Development and Validation of Indocyanine Green Fluorescence Imaging and AI-Assisted Analysis for Assessing Myocardial Viability in DCD Hearts During Cold Storage Preservation

Development and Validation of Indocyanine Green Fluorescence Imaging and AI-Assisted Analysis for Assessing Myocardial Viability in DCD Hearts During Cold Storage Preservation is sponsored by ZOLL Foundation. This is an example of a previously funded project by the ZOLL Foundation that directly aligns with imaging and AI, specifically for medical applications.

The ZOLL Foundation generally supports research related to resuscitation and acute critical care.

Funded Projects - ZOLL Foundation Early-stage research funding Since awarding the first grants in 2014 through March 31, 2026, the Foundation has awarded nearly $10 million in grants to 206 grantees .

Endothelial Nitric Oxide Flux as a Novel Antithrombotic Strategy in ECMO Using Sweep Gas Delivery Massachusetts General Hospital Optimising Minimally Invasive Surfactant Therapy for Preterm Infants Murdoch Children's Research Institute Frederique Donnelly, PhD Candidate Physiology-Guided CPR: Optimizing Chest Compression Location Using Real-Time Carotid Doppler Monitoring St.

Olavs University Hospital Sunniva Gjerald Birkeli, RN Prediction scores in DNACPR-decisions: A simulated randomized controlled trial Causal Cutoff: Outcome-Optimized Thresholds for Intubation Timing After High-Flow Nasal Cannula Oxygen Therapy and Other Life-Saving ICU Decisions Fukushima Medical University Ryohei Kobayashi, MD, PhD Targeting STARD7 to improve mitochondrial function in HFpEF Targeting leukocyte oxidative stress to prevent coagulopathy during extracorporeal cardiopulmonary resuscitation From Reactive Management to Proactive Prevention: Implementing a Multi-Component Bundle to Reduce Delirium in the Aging CICU Population mRNA-Hydrogel Bridging Therapy to Prevent Fatal Burn Wound Progression Brigham and Women's Hospital Qimanguli Saiding.

MD, PhD REACT (Relating EEG Activity to Cerebral Injury via TBI Biomarkers) Icahan School of Medicine, Mount Sinai Neutrophil state transitions in ICU sepsis: a multi-compartment translational programme to identify theranostic targets for precision immunotherapy Penn Cardiac Arrest bioRepository for Discovery and Innovative Omics research study (Penn CARDIO) University of Pennsylvania Proteomic Evaluation Of Csf And Blood Samples In A Rat Model Of Asphyxial Cardiac Arrest MULti-Omic approach for the prediction of delayed cerebral ischemia in Traumatic Brain Injury (MUL-TBI) Paris University, Lariboisiere Hospital Pierre-Simon Zuddas, Resident Synthetic augmentation of cardiac mitochondria using CRISPR-based tools Mario Escobar Galdamez, PhD Lactate as a Therapy for the Post-Cardiac Arrest Brain Injury Chenghao Wu, MD, PhD candidate The Gut Microbiome as Mediator of Sepsis Subphenotypes Pharmacological interventions preceding in-hospital cardiac arrest: a matched case-control study Frederik Gautier Hansen, BSc.

