Centers for Chemical Innovation (CCI) Phase I

Complementary and Integrative Health - Training, Institutional is sponsored by Department of Health And Human Services. NCCIH is the lead Federal agency for scientific research on the fundamental science, usefulness, and safety of complementary and integrative treatments and practices. NCCIH seeks to build knowledge across disciplines, focusing on the whole person, and taking a transdisciplinary approach that integrates the natural, social, and health sciences and transcends traditional boundaries. To address the need for objective evidence on the fundamental science, safety and efficacy of complementary and integrative health approaches, NCCIH supports rigorous scientific investigation to better understand how these interventions impact health, for whom, and the optimal methods of practice and delivery. By deepening our scientific understanding of the connections that exist across domains of human health, we can better understand how conditions interrelate, define multicomponent interventions that address these problems, and expand how we support patients through the full continuum of their health experience, including the return to health. To evaluate complementary and integrative health approaches. The following objectives support this goal: (1) coordinate and facilitate the investigation of complementary and integrative health approaches through peer-reviewed grant solicitations; (2) interface with the NCCIH National Advisory Council; (3) conduct technology assessment conferences for the purpose of establishing areas of Clinical and Pre-clinical research that need to be further developed within complementary health approaches; and (4) maintain a comprehensive bibliographic data base in conjunction with the National Library of Medicine. The National Center for Complementary and Integrative Health (NCCIH) regularly examines and redefines its research priorities. In setting research priorities, NCCIH considers its existing research portfolio, its 5-year strategic plan, the recommendations of the National Advisory Council for Complementary and Integrative Health, current scientific advances, the plans of other NIH institutes and centers, and input from expert panels and stakeholders. Research constituting a rigorous evidence base for complementary health approaches will be developed through a range of research strategies including basic and translational research, and clinical investigation. Priority setting also takes into account: 1)scientific promise, 2)amenability to rigorous scientific inquiry,3) potential to change health practices, and 4) relationship to use and practice. Research Approaches Basic, translational, efficacy/effectiveness, and implementation research for Complementary and Integrative Health approaches need to be studied across the research continuum. NCCIH continues to emphasize basic research that defines biological effects and mechanisms of action; this research is aimed at understanding the nature of complementary health approaches such as their biology, physiology, and physical, chemical and behavioral properties. NCCIH also supports the development of tools, models, and methodologies for studying these approaches. NCCIH continues to encourage efficacy studies to determine specific clinical effects of complementary health approaches under carefully controlled conditions that minimize nonspecific and contextual effects. There is also the need to strengthen translational and preliminary clinical research required to design and implement definitive clinical research and "real world" outcomes and effectiveness research that capitalizes on the reality that many complementary health approaches are in widespread public use. NCCIH’s support of translational research addresses the need for valid, reliable and relevant research tools, outcome measures, and innovative methodology to enhance the rigor of complementary health approaches within clinical studies and to ensure that they are maximally informative. NCCIH emphasizes studies that inform the design of future trials such as those that will: develop and validate outcome measures; standardize treatment protocols or algorithms; validate treatment algorithms and/or; develop measures of quality control or treatment fidelity; assess effects of various doses or intervention durations; or establish feasibility of interventions or study designs in specific populations for future studies. This listing is currently active. Program number: 93.485. Last updated on 2026-01-12.