Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional)

Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional) is sponsored by National Institutes of Health (NIH). Supports environmental health sciences research, including mental health aspects.

RFA-ES-25-002: Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional) This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations National Institute of Environmental Health Sciences ( NIEHS ) Funding Opportunity Title Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional) September 9, 2025 - Notice of Change to Receipt Dates for RFA-ES-25-002 Environmental Health Sciences Core Centers Program (P30 Clinical Trial Optional).

See Notice NOT-ES-25-006 . March 31, 2025 - This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.

April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084 . August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023.

See Notice NOT-OD-22-198 . August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189 .

Funding Opportunity Number (FON) Companion Notice of Funding Opportunity See Section III. 3. Additional Information on Eligibility .

Assistance Listing Number(s) Notice of Funding Opportunity Purpose Funding Opportunity Goal(s) To foster understanding of human health effects of exposure to environmental agents in the hope that these studies will lead to: the identification of agents that pose a hazard and threat of disease, disorders and defects in humans; the development of effective public health or disease prevention strategies; the overall improvement of human health effects due to environmental agents; the development of products and technologies designed to better study or ameliorate the effects of environmental agents; and the successful training of research scientists in all areas of environmental health research.

Supported grant programs focus on the following areas: (8) Providing support for broadly based multi-disciplinary research and training programs in environmental health. These programs include the Environmental Health Sciences Core Centers, which serve as national focal points and resources for research and manpower development.

Through these programs, NIEHS expects to achieve the long-range goal of developing new clinical and public health applications to improve disease prevention, diagnosis, and therapy Open Date (Earliest Submission Date) Dates in bold and italics reflect changes per NOT-ES-25-006 .

Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed March 18, 2025 March 18, 2025 Not Applicable July 2025 January 2026 April 2026 April 20, 2026 April 20, 2026 Not Applicable November 2026 January 2027 April 2027 April 20, 2027 April 20, 2027 Not Applicable November 2027 January 2028 April 2028 All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. No late applications will be accepted for this Notice of Funding Opportunity (NOFO). New Date April 21, 2027 per NOT-ES-25-006 (Prior Date January 30, 2027).

Required Application Instructions It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide , follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Part 1. Overview Information Part 2.

Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II. Award Information Section III.

Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI.

Award Administration Information Section VII. Agency Contacts Section VIII. Other Information Part 2.

Full Text of Announcement Section I. Notice of Funding Opportunity Description Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs. See Section VIII.

Other Information for award authorities and regulations. Section II. Award Information Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO. Optional: Accepting applications that either propose or do not propose clinical trial(s).

Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards NIEHS intends to commit $6. 0M in FY 2026 to fund up to 4 awards.

New or first-time applicants are limited to $850,000 Direct Costs per year. Renewal applications are limited to $1. 0M Direct Costs per year.

See Eligibility requirement New or first-time applicants may apply for up to 4 years of support. Renewal application may request up to 5 years of support. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III.

Eligibility Information Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Examples of NIH peer-reviewed mechanisms that may be included for determining eligibility: DP1, DP2, R00, R01, R03, R15, R21, R24, R25, R33, R35, R37, R41, R42, R43, R44, P01, P20, P30s other than the EHSCC, P42, P50, SC1, SC2, U01, U10, U19, U24, U54, U56, UH2, UH3, UG3, K and F series awards.

T-awards, U45, and Conference awards (R13, U13) do not count towards this requirement. Furthermore, grants and cooperative agreements in extension periods, either with or without additional funds, as well as supplements of any kind, do not count toward this requirement. Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are allowed. Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.

3. 9. 2 Electronically Submitted Applications for additional information.

System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.

NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM. gov registration process.

The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants. gov registration; all registrations must be in place by time of submission.

eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants. gov – Applicants must have an active SAM registration in order to complete the Grants.

gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons.

If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide . This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1. 2- Definitions of Terms.