med Implementation of Systematic Clinical and Genetic Evaluation of Sudden Cardiac Arrest Probands and their Families Reducing Radiation Burden in Preterm Babies Using Lung Ultrasound: A Randomised Controlled Trial The University of Melbourne TraLI: Transforming Trauma and Life-Saving Information for Prehospital Care in Hawassa, Ethiopia (DATA SHARING) Emnet Tesfaye Shimber, MD Optimal Compression Point in Children with Congenital Heart Disease Using 3D Modeling Boston Children's Hospital A Randomized Controlled Clinical Trial of 300 ppm Inhaled Nitric Oxide as an Antimicrobial Therapy in Critically Ill Patients with Pneumonia: A Phase IIa Study Massachusetts General Hospital Feasibility and sensitivity of cerebral oximetry to assess ventilatory burden in children with sleep-disordered breathing Boston Children's Hospital Novel SGLT2 Inhibitor Strategy for Heatstroke: Mechanistic Validation and Translational Pathway Early Rearrest after Return of Spontaneous Circulation during In-Hospital Cardiac Arrest: Epidemiology, Predictors, and Association with Processes of Care and Outcomes Albert Einstein College of Medicine Josh Kimbrell, BA, CCP-C, C-NPT ROSC (Reducing Oxidative Stress after Cardiac arrest): A Phase II Randomized Controlled Trial Erasmus University Medical Center Towards Personalized Defibrillation: AI-Guided Prediction of Shock Response and Optimal Strategy in Cardiac Arrest CIUSSS du Nord-de-l'Île-de-Montréal Systematic Profiling of Cerebral Metabolites In A Mouse Model of Asphyxial Cardiac Arrest National University of Singapore Improving Access to Prehospital Extracorporeal Cardiopulmonary Resuscitation for Refractory Out-Of-Hospital Cardiac Arrest: A Mixed-Methods Study Non-Invasive Monitoring of Hyperammonemia in Sepsis and Critical States Autonomous Reanimation & Evacuation Research Institute Ketone Bodies as a Treatment for Reducing Brain Injury After Cardiac Arrest Aarhus University Hospital Christian Staehr, MD, PhD Optimising Breathing Support at Extubation in Very Preterm Infants Murdoch Children's Research Institute Combination vs Monotherapy with Broad-spectrum antibiotics and Aminoglycoside Treatment for Gram-Negative bloodstream Infections in ICU: COMBAT-GN ICU Study Aysun Tekin, MBBS, MS FACP, FCCP The effect of glucose-insulin-potassium on cardiac arrest resuscitation in a swine model of prolonged untreated ventricular fibrillation University of Alabama at Birmingham Multidisciplinary healthcare professionals' perceptions on the effectiveness of innovative basic life support education sessions.

University of the Sunshine Coast Jennifer Dermer, PhD Candidate A novel measure for assessing post-cardiac arrest syndrome severity by using real-time measurements of transcutaneous tissue carbon dioxide Feinstein Institutes for Medical Research Fresh Frozen Plasma Treatment for Glycocalyx Degradation in Sepsis Beth Israel Deaconess Medical Center Monitoring pulmonary edema in mechanically ventilated patients using wearable stethoscopes.

Beth Israel Deaconess Medical Center New digital tools for prehospital resuscitation research (Rebecca study) Medical University of Vienna Josef Michael Lintschinger, MD The multiorgan impact of assisted ventilation to support the preterm lung Murdoch Children Research Institute Selective Targeting of Peripheral α2-Adrenoceptors with α-Methylnorepinephrine as a Superior Alternative to Epinephrine for Resuscitation from Cardiac Arrest Rosalind Franklin University of Medicine and Science Investigating Anti-Inflammatory Mechanisms of a Novel Pump Prime Solution for CPB and ECMO Virginia Commonwealth University Optimizing the Hemodynamic Management of Septic Shock by Continuous Monitoring of Microcirculatory Parameters Rosalind Franklin University of Medicine and Science Double sequential external defibrillation in refractory ventricular fibrillation - the DOSEVF2 trial, a multicentric cluster randomized study Heidelberg University Hospital Stephan Katzenschlager, MD Rate Optimization of the Vest CPR-T Comprehensive Cardiac Arrest Recovery System Utilizing a Porcine Ventricular Fibrillation Model Dartmouth Hitchcock Medical Center The use of extracorporeal photopheresis as immunomodulatory therapy of subclinical antibody-mediated rejection after lung transplantation: a prospective RCT Medical University of Vienna Permissive hypotension after cardiac surgery: a pilot randomized clinical trial Massachusetts General Hospital Delivery of High-dose Nitric Oxide through Standard ECMO in a Swine Model to Fight the Worldwide Munti-drug Resistant Pathogens Emergency in Critically Ill Patients University of Milan/Mass General Lower gas flows during respiratory support for extremely preterm infants Murdoch Children's Research Institute Kristin Ferguson, BSc, MBBS Improving Cardiopulmonary Resuscitation and Survival in Children following Drowning Decoding rhinovirus pneumonia: host dependencies and aberrant inflammation in the alveolus Treatment Outcomes in New-Onset Atrial Fibrillation in the Surgical ICU: an Exploratory Study using High-Fidelity ECG Waveform Data Medical University of Vienna Evaluation of plasma renin concentrations in cardiac surgery Patrick Wieruszewski, PharmD Targeting Proteostasis to Improve Cardiac Function after Arrest Case Western Reserve University Development and Validation of Indocyanine Green Fluorescence Imaging and AI-Assisted Analysis for Assessing Myocardial Viability in DCD Hearts During Cold Storage Preservation Virginia Commonwealth University Helping respiratory-distressed neonates survive using integrated bubble continuous positive airway pressure innovations within primary health care in Ethiopia Intramuscular Epinephrine for the Treatment of Cardiac Arrest Aarhus University Hospital Clinical predictors of thrombosis in extracorporeal membrane oxygenators used for acute critical care The Brigham and Women's Hospital Farhad Rikhtegar Nezami, PhD The effect of early Landiolol in patients with ST-elevation acute coronary syndrome undergoing primary percutaneous coronary intervention – A prospective, randomized, double-blinded, placebo-controlled, phase IV pilot trial (STEMILAND-1) Medical University of Vienna Sebastian Schnaubelt, MD, PhD Application of Diving Reflex in a Porcine Model of Acute Shock Feinstein Institutes for Medical Research Willians Tambo, PhD Candidate Injury-specific differences in the ADAMTS13 - vWF axis in major trauma patients Antwerp University Hospital Data-driven Modeling of Pathological Mechanisms of Dyspnea in Heart Failure Karina Krevsky-Phillips, PhD Selective Brain Hypothermia Combined with Core Warming with Endovascular Devices Mitsuaki Nishikimi, MD, PhD Quantification of severity of hypoxic-ischemic encephalopathy in postmortem brain autopsy to improve neuroprognostication and temperature control after cardiac arrest Charite-Universitatsmedizin Multimodal assessment of angiotensin ll effects in a swine model of post-myocardial infarction circulatory failure supported by veno-arterial ECMO.

