Data Coordinating Center for the Aging and Alzheimer’s Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed) RFA-AG-27-010

Data Coordinating Center for the Aging and Alzheimer’s Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed) RFA-AG-27-010 is sponsored by National Institute on Aging (NIA). This opportunity seeks a Data Coordinating Center for the Aging and Alzheimer's Disease Mouse Brain Atlas. This would involve managing and coordinating data related to the atlas.

RFA-AG-27-010: Data Coordinating Center for the Aging and Alzheimer’s Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed) Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations NATIONAL INSTITUTE ON AGING ( NIA ) Funding Opportunity Title Data Coordinating Center for the Aging and Alzheimer's Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed) U24 Resource-Related Research Projects – Cooperative Agreements Check for any recent Notices of NIH Policy Changes that may impact application requirements.

Funding Opportunity Number (FON) Companion Funding Opportunity See Part 2, Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s) Funding Opportunity Purpose This Notice of Funding Opportunity (NOFO) invites applications proposing a Data Coordinating Center that integrates and disseminates multiscale mouse brain datasets for the aging and Alzheimer's disease (AD) research community.

The Data Coordinating Center will establish the Aging and AD Mouse Brain Atlas (AD-MBA), which will serve as a central, unified research resource for multi-omic and connectomic mouse brain datasets emerging from the NIA AD Multimodal Atlas Projects (AD-MAPs).

The Data Coordinating Center will (1) leverage the NIA-supported AD Knowledge Portal data infrastructure to facilitate hosting, deposition, and dissemination of multimodal datasets generated by the AD-MAPs program, (2) facilitate collaborative analyses among the data-contributing teams, (3) develop/optimize and incorporate tools for multiscale integration of multi-omics and connectomics datasets, and (4) create a broadly accessible web-based interface for the visualization and dissemination of integrated multiscale data.

Funding Opportunity Goal(s) To encourage biomedical, social, and behavioral research and research training directed toward greater understanding of the aging process and the diseases, special problems, and needs of people as they age.

Open Date (Earliest Submission Date) Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed All applications are due by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

No late applications will be accepted for this Notice of Funding Opportunity (NOFO). Required Application Instructions It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts ).

Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide , follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review. There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners.

You must use one of these submission options to access the application forms for this opportunity. Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.

gov and eRA Commons to track your application. Check with your institutional officials regarding availability. Use Grants.

gov Workspace to prepare and submit your application and eRA Commons to track your application. Part 1. Overview Information Part 2.

Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II. Award Information Section III.

Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI.

Award Administration Information Section VII. Agency Contacts Section VIII. Other Information Part 2.

Full Text of Announcement Section I. Notice of Funding Opportunity Description Alzheimer's disease (AD) is a progressive neurodegenerative disease of the brain and the most common form of dementia in older adults. It is estimated that AD starts 15–20 years before the appearance of the onset of clinical symptoms and ultimately leads to a loss of memory and cognitive skills and a decline in quality of life in older adults.

The progression of AD often follows a predictable temporal and spatial pattern where specific brain regions are affected at different stages of the disease. However, it is unclear why the disease affects certain regions of the brain or which specific cell types within these brain regions are selectively vulnerable.

To better understand the mechanisms and impact of selectively vulnerable brain regions, cell types, and circuits in AD progression, NIA established the AD Multimodal Atlas Projects (AD-MAPs). The goal of AD-MAPs is to generate comprehensive multimodal atlases and brain-wide connectomes across species as a platform to discover cell types and circuits that are altered in normal aging and AD progression.

In addition, the AD-MAPs program supports projects performing secondary analyses of these datasets. One focus of the AD-MAPs program is to characterize cells and circuits in mouse models of aging and AD. These mouse model studies are performing high-resolution transcriptomic and epigenomic profiling, as well as executing spatial transcriptomics and circuit-level mapping.

These projects also incorporate neuropathological data across multiple mouse models of aging and AD. Many of these datasets have the potential to be integrated and shared as a common resource, increasing the overall value of each individual project by enhancing adherence to FAIR (Findable, Accessible, Interoperable, Reuseable) data principles.

However, these large projects remain siloed, and there is a need for a centralized data sharing infrastructure to integrate and disseminate these valuable datasets. This NOFO invites applications proposing a Data Coordinating Center that will develop a centralized resource for discovery, access, and integration of mouse model datasets generated by projects in the AD-MAPs program.

A successful Data Coordinating Center will implement open science principles and FAIR data practices to integrate disparate multiscale datasets from across projects and create the Aging and AD Mouse Brain Atlas (AD-MBA) as a robust resource for the research community. The Data Coordinating Center will take advantage of the unique opportunity to unify aging and AD mouse brain datasets spanning multi-omics and connectomics.

