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Clinical Investigator Award (K08) and Mentored Patient-Oriented Research Career Development Award (K23) is sponsored by National Institutes of Health (NIH) / National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). These career development awards are designed for clinicians who have a doctoral degree and are committed to a career in patient-oriented research.
NIAMS supports training for basic and clinical scientists to carry out research into arthritis and musculoskeletal diseases.
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Research Career Development Awards: K Awards | NIAMS The overall goal of the NIH Research Career Development program is to help ensure that a pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's biomedical, behavioral, and clinical research needs.
NIAMS support a variety of mentored and non-mentored career development award programs designed to foster the transition of new investigators to research independence and to support established investigators in achieving specific objectives. Candidates should review the different career development (K) award programs to determine the best program to support their goals.
Please refer to the individual awards for current eligibility information. This page serves as a resource and does not supersede or change the eligibility outlined in the specific NOFOs listed unless otherwise noted. Please contact us at: [email protected] with questions.
General Eligibility Information For all the following Research Development awards, these general eligibility criteria apply to all individuals that apply. Any candidate with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director/Principal Investigator (PD/PI) is invited to work with their mentor and organization to develop an application for support.
Applicants must be: in a mentored research position; at the time of award, the candidate must have a “full-time” appointment at an academic institution; candidates are required to commit a minimum of 75% of full-time professional effort (i.e., a minimum of 9 person-months) to their program of career development; NIAMS specific: NIAMS allows for a minimum of 50% full time professional effort (i.e., a minimum of 6 person-months) for orthopedic scientists; and, excluding the Parent K99/R00, by the time of award, the individual must be a citizen or a non-citizen national of the United States or have been lawfully admitted for permanent residence (i.e., possess a currently valid Permanent Resident Card USCIS Form I-551, or other legal verification of such status).
NOTE: Current and former Program Directors/ Principal Investigators (PDs/PIs) on an NIH research project (R01), program project (P01), center grants (P50), Project Leads of program project (P01), or center grants (P50), other major individual career development awards (e.g., K01, K07, K08, K22, K23, K25, K76, K99/R00), or the equivalent are not eligible .
Current and former PDs/PIs of an NIH Small Grant (R03), Exploratory/Developmental Grants (R21/R33), Planning Grant (R34/U34), Dissertation Award (R36), or SBIR/STTR (R41, R42, R43, R44) remain eligible, as do PD/PIs of Transition Scholar (K38) awards and individuals appointed to institutional K programs (K12, KL2).
Information on NIAMS-supported Research Career Development Programs K01: Mentored Research Scientist Career Development Awards Program Purpose: To provide research scientists with an additional period of sponsored research experience as a way to gain expertise in a research area new to the applicant or in an area that would demonstrably enhance the applicant's scientific career These awards are generally reserved for individuals interested in switching to a new research field, for individuals who have interrupted their career because of illness or pressing family care responsibilities, or for faculty at minority institutions who wish to enhance their capacity for independent research.
Salary Support: Up to $75,000 plus fringe benefits per year Research Support: Up to $20,000 per year Eligibility Information: Candidates for the K01 award must have a research or health-professional doctoral degree. This funding opportunity may support individuals who propose to train in a new field or individuals who have had a hiatus in their research career because of illness or pressing family circumstances.
Links to Application Information: Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required) Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) K08: Mentored Clinical Scientist Research Career Development Awards Program Purpose: The purpose of this program is to prepare clinically trained individuals for careers that have a significant impact on the health-related research needs of the nation.
This program provides support and protected time for an intensive, supervised research career development experience in the fields of biomedical, behavioral, or clinical research, including translational research. Salary Support: Up to $100,000 plus fringe benefits per year for 75% minimum effort, 50% for orthopaedic surgeon K08 and K23 recipients. See NOT-AR-16-012 for more information.
Research Support: Up to $20,000 per year. Eligibility Information: Candidates for the K08 award must have a clinical doctoral degree. Such degrees include, but are not limited to M.
D. , D. O.
, D. D. S.
, D. M. D.
, O. D. , D.
C. , Pharm. D.
, N. D. (Doctor of Naturopathy), and D.
V. M. Individuals with the Ph.
D. or other doctoral degree in clinical disciplines such as clinical psychology, nursing, clinical genetics, speech-language pathology, audiology or rehabilitation are also eligible. Individuals holding the Ph.
D. in a non-clinical discipline who are certified to perform clinical duties should contact the appropriate NIH Institute concerning their eligibility for a K08 award.
Links to Application Information: Mentored Clinical Scientist Research Career Development Award (Parent K08 – Independent Clinical Trial Not Allowed) NIH HEAL (Helping to End Addiction Long-term) Initiative Career Development Awards: Learn more about the NIH HEAL initiative NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Not Allowed) NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Basic Experimental Studies with Humans (BESH) Required) NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Required) K23: Mentored Patient-Oriented Research Career Development Awards Program Purpose: The purpose of the NIH Mentored Patient-Oriented Research Career Development Award (K23) is to support the career development of individuals with a clinical doctoral degree who have made a commitment to focus their research endeavors on patient-oriented research.