Universite Libre de Bruxelles Handover of information from ward staff to the cardiac arrest team during in-hospital cardiac arrest: Identifying deficiencies and building a new model Cecilie Langkilde Lauesen, BsC Impact of spatiotemporal reorganization of resident macrophages on tissue phenotype during sepsis Natural Language Processing to Identify In-Hospital Cardiac Arrest University of Pennsylvania Assessing Changes in Muscle Health Throughout Hospitalization After Cardiac Arrest A Prospective Observational Study of Safety Threats and Adverse Events in Trauma (PrO-STAT) Physiologic Targets for Pulseless Electrical Activity Assessing school readiness outcomes in young children admitted to the pediatric intensive care unit using machine learning and population-based registry data in Queensland, Australia.

Novel Cardiopulmonary Resuscitation Training Strategies to Improve In-hospital Cardiac Arrest Outcomes Randers Regional Hospital Sustainable Emergency Medical Systems and Resuscitation Strategies in Developing Countries.

Graduate School of Nippon Sport Science University Haruka Takahashi, PhD student Detecting Return of Spontaneous Circulation using Femoral Arterial Doppler Waveforms during Chest Compressions The Feinstein Institutes for Medical Research / Northwell Health Investigating A Novel Non-invasive Ultrasonic Measure of Cardiac Output for the Diagnosis of Cardiogenic Shock Reducing the burden of MRSA pneumonia in post cardiac arrest patients using high dose inhaled NO in an experimental swine model Massachusetts General Hospital Foundation’s September 30, 2023 grant cycle.

The purpose of this grant is for the study entitled "A systematic scoping review of international uncontrolled donation after cardiac death (uDCD) practices after out-of-hospital cardiac arrest" Evaluation of Resuscitation Algorithms (NRP vs. PALS) in Asphyxiated Cardiac Arrested Ovine Model of Differing Ages University of California, Davis Dose finding study for optimal dose of early intramuscular epinephrine in a porcine model of out-of-hospital cardiac arrest University of Pittsburgh Department of Emergency Medicine A novel risk assessment tool for hyperkalaemia and development of cardiac arrhythmia Research Center for Emergency Medicine, Aarhus University Hospital Paramedic Use of Carotid Artery Ultrasound for Pulse Checks in Patients with Out-of-Hospital Cardiac Arrest: A Feasibility Study Johns Hopkins School of Medicine Establishment of a Multicenter Video Review Registry to Assess Chest Compression Interruptions during Cardiac Arrest Resuscitation The Feinstein Institutes for Medical Research / Northwell Health The Effect of PEEP on RV Function in ECPR: A Pre-Clinical VA-ECMO-Supported Swine Model Weil Medical College of Cornell University Use of Immunoadsorption Filter for Conversion of High-Titer to Low-Titer Type O Whole Blood Madigan Army Medical Center Assessment of Basic Life Support and Work Experience of Healthcare Providers in Limited-resource Setting: A Quality Improvement Project Ethiopian Society of Emergency and Critical Professionals Mechanism of selective vulnerability in the thalamic reticular nucleus after cardiac arrest Children's National Hospital Hemodynamics and hypoxic organ damage during cardiopulmonary resuscitation with inflated aortic balloon catheter in combination with infusion of organ preservation solution in a pig model of cardiac arrest.