This multiscale integration builds on a key takeaway from an NIA-hosted workshop in March 2023 that emphasized the value of incorporating data across scales to better understand aging and AD/ADRD and identified this gap as "the next big opportunity" facing the field. Furthermore, current advances in technology have enabled multiscale integration of mouse brain data spanning single-cell transcriptomics to circuit-level connectomics.

This NOFO is intended to support the creation of a centralized infrastructure that brings together multi-omics and connectomics mouse data for the AD-MBA, a first-of-its-kind data resource for the aging and AD research community.

To create the AD-MBA, a Data Coordinating Center is needed to: Leverage the NIA-supported AD Knowledge Portal FAIR data infrastructure to facilitate hosting, deposition, and dissemination of multimodal datasets generated by the AD-MAPs program. Facilitate collaborative analyses among the data-contributing teams. Develop/optimize and incorporate open-source tools for multiscale integration of multi-omics and connectomics datasets.

Create open-source, web-based interfaces for visualization query of integrated multiscale data. The Data Coordinating Center will achieve two major goals: 1. Unify disparate, multimodal data generated in brain tissue of mouse models of aging and AD by aggregating and harmonizing datasets across at least 5 projects in the AD-MAPs program.

The Data Coordinating Center must aggregate and harmonize multiscale data from multiple mouse models of aging and AD, including different AD pathologies, multiple brain regions, both sexes, and early to late-stage AD progression. These separate projects are collecting datatypes spanning genomics and connectomics.

The Data Coordinating Center must develop/optimize and share tools for multiscale integration of multi-omics and connectomics datasets. 2. Create a community portal that will serve as a knowledge base for discovery and enable access to the datasets from the contributing projects from the AD-MAPs program, the associated open-source tools, and web-based interfaces for data visualization and query.

The Data Coordinating Center must facilitate the hosting, deposition, and dissemination of multimodal datasets generated by the contributing AD-MAPs teams. The data repository for the raw, processed, and harmonized datasets must be the NIA-supported AD Knowledge Portal.

The AD Knowledge Portal is a FAIR data infrastructure containing both human and animal datasets from over a dozen NIA-supported systems biology consortia and translational centers such as AMP-AD and MODEL-AD. The Data Coordinating Center applicants are strongly encouraged to complement and align with existing NIA/NIH data resources, such as those produced by the MODEL-AD consortium and those produced by the BRAIN Initiative .

Specific Areas of Research Interest Activities appropriate for the AD-MBA Data Coordinating Center include, but are not limited to the following examples: Develop the AD-MBA as a public portal for the broad sharing of raw and processed data, multiscale models, and analytical tools. Coordinate timely deposition and release of newly generated datasets contributed by AD-MAPs members.

Coordinate and provide adequate annotation and curation of datasets to enable data integration and harmonization and to maximize data usability. Facilitate collaborative analyses among AD-MAPs data-contributing teams that will leverage combined resources across partners to more effectively answer pressing scientific questions.

Develop web-based, open-source data visualization interfaces and tools to enable data scientists and biologists to query and interact with the rich datasets and multiscale models being developed by the AD-MAPs program. Applicants are strongly encouraged to consult with the NIA Scientific Contact early in the pre-submission process to ensure that the application is responsive to the programmatic goals of this NOFO.

Applications Not Responsive to this NOFO The following types of applications are not responsive to this NOFO and will not be reviewed: Applications that do not propose to aggregate and harmonize datasets across at least five projects in the AD-MAPs program. Applications that do not propose to integrate data types including, at minimum, single-cell/nucleus transcriptomics and connectomics.

Applications that do not propose to create an accessible community portal to enable broad dissemination. Applications that do not propose to develop, optimize, and/or utilize appropriate computational tools to integrate datasets spanning modalities (genomics and connectomics). Applications that propose to incorporate datasets not collected by projects in the AD-MAPs program.

Applications that propose to directly acquire new primary data. Applications that propose to integrate data that were not generated from mouse models. See Section VIII.

Other Information for award authorities and regulations. Section II. Award Information Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement.

Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities. See Section VI. 2 for additional information about the substantial involvement for this NOFO.

Application Types Allowed The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO. Not Allowed: Only accepting applications that do not propose clinical trials.

Note: Applications may propose activities involving human subjects that are not deemed clinical trials. Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards NIA intends to commit $2.

5 million in FY 2027 to fund 1 award. Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum project period is 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO. Section III.

Eligibility Information Higher Education Institutions - Includes all types Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Foreign Organizations/Foreign Collaborations Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts.

All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16. 8 Collaborative International Research Awards .

Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding.

This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components , funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible.

Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2. 3. 9.

2 Electronically Submitted Applications for additional information System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration.

SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Foreign organizations must obtain a NATO Commercial and Government Entity (NCAGE) Code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM.

gov registration process. The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.

gov registrations; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants.

gov – Applicants must have an active SAM registration in order to complete the Grants. gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. Obtaining an eRA Commons account can take up to 2 weeks. All PD(s)/PI(s) must be registered with ORCID .

The personal profile associated with the PD(s)/PI(s) eRA Commons account must be linked to a valid ORCID ID. For more information on linking an ORCID ID to an eRA Commons personal profile see the ORCID topic in our eRA Commons online help .

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide . This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement NIH Grants Policy Statement Section 1. 2 Definition of Terms.

3. Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct. The NIH will not accept duplicate or highly overlapping applications under review at the same time, per NIH Grants Policy Statement Section 2.

3. 7. 4 Submission of Resubmission Application .

This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2. 3. 9.

4 Similar, Essentially Identical, or Identical Applications ). Section IV. Application and Submission Information 1.

Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants. gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.

gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution. 2.

Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise (in this NOFO, in a policy notice , or other notice from NIH Guide for Grants and Contracts ).

Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review. All page limitations described in the How to Apply – Application Guide and the Table of Page Limits must be followed.

Instructions for Application Submission The following section supplements the instructions found in the How to Apply – Application Guide and should be used for preparing an application to this NOFO. All instructions in the How to Apply - Application Guide must be followed. SF424(R&R) Project/Performance Site Locations All instructions in the How to Apply - Application Guide must be followed.

SF424(R&R) Other Project Information All instructions in the How to Apply - Application Guide must be followed. SF424(R&R) Senior/Key Person Profile All instructions in the How to Apply - Application Guide must be followed. All instructions in the How to Apply - Application Guide must be followed.

All instructions in the How to Apply - Application Guide must be followed. PHS 398 Cover Page Supplement All instructions in the How to Apply - Application Guide must be followed. All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions: Applications must describe plans to achieve the following five objectives.

1) Aggregate and harmonize mouse brain multi-modal (genomics and connectomics) datasets emerging from at least 5 projects in the AD-MAPs program. Applications must describe plans to coordinate with project PIs to ingest existing and future datasets and associated metadata from at least 5 projects in the AD-MAPs program. Data types to be aggregated must include, at minimum, single-cell/nucleus transcriptomics and connectomics.

Plans must include harmonization of datasets within the same modality. Applications must include plans to aggregate and harmonize data from multiple mouse models of aging and AD, including different AD pathologies, multiple brain regions, both sexes, and early to late-stage AD progression.

Data types should include, but are not limited to, the following: Single-cell/single-nucleus transcriptomics and epigenomics Animal age, sex, genetic background, and AD model Applications must describe plans to determine which datasets meet minimum standards for rigor and reproducibility to ensure that only data of sufficient quality is incorporated.

2) Develop and incorporate tools for multiscale modeling of multi-omics and connectomics datasets. To achieve multiscale modeling, applications must include plans to develop, optimize, and/or utilize appropriate multiscale computational tools to integrate datasets spanning modalities (genomics and connectomics). Datasets for multiscale integration must include, at minimum, single-cell/nucleus transcriptome and connectome.

Inclusion of other modalities is strongly encouraged, such as epigenome, spatial transcriptome, and pathology. 3) Create an accessible platform to disseminate the data and tools to the research community: the AD-MBA.

Applications must propose a web-based interface that meets the needs of the research community and must serve as a knowledge base that includes the following: Open-access tools to visualize and query harmonized, multiscale datasets, including methods developed for multiscale data integration in (2) above. Access points for raw and processed datasets from the contributing projects.

Applications must describe plans to facilitate hosting, deposition, and dissemination of multimodal datasets generated by the contributing AD-MAPs teams. 4) Capitalize on existing resources and infrastructure. The data repository for the raw, processed, and harmonized datasets must be the NIA-supported AD Knowledge Portal.

The web-based portal should be modeled after existing resources, including but not limited to NIA's MODEL-AD and/or the Allen Institute for Brain Science portals for the Allen Brain Cell Atlas and the Mouse Brain Connectivity Atlas for normal mouse brain.

Applications are strongly encouraged to complement and align with existing NIA/NIH data resources, such as those produced by the MODEL-AD consortium and those produced by the BRAIN Initiative . Applications must include a well-defined plan for evaluating the activities supported by the award. The evaluation plan must include specific and feasible measures of progress and a timeline with major milestones.

The measures of progress included should assess the administrative and scientific accomplishments, both yearly and overall. The milestones must include clear outcomes and actionable criteria for evaluating progress and decisions on project continuation and direction. Plans for ongoing feedback and critical evaluation by NIH Program Staff should be included.

