Driving Clean Assistance Program

Wildfire Smoke Clean Air Center for Vulnerable Populations Incentive Pilot is sponsored by California Air Resources Board. This pilot program provides funding to upgrade ventilation systems and purchase portable air cleaners to create a network of clean air centers where vulnerable populations can find respite from wildfires and other smoke events.

Biotech routes for valorisation of residual biomass is sponsored by European Commission — Horizon Europe. Expected Outcome: Successful proposals will contribute to the implementation of the EU initiative on Biotechnology and Biomanufacturing and the EU Life Sciences Strategy as well as the updated EU Bioeconomy Strategy, the Clean Industrial Deal, the European Chemical Industry Action Plan, the upcoming EU Biotechnology and Circular Economy Acts. Projects results are expected to contribute to the following expected outcomes: Increased added value of residual biomass for biorefinery applications. Availability of a wider portfolio of sustainable bio-based products via industrial biotech. Robust, scalable and efficient biotech process(es) applicable to residual biomass. Scope: Diversifying biomass feedstock resources for bio-based products is key to contribute to resilience and strategic autonomy of bio-based operations. Industrial biotechnologies have showcased that they can play a key role to address residual biomass into valuable bio-based products. However, scaling up from research to demo scale requires addressing systemic and technical challenges. This entails the integration of adequate pretreatment and conversion processes, tailored to the targeted residual biomass and its composition variability, in order to achieve high yield, titre and selectivity. At the same time, it requires that these processes are scalable and sustainable. Moreover, effective logistics are needed to mobilise the residual biomass, requiring cooperation with primary producers, waste management operators and other biomass providers. Proposals under this topic should: Demonstrate (at least TRL 6) efficient biotechnology based processes to convert residual biomass streams into bio-based chemicals, intermediates, polymers, materials, ingredients [1] and/or enzymes. The topic focuses on processes in which biotechnology is the key enabling technology; the integration of supporting unit operations based on technologies other than biotechnology is in scope. Optimisation of selected cells, enzymes and/or microorganisms, including microbiomes, is also in scope. The feedstock in scope includes: Forestry and agricultural residues and/or side streams from the processing of forestry and agricultural biomass (including livestock-based ones such as manure and animal byproducts), residues from aquatic biomass, including from fisheries, micro/macro algae production and aquaculture, urban and/or industrial bio-based waste and side-streams (including food industry waste and side-streams, cellulose from post-consumer and post-industrial waste, urban biowaste and sewage sludge, and other bio-based waste/side-streams from industrial operations including wood and pulp and paper industry), mixed streams from the above. Integrate optimised biomass pretreatment/fractionation processes tailored to selected residual biomass and optimise (energy)-efficient separation and/or purification process step(s) across the value chain. The valorisation of by-products and side streams across the value chain via the cascading approach is in scope. Validate (at TRL 5 and above) conversion (or use) of biorefinery product(s) into end-products proving to fulfil market requirements for selected applications sectors. Address resource efficiency and circularity. When pursuing circular models, ensure that neither pathogens nor contaminants are injected back in the loop, to avoid negative effects on human health and the environment. In addition to the specific requirements applicable for the type of action, as described in section 2.2.3.1 of the CBE JU Annual Work Programme 2026 [2] , proposals under this topic should: Under the multi-actor approach (MAA), ensure the sufficient involvement of feedstock producers/managers for residual feedstock supply. Optimise logistic models (including sourcing, storage and transport) of residual feedstock, minimising distances and costs. Ensure seamless integration with biomass providers, while promoting win-win business models. Perform a risk assessment on impacts, p Programme areas: Global Challenges and European Industrial Competitiveness, Food, Bioeconomy Natural Resources, Agriculture and Environment, Bio-based Innovation Systems in the EU Bioeconomy, Horizon Europe (HORIZON) Keywords: Applied and industrial chemistry, Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation, Industrial bioengineering, Industrial biotechnology, bio-based chemicals, bio-based ingredients, bio-based materials, bio-based polymers, bio-based products, bio-conversions, biotechnology, STEP-Biotech