Reducing neurological injury following cardiac arrest.

Aarhus University Hospital Cecilie Munch Johannsen, MD Activation of tissue-resident stem cells during acute burn trauma care The Brigham and Women’s Hospital, Inc. Mathematical and In-Vivo Modeling of Limb Compression to Enhance Cardiopulmonary Resuscitation Pulmonary vasodilatation to improve outcome following cardiac arrest -- an experimental study Aarhus University Hospital Endothelial cell immunogenicity in sepsis: study on a 3D microfluidic model with pulsed flow INSERM UMRS 976 (St.

Louis Hospital) The Role of Sulfide Catabolism in Myocardial Ischemia and Reperfusion Injury Kyushu University/Mass General Effect of peripheral venous route and dose on epinephrine pharmacokinetics during neonatal resuscitation.

University of California, Davis Prognostic impact of hypochloremia in patients with Acute heart failure: Prospective Cohort Study Arterial Blood pressure and Cardiac Arrest Study (ABaCAs) Manchester Foundation Trust Evaluation of Peripheral Venous Catheters to Administer Norepinephrine Compared to Central Venous Catheters in Patients with Hypotension Medstar Health Research Institute Combination of LPC(22:6) and LPC(18:2) as an improved therapeutic approach in cardiac arrest Feinstein Institutes for Medical Research Muhammad Shoaib, MD/PhD Candidate Utility of an obstetric high dependency unit in tertiary medical center in Ethiopia 2022 St.

Paul's Hospital Millennium Medical College Assefa Abdissa Jegora, Msc A study to assess the feasibility and acceptability of video-based training in bystander CPR and AED use in schools across Canada Katherine Allan, PhD and Natalie Wong, MD Establishing the Center for Medical Transport Statistics: A New Public Health Tool to Support Research and Policy Case Western Reserve University Prehospital social risk factor identification and EMS provider follow up process for critically ill patients Feinstein Institutes for Medical Research High-flow nasal oxygen in cardiac arrest: a randomised, controlled study in pigs Impact of simulation-based pediatric critical care training in Nigeria, West Africa Tulane University School of Medicine Explore the mechanism of ferroptosis on post-cardiac arrest myocardial dysfunction Xuzhou Medical University Traumatic Resuscitation with Whole Blood from Term Pregnant Donors in a Swine (Sus scrofa domestica) Hemorrhage Model Madigan Army Medical Center Role of Norepinephrine in Regulating Oxidative Metabolism in Sepsis UT Southwestern Medical Center Tellate ganglion blockade for the prevention of atrial fibrillation after cardiac surgery: A Randomized Placebo-Controlled Trial Improving the Time to Pain Relief in the Emergency Department through Triage Nurse-Initiated Analgesia: an Implementation Science Evaluated Using a Quasi-Experimental Design Machine Learning based optimization strategy for use of extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest Intratracheal milrinone enhanced CPR during cardiac arrest: a pig model Mechanistic Approach of Vagus Nerve Stimulation for Reducing Anatomical Brain Injury after Cardiac Arrest Tranexamic Acid for ACE-Inhibitor Induced Angioedema - A Randomized, Double-Blinded, Placebo-Controlled Trial Lewis Katz School of Medicine, Temple University Evaluating the therapeutic potential of LPC in cardiac arrest using pigs The Feinstein Institutes for Medical Research Acute Hemodynamic Support During and After Ventricular Fibrillation Cardiac Arrest: Comparison of LUCAS & Impella Versus VA-ECMO University of Arizona, Sarver Heart Center Feasibility of muti-domain data acquisition in patients at risk for hypoxic-ischemic brain injury following cardiac arrest: a cohort study (ACQUIRE).