3. Additional Information on Eligibility Only one application per institution (normally identified by having a unique identifier (UEI) number or NIH IPF number) is allowed. The NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.

3. 7. 4 Submission of Resubmission Application .

This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2. 3. 9.

4 Similar, Essentially Identical, or Identical Applications ). Section IV. Application and Submission Information 1.

Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. A button to apply using ASSIST is available in Part 1 of this NOFO. See the administrative office for instructions if planning to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide , except where instructed in this notice of funding opportunity to do otherwise and where instructions in the How to Apply - Application Guide are directly related to the Grants. gov downloadable forms currently used with most NIH opportunities.

Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review. All page limitations described in the How to Apply- Application Guide and the Table of Page Limits must be followed.

Component Type for Submission Translational Research Support Core Community Engagement Core Instructions for the Submission of Multi-Component Applications The following section supplements the instructions found in How to Apply- Application Guide and should be used for preparing a multi-component application. Revision applications must include an Overall component and the components that are affected by the revision.

Therefore, the component requirements listed below may not apply to the revision application.

The application should consist of the following components: Administrative Core: Required, 1 maximum Translational Research Support Core (TRSC); Required, 1 maximum Facility Cores: Required, 1 minimum; maximum of 3 Community Engagement Core (CEC): Required, 1 maximum Pilot Projects: Required, 1 maximum When preparing the application, use Component Type ‘Overall’.

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions, as noted. SF424(R&R) Cover (Overall) PHS 398 Cover Page Supplement (Overall) Note: Human Embryonic Stem Cell lines from other components should be repeated in cell line table in Overall component. Research & Related Other Project Information (Overall) Follow standard instructions.

Project Narrative. In the project narrative (i.e., the "public health relevance" statement), briefly state the relevance of the EHSCC’s research to public health. Facilities and Other Resources: Describe the Institutional Commitment for the proposed EHSCC at the applicant institution.

Document previous and planned institutional support: e.g., financial, personnel, positions, and/or priority access to resources. Also describe the organizational position of the EHSCC in the institutional hierarchy. Address the commitment of the parent organization or any of its partners to the EHSCC and its goals.

The parent institution is expected to recognize the EHSCC as a formal organizational unit and provide documented evidence of space dedicated to the needs of the Center, protected time to devote to Center activities, staff recruitment, dedicated equipment, or other financial support for the proposed Center.

The parent institution should provide assurance of its commitment to continuing support of the EHSCC in the event of a change in directorship and a well-defined plan for this eventuality should be in place. In addition, it is expected that the Institution will support the goal of providing to Center members' priority access to Institution's and Center's facilities and services at minimal or reduced cost.

The filenames provided for the attachments will be the name used for the bookmark in the application image. Table listing grant support of Center Members to determine eligibility (use file name: Grant Support) Organize table listing NIEHS grant support first, followed by other NIH grant support, then other non-NIH support. Only grants that meet the eligibility criteria listed in Section III, above, should be cited.

Include the following information : Table Listing Non-key/senior personnel associated with the Center (use file name: Center Members) Organize table alphabetically by Last Name and include the following information: Role(s) within the Center Project/Performance Site Locations (Overall) A summary of Project/Performance Sites in the Overall section of the assembled application image in eRA Commons compiled from data collected in the other components will be generated upon submission.

Research and Related Senior/Key Person Profile (Overall) Include only the Project Director/Principal Investigator (PD/PI) and any multi-PDs/PIs (if applicable to this NOFO) for the entire application. A summary of Senior/Key Persons followed by their Biographical Sketches in the Overall section of the assembled application image in eRA Commons will be generated upon submission.

The only budget information included in the Overall component is the Estimated Project Funding section of the SF424 (R&R) Cover. A budget summary in the Overall section of the assembled application image in eRA Commons compiled from detailed budget data collected in the other components will be generated upon submission.

