Catalyze: Product Definition – Medical Device Prototype Optimization (R33 - Clinical Trial Not Allowed)

To increase research capacity for NF, the NFRP is offering the NFRA. The intent of the NFRA is to provide a framework of intensive mentoring and iterative guidance with proposed research, national networking, collaborations, and a peer group of junior faculty (Scholars). The NFRP NFRA will bring together established NF investigators (one Director and one Deputy Director) and early-career independent investigators (Scholars) and their Career Guides to develop successful, highly productive NF scientists and clinicians that will conduct research with the aim of lessening the clinical impact of NF1, NF2, and schwannomatosis. The NFRA is a multi-institutional interactive virtual academy platform designed to offer support to NFRA Scholars with the goal to advance innovative, high impact NF research through a collaborative and career development environment.The functioning NFRA will consist of Scholars and their Career Guides (mentors) from different institutions, and an Academy Director and Deputy Director (see Figure 1 below). The Academy Director and Deputy Director will catalyze the growth and professional development of the Scholars in collaboration with their Career Guides, assess the progress of the Scholars, and facilitate communication and collaboration among all Academy members. The Career Guide is not required to be at the same institution as the Scholar; however, if the (primary) Career Guide is from a different institution, a secondary Career Guide at the Scholar’s institution is needed. The NFRA will afford Scholars opportunities to operate in a collegial, highly dynamic, and cutting-edge center to move early-career investigators towards positions as leaders in NF conducting impactful research.During this first phase of the academy, the NFRP is offering the FY24 NFRALA funding opportunity to solicit applications for an Academy Director and Deputy Director to lead the NFRA. The Academy Director and Deputy Director (referred to as Academy Leadership) must be established NF researchers and can be at different institutions. The Academy Leadership must demonstrate a strong record of mentoring and training early-career independent investigators, a commitment to leadership, the ability to articulate methods toward research collaborations, and the ability to objectively assess the progress of all Scholars in the NFRA. An objective of the NFRA leadership team is to establish the Academy structure in its first year and in subsequent years, conduct oversight of this activity. Other objectives will include execution of research that will engage NFRA FY25 Scholars (including subsequent-year Scholars), develop tools for Scholars to enable success, and provide opportunities to broaden their knowledge in NF disorders. The leadership team will identify and offer opportunities to network with other NFRP FY25 Early Investigator Research Award recipients (and subsequent year awardees) and NFRP FY25 New Investigator Award – Early-Stage Investigator (NIA – ESI) Award recipients (and subsequent year awardees). In the second stage of the academy, the NFRP anticipates release of funding opportunities for the Scholars who will conduct their research under the guidance of the NFRA leadership team. Funding Opportunity Number: HT942524NFRPNFRALA. Assistance Listing: 12.420. Funding Instrument: CA,G. Category: ST. Award Amount: $1.5M total program funding.