University of British Columbia Donald Griesdale, MD, MPH Therapeutic drug monitoring of linezolid in vvECMO adult patients University Clinical Center Republic of Srpska Tijana Kovacevic, Pharm D Creating Order Out of Chaos: Developing an Emergency Medical Services to Emergency Department Handoff Checklist for Cardiac Arrest Patients Feinstein Institutes for Medical Research Optimizing the duration of delayed umbilical cord clamping during preterm resuscitation using an asphyxiated model Cerebral physiology under pulsatile vs continuous circulatory flow patterns in a porcine model Posttraumatic growth and post-ICU psychological symptoms in ICU survivor and family caregiver dyads The Ohio State University Safety and Feasibility of Kefir Administration in Critically Ill Adults Receiving Antibiotics Use of the Cold Shock Protein Fibroblast Growth Factor 21 to Enhance Hypothermic Neuroprotection in a Rat Model of Pediatric Asphyxial Cardiac Arrest University of Pittsburgh School of Medicine Detecting intrathoracic airway closure during prehospital cardiopulmonary resuscitation University Hospital Ghent Immunomodulatory therapy for treating brain injury after cardiac arrest Brigham and Women's Hospital Tamura Tomoyoshi, MD, PhD Lipidomics For Prognostication After Cardiac Arrest (LOGIC) Study National University Heart Centre Singapore Novel insights into the prediction and etiology of in-hospital cardiac arrest Department of Intensive Care, Aarhus University Hospital Ex vivo use of a cell-permeable Succinate Prodrug will rescue ischemia and reperfusion injury to mitochondria and cardiac function in donation after circulatory death (DCD) hearts Virginia Commonwealth University Effect of Resuscitation Quality Improvement (RQI) Program on CPR Quality in Out-of-Hospital Cardiac Arrest Feinstein Institutes for Medical Research / Northwell Health Influence of sedation on neurocognitive outcomes and quality of life following extracorporeal membrane oxygenation for cardiac arrest and post-cardiotomy shock Stanford University School of Medicine Investigation of Myocardial Sympathetic Denervation as a Novel Mechanism of Ischemia-Induced Pulseless Electrical Activity Cardiac Arrest State University of New York at Buffalo An Informatics-Driven Approach to a Multicenter Neonatal Resuscitation Network Children's Hospital of Philadelphia Translationally Relevant Swine Model of Lipopolysaccharide-Induced Septic Shock to Assess a Perfusion-Centered Approach for the Management of Septic Shock Rosalind Franklin University of Medicine and Science Changes in Adult Out-of-Hospital Cardiac Arrest Outcomes and Contributing Factors During the COVID-19 Pandemic in Texas University of Texas Health Science Center at Houston Summer Chavez, DO, MPH, MPM Impact of mask application on aerosol generation during CPR in a swine cardiac arrest model Nebulized nitroglycerin to improve blood flow during cardiac arrest Role of Hemolysis and Nitric Oxide Consumption After Cardiac Arrest Massachusetts General Hospital Optimizing Chest Compression Location: Is the Lower Sternum Really Ideal?

