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DOD Amyotrophic Lateral Sclerosis, Pilot Clinical Trial Award is a grant from the Department of the Army -- USAMRAA that funds the rapid implementation of clinical trials targeting the treatment or management of ALS.
Administered through the FY25 Amyotrophic Lateral Sclerosis Research Program (ALSRP), the award supports phase 1 through small-scale phase 2 trials, with a focus on biomarker-driven interventions and improvements to clinical care and symptom management. All projects must support a clinical trial, incorporate biomarkers into therapeutic intervention designs, and include a Community Collaboration Plan.
Trials must begin no later than 12 months after the award date, or 18 months for FDA-regulated studies. Open to unrestricted applicants. Award amounts are not specified.
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Opportunity Listing - DOD Amyotrophic Lateral Sclerosis, Pilot Clinical Trial Award DOD Amyotrophic Lateral Sclerosis, Pilot Clinical Trial Award Agency: Dept. of the Army -- USAMRAA Assistance Listings: 12. 420 -- Military Medical Research and Development Last Updated: May 13, 2026 View version history on Grants.
gov Summary: The fiscal year 2025 (FY25) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Pilot Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of Amyotrophic Lateral Sclerosis (ALS). Projects may range from phase 1 to small-scale phase 2 trials.
Applications must address one of the following focus areas: Biomarker-Driven Interventions: Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway. Clinical Care: Improving aspects of clinical care and symptom management for ALS.
Distinctive Features: Funding from this award mechanism must support a clinical trial. Projects proposing a therapeutic intervention (drug, biologic, and/or device) must incorporate biomarkers specific to the intervention into the trial design. All applications are required to incorporate a Community Collaboration Plan, as described in Attachment 8 to optimize research impact.
The clinical trial should begin no later than 12 months after the award date or 18 months for FDA-regulated studies. Grantor contact information File name Description Last updated HT9425FY25ALSRPPCTA_updated.
pdf FY25 ALSRP PCTA Program Announcement May 23, 2025 12:52 PM UTC Link to additional information Archived: September 26, 2025 Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Science technology and other research and development Your account requires additional identity verification.
According to the current listing, eligibility includes: Unrestricted. Confirm the full requirements in the official notice before applying.
DOD Amyotrophic Lateral Sclerosis, Pilot Clinical Trial Award is funded by Department of the Army -- USAMRAA. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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