Applications must provide letters of support from the PIs of each project proposed for integration into the AD-MBA. Resource Sharing Plan : Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide .

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions: A Data Management and Sharing Plan (DMS Plan) is required for any NIH-funded or conducted research that will generate scientific data. Applicants must submit the DMS Plan at the time of application using the NIH DMS Plan Format Page . The DMS Plan must address the elements in the structured format.

Where the DMS Plan Format Page requires a "Yes or No" response, no additional narrative is allowed. Appendix: Only limited Appendix materials are allowed. Follow all instructions for the Appendix as described in the How to Apply - Application Guide .

No publications or other material, with the exception of blank questionnaires or blank surveys, may be included in the Appendix.

PHS Human Subjects and Clinical Trials Information When involving human subjects research, clinical research, and/or NIH-defined clinical trials (and when applicable, clinical trials research experience) follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply - Application Guide , with the following additional instructions: If you answered "Yes" to the question "Are Human Subjects Involved?"

on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or Delayed Onset Study record. Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the How to Apply - Application Guide must be followed.

Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply - Application Guide must be followed. PHS Assignment Request Form All instructions in the How to Apply - Application Guide must be followed.

3. Unique Entity Identifier and System for Award Management (SAM) See Part 2. Section III.

1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants. gov 4. Submission Dates and Times Part I.

contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday , the application deadline is automatically extended to the next business day.

Organizations must submit applications to Grants. gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons , NIH's electronic system for grants administration.

NIH and Grants. gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.

gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Grants Policy Statement Section 2.

3. 9. 2 Electronically Submitted Applications .

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission. Information on the submission process and a definition of on-time submission are provided in the How to Apply – Application Guide . 5.

Intergovernmental Review (E. O. 12372) This initiative is not subject to intergovernmental review.

All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement . Pre-award costs are allowable only as described in the NIH Grants Policy Statement Section 7. 9.

1 Selected Items of Cost . 7. Other Submission Requirements and Information Applications must be submitted electronically following the instructions described in the How to Apply - Application Guide .

Paper applications will not be accepted. Applicants must complete all required registrations before the application due date. Section III.

Eligibility Information contains information about registration. For assistance with your electronic application or for more information on the electronic submission process, visit How to Apply – Application Guide . If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Dealing with System Issues guidance.

For assistance with application submission, contact the Application Submission Contacts in Section VII. All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form . Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.

See Section III of this NOFO for information on registration requirements. The applicant organization must ensure that the unique entity identifier provided on the application is the same identifier used in the organization's profile in the eRA Commons and for the System for Award Management. Additional information may be found in the How to Apply - Application Guide .

See more tips for avoiding common errors. Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review and responsiveness by components of participating organizations, NIH. Applications that are incomplete, non-compliant and/or nonresponsive will not be reviewed.

Recipients or subrecipients must submit any information related to violations of federal criminal law involving fraud, bribery, or gratuity violations potentially affecting the federal award. See Mandatory Disclosures, 2 CFR 200. 113 and NIH Grants Policy Statement Section 4.

1. 35 . Send written disclosures to the NIH Chief Grants Management Officer listed on the Notice of Award for the IC that funded the award and to the HHS Office of Inspector Grant Self Disclosure Program at grantdisclosures@oig.

hhs. gov . Post Submission Materials Applicants are required to follow the instructions for post-submission materials, as described in the policy Section V.

Application Review Information Only the review criteria described below will be considered in the review process. Applications submitted to the NIH in support of the NIH mission are evaluated for scientific and technical merit through the NIH peer review system.

Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).

Reviewers will consider each of the review criteria below in the determination of scientific merit and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.

Does the proposed Center address the needs of the research projects that it will coordinate? Is the scope of activities proposed for the Center appropriate to meet those needs? Will successful completion of the aims bring unique advantages or capabilities to the research projects?

How well does the proposed portal and knowledge base meet the needs of the research community? Are the PD(s)/PI(s) and other personnel well suited to their roles in the Center? Do they have appropriate experience and training, and have they demonstrated experience and an ongoing record of accomplishments in managing collaborative research?

Do the investigators demonstrate significant experience with coordinating collaborative basic research? If the Center is multi-PD/PI, do the investigators have complementary and integrated expertise and skills; are their leadership approach, governance, plans for conflict resolution, and organizational structure appropriate for the Center? Does the applicant have experience overseeing selection and management of subawards, if needed?

How well do the letters of support from the PIs of the contributing AD-MAPs projects demonstrate feasibility of collaboration? Does the application propose novel organizational concepts, management strategies, or instrumentation in coordinating the research projects the Center will serve? Are the concepts, strategies, or instrumentation novel to one type of research program or applicable in a broad sense?

Is a refinement, improvement, or new application of organizational concepts, management strategies or