Disorders of Gastrointestinal Interoception Consortium (DGIC)

Disorders of Gastrointestinal Interoception Consortium (DGIC) is sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This initiative will broaden the scope beyond gastroparesis to include other adult and pediatric GI conditions associated with impaired interoceptive processing to form a Disorders of Gastrointestinal Interoception Consortium (DGIC).

Opportunity Listing - The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC) The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC) Agency: National Institutes of Health Assistance Listings: 93. 847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research Last Updated: May 13, 2026 View version history on Grants.

gov The National Institute of Diabetes and Digestive Diseases and Nutrition (NIDDK) seeks to advance its mission by continuing the work of the NIDDK Gastroparesis Consortium (GpCRC) but also to expand its scope.

The collaborative efforts of the GpCRC provided a large database, the Gastroparesis Registry, which is located in the NIDDK central repository and contains information on patients with symptoms of either delayed or normal gastric emptying. It also houses the first U.S. registry of children and adolescents with gastroparesis.

The GpCRC provided clarity and insight that set the stage for transforming our understanding of gastroparesis and laid out a road map for approaching other disorders of gastrointestinal (GI) motility. The findings from clinical studies and trials clearly demonstrated that the clinical burden of gastroparesis is significantly greater than previously realized and involves much more than the stomach.

Importantly, the underlying mechanisms remain unclear. style="margin-left:0px;"> Interoception is the ability of the nervous system to sense, interpret and coordinate signals from various bodily systems including the gastrointestinal tract. Many functional GI disorders are associated with a spectrum of overlapping symptoms including nausea, vomiting, and altered bowel habits all of which involve altered interoceptive signaling.

This initiative would broaden the scope beyond gastroparesis to include other adult and pediatric GI conditions associated with impaired interoceptive processing to form a Disorders of Gastrointestinal Interoception Consortium (DGIC). The consortium may include up to 6 Clinical Research Centers and a Scientific Data Research Center (SDRC, described in a companion notice).

There would be an emphasis on multidisciplinary approaches that would reveal the underlying mechanisms that connect GI function (e. g motility) more directly to symptoms, identify disease or response biomarkers that assess treatment efficacy, and leverage state-of-the-art technologies to identify novel therapeutic targets that could be assessed in future clinical trials.

Public and state institutions of higher education Independent school districts Private institutions of higher education For-profit organizations other than small businesses Public and Indian housing authorities City or township governments Special district governments Federally recognized Native American tribal governments Other Native American tribal organizations Nonprofits non-higher education with 501(c)(3) Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Grantor contact information Terez Shea-Donohue, Ph. D. terez.

shea-donohue@nih. gov terez. shea-donohue@nih.

gov No documents are currently available. Link to additional information Estimated Application Due Date : Estimated Due Date Description : Estimated Project Start Date : Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.