For the purposes of the K23 award, Patient-Oriented Research is defined as research conducted with human subjects (or on material of human origin such as tissues, specimens and cognitive phenomena) for which an investigator (or colleague) directly interacts with human subjects. This area of research includes: 1) mechanisms of human disease; 2) therapeutic interventions; 3) clinical trials; and 4) the development of new technologies.
Excluded from this definition are in vitro studies that utilize human tissues but do not deal directly with patients. In other words, patient-oriented research is research in which it is necessary to know the identity of the patients from whom the cells or tissues under study are derived. Studies falling under Exemption 4 for human subjects research are not included in this definition.
Salary Support: Support is provided for salary up to $100,000 for a minimum 75% effort (with the exception of orthopaedic surgeons, who may devote a minimum of 50% effort), fringe benefits. Research Support: research expenses up to $30,000.
Eligibility Information: By the time of award, the individual must be a citizen or a non-citizen national of the United States or have been lawfully admitted for permanent residence (i.e., possess a currently valid Permanent Resident Card USCIS Form I-551, or other legal verification of such status). Candidates for the K23 award must have a health-professional doctoral degree. Such degrees include, but are not limited to, M.
D. , D. O.
, D. D. S.
, D. M. D.
, O. D. , D.
C. , Pharm. D.
, N. D. (Doctor of Naturopathy), as well as a doctoral degree in nursing research or practice.
Individuals with the Ph. D. or other doctoral degree in clinical disciplines such as clinical psychology, clinical genetics, speech-language pathology, audiology or rehabilitation are also eligible.
Individuals holding the Ph. D. in a non-clinical discipline but who are certified to perform clinical duties should contact the appropriate Institute concerning their eligibility for a K23 award.
Candidates also must have completed their clinical training, including specialty and, if applicable, subspecialty training prior to receiving an award. However, candidates may submit an application prior to the completion of clinical training.
Links to Application Information: Mentored Patient-Oriented Research Career Development Award (Parent K23 – Independent Clinical Trial Not Allowed) Mentored Patient-Oriented Research Career Development Award (Parent K23 – Independent Clinical Trial Required) NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Patient-Oriented Research Career Development award (K23 - Clinical Trial Required) NIAMS Participation in Additional Career Development Award Programs The Helping to End Addiction Long-term® Initiative The Helping to End Addiction Long-term® Initiative , or the NIH HEAL Initiative®, is an NIH-wide effort to speed scientific solutions to stem the national opioid public health crisis.
NIAMS participates in several of the HEAL initiatives career programs: K08: NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Clinical Trials Not Allowed ; Basic Experimental Studies with Humans (BESH) ; and, Clinical Trial Required K23: NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Patient-Oriented Research Career Development award (K23).
Read the NOFO: K23: Clinical Trial Required K99/ R00: HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research K99/R00. Read the NOFO: K99/R00: Independent Basic Experimental Studies with Humans Required Training & Career Resources from Around NIH NIAMS Intramural Training Program NIAMS Scientific Advances Last Updated: February 2025
According to the current listing, eligibility includes: Applicants must have a health-professional doctorate degree, be licensed to practice clinically, and have completed their clinical training. Confirm the full requirements in the official notice before applying.
The current listing shows up to $100,000 in salary/year plus fringe benefits. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Clinical Investigator Award (K08) and Mentored Patient-Oriented Research Career Development Award (K23) is funded by National Institutes of Health (NIH) / National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Leveraging New Approach Methodologies and Non-Animal Technologies to Accelerate Osteoarthritis Research is sponsored by National Institutes of Health (NIH) / National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This grant invites research applications utilizing New Approach Methodologies (NAMs) and Non-Animal Technologies (NATs), such as archived human joint tissues, organoids, tissue chips, advanced in vitro systems, computational and mathematical models, and non-invasive imaging techniques to investigate biological mechanisms driving osteoarthritis.
Supporting Research Using the Resources from the Osteoarthritis Initiative (OAI) is sponsored by National Institutes of Health (NIH) / National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This opportunity invites research grant applications focused on utilizing the Osteoarthritis Initiative (OAI) database, clinical data, and images. It aims to expand the use of these resources for novel analyses, exploration of OA epidemiology and progression, and application of new technologies to biospecimens and genetic data. Topics include the use of biospecimens to discover biochemical markers for early or progressive disease, integration of biospecimens with imaging and clinical data, and development of robust tools for automated image analysis for OA diagnosis and monitoring.
Career Transition Award (K99/R00) is sponsored by National Institutes of Health (NIH) / National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This award is designed to facilitate the transition of outstanding postdoctoral researchers from mentored research positions to independent research careers. It combines a mentored (K99) and an independent (R00) phase.
PA-27-037 consolidates the Predoctoral to Postdoctoral Transition Award into a single parent announcement across 20 NIH components, with the next deadline December 8, 2026. The eligibility gate is not the science — it is a mandatory change of institution and mentor between the F99 and K00 phases.
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Read articlePA-27-034, PA-27-035 and PA-27-036 replace the institute-specific R25 announcements that research education programs have been built around for a decade. NCI, NIDA and NIGMS have already expired theirs early. Here is what the consolidation actually changes: an 8% indirect cost ceiling, a US-citizens-and-permanent-residents participant rule, a cooperative agreement variant that only exists on one of the three, and no clinical-trial-allowed companion anywhere.
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