The Feinstein Institutes for Medical Research Daniel Rolston, MD, MDHPM The therapeutic potential of combinational Lysophosphatidylcholine (LPC) therapy in the treatment of severe injury rodent cardiac arrest The Feinstein Institutes for Medical Research Muhammad Shoaib, MD, PhD Candidate Reduction of Prothrombotic Antibodies in COVID-19 Patients Who Received Convalescent Plasma in the Clinical Trial of COVID-19 Convalescent Plasma in Outpatients (C3PO) University of Pittsburgh School of Medicine Burst suppression with Propofol for seizure control post-cardiac arrest Assessing synaptic density in cardiac arrest survivors using [11C]UCB-J PET: a pilot study A novel approach to bradycardia during pre-term neonatal resuscitation using an ovine model of asphyxia Praveen Chandrasekaran, MD, MS Time for a change: use of Doppler ultrasound for checking pulses in cardiac arrest Feinstein Institutes for Medical Research Using unstructured clinical data to predict critical illness CPR-REBOA: improving outcome of prehospital cardiopulmonary resuscitation with balloon occlusion of the descending aorta Derivation and validation of a clinical decision rule for the early prediction of shock-refractory VT/VF out-of-hospital cardiac arrest Oregon Health and Science University Mitochondrial injury differs with age in rat model Bioadhesive Paste for Instant Hemorrhage Control of Vascular and Solid Organ Injuries Dodecafluoropentane to Reduce Ischemic-Reperfusion Injury in a Swine Model of Cardiac Arrest Evaluating Neuroprotective Therapies that Modulate Leukocyte Infiltration into the Brain Following Cardiac Arrest and Resuscitation Humanizing the Intensive Care Unit (ICU): Perspectives of patients and their families on the use of the Get to Know Me board Mitochondrial dynamics as target for inhaled argon therapy after cardiac arrest Istituto di Ricerche Farmacoogiche Mario Negri Increased Mitochondrial-Mediated Survival with Improved Neurological Recovery after Metformin Treatment for Brain Injury after Cardiac Arrest Feinstein Institutes for Medicine, Northwell Health Methylene blue for treatment of cardiac arrest Aarhus University Hospital Using Machine Learning Algorithms to Predict Critical Care Outcomes from Emergency Department Triage Data Effects of sedation on post-cardiac arrest neurological recovery Massachusetts General Hospital Multidisciplinary Implementation of Inspiratory Muscle Training for Mechanically Ventilated Patients: A Feasibility Study CAMeLOT study: Cardiac Arrest Prediction by Machine Learning to Improve Outcome in Tots University of Texas Southwestern Medical Center Impaired organ repair after sepsis: role of tissue resident macrophages and recruited monocytes (ORISMO) Charles de Roquetaillade, MD Augmented Reality - Cardiopulmonary Resuscitation (AR-CPR) Interactive Handbook: A FeasibilityStudy of Augmented Reality Basic Life Support Training for Malaysia Public Users Universiti Teknologi Mara Malaysia Aloud Real-time Reading of ICU Diaries for Prevention of Negative Post-ICU Psychological Outcomes: A Feasibility Study Delivery Room Peak Performance for Neonates with Congenital Anomalies Children's Hospital of Philadelphia Investigate the effects of WIN55, 212-2 on CB2 receptors following cardiopulmonary resuscitation Virginia Commonwealth University Jennifer Bradley, MS, CRA Compare personalized selection of an optimal MAP to each patient versus standard hemodynamic management with all having same BP goal University of Pittsburgh School of Medicine Aim to improve initial & long-term survival & diminish neurological damage after global ischemia & reperfusion by administration of Hemarina-M101 after CA Inselspital Bern University Hospital Michael Glas, Dr. Medicine Hypothesize that CPR augmented by balloon aortic occlusion benefits from adaptive balloon-wealing protocol tailored to maintain a blood pressure Travis Air Force Base, Clinical Investigation Facility Guillaume Hoareau, DVM, PhD Will test the prognostic potential of LPC using an established rate model of cardiac arrest and human patients Feinstein Institute for Medical Reaserch Effect of MAP on cerebral perfusion & metabolism after CA in porcine Improving simulation-based medical education in pediatric resuscitation: Real-time feedback and visual attention Medical University of Vienna Test the feasibility and yield of nanopore sequencing, as compared to culture, for assessment of body fluid speciments from post Cardiac Arrest patients Univerisity of Pittsburgh Mechanisms ot pharmacological hypothermia induced by cannabinoid receptor agonist WIN55, 212-2 on outcomes of CPR Soochow University Second Affiliated Hospital (Research at Virginia Commonwealth University) Amplitude spectral area to assess hemodynamic and metabolic interventions during cardiac arrest Rosalind Franklin University of Medicine & Science Salvatore Aiello, MD, PhD Student Intensive care knowledge translation in practice (ICU knowledge-TIP) University Clinical Center of Republika Srpska Targeting heme oxygenase-1 with H2 gas inhalation to improve cardiac arrest outcomes The Feinstein Institutes for Medical Research Mitigation of ischemia-reperfusion injury and cardiovascular collapse during resuscitative endovascular balloon occlusion of the aorta in trauma using adenosine, lidocaine, and magnesium Madigan Army Medical Center Endothelial dysfunction and repair during septic shock: transcriptome analysis of circulating endothelial cells and blood outgrowth endothelial cells by RNA-seq Level of soluble CD73 association with outcome, and predictive utility for post-cardiac arrest cerebral edema Sex hormone differences in cardiac arrest patients University of Illinois at Chicago Improving successful defibrillation of ventricular fibrillation in a porcine model of cardiac arrest using machine learning algorithms with physiology guided resuscitation Li Ka Shing Knowledge Institute Testing the impact of intra-shift naps during night shifts on blood pressure dipping and heart rate variability among EMS clinicians Test hypothesis that rapidly induced therapeutic hypothermia in those with acute coronary occlusion extends the door to perfusion time from 120 to 240 minutes with no increase in myocardial infarct size.

