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Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) is sponsored by National Institutes of Health (NIH) - National Center for Complementary and Integrative Health (NCCIH), National Institute on Aging (NIA), National Institute of Dental and Craniofacial Research (NIDCR), National Cancer Institute (NCI), Office of Dietary Supplements (ODS), Office of Research on Women's Health (ORWH), and Office of Nutrition Research (ONR). Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) is sponsored by National Institutes of Health (NIH) - National Center for Complementary and Integrative Health (NCCIH), National Institute on Aging (NIA), National Institute of Dent…
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Opportunity Listing - Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93. 393 -- Cancer Cause and Prevention Research 93. 313 -- NIH Office of Research on Women's Health 93.
213 -- Research and Training in Complementary and Integrative Health 93. 121 -- Oral Diseases and Disorders Research Last Updated: May 13, 2026 View version history on Grants. gov The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions using a milestone-driven, biphasic award mechanism, R61/R33 Phased Innovation Award.
Specifically, this NOFO solicits applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account...
for the heterogenicity in humans that causes inconsistent probiotic responses. The first phase, funded by the R61, will providing for up to 2 years to identify unique host biological patterns (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with heterogeneity of probiotic clinical effects using observational or secondary data analysis studies.
The second phase, funded under the R33, will support studies to assess the ability of the unique patterns determined in the R61 phase to detect the improvement of probiotic responsiveness in rigorously designed mechanistic studies in relevant animal models or in human subjects. The combined R61/R33 should not exceed 5 years.
Transition from the R61 to the R33 phase of the award will be administratively reviewed and will be determined based on successful completion of Transition Milestones that need to be clearly specified in the R61 phase application. Support for a single phased award that does not need the R61 Exploratory phase is available in the companion (R33) NOFO, PAR-AT-24-XXX (TEMP-25413).
Public and state institutions of higher education Private institutions of higher education Independent school districts Other Native American tribal organizations Nonprofits non-higher education with 501(c)(3) Nonprofits non-higher education without 501(c)(3) Special district governments Public and Indian housing authorities City or township governments Federally recognized Native American tribal governments For-profit organizations other than small businesses Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. Grantor contact information See Section VII.
Agency Contacts within the full opportunity announcement for all other inquires. File name Description Last updated PAR-25-211-Full-Announcement. html PAR-25-211 Full Announcement Text Oct 31, 2024 06:25 PM UTC Link to additional information https://grants.
nih. gov/grants/guide/pa-files/PAR-25-211. html Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: Open to various organizations including federal government agencies, faith-based or community-based organizations, Hispanic-serving institutions, historically Black colleges and universities, Indian/Native American trib…. Confirm the full requirements in the official notice before applying.
Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) is funded by National Institutes of Health (NIH) - National Center for Complementary and Integrative Health (NCCIH), National Institute on Aging (NIA), National Institute of Dental and Craniofacial Research (NIDCR), National Cancer Institute (NCI), Office of Dietary Supplements (ODS), Office of Research on Women's Health (ORWH), and Office of Nutrition Research (ONR). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
The NOURISH Autoimmunity Digital Health Challenge runs three phases to August 2028: 10 winners at $20,000, then 5 at $30,000, then 3 at $100,000. It is a prize competition, not a grant — no indirect costs, no cost reimbursement, and a rule that quietly disqualifies the obvious applicant.
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