PHS 398 Research Plan (Overall) Introduction to Application: For Resubmission and Revision applications, an Introduction to Application is required in the Overall component.

Specific Aims: The specific aims for the Center should describe the strategic vision including translational research vision, theme, and goals to be accomplished The Strategic Vision must address the following critical elements: Theme – Provide the central theme(s) of the EHSCC and the likely supported research, resources, and relevance to environmental health.

The theme may be broad or focused, depending upon the goals of the EHSCC but should indicate translational research opportunities along the spectrum from fundamental, mechanistic and toxicological science to population and public health, disease prevention, and community engagement. Within this section, describe the research capacity and clearly identifiable major scientific focus in environmental health and related biomedical research.

Goals and directions – Describe current and future directions for the EHSCC in the forthcoming project period. The impact of Center-based science should be discussed in detail as well as how the facility/service cores contribute to advancing Center goals. Provide an overview of the research supported by the EHSCC and its likely impact on understanding environmental health and, ultimately, public health.

Describe how the central themes and goals integrate with the needs and concerns of the target audience(s). Describe short and long-term goals and measures of success. Describe examples of research conducted by Center members or teams that have successfully been translated to the identified audience(s) or identify plans to translate research findings during the project period.

Describe new or innovative tools or methods to support the Center’s emphasis. Document how the Center forms, organizes, and leads its teams towards answering complex questions and the role of target audience(s) or key partner advisors in these decisions. Identify levels of risk for these goals, potential roadblocks to achieving them, and how the Center might respond to these challenges.

Translational Research Vision - Describe your translational research vision and how it will support the overall goals of your Center. Provide examples of how the EHSCC structure facilitates translational research. Provide details on staff and resources that will be drawn upon to implement the Center's translational research vision.

Integration of investigators of multiple skills and talents – Outline steps the EHSCC will take to promote interdisciplinary studies and collaborations, especially among basic scientists and clinical researchers, and, where appropriate, community engagement experts. Explain the types of initiatives planned to stimulate teams and attract high-caliber professionals.

Describe the expected level of high-risk/high-payoff research that may require long-term support. Building research capacity – Provide details on the special talents and resources that will be drawn to and built upon at the EHSCC. Offer how these talents will be used to promote new collaborations and produce multidimensional teams to address complex questions.

Include a plan for bringing investigators into the EHSCC from within and outside the area of environmental health sciences and needed expertise. Describe academic and research partnerships and/or initiatives that will be pursued by the EHSCC to advance its goals and missions. Provide a plan to determine the need for services, instrumentation, or other infrastructure of the EHSCC.

Address the steps that will ensure that the EHSCC proceeds at the cutting edge of technology and concepts. As it is expected that facility core needs will change over time, include the process to evaluate needs and implement changes. The application must define, in this section, the eligibility criteria for EHSCC membership and note which individuals play key leadership roles in the EHSCC.

Indicate the steps to engage full and/or junior members in EHSCC activities and to enhance collaborations and translational research among Center members. Describe how established investigators/community engagement experts are expected to interact with early career investigators in the Center.

For renewals, summarize activities carried out during the preceding performance period that demonstrate the level of success in reaching previously stated goals. Environmental Health Identity and Impact of Research Base - The existence of a strong research capability in environmental health sciences is fundamental to establishment or continuation of an EHSCC.

To qualify for support, an institution must demonstrate this research capability to have a clearly identifiable, major scientific focus in environmental health research. Describe the Environmental Health Identity and Impact of the Research Base on the plans for promoting translational research and outreach efforts.

Please note that if an applicant chooses to include a listing of research grant support, it must be uploaded under "Other Attachments" in the Overall section and titled "Grant Support" Progress Report Publication List: For renewal applications, include a list of publications related to or derived from EHSCC support or assistance. Indicate whether the EHSCC was cited in the acknowledgments and provide the PMCID.

Letters of Support: Letters of support should be provided where appropriate to demonstrate collaboration, access to resources, institutional commitment, etc. Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide .

All instructions in the How to Apply- Application Guide must be followed, with the following additional instructions: All applicants planning research (funded or conducted in whole or in part by NIH) that results in the generation of scientific data are required to comply with the instructions for the Data Management and Sharing Plan.

All applications, regardless of the amount of direct costs requested for any one year, must address a Data Management and Sharing Plan. Only limited items are allowed in the Appendix. Follow all instructions for the Appendix as described in How to Apply- Application Guide ; any instructions provided here are in addition to the How to Apply - Application Guide instructions.

PHS Human Subjects and Clinical Trials Information (Overall) When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply - Application Guide , with the following additional instructions: If you answered “Yes” to the question “Are Human Subjects Involved?

” on the R&R Other Project Information form, there must be at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record within the application. The study record(s) must be included in the component(s) where the work is being done, unless the same study spans multiple components.

To avoid the creation of duplicate study records, a single study record with sufficient information for all involved components must be included in the Overall component when the same study spans multiple components. Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the How to Apply - Application Guide must be followed.

Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply- Application Guide must be followed. PHS Assignment Request Form (Overall) All instructions in the How to Apply- Application Guide must be followed.

When preparing your application, use Component Type ‘Insert Name. ’ All instructions in the How to Apply- Application Guide must be followed, with the following additional instructions, as noted.

SF424 (R&R) Cover (Administrative Core) Complete only the following fields: Type of Applicant (optional) Descriptive Title of Applicant’s Project Proposed Project Start/Ending Dates PHS 398 Cover Page Supplement (Administrative Core) Enter Human Embryonic Stem Cells in each relevant component. Research & Related Other Project Information (Administrative Core) Human Subjects: Answer only the ‘Are Human Subjects Involved?

’ and 'Is the Project Exempt from Federal regulations? ’ questions. Vertebrate Animals: Answer only the ‘Are Vertebrate Animals Used?

’ question. Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required.

However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components. Project /Performance Site Location(s) (Administrative Core) List all performance sites that apply to the specific component. Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachment for additional entries.

Research & Related Senior/Key Person Profile (Administrative Core) In the Project Director/Principal Investigator section of the form, use Project Role of ‘Other’ with Category of ‘Core Lead’ and provide a valid eRA Commons ID in the Credential field. In the additional Senior/Key Profiles section, list Senior/Key persons that are working in the component.

Include a single Biographical Sketch for each Senior/Key person listed in the application regardless of the number of components in which they participate. When a Senior/Key person is listed in multiple components, the Biographical Sketch can be included in any one component. If more than 100 Senior/Key persons are included in a component, the Additional Senior Key Person attachments should be used.

Budget (Administrative Core) Budget forms appropriate for the specific component will be included in the application package. Budget to cultivate junior and mid-level and recruited investigators to enhance their careers and research programs in environmental health sciences should be included in the administrative core budget.

Allowable expenses include: Temporary salary support (up to 9 months effort) for 1 - 2 years and equipment may be provided in the application for a named New Investigator in a specified area of research. The investigator can work in the basic sciences, clinical research, or public health disciplines relevant to environmental health.

Former post-doctoral fellows are eligible for this position only in exceptional cases where if can be demonstrated that they have established independent research careers (for example have transitioned to an R00 award) and will provide critical expertise. The New Investigator indicated in the application is eligible to compete for support for up to 2 years through the pilot project program.

Subsequently, recruited individuals are to be named by the Center Director and submitted for approval to the EHSCC's Internal or External Advisory Board, as appropriate. Recruited Center Investigators: Partial salary support (up to 9 months effort) for not more than 2 years, technical support, and equipment for independent investigators newly recruited from outside the Center.

The recruit would be expected to bring new technologies or novel scientific areas of expertise into the environmental health sciences arena that enhance the Center's research capabilities.