Boosting biorefinery competitiveness through biotech is sponsored by European Commission — Horizon Europe. Expected Outcome: Successful proposals will contribute to the implementation of the EU initiative on Biotechnology and Biomanufacturing, the EU Life Sciences Strategy, the updated EU Bioeconomy Strategy, the EU Biotechnology Act, the Clean Industrial Deal, the European Chemical Industry Action Plan and the upcoming EU Circular Economy Act. Projects results are expected to contribute to the following expected outcomes: Full industrial scale biorefinery and related value chain(s) for the sustainable production of bio-based products using biotech as a key enabling technology. Availability of bio-based products meeting market and technical performance requirements as relevant for their respective application areas. Improvement of sustainability, circularity and resource efficiency compared to relevant benchmark(s). Contribution to increasing the EU’s strategic autonomy, resilience and competitiveness. Scope: Biorefineries integrating biotechnologies, underpinned by sustainably sourced bio-based feedstock, have a huge potential to transform the EU manufacturing landscape, spurring socio-economic growth, fostering job creation and contributing to defossilisation of the EU economy. Europe is strong in life sciences including industrial biotechnology. However, research results often struggle to be deployed to the market; in most cases, scale-up needs de-risking and requires overcoming challenges in large-scale process and reactor design, cell productivity, efficient use of feedstock, operative condition stability, reactor sterility and efficient integration of downstream operations among others. Proposals under this topic should: Demonstrate (at TRL 8) a sustainable and robust biomanufacturing route to obtain bio-based product(s). The proposal should focus on processes in which biotechnology is the key enabling technology; the integration of (upstream and/or downstream) supporting unit operations based on technologies other than biotechnology is in scope. Products in scope include chemicals, intermediates, polymers, ingredients and enzymes. Food and feed ingredients as main application are out of scope. Optimisation of selected cells, enzymes and/or microorganisms is also in scope provided that the starting TRL is at least 6. Demonstrate (at TRL 8) the further conversion or use of the obtained biorefinery product(s) into at least one end-product driving the business case; validate it (TRL 6 and above) in relevant market applications. Additional end-product(s) with high prospective market potential can be targeted, reaching at least TRL 6. In addition to the specific requirements applicable for the type of action, as described in section 2.2.3.1 of the CBE JU Annual Work Programme 2026 [1] , proposals under this topic should: As part of the multi-actor approach (MAA), ensure adequate involvement of all key actors in the value chains relevant for this topic and across the sustainable circular bio-based system, including feedstock providers, policymakers and end users. Address compliance with EU regulatory frameworks as relevant for targeted products and applications, identify potential gaps and provide recommendations to overcome them. Perform a risk assessment on impacts, potentially deriving from the use of biotechnology, on human and ecosystem safety and identify adequate mitigation measures. Assess the adequacy of policy and regulatory means to manage these risks and provide recommendations to overcome potential identified bottlenecks. Include a task to apply the SSbD framework, developed by the European Commission, for the assessment of the production process of targeted biorefinery product(s) as well as the chosen derived end product(s). For more information on the SSbD framework and criteria, refer to Safe and sustainable by design . Seek complementarities and avoid overlaps with past and ongoing R&I projects addressing similar challenges, including those funded by BBI JU/CBE JU and under Horizon 2020/Horizon Europe (under Cl Programme areas: Global Challenges and European Industrial Competitiveness, Food, Bioeconomy Natural Resources, Agriculture and Environment, Bio-based Innovation Systems in the EU Bioeconomy, Horizon Europe (HORIZON) Keywords: Applied and industrial chemistry, Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation, Industrial bioengineering, Industrial biotechnology, bio-based feedstock, bio-based products, bio-conversion, bioreactors, biorefineries, downstream technologies, safe and sustainable by design, STEP-Biotech

Addressing separation and purification challenges in biorefineries is sponsored by European Commission — Horizon Europe. Expected Outcome: Successful proposals will contribute to the updated EU Bioeconomy Strategy, the Circular Economy Act, the Clean Industrial Deal, the European Chemical Industry Action Plan and the Chemicals Strategy for Sustainability. Projects results are expected to contribute to the following expected outcomes: Enhancing competitiveness, efficiency, sustainability, circularity and safety of industrial biorefineries. Efficient, selective and scalable separation and purification technology platform(s) with high potential to be integrated within existing and/or new biorefineries. Purity and stability of targeted intermediates/product(s) compatible with further conversion requirements. Scope: While significant advancements have been made in recent years in the development of core biorefinery processes, challenges remain in separation and purification steps. Separation and purification, both upstream and downstream of biorefinery processes, play a key role in determining quality and purity of the intermediates and products. They usually account for a significant share of the whole process costs and are often a relevant bottleneck towards full-scale deployment and commercialisation of bio-based products (including intermediates, chemicals, ingredients, materials). It is therefore crucial to develop new technologies to improve separation and purification performances, while at the same time improving resource efficiency and reducing costs. Proposals under this topic should: Develop scalable separation and purification technologies and test the developed innovative solutions on at least 3 use cases from biorefinery processes at industrial or demo scale. Each technology should address at least two of the following: increase efficiency when using available green solvents (including water), or develop novel ones and in both cases minimise the use of harsh solvents; applying process intensification including through reduction of process steps; reducing thermal and/or electric energy and water consumption. Address compatibility of the innovative separation and purification solutions with existing upstream technologies or develop solutions that address simultaneously the upstream and downstream challenges. Test and validate the performance of targeted technologies and their effect on selected bio-based product(s). Both novel (not yet available on the market) and well-established bio-based products are in scope. In addition to the specific requirements applicable for the type of action, as described in section 2.2.3.1 of the CBE JU Annual Work Programme 2026 [1] , proposals under this topic should: Include a task to apply the SSbD framework, developed by the European Commission for the assessment of targeted biorefinery products obtained using the developed separation and purification processes. For more information on the SSbD framework and criteria, refer to Safe and sustainable by design . Ensure complementarities with past and ongoing R&I projects addressing similar challenges, including projects funded under Horizon 2020/Horizon Europe (under Cluster 6 and other Clusters of Horizon Europe) and BBI JU/CBE JU projects. [1] https://www.cbe.europa.eu/reference-documents Programme areas: Global Challenges and European Industrial Competitiveness, Food, Bioeconomy Natural Resources, Agriculture and Environment, Bio-based Innovation Systems in the EU Bioeconomy, Horizon Europe (HORIZON) Keywords: Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation, Industrial biotechnology, bio-based products, biorefineries, downstream, green solvents, purification technologies, resource efficiency, safe and sustainable by design, separation technologies