Digital Europe Programme Work Programme 2025-27: GenAI4EU calls

Digital Europe Programme Work Programme 2025-27: GenAI4EU calls is sponsored by European Commission. These calls support the development and deployment of generative AI in Europe's strategic sectors as part of the GenAI4EU flagship initiative. They focus on mature, working AI rolled out at scale.

Three pilot projects for GenAI for public administration were already launched. They aim to accelerate the responsible adoption of AI across strategic sectors, including the public sector. These projects bring together public administrations, research organisations and technology providers from across Europe to demonstrate how GenAI can streamline decision-making, internal processes, accessibility, and bureaucratic procedures.

Explore the calls for proposals supporting the development and uptake of generative AI under the GenAI4EU initiative. Other calls can also be found on the EU’s Funding & Tenders Portal . Stakeholders are encouraged to use the b2match platform for networking and matchmaking.

Support in the application process is offered by Ideal-Ist .

Digital Europe Programme Work Programme 2025-27: GenAI4EU calls Testing Apply AI sectorial applications at scale and under real-world conditions DIGITAL-2026-AI-PILOT-10-SCREENING : Apply AI: Piloting AI-based image screening in medical centres 21 April 2026 – 1 October 2026 Horizon Europe Work Programme 2025: GenAI4EU calls HORIZON-HLTH-2025-01-TOOL-03: GenAI4EU: Leveraging multimodal data to advance Generative Artificial Intelligence applicability in biomedical research 22 May – 16 September 2025 HORIZON-HLTH-2025-01-CARE-01: GenAI4EU: End user-driven application of Generative Artificial Intelligence models in healthcare 22 May – 16 September 2025 Cluster 3 (Civil security for society) HORIZON-CL3-2025-02-EDCC-01: Generative AI for Cybersecurity applications 12 June – 12 November 2025 Cluster 4 (Digital, Industry, Space) HORIZON-CL4-2025-04-DIGITAL-EMERGING-07: Enhanced Learning Strategies for General Purpose AI: Advancing GenAI4EU Cluster 4 (Digital, Industry, Space) HORIZON-CL4-2025-04-DIGITAL-EMERGING-04: Assessment methodologies for General Purpose AI capabilities and risks Cluster 4 (Digital, Industry, Space) HORIZON-CL4-2025-03-DIGITAL-EMERGING-09: Challenge-Driven GenAI4EU Booster (Pharma/Telco and Aerospace) Cluster 4 (Digital, Industry, Space) HORIZON-CL4-2025-03-DIGITAL-EMERGING-07: Robust and trustworthy GenAI4EU in Robotics and industrial automation Cluster 4 (Digital, Industry, Space) HORIZON-CL4-2025-03-HUMAN-18: GenAI4EU central Hub Cluster 4 (Digital, Industry, Space) HORIZON-CL4-2025-03-HUMAN-15: GenAI4EU: Generative AI for Virtual Worlds: Advanced technologies for better performance and hyper personalised and immersive experience Cluster 4 (Digital, Industry, Space) HORIZON-CL4-2025-04-DATA-03: Software Engineering for AI and Generative AI Cluster 4 (Digital, Industry, Space) HORIZON-CL4-2025-04-DATA-02: Empowering AI/Generative AI along the Cognitive Computing continuum Cluster 4 (Digital, Industry, Space) HORIZON-CL4-2025-03-DATA-13: Fostering Innovative and Compliant Data Ecosystems Cluster 4 (Digital, Industry, Space) HORIZON-CL4-INDUSTRY-2025-01-DIGITAL-61: AI Foundation models in science (GenAI4EU) 22 May – 23 September 2025 HORIZON-CL5-2025-04-D6-01: Advancing remote operations to enable the sustainable and smart mobility of people and goods based on operational and societal needs (CCAM Partnership) – Societal Readiness Pilot HORIZON-CL5-2025-01-D5-01: Efficient wireless stationary bidirectional charging solutions for road Light Duty Vehicles HORIZON-CL5-2025-01-D5-02: Cybersecure and resilient road e-mobility ecosystem HORIZON-CL5-2025-02-D3-19: Innovative solutions for a Generative AI-powered digital spine of the EU energy system 16 September 2025 – 17 February 2026 HORIZON-CL5-2025-01-D6-08: Accelerating freight transport and logistics digital innovation 16 September 2025 - 20 January 2026 HORIZON-CL5-2025-01-D2-05: Accelerated multi-physical and virtual testing for battery aging, reliability, and safety evaluation (Batt4EU Partnership) 16 September 2025 - 20 January 2026 HORIZON-CL5-2026-01-D6-09: Reliable data and practices to measure and account transport emissions in multimodal transport chains 16 September 2025 - 20 January 2026 HORIZON-CL5-2026-01-D6-10: Integrating inland waterway transport in smart shipping and multimodal logistics chains 16 September 2025 - 20 January 2026 HORIZON-CL6-2025-01-ZEROPOLLUTION-06: Provide digital solutions tailored to small and medium-sized farms to monitor and sustainably manage agricultural inputs and natural resources 6 May – 17 September 2025 HORIZON-CL6-2025-03-GOVERNANCE-09: Delivering Earth Intelligence to accelerate the green and digital transition 6 May – 24 September 2025 HORIZON-CL6-2025-03-GOVERNANCE-14: Preparing farmers, their workforce and advisors to the future of agriculture by providing the right knowledge and skills at the right time and place 6 May – 24 September 2025 HORIZON-CL6-2025-01-CIRCBIO-09: Unleashing the potential and advancing the impact of the digitalisation/AI of the bio-based value chains 6 May – 17 September 2025 HORIZON-CL6-2025-01-BIODIV-08: Strengthening pathways to alternative socio-economic models for continuous improvement of biodiversity 6 May – 17 September 2025 HORIZON-CL6-2025-01-CIRCBIO-01-two-stage: Open Topic: Innovative solutions for the sustainable and circular transformation of SMEs 4 September 2025 – 18 February 2026 European Innovation Council 2025 GenAI4EU: Creating European Champions in Generative AI Generative-AI based Agents to Revolutionize Medical Diagnosis and Treatment of Cancer Digital Europe Programme Work Programme 2025-27: GenAI4EU calls DIGITAL-2025-AI-08-SUPPLY-AI: GenAI for the public administrations 15 April – 2 October 2025 DIGITAL-2025-SKILLS-08-GENAI-ACADEMY-STEP: Sectoral digital skills academies: Digital Skills Academy in GenAI 15 April – 2 September 2025 DIGITAL-2026-AI-09-GENAI-PA: Apply AI: GenAI for the public administrations 4 November 2025 – 3 March 2026 DIGITAL-2026-AI-09-SOLUTIONS-CANCER-STEP: Deployment of cutting-edge multi-modal AI-based solutions in medical imaging 4 November 2025 – 3 March 2026 GenAI4EU: moving generative AI from a promising potential to concrete applications The specific sectors – manufacturing, robotics, health, energy, agrifood, mobility, and aerospace – are aligned with those identified in the EU Industrial Strategy and the Draghi Report .

