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"DOE Genesis Mission SBIR/STTR Phase I for AI-Driven Biotechnology, Quantum, Materials Design, and Autonomous Laboratories" is currently closed and not accepting applications.
Under DOE's new Genesis Mission umbrella, the Office of Technology Commercialization opened an SBIR/STTR Phase I opportunity providing non-dilutive funding to small businesses across four AI-driven topic areas: biotechnology, quantum computing, materials design, and autonomous laboratories.
DOE intends to make roughly 40 awards totaling about $10 million in Phase I (approximately $250,000 each), representing up to ~$44 million in cumulative funding across the full project lifecycles. Project pitches were due September 10, 2026.
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Or search similar grants →According to the current listing, eligibility includes: U.S. small businesses (fewer than 500 employees, majority U.S.-owned); STTR requires partnership with a U.S. research institution. Confirm the full requirements in the official notice before applying.
The current listing shows approximately 40 Phase I awards totaling ~$10,000,000 (about $250,000 each), with up to ~$44,000,000 in cumulative funding across projects' full lifecycles. Verify award ceilings, matching requirements, and allowable costs in the official notice.
The published deadline was September 10, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
DOE Genesis Mission SBIR/STTR Phase I for AI-Driven Biotechnology, Quantum, Materials Design, and Autonomous Laboratories is funded by U.S. Department of Energy (DOE), Office of Technology Commercialization (SBIR/STTR Programs Office). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
The NSF Computer and Information Science and Engineering: Future Computing Research (Future CoRe) program (NSF 25-543) supports foundational computing research and education with a strong emphasis on AI and machine learning. The program funds research that advances the foundations of computing including AI/ML theory, algorithms, systems, and applications. Future CoRe supports small to medium-sized research projects that can have significant impact on computing foundations. The program has target dates of February 5, 2026 and September 10, 2026 for proposal submissions (note: these are target dates, not deadlines, meaning proposals may be submitted at any time but will be reviewed in batches around these dates). Investigators may not serve as PI, co-PI, or Senior/Key Personnel on more than two proposals submitted within any consecutive 12-month period across all Future CoRe programs. This is one of NSF's primary mechanisms for funding fundamental AI and machine learning research at U.S. academic institutions, covering areas such as machine learning theory, natural language processing, computer vision, robotics foundations, and human-AI interaction.
The ONR Long Range Broad Agency Announcement (N00014-25-S-B001) is the Office of Naval Research's primary mechanism for soliciting research proposals across all naval science and technology priority areas. The BAA accepts proposals on a rolling basis through September 30, 2026 and covers ONR's full spectrum of research interests with particular emphasis on AI-related topics including autonomous maritime systems, human-machine teaming, machine learning for sensor fusion, cooperative autonomous swarm technology, undersea autonomy, and AI-enabled decision superiority. Proposals can be funded through multiple mechanisms including individual investigator grants, the Young Investigator Program (~$510K over 3 years for early-career faculty), and Multidisciplinary University Research Initiative (MURI) awards ($1.5M/year for 3-5 years for research teams). ONR recommends contacting relevant program officers before submitting to discuss alignment with current research priorities. The BAA supports basic research (6.1), applied research (6.2), and advanced technology development (6.3) across the full range of naval-relevant science and engineering disciplines.
DE-FOA-0003600 is the DOE Office of Science's FY 2026 open, rolling solicitation for financial assistance, providing roughly $500 million across seven program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and Production. AI and machine learning research is supported directly through Advanced Scientific Computing Research, while Biological and Environmental Research funds atmospheric process research, environmental systems process research, and earth-energy systems modeling — making this a major channel for AI-enhanced climate and earth system modeling work. DOE anticipates 200 to 350 new awards ranging from $5,000 to $5 million each, with project periods from six months to five years. The FOA opened September 30, 2025 and accepts applications on a rolling basis through the end of FY 2026.
The Energy Department's first Genesis Mission SBIR/STTR Phase I solicitation offers roughly 40 awards of up to $250,000 against $10 million — but you cannot submit a full application anymore. A four-question, 700-word pitch now decides who gets to apply, there is no Direct to Phase II path for new entrants, and the $147.4 million Phase II pool is closed to everyone who has never won a DOE award.
Read articleOn July 22, 2026, the Department of Energy opened the first Phase I SBIR/STTR release tied to its Genesis Mission — roughly 40 awards across biotechnology, AI-for-quantum, predictable-materials design, and autonomous laboratories — alongside about $147M in FY25 Phase II funding. Here is what each topic area actually wants, who is eligible, how this connects to the $5B Genesis Mission, and how a small business should position before the broader fall solicitation.
Read articleThe Department of Energy attached its small-business program to the Genesis Mission on July 22, 2026 — opening a $10 million Phase I opportunity across four AI-for-science topic areas closing September 10, plus roughly $147 million in Phase II funding for prior awardees. Here is what the four topics fund, how the redesigned 'faster, simpler' program changes the math for founders, and how to move on a tight window.
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