Erythropoiesis & Hemoglobin Research Program

Erythropoiesis & Hemoglobin Research Program is sponsored by NIDDK. Supports research on the molecular and cellular biological pathways involved in erythroid cell differentiation, including studies on sickle cell disease.

Erythropoiesis & Hemoglobin - NIDDK The information provided on niddk. nih. gov is not being updated regularly.

Please refer to nih. gov . Research Programs & Contacts Erythropoiesis & Hemoglobin Erythropoiesis & Hemoglobin The molecular and cellular biological pathways involved in erythroid cell differentiation.

The Erythropoiesis and Hemoglobin program supports work on the molecular and cellular biological pathways involved in erythroid cell differentiation. This includes not only adult or definitive erythropoiesis (differentiation), but also ontological or primitive erythropoiesis (development).

Specific areas of interest include: transcriptional, post-transcriptional, and translational regulation of erythroid-specific genes; mechanisms underlying normal and disordered globin gene regulation; heme biosynthesis and iron metabolism during erythropoiesis; erythroid cell membrane structure and function and the interaction of transport and receptor molecules; erythropoietin receptor signaling and its effects on gene regulation; mechanistic determinants of red blood cell survival; detection of abnormal hemoglobins; development of genetically targeted therapies for sickle cell anemia and thalassemias; and development of clinically applicable approaches for controlling fetal versus adult b-globin gene expression.

Iron; Heme Biosynthesis; Globin Regulation; Terminal Erythropoiesis; Systemic amyloidosis; Porphyrias NIDDK Grant Opportunities Highlighted Topics of Interest to NIDDK Innovative Science Accelerator (ISAC) Program NIDDK Molecular Hematology Centers NIDDK Active Trials in Hematologic Disease View related clinical trials from ClinicalTrials. gov. Study sections conduct initial peer review of applications in a designated scientific area.

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