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DOE Genesis Mission SBIR/STTR FY26 Phase I Funding Opportunity for AI-Driven Autonomous Laboratories, AI for Quantum, Materials Design and Biotechnology is sponsored by U.S. Department of Energy (DOE) Office of Science / Office of Technology Commercialization. This SBIR/STTR Phase I release is tied explicitly to DOE's Genesis Mission, the department's AI-for-science initiative, and is aimed at small businesses.
It invites American small businesses to develop breakthrough technologies that advance U.
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DOE Announces $10M in SBIR/STTR Funding Opportunity Supporting the Genesis Mission | Department of Energy DOE Announces $10M in SBIR/STTR Funding Opportunity Supporting the Genesis Mission American small businesses are invited to develop breakthrough technologies that advance the U.S. Department of Energy’s Genesis Mission. Office of Technology Commercialization Washington, D. C.
— The U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC) today announced the opening of a new Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase I award opportunity. Focused on technologies that support DOE’s Genesis Mission, this initial release precedes a broader Phase I funding opportunity expected later this fall.
“The Genesis Mission brings together the capabilities needed to accelerate scientific discovery and unlock breakthroughs that will shape the future,” said DOE Under Secretary for Science and Genesis Mission Lead Dr. Darío Gil .
“The SBIR and STTR programs extend that effort to America's small businesses, helping transform advances in AI, quantum information science, biotechnology, and advanced materials into breakthroughs that strengthen U.S. scientific and technological leadership.
” The Phase I projects will support an anticipated 40 awards across the following four Genesis Mission-focused topic areas: Scaling the Biotechnology Revolution Realizing Quantum Systems for Discovery: AI for Quantum Computing and Networking Designing Materials with Predictable Functionality Achieving AI-Driven Autonomous Laboratories The DOE SBIR/STTR programs play a vital role in advancing high-impact research and economic development through non-dilutive funding for American small businesses.
Newly under the management of OTC, the program leverages DOE’s Partnership Intermediary, ConnectWerx, to streamline program delivery, increase speed, and expand access to American small businesses. “We’ve redesigned the DOE SBIR and STTR programs to make them faster, simpler, and more accessible for America’s innovators,” said DOE Chief Commercialization Officer and Director of OTC Anthony Pugliese .
“By reducing unnecessary burden and improving applicant support, we’re making it easier for small businesses to focus on developing technologies that strengthen our nation’s energy leadership, scientific discovery, and national security. ” Small businesses with high-potential technologies are encouraged to submit their pitches by Thursday, September 10, via the DOE SBIR/STTR Application Hub .
For more information about SBIR/STTR, including applicant resources, visit the DOE SBIR/STTR programs webpage . NNSA Removes High-Risk Cesium from North Dakota, Bolstering U.S. Security View Previous Press Release Secretary of Energy Chris Wright Announces First Genesis Mission Projects Selected to Accelerate AI-Driven Scientific Discovery
According to the current listing, eligibility includes: American small businesses. Confirm the full requirements in the official notice before applying.
The current listing shows approximately $250,000 (Phase I). Verify award ceilings, matching requirements, and allowable costs in the official notice.
DOE Genesis Mission SBIR/STTR FY26 Phase I Funding Opportunity for AI-Driven Autonomous Laboratories, AI for Quantum, Materials Design and Biotechnology is funded by U.S. Department of Energy (DOE) Office of Science / Office of Technology Commercialization. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
On July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
Read articleOn July 22, 2026 the White House committed more than $5 billion to expand the Genesis Mission — the government-wide 'AI for science' effort — announcing 278 first projects and 14 National Science and Technology Challenges spanning health, energy, infrastructure, manufacturing, and national security. More than 15 federal agencies are contributing awards, datasets, and facilities. Here is how the pieces fit, why it reorganizes the science-funding map, and how to position for the awards flowing out of it.
Read articleOn July 22, 2026 the White House announced more than $5 billion and 15-plus federal agencies behind the Genesis Mission — a national effort to point AI at the hardest problems in science. Here is what the mission actually funds, how its five National Science and Technology Challenges map to real solicitations already opening, and how a research team or small business should position for the money flowing out of it.
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