Former graduate students and postdoctoral fellows of Center members should not be considered for support unless, in exceptional cases, it can be demonstrated that they have established independent research careers (for example have transitioned to an R00 award) and will provide critical expertise.

Specific individuals to be awarded Recruited Center Investigator support need not be identified in the application, but the amount budgeted for this purpose should be declared, and, to the extent possible, the types of individuals sought and their expected roles in the Center described. All travel associated with the annual EHSCC Meeting or External Advisory Board members should be budgeted within the Administrative Core.

CEC is to budget travel for its field or community workwithin the CEC section. Annual EHSCC Meetings: Each Center must budget at least $6,000 per year to support the annual EHSCC Meetings in venues to be determined in collaboration with the Center Investigators and NIEHS. These funds can be used for travel costs of EHSCC members to travel to the annual 2 - 3-day meeting.

At a minimum the Director, CEC Director, and the Business Administrator should plan to attend. Other center members, especially junior investigators are also encouraged to attend. An EHSCC should expect to host the EHSCC meeting once within the project period and may want to set funds aside for the event.

Please consult with program staff for details. Travel budget should also include travel for 1-2 CEC staff to attend annual Partnerships for Environmental Public Health (PEPH) meeting. Items Not Allowed Under a P30 EHSCC Grant Include: Salary for Co-Directors, Collaborators, or individuals unless clearly defined roles are documented in the operation of the EHSCC.

Travel to workshops or scientific meetings, except for junior, mid-level and recruited investigators for cultivating career enhancements. Page and publication charges. Director's Funds or Discretionary Fund.

Note: The R&R Budget form included in many of the component types allows for up to 100 Senior/Key Persons in section A and 100 Equipment Items in section C prior to using attachments for additional entries. All other SF424 (R&R) instructions apply. PHS 398 Research Plan (Administrative Core) Introduction to Application: For Resubmission and Revision applications, an Introduction to Application is allowed for each component.

Specific Aims: The administrative core provides oversight and coordination of EHSCC activities. State the aims of the Administrative Core . Research Strategy: Applicants should describe the administrative structure of the Center and the roles and responsibilities of all key personnel.

The administrative core is responsible for overseeing organizational structure, budgeting and reporting functions and provides the leadership for scientific and programmatic activities of the EHSCC. Through the required Administrative Core, the Center Director provides leadership and guidance in fulfilling the stated objective of his or her Center.

It is expected that the organization of the Administrative Core will provide a supportive structure sufficient to promote the scientific vision of the center and to accomplish the following: Coordinate and integrate EHSCC components and activities.

Cultivate junior and mid-level and recruited investigators to enhance careers and research programs in environmental health sciences Assess productivity, effectiveness, and appropriateness of EHSCC activities and determine EHSCC membership, assessment of scientific opportunities and areas for collaboration among EHSCC members. Organize EHSCC activities, such as retreats, invitation of consultants, meetings, and focus groups.

Maintain records of meeting minutes and measures of success including: use of EHSCC facility cores, publications, pilot project awards, and new grant applications resulting from preliminary data enabled by the EHSCC, and other relevant outcomes and impacts. The NIEHS Evaluation Metrics Manual ( https://www. niehs.

nih. gov/research/supported/translational/peph/metrics ) may assist applicants in developing measures of success. Organize Internal and External Advisory Groups.

Interact with other EHSCCs, the NIEHS, and other appropriate individuals, groups, organizations.

Coordination and integration : Describe how the Administrative Core will take a leadership role in ensuring the synthesis of findings and activities from research projects and cores towards solving the central problem proposed by the Center; strategies for stimulating interaction among center members (i.e., retreats, invitation of consultants, meetings, and focus groups).

In addition, describe direct lines of communication between the Administrative Core and Community Engagement Cores (as well as with the other cores, as appropriate). Cultivating careers : Describe a plan bringing in junior investigators and cultivating their careers for assistance towards independent status. Include examples of planned scientific enrichment activities