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DOE AI and Advanced Computing for Science Program is a grant from the Department of Energy Office of Science that funds small and large team applications developing AI solutions across critical science and energy domains.
The Genesis Mission program supports work in advanced manufacturing, biotechnology, critical materials, nuclear fission and fusion, quantum information science, semiconductors and microelectronics, and energy discovery science. Phase I small team awards range from $200,000 to $2 million, with larger Phase II team awards available. Eligible applicants include universities, national laboratories, and nonprofit organizations.
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Opportunity Listing - The Genesis Mission: Transforming Science and Energy with AI The Genesis Mission: Transforming Science and Energy with AI Agency: Office of Science Assistance Listings: 81. 049 -- Office of Science Financial Assistance Program Last Updated: April 10, 2026 View version history on Grants.
gov DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards.
In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications. Grantor contact information GenesisMissionNOFO@science. doe.
gov GenesisMissionNOFO@science. doe. gov GenesisMissionNOFO@science.
doe. gov File name Description Last updated Genesis_Mission_Phase_I_Application_Template_v2. xlsx Phase I Application Template Apr 10, 2026 01:23 PM UTC Genesis_Mission_Phase_II_LOI_Template_v2.
xlsx Phase II LOI Template Apr 10, 2026 01:23 PM UTC Sample_OT_and_Project_Agreements_for_DE-FOA-0003612. pdf Sample OT and Project Agreements Mar 31, 2026 03:33 PM UTC Genesis_Mission_Phase_II_Application_Template. xlsx Phase II Application Template Apr 10, 2026 01:24 PM UTC DE-FOA-0003612.
000003. pdf DE-FOA-0003612 Apr 20, 2026 09:28 PM UTC Link to additional information Closing: December 17, 2026 Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Science technology and other research and development
According to the current listing, eligibility includes: Universities, national laboratories, and non-profit organizations. Confirm the full requirements in the official notice before applying.
The current listing shows $200,000 - $2,000,000. Verify award ceilings, matching requirements, and allowable costs in the official notice.
DOE AI and Advanced Computing for Science Program is funded by Department of Energy (DOE). Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
The $159 million Phase II slate announced October 8, 2026 pays $6M to $15M over three years. Read the twelve project titles as a prospectus: facility adjacency, not AI novelty, is what got funded — and six new Phase I awards at $500K to $750K are the entry ramp.
Read articleDE-FOA-0003673 posted October 8, 2026 with up to $100 million for roughly 100 Ph.D. fellows. Letters of intent are due November 9, applications January 12, 2027. Institutions apply, not students — and the math works out to six times what an NSF GRFP fellow costs.
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