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Colton Center for Autoimmunity at Yale University Awards is a Yale University program administered through Yale Ventures that provides $50,000 to $100,000 in one-year Pilot Awards, competitively renewable to year three, to support innovative translational research in autoimmune and allergic diseases.
The program funds discovery and development of therapeutics, diagnostics, and tolerogenic vaccines; investigations into biological mechanisms of immunological and allergic diseases; and platform technologies for such research. Awards are evaluated by Yale Ventures' Executive-in-Residence Program advisors and an independent Advisory Committee of academic scientists, pharmaceutical industry experts, and life science investors.
Eligible applicants are all Yale faculty members, including assistant, associate, and full professors and non-ladder research track faculty. Multi-PI and interdisciplinary applications are encouraged. The application deadline is November 20, 2025, with awards starting July 1, 2026.
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Application Information | Yale Ventures The Colton Center for Autoimmunity at Yale The Colton Center for Autoimmunity at Yale (CCAY) requests project proposals to advance innovative translational research in autoimmune and allergic diseases, including but not limited to: discovery and development of therapeutics, diagnostics, and tolerogenic vaccines; investigations to elucidate biological mechanisms of complex immunological and allergic diseases; and development of platform technologies to facilitate such research.
The CCAY will provide $50,000 - $100,000 for 1-year Pilot Awards, competitively renewable to Year 3, with the goal of providing seed funding for early high-risk/high-reward research with a future potential for commercialization through industry partnerships, licensing, and venture company formation.
Proposals will be evaluated by CCAY's advisors from Yale Ventures' Executive-/Entrepreneur-in-Residence Program, and by CCAY’s independent Advisory Committee comprised of academic and pharmaceutical industry scientists, and life science investors, with confidentiality maintained throughout the reviewing process. Connect with our team through 1-1 office hours.
Application Deadline: 11:59 PM, November 20 (Thursday), 2025 Anticipated Announcement of Awards: May 1, 2026 Funding Start Date: July 1, 2026 All Yale faculty (assistant, associate and full professors, and non-ladder research track) are eligible to submit proposals. Multi-PI applications, including applications from inter-disciplinary group of investigators, are encouraged.
Postdoctoral fellows should engage supervisory faculty members to submit applications. Specific areas of interest include, but are not limited to: 1. Discovery and development of novel therapeutics (e.g., small molecules, peptides, antibodies, proteins, nucleic acids, cell therapies, gene therapies, digital therapeutics); or breakthrough therapeutic approaches targeting autoimmune and allergic diseases.
2. Discovery and development of diagnostics (e.g., in vitro assays/tests, imaging agents, computational algorithms), or biomarkers applicable to endotype determination or patient stratification. 3.
Discovery and development of tolerogenic vaccines for autoimmune and allergic diseases. 3. Development of platform technologies that can accelerate the development of therapeutics, diagnostics, and tolerogenic vaccines.
4. Research projects to gain deeper insight into complex biological mechanisms of autoimmune and allergic diseases; and to identify and characterize novel drug targets. Cross-disciplinary projects such as chemistry/medicinal chemistry, chemical engineering, computer science (including the use of artificial intelligence), engineering, medical devices, and materials sciences, are encouraged.
The essential component of a successful proposal is a long-term translational goal to deliver therapeutics or diagnostics with a clear plan toward clinical development and commercialization. Please contact coltoncenter@yale. edu for any questions.
According to the current listing, eligibility includes: Yale University faculty members. Confirm the full requirements in the official notice before applying.
Colton Center for Autoimmunity at Yale University Awards is funded by Yale University. Verify program details on the funder's official page before applying.
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