Madhan Shanmugasundaram, MD Determining the impact of telemedicine on outcomes after pediatric out-of-hospital cardiac arrest Role of electrical impedance in pseudo pulseless electrical activity The usage and effects of epinephrine in pseudo-PEA University of Pennsylvania Impact of kynurenin pathway (KP) inhibition on survival and neurological outcome after cardiac arrest and CPR Istituto di Ricerche Farmacologiche Mario Negri Define subsets of pulseless electrical activity (PEA) following initial out-of-hospital cardiac rhythm analysis using machine learning University of Pennsylvania Advance healthcare provider resuscitation quality using an immersive augmented reality CPR training system University of Pennsylvania Mechanisms of coagulation following OHCA and how influenced by post arrest care including therapeutic hypothermia.

Yeouido St. Mary’s Hospital, Seoul Testing hypothesis that shock burden will intensify myocardial injury Rosalind Franklin University of Medicine and Science Feasiblity of random allocation to active RIC vs. Sham RIC quickly upon ED arrival following resuscitation Investigate the pharmacokinetics of ART-123 in healthy pigs to verify that the relatively prolonged circulation times seen in other species will be reproduced in swine.

Determine potential neuroprotective effects of dexmedetomidine Massachusetts General Hospital, Simches Research Center Rapid Cycle Deliberate Practice in First Five Minutes Training to Improve Team Dynamics and Resuscitation Skills Northeast Ohio Medical University Determine whether systemic allogeneic CDC administration reduces myocardial and neurological injury in swine with post-cardiac arrest syndrome.

Investigate whether the three second pause in compressions is long enough to provide two ventilations when using mechanical chest compressions during out-of-hospital cardiac arrest Amsterdam University Medical Center Establish the effectiveness of physiologically guided resuscitation by use of NIRS during CPR Kyoto University Health Service Investigation of organ dysfunction of diabetics following cardiac arrest Aarhus University Hospital The study of adrenaline and its effects on cardiac arrest Use eye-tracking technology to characterize how providers focus their visual attention during newborn resuscitation and assess the impact of a novel resuscitation monitor University of Pennsylvania Study involving cardiogenic shock patients randomized to therapeutic hypothermia plus standard medical care or standard medical care alone University of Chicago Medicine Test use of Coenzyme Q10 for neuroprotection in post-cardiac arrest patients to mitigate mitochondrial injury Aarhus University Hospital A scoping review of existing studies investigating OHCA in the Arab Gulf Region Implementation of a multicenter registry for pediatric ED resuscitations using video recording University of Pennsylvania Development of multimodal monitoring and treatment protocols for high-risk post-arrest patients Optimizing public access defibrillation deployment incorporating hours of operation Test hypothesis that therapeutic hypothermia will be anti-arrhythmic during resuscitation and improve ROSC after VF arrest Case Western Reserve University Joseph Stephen Piktel, MD To investigate temporal differences between asphyxial induced cardiac arrest (ACA) and ventricular fibrillation induced cardiac arrest (VFCA) and its impact on myocardial and neurological injury; to examine the temporal changes in brain and cardiac ATP levels, antioxidant reserve, and the generation of reactive oxygen species Aarhus University Hospital Potassium cardioplegia with calcium reversal for ventricular fibrillation arrest: a blinded randomized controlled trial (Click here to download the full report.)

Definition of a Young Investigator