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DE-FOA-0003612: The Genesis Mission: Transforming Science and Energy with AI is sponsored by U.S. Department of Energy (DOE) Office of Science, Office of Fusion Energy Sciences (FES). FES is interested in applications for preliminary design studies exploring the creation of volumetric neutron sources (VNS) based on the next generation of fusion concepts, with the potential for significant cost share through public-private partnerships.
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The Genesis Mission | Department of Energy A national initiative to build the world’s most powerful scientific platform. The Genesis Mission unites DOE National Labs, industry, academia, and more to harness AI for breakthroughs in energy dominance, discovery science, and national security.
Addressing National Science and Technology Challenges in Key Areas DOE has identified an initial 26 national science and technology challenges to accelerate U.S. innovation and leadership. These challenges will deliver tangible benefits for the American people through the Genesis Mission’s AI platforms and partnerships.
American Science and Security Platform The American Science and Security Platform The Genesis Mission will build a complex integrated platform, connecting the world’s best supercomputers, experimental facilities, AI systems, and unique datasets.
Collaboration and Consortium Bringing Together World-Class Innovators The Genesis Mission brings together cross-sector and cross-functional leading experts to solve critical challenges at unprecedented speed. Learn More about Genesis Collaboration and Consortium In March 2026, DOE announced funding to advance the Genesis Mission’s efforts to tackle the nation’s most complex science and technology challenges.
Get details on the Request for Applications here: The Genesis Mission: Transforming Science and Energy with AI .
Energy Department Launches ‘Genesis Mission’ to Transform American Science and Innovation Through the AI Computing Revolution Energy Department Announces 26 Genesis Mission Science and Technology Challenges to Accelerate AI-Enabled American Innovation and Leadership From Axios: What's next for the Genesis Mission Energy Department Announces $293 Million in Funding to Support Genesis Mission National Science and Technology Challenges From PowerMag: The Genesis Mission: How AI Supercomputing Is About to Reshape American Science and Energy From CSIS: Betting on America | Can AI Accelerate Scientific Discovery?
Featuring Under Secretary Darío Gil Get Genesis Mission updates from the Under Secretary for Science. Explore the Genesis Mission Genesis Mission National Science and Technology Challenges The American Science and Security Platform Genesis Mission Collaboration Office of the Under Secretary for Science Get Genesis Mission Updates Follow Under Secretary Gil on LinkedIn Follow Under Secretary Gil on X
According to the current listing, eligibility includes: Private companies, universities, and national laboratories. Confirm the full requirements in the official notice before applying.
Applications for DE-FOA-0003612: The Genesis Mission: Transforming Science and Energy with AI are due December 17, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
DE-FOA-0003612: The Genesis Mission: Transforming Science and Energy with AI is funded by U.S. Department of Energy (DOE) Office of Science, Office of Fusion Energy Sciences (FES). Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
DOE's FY2026 Office of Science open-call solicitation (DE-FOA-0003600) makes roughly $500 million available across about 500 awards of $50,000 to $5 million — across computing, physics, chemistry, biology, fusion, and isotopes — with a rolling window that stays open through September 30, 2026. Unlike a targeted NOFO, it lets investigators propose almost anything within the agency's mission. Here is how the open call actually works, why it is chronically underused, and how to write into it.
Read articleThe DOE Genesis Mission RFA closed its Phase II window on May 19. With $293.76M, 21 topics, and 99 focus areas, it is the largest single federal AI-for-science procurement in 2026. Here is what survived the cut and what comes next.
Read articleOn July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
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