Ethical, Legal, and Societal Implications (ELSI) Research Program (R01 Clinical Trial Optional)

Ethical, Legal, and Societal Implications (ELSI) Research Program (R01 Clinical Trial Optional) is sponsored by National Institutes of Health (NIH) - National Human Genome Research Institute (NHGRI). While broader, given Dr.

Ethical, Legal and Social Implications Research Program NIH Websites Are Changing Get the Latest Updates and FAQs Funded Programs and Projects Ethical, Legal and Social Implications Research Program The ELSI Research Program fosters basic and applied research on the ethical, legal and social implications of genetic and genomic research for individuals, families and communities.

ELSI Abstracts and Activities Database ELSI Publications and Products Database Sample ELSI Applications and Summary Statements Centers of Excellence in ELSI Research Since its creation in 1990, the ELSI Research Program has supported a large body of research on a wide range of topics.

ELSI research addresses the new and sometimes unexpected ways that genomics interacts with many aspects of daily life, from how healthcare is designed and delivered to the ways individuals, families and communities understand such basic concepts as belonging and what it means to be human.

Of particular interest are studies that explore these issues with and within communities that have been underrepresented, underserved and/or mistreated in biomedical research and healthcare.

To capture this diversity of issues, the ELSI Research Program has identified four broad areas of research: Genomics and Sociocultural Structures and Values These projects may explore and elucidate the personal, social and cultural factors that shape the generation, interpretation, understanding and use of genetic and genomic information and associated technologies.

Genomics at the Institutional and System Level These projects may explore the interplay and influences between genetics and genomics and organizations, institutions, governments, systems or other organized stakeholders. Genomic Research Design and Implementation These projects may investigate the ethical, legal, social and policy issues that arise in connection with the design and conduct of genetic and genomic research.

These projects may examine issues that arise as genetic and genomic research are integrated into clinical medicine and healthcare in a variety of settings. These four research areas are overlapping, and many research projects will likely address issues that cut across areas. A more detailed discussion of each research area and examples of possible research topics are available at ELSI Research Areas .

Centers of Excellence in ELSI Research The Centers of Excellence in ELSI Research bring investigators from multiple disciplines together to work in innovative ways to address important new, or particularly persistent, ethical, legal, and social issues related to advances in genetics and genomics.

This page lists active Notices of Funding Opportunity (NOFOs) that are most often used for research, training and career development, and conferences addressing ethical, legal, and social implications (ELSI) of advances in genetics and genomics. Prospective applicants are strongly encouraged to contact an ELSI Program Officer (PO) prior to initiating plans for application submission.

POs are available to discuss research ideas via email or a virtual meeting. Please share your specific aims or a brief overview of your project. The earlier you reach out, the more effectively we can assist you in developing a competitive application.

Parent R01 Research Grants PA-25-301 : NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) PA-25-305 : NIH Research Project Grant (Parent R01 Clinical Trial Required) PA-25-304 : NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) PA-25-306 : NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required) PA-25-302 : NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) Due Dates for New R01 Applications : June 5, 2025; October 5, 2025 February 5, 2026; June 5, 2026; October 5, 2026 February 5, 2027; June 5, 2027; October 5, 2027 Expiration Date : January 8, 2028 Parent R21 and R03 Research Grants PA-25-304 : NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) PA-25-306 : NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required) PA-25-302 : NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) Due Dates for New R01 Applications : June 16, 2025; October 16, 2025 February 16, 2026; June 16, 2026; October 16, 2026 February 16, 2027; June 16, 2027; October 16, 2027 Expiration Date : January 8, 2028 ELSI Research Supplements An administrative supplement is an increment in funding to support research that is within the original scope of an active NIH research grant (parent grant).

PA-20-272 Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) Expiration Date: September 30, 2025 For more guidance, please reference NHGRI Guidelines for Grantees Requesting Administrative Supplements .

Due Dates: Administrative supplements may be submitted throughout the fiscal year, but should be requested at least 90 days prior to the anticipated need, and no later than May 15.

