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ActiveOpenAI Foundation · 2026

Breakthroughs to Follow-Through Initiative

Quick Facts

Agency: OpenAI Foundation
Funding: $100 million total commitment (for state/local jurisdictions)
Deadline: Check Source
Status: Active
Eligibility: States and other local jurisdictions.

About This Grant

Breakthroughs to Follow-Through Initiative is sponsored by OpenAI Foundation. This initiative provides funding for states and other local jurisdictions to accelerate medical treatment research deliveries for serious health conditions by implementing AI tools. The initial focus is on hepatitis C treatment development.

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Official Opportunity Details

Extracted from the official opportunity page/RFP to help you evaluate fit faster.

OpenAI Foundation gives $100 million fund state AI implementation for public health - Nextgov/FCW Exercise Your Privacy Rights Sponsored: Resource Center Seizing the Intelligence Advantage Law Enforcement Technology Efficiency, After a Year of DOGE Stop chasing, start preventing.

The Next Five Years of Fraud: We Better Get Ready Now Staff Correspondent, Nextgov/FCW The organization announced the launch of the Breakthroughs to Follow-Through Initiative, which will implement artificial intelligence tools in public health research work.

OpenAI Foundation, the overarching nonprofit that governs OpenAI, has announced a new public health partnership with the Common Health Coalition to bring artificial intelligence tools to developing scientific breakthroughs for medical research across the country.

OpenAI Foundation on Thursday announced its commitment of $100 million to the Breakthroughs to Follow-Through Initiative, a program where states and other local jurisdictions can accelerate medical treatment research deliveries for serious health conditions. Participating jurisdictions will be able to determine what types of AI tools, including generative AI, are needed for their individual projects.

The B2F’s research funding will initially focus on hepatitis C treatment development. Local organizations and non-profits will be in charge of dispersing grant money — first in states including Alabama, Illinois, Louisiana and Massachusetts. More state participants will be unveiled in the coming six months.

“The organizations closest to society’s greatest challenges have the deepest understanding of what communities need, but not always the resources or technical expertise to harness the latest advances in AI,” Anna Makanju, Head of AI for Civil Society and Philanthropy at OpenAI Foundation, said in a press release.

“We believe this initiative is a model for how AI can strengthen public and community health work and deliver tangible benefits to communities. ” Makanju told Nextgov/FCW that the foundation’s grants aren’t tied to one AI platform or system provider, granting participants flexibility in the tools they choose.

“We want our partners to have the agency to decide which tools to use — or what not to use — and to choose what best fits their needs and the communities they serve,” she said. Dave Chokshi, the chair of the Common Health Coalition, echoed Makanju’s sentiment. “Jurisdictions will determine which tools are needed to help ensure existing medical breakthroughs actually reach the people who need them,” Chokshi told Nextgov/FCW .

“These tools range from identifying people overdue for screening or treatment, to outreach platforms for re-engaging patients, AI copilots that free up clinicians' time, navigation tools that keep patients on track through cure, and beyond, and are intended to support the human relationships at the center of care.

” In addition to offering access to advanced AI tools, Chokshi said that B2F will provide the infrastructure needed to facilitate the implementation and usage of AI tools, such as technical support to help shift from the pilot stage into deployment. The current focus of B2F is to foster collaborative state-level partnerships, but Chokshi said they are open to participation from the federal government.

“We remain very open to partnership and collaboration with the federal government as this work develops,” said Chokshi. A similar initiative was previously floated in congressional legislation. Rep.

Michael McCaul, R-Texas, introduced his bill on July 9, — the Accelerating Innovation for Kids with Cancer Act — to allocate more federal attention to leveraging AI to aid pediatric cancer research efforts. Pilotless Air Taxis Are Here. Your Daily Commute?

Still Stuck on the Ground.

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Eligibility Requirements

States and other local jurisdictions.

Frequently Asked Questions

Who can apply for Breakthroughs to Follow-Through Initiative?

According to the current listing, eligibility includes: States and other local jurisdictions. Confirm the full requirements in the official notice before applying.

How much funding does Breakthroughs to Follow-Through Initiative offer?

The current listing shows $100 million total commitment (for state/local jurisdictions). Verify award ceilings, matching requirements, and allowable costs in the official notice.

Who funds Breakthroughs to Follow-Through Initiative?

Breakthroughs to Follow-Through Initiative is funded by OpenAI Foundation. Verify program details on the funder's official page before applying.

How do I apply for Breakthroughs to Follow-Through Initiative?

Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.

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