name, institution, and proposed role for each individual providing a letter of support.

Fee structure: Applicants may include a 1 page attachment detailing current and/or planned fee structure. SF424(R&R) Senior/Key Person Profile All instructions in the How to Apply - Application Guide must be followed. with the following additional instructions: Applicants may include project management personnel as Senior/Key Person(s).

All instructions in the How to Apply - Application Guide must be followed. with the following additional instructions: The budget should include funds necessary for travel for up to two key personnel to participate in a BRAIN investigator meeting, lasting not more than two days and including up to two overnight stays. Projects may include budget for project manager.

All instructions in the How to Apply - Application Guide must be followed. PHS 398 Cover Page Supplement All instructions in the How to Apply - Application Guide must be followed. All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions: Research Strategy: The Research Strategy section must include the following required information.

Technology readiness for dissemination: Describe the current status of the technology and readiness for broad dissemination and if/how the technology has been validated. Currently Available Facilities and Services: Investigators must specifically define currently available facilities and services that are comparable to their proposed resource and highlight major value their resource will add.

Technology evolution (in Approach): In order to justify the requested length of support (up to 5 years), applicants should provide an evaluation of the speed of technology evolution in the scientific field and provide justification that the user base will maintain and/or grow during the entire support period requested.

For example, if the applicant is proposing 5 years of funding, is there evidence based on the speed at which this technology has been evolving in the past few years that indicates that the proposed resource will remain relevant, cutting edge, and highly desirable by the user community over the entire 5 years of support?

Steering Committee (in Approach) : A proposed Steering Committee is required to provide guidance and feedback on strategic priorities and on user access and prioritization. The steering committee should also ensure that the project is well integrated, and not redundant, with related efforts on an international scale. The committee should include established researchers with relevant technical and scientific expertise.

The composition of this committee depends on the nature and scope of the project, and the committee may include, as appropriate to the project, individuals employed by the PD/PI's institution.

Specific committee members do not need to be named to avoid potential conflicts and membership can be negotiated with program staff at the time of award; however, information on the proposed number of members, their scientific expertise, committee operations and frequency of meetings should be included.

Dissemination, Access, and Project Prioritization Plan (in Approach) : Projects must describe planned mechanisms for thorough advertisement and dissemination of the resources broadly to the community of relevant investigators. It must be made clear that the resource will be disseminated broadly- to users spanning many unique labs and institutions and not confined to a homogenous user group concentrated in the same geographic region.

A concrete Project Prioritization Plan should detail how the capacity of the proposed resource will be evaluated and allocated. Prioritization may be facilitated by a fee structure, by formal project evaluation mechanisms, or by other appropriate considerations.

Cost offsets via user fees are not required, but they should be considered as part of the project plan, because they provide potential mechanisms for efficient resource allocation and for resource sustainability. Access should be as broad as possible for the technology, including national and international users where possible.

Quality Assurance and Control Plan (in Approach) : Projects must describe the planned strategy and mechanisms for quality control / assurance for the disseminated resource. Team Management and Logistics Plan (in Approach) : Investigators must describe the planned strategy for managing the personnel and resources on the team.

The plans should highlight expertise and prior experience in managing any efforts outside the needs of their own research programs. Progress Report for Renewal Applications (in Approach) : Renewal applications must include a detailed account of experiences in dissemination and engagement highlighting outreach to community of users during the previous funding period, including successful and unsuccessful strategies.

Information should be included on how the program's past experiences inform the current plan. Any non-public demographic information collected should be aggregated and anonymized. PIs proposing a renewal may consider aggregating user institution type using: NIGMS nomenclature https://www.

nigms. nih. gov/training/RISE/Documents/Determining-Eligibilty-RePORTER.

pdf -” research-intensive, i.e., those with an average of NIH research project grant (RPG) funding greater than or equal to $7. 5 million total costs per year over the past 3 fiscal years, and research-active, i.e., those with an average of RPG funding less than $7.

5 million total costs per year over the past 3 fiscal years (RPG data are available through NIH RePORTER) ” Institutions with Specific Department of Education Statuses : https://www. ed. gov/grants-and-programs/grants-higher-education/eligibility-designations-higher-education-programs#tips Institutions in IDeA- eligible states: https://www.

nigms. nih.

gov/Research/DRCB/IDeA PIs may consider aggregating user career stage using: Early career: 0-14 years since terminal degree Mid career: 15-29 years since terminal degree Late career: 30+ years since terminal degree Renewal applicants are expected to have sought additional resources to maintain their operations after NIH funding and should include plans for other sources of support for program sustainability, including descriptions of all institutional support, financial and collaborative arrangements, and/or agreements for payment for services.

Appropriate documentation should be included in the application- see instructions under “Other Attachments”. Provide other relevant information about the applicant’s approach for self-sustaining infrastructure and operations, and why NIH support in particular is needed to disseminate this resource.

Resource Sharing Plan : Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide . All instructions in the How