ELSI Research Grants (R01, R21, R03) The below three Notices of Funding Opportunity (NOFOs) are the primary mechanisms used by NHGRI and other Institutes and Centers to support investigator-initiated research on the ethical, legal and social implications (ELSI) of genomics. Please click here for the informational webinar recording, presentation slides, and frequently asked questions (FAQs).

PAR-25-371 Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional) PAR-25-369 Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional) PAR-25-370 Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional) Due Dates for New Applications : June 17, 2025; October 20, 2025 February 19, 2026; June 18, 2026; October 20, 2026 Expiration Date : November 19, 2026 New Program to Advance ELSI Research (UM1) The NHGRI ELSI Research Program seeks to broaden the types of knowledge, skills, expertise, experience, and perspectives brought to bear in research addressing the ELSI of advances in human genetics or genomics.

The Building Partnerships and Broadening Perspectives to Advance ELSI Research (BBAER) Program will support: 1) transdisciplinary ELSI research addressing timely, complex, and understudied topics associated with advances in human genetics and genomics, 2) the establishment of ELSI research teams that include partnerships with relevant communities affected by and with an interest in the proposed research, 3) research capacity building to develop, conduct, and sustain ELSI research, and 4) workforce development opportunities for early career scholars, research team members, and other BBAER project staff.

This Notice of Funding Opportunity (NOFO) is a limited competition whereby eligible applicants must be domestic organizations located in the United States and its territories that received less than $30 million per year in total NIH funding for the past three fiscal years. These organizations are underrepresented among those receiving NHGRI funding for ELSI research.

More information for potential applicants including a pre-application webinar can be found here .

RFA-HG-24-026 Limited Competition: Building Partnerships and Broadening Perspectives to Advance Ethical, Legal, and Social Implications (ELSI) Research (BBAER) Program (UM1), Clinical Trial Optional (see the NOFO diagram ) Due Dates for New Applications (letters of intent requested 60 days prior to due date): ELSI Training and Career Development (K99/R00, K01, R25, T32) In general, when deciding whether to apply to a particular NOFO, potential applicants should be sure to read the entire NOFO.

Keep in mind that similar programs may vary in specific requirements across NIH Institutes, Centers, or Offices. Never hesitate to contact the program officer listed in the NOFO about your research ideas and any questions you may have. Training Opportunities for Individuals (K99/R00, K01) All of these NOFOs have the same new application due dates and expiration date.

PA-24-193 : NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required) PA-24-182 : NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed) PA-24-175 : Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required) PA-24-176 : Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) Due Dates: February 12, June 12, October 12 Expiration Date: May 8, 2027 Training Opportunities for Institutions (T32) PA-23-048 : Ruth L.

Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) Any new or competing application may include a request for (1) pre-doctoral, (2) post-doctoral, or (3) pre-doctoral and post-doctoral training positions, provided that there is appropriate coordination and collaboration amongst the trainee cohorts.

Due Dates: January 25, May 25, September 25 Expiration Date: May 8, 2026 The NHGRI ELSI Program accepts applications to support Conference Grants (R13) that are submitted to the general NIH-wide funding opportunity, PA-24-141.

For specific instructions for preparing a conference grant application, see: PA-24-141 : NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) Upcoming Due Dates for New Applications : August 12, 2024; December 12, 2024 April 12, 2025; August 12, 2025; December 12, 2025 April 12, 2026; August 12, 2026; December 12, 2026 Expiration Date : January 8, 2027 NHGRI Resources for Funding for Research Training NIH Guide for Grants and Contracts Joy Boyer retires after championing bioethics research at the cutting-edge of genomics NIH funds new studies on ethical, legal and social impact of genomic information 6th Annual ELSI Congress (2024) Pre-Application Webinar for the Building Partnerships and Broadening Perspectives to Advance ELSI Research (BBAER) Program ELSI Research and the New NIH Data Management and Sharing (DMS) Policy Webinar ELSI Webinars March 13 and March 26, 2018 The 4th ELSI Congress: Genomics and Society: Expanding the ELSI Universe Trans-NIH Workshop to Explore the Ethical, Legal and Social Implications (ELSI) of Citizen Science Follow-up Workshop to the Consensus Development Conference on Genetic Testing for CF