Disorders of Gastrointestinal Interoception Consortium (DGIC) (Forecast)

Disorders of Gastrointestinal Interoception Consortium (DGIC) (Forecast) is sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This opportunity supports mission-aligned projects and measurable outcomes.

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gov Maintenance Calendar # View Grant Opportunity Forecast View similar opportunities The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC) Department of Health and Human Services National Institutes of Health Note: This is a Forecasted Opportunity.

Document Type:Grants Notice Opportunity Number:RFA-DK-27-117 Opportunity Title:The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC) Opportunity Category:Discretionary Opportunity Category Explanation: Funding Instrument Type:Cooperative Agreement Category of Funding Activity:Health Expected Number of Awards:6 Assistance Listings:93.

847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research Cost Sharing or Matching Requirement:No Forecasted Date:Sep 18, 2025 Last Updated Date:Sep 18, 2025 Estimated Post Date:Aug 01, 2026 Estimated Application Due Date:Nov 01, 2026 Estimated Award Date:Jul 01, 2027 Estimated Project Start Date:Jul 01, 2027 Estimated Total Program Funding:$ 3,000,000 Eligible Applicants:Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Others (see text field entitled "Additional Information on Eligibility" for clarification) For profit organizations other than small businesses Native American tribal governments (Federally recognized) Special district governments Independent school districts Public and State controlled institutions of higher education City or township governments Additional Information on Eligibility:Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

## Additional Information Agency Name:National Institutes of Health Description:The National Institute of Diabetes and Digestive Diseases and Nutrition (NIDDK) seeks to advance its mission by continuing the work of the NIDDK Gastroparesis Consortium (GpCRC) but also to expand its scope.

The collaborative efforts of the GpCRC provided a large database, the Gastroparesis Registry, which is located in the NIDDK central repository and contains information on patients with symptoms of either delayed or normal gastric emptying. It also houses the first U.S. registry of children and adolescents with gastroparesis.

The GpCRC provided clarity and insight that set the stage for transforming our understanding of gastroparesis and laid out a road map for approaching other disorders of gastrointestinal (GI) motility. The findings from clinical studies and trials clearly demonstrated that the clinical burden of gastroparesis is significantly greater than previously realized and involves much more than the stomach.

Importantly, the underlying mechanisms remain unclear. Interoception is the ability of the nervous system to sense, interpret and coordinate signals from various bodily systems including the gastrointestinal tract. Many functional GI disorders are associated with a spectrum of overlapping symptoms including nausea, vomiting, and altered bowel habits all of which involve altered interoceptive signaling.

This initiative would broaden the scope beyond gastroparesis to include other adult and pediatric GI conditions associated with impaired interoceptive processing to form a Disorders of Gastrointestinal Interoception Consortium (DGIC). The consortium may include up to 6 Clinical Research Centers and a Scientific Data Research Center (SDRC, described in a companion notice).

There would be an emphasis on multidisciplinary approaches that would reveal the underlying mechanisms that connect GI function (e. g motility) more directly to symptoms, identify disease or response biomarkers that assess treatment efficacy, and leverage state-of-the-art technologies to identify novel therapeutic targets that could be assessed in future clinical trials. Link to Additional Information:[](https://www.

grants. gov/search-results-detail/360625) Grantor Contact Information:Terez Shea-Donohue, Ph. D.

terez. shea-donohue@nih. gov ## Similar Opportunities (identified by AI) #### Health & Human Services * Frequently Asked Questions ## Your session will expire in 3 minutes.

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