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DOE AI and Advanced Computing for Science Program is a grant from the Department of Energy Office of Science that funds small and large team applications developing AI solutions across critical science and energy domains.
The Genesis Mission program supports work in advanced manufacturing, biotechnology, critical materials, nuclear fission and fusion, quantum information science, semiconductors and microelectronics, and energy discovery science. Phase I small team awards range from $200,000 to $2 million, with larger Phase II team awards available. Eligible applicants include universities, national laboratories, and nonprofit organizations.
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Opportunity Listing - The Genesis Mission: Transforming Science and Energy with AI The Genesis Mission: Transforming Science and Energy with AI Agency: Office of Science Assistance Listings: 81. 049 -- Office of Science Financial Assistance Program Last Updated: April 10, 2026 View version history on Grants.
gov DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards.
In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications. Grantor contact information GenesisMissionNOFO@science. doe.
gov GenesisMissionNOFO@science. doe. gov GenesisMissionNOFO@science.
doe. gov File name Description Last updated Genesis_Mission_Phase_I_Application_Template_v2. xlsx Phase I Application Template Apr 10, 2026 01:23 PM UTC Genesis_Mission_Phase_II_LOI_Template_v2.
xlsx Phase II LOI Template Apr 10, 2026 01:23 PM UTC Sample_OT_and_Project_Agreements_for_DE-FOA-0003612. pdf Sample OT and Project Agreements Mar 31, 2026 03:33 PM UTC Genesis_Mission_Phase_II_Application_Template. xlsx Phase II Application Template Apr 10, 2026 01:24 PM UTC DE-FOA-0003612.
000003. pdf DE-FOA-0003612 Apr 20, 2026 09:28 PM UTC Link to additional information Closing: December 17, 2026 Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Science technology and other research and development
Based on current listing details, eligibility includes: Universities, national laboratories, and non-profit organizations. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates $200,000 - $2,000,000 Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.
Research on Circular Economy, Smart Manufacturing, and Energy-Efficient Microelectronics is sponsored by U.S. Department of Energy (DOE) Advanced Materials & Manufacturing Technologies Office (AMMTO). This funding opportunity supports innovative technology R&D across the manufacturing sector with a focus on circular economy, smart manufacturing, and energy-efficient microelectronics. While the stated deadline for full applications has passed, AMMTO frequently issues similar solicitations, and this highlights a relevant area of interest for the DOE.
Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs (Department of Energy) is sponsored by U.S. Department of Energy (DOE). These programs offer competitively awarded grants to small businesses for scientific excellence and technological innovation, encouraging participation by women-owned and minority-owned small businesses. The DOE supports high-quality research and development (R&D) on innovative concepts with high potential for commercialization, particularly in climate and energy efficiency sectors.
Research on Circular Economy, Smart Manufacturing, and Energy-Efficient Microelectronics is sponsored by U.S. Department of Energy (DOE) Advanced Materials & Manufacturing Technologies Office (AMMTO). This funding opportunity supports innovative technology R&D across the manufacturing sector with a focus on circular economy, smart manufacturing, and energy-efficient microelectronics. While the stated deadline for full applications has passed, AMMTO frequently issues similar solicitations, and this highlights a relevant area of interest for the DOE.
Manufacturing USA Institute — AI for Resilient Manufacturing is sponsored by National Institute of Standards and Technology (NIST). This funding opportunity supports the establishment and operation of a new Manufacturing USA institute focused on utilizing artificial intelligence (AI) to enhance the resilience of U.S. manufacturers. The institute will develop cost-effective, AI-based advanced manufacturing capabilities, advance technology development, foster a skilled workforce, and develop shared infrastructure and facilities.