In parallel, GenAI4EU also supports the uptake of generative AI in the public sector, including public administrations. GenAI4EU will support the transition pathways outlined in these strategies by driving innovation, streamlining production, and fostering sustainable growth in these sectors through the tailored adoption of generative AI.

This initiative will promote the development of large, open innovation ecosystems that encourage collaboration between AI developers—including startups and scale-ups—and strategic European industrial players and public sector actors. As such, GenAI4EU contributes to the Commission’s overarching goals of enhancing competitiveness and economic growth through AI, as outlined in the AI Continent Action Plan and the Apply AI strategy .

GenAI4EU aims to increase the adoption of AI among EU companies , which currently stands at just 13. 5%. This highlights the significant potential for growth, innovation, and competitiveness through broader AI uptake.

This initiative builds on the Horizon Europe ’s AI Boost project (2023) , which awarded €1 million and 8 million GPU hours to four winners developing large AI models. It also builds on the Digital Europe Programme (DEP) support for open-source, multilingual large language models through OpenEuroLLM .

Ongoing efforts aim to embed generative AI in future calls across Horizon Europe, DEP , and the EIC for 2026 and 2027, reinforcing Europe’s position as a global hub for secure, inclusive, and innovative AI technologies.

14 September 2026: Kick-off of new GenAI pilots for public administration & Apply AI stakeholder meeting 17 December 2025: Infoday - GenAI Meets Public Administrations 3 September 2025: Online matchmaking event on public administrations and GenAI 14 April 2025: Infoday on public administration and GenAI 16 May 2025: General information and brokerage event (Horizon Europe Cluster 4) 22 May 2025: Infoday on public administration and GenAI 6 June 2025: AI in cluster 1 of Horizon Europe (health) 16 June 2025: EFFRA infoday on GenAI4EU robotics and manufacturing calls 18 June 2025: Infoday on GenAI4EU challenge-driven booster call 25 June 2025: Living-in.

EU info session and matchmaking on GenAI & public administrations call Pitching day: Finalists of the Apply AI Startup Award AI-powered robotics in Europe: Live demonstrations and strategic debate Kick-off of new GenAI pilots for public administration & Apply AI stakeholder meeting | 20 October 2026 - 21 October 2026 Advanced Virtual Human Twins (VHT) Platform - Annual Event | 14 October 2026 - 15 October 2026 Horizon Europe info days - Cluster 4: Digital, Industry and Space AI Challenge Competition Info Webinar Browse Artificial intelligence European research development and deployment of AI The EU is spearheading AI research, collaborating with scientists, and funding projects to achieve excellence in frontier AI and foster AI “made in Europe”.