The CADI, funded through an interagency agreement between the U.S. Department of Agriculture's Foreign Agricultural Service (USDA/FAS) and the State Department's Bureau of European and Eurasian Affairs, supports a portfolio of projects in Eastern Europe (non-E.U.), the South Caucasus, and Central Asia. These projects are designed to make American agriculture safer, stronger, and more prosperous. Specifically, the portfolio seeks to prevent and remove trade barriers for U.S. agricultural exports and support U.S. exporters and trading partners. Collectively, the portfolio is working to:• Add over $622 million to the U.S. economy by removing trade barriers.• Contribute an additional $312 million to the U.S. economy through direct support to American exporters and trading partners.• Avoid over $50 billion in potential economic harm to the U.S. economy by preventing lost market access due to the spread of livestock contagions to the United States and new trade barriers.The awardee will conduct original basic and applied research that will focus on advancing a trade agenda that benefits America’s ranchers, farmers, and producers.Through this applied research, the awardee will:• Provide throughout the period of performance actionable recommendations to help achieve the CADI portfolio’s targets.• Track the portfolio’s attributable accomplishments toward these trade outcomes, including the development of U.S. county-level impact estimates.DELIVERABLES1. Final report on the recipient’s research to quantify the CADI portfolio’s direct economic impact on American farmers;2. Annual economic impact report that quantifies the CADI portfolio’s direct economic impact on American farmers. This report will specifically analyze the CADI’s portfolio of projects’ progress toward achieving the following targets:a. Armenia:i. Add $92,851,795 to the U.S. economy by increasing the sale of 200,000 MT U.S. wheat (40k MT sold once per year, for 5 years) through technical assistance to trading partners.ii. Add $2,197,937 to the U.S. economy by increasing U.S. exports to Armenia by 5% using short-term training and technical assistance to remove food safety-related technical barriers to trade.b. Georgia:i. Add $92,851,795 to the U.S. economy by facilitating the sale of 200,000 MT U.S. wheat (40k MT sold once per year, for 5 years) through technical assistance to trading partners.ii. Add $15,443,458 to the U.S. economy by increasing the U.S. market share of the Georgian poultry market by 1.1% over 5 years through short-term agricultural trade promotion and technical assistance.iii. Add $892,190 to the U.S. economy by facilitating $433,102 in the export of U.S. aquaculture inputs short-term agricultural trade promotion and technical assistance.c. Kazakhstan:i. Contribute $28,000,000 to the U.S. economy by supporting 1,000,000 bushels of expanded market opportunity for U.S. wheat, per year for 5 years, through improved agricultural production data.d. Ukraine:i. Maintain $439,441,866 in U.S. economic activity by ensuring $224,994,460 in U.S. agricultural exports to Ukraine continue over 5 years by preventing new barriers to U.S. agricultural exports.ii. Protect $50,000,000 in damage to the U.S. economy by maintaining U.S. pork’s global market access by preventing the spread of African Swine Fever to the United States.iii. Catalyze $1,030,000 in U.S. economic activity by unlocking the Ukrainian livestock genetics market and facilitating $500,000 in U.S. livestock genetics exports through short-term agricultural trade promotion and technical assistance.iv. Add $31,135,852 to the U.S. economy by unlocking the Ukrainian purebred cattle market, and supporting U.S. exporters in achieving 50% market share for 5 years.v. Contribute $14,255,778 to the U.S. economy by supporting 250,000 bushels of expanded market opportunity for U.S. wheat, per year for 5 years, through improved agricultural production data.vi. Contribute $16,731,044 to the U.S. economy by supporting 250,000 bushels of expanded market opportunity for U.S. oilseeds, per year for 5 years, through improved agricultural production data.e. Uzbekistan:i. Add $9,177,352 to the U.S. economy by increasing U.S. market share of soybean exports by 5%, and sustain this market share for 5 years through short-term agricultural trade promotion and technical assistance.ii. Add $4,735,105 to the U.S. economy by increasing U.S. market share of distilled spirits exports by 6.2%, and sustaining that market share for 5 years through short-term agricultural trade promotion and technical assistance.3. A quarterly presentation to the USDA/FAS CADI management team on the CADI portfolio’s progress toward achieving America First trade targets, providing strategic recommendations to maximize outcomes for the benefit of American agriculture; and,4. Annually, provide at least one success story per country where CADI operates. Each story must include a detailed analysis of USDA/FAS accomplishments in one of the following areas:a. Preventing or removing trade barriersb. Assisting U.S. exporters and trading partnersAll work under this research program is unclassified. The awardee shall ensure that all information is safeguarded against unauthorized access. Any personnel performing work under this agreement who will have access to non-public information will require Public Trust (Moderate Risk) background investigations (also known as T2 background investigation) that will be issued by USDA prior to beginning work.The projected Period of Performance is from November 1, 2026 - September 31, 2028, with the possibility of an extension as described in Section 9.1.The work will require Temporary Duty Travel (TDY) to foreign and domestic locations that remain to be determined. A total of 4 one-week international TDYs to Eastern Europe (non-E.U.), the South Caucasus and Central Asia should be included in the budget, as well as four one-week domestic trips to locations to be determined. Funding Opportunity Number: USDA-FAS-10960-0700-109-26-0003. Assistance Listing: 10.960. Funding Instrument: G. Category: AG. Award Amount: Up to $333K per award.

The CHIPS Incentives Program aims to catalyze long-term economically sustainable growth in the domestic semiconductor industry in support of U.S. economic and national security. This is the second Notice of Funding Opportunity under this program and seeks applications for projects for the construction, expansion, or modernization of commercial facilities for semiconductor materials and manufacturing equipment. For more information, additional resources, and instructions on how to apply, please visit chips.gov. Note that all applications must be submitted through the CHIPS Incentives Portal at https://applications.chips.gov. If you have any questions on how to apply, please email apply@chips.gov. Funding Opportunity Number: 2023-NIST-CHIPS-SMME-01. Assistance Listing: 11.037. Funding Instrument: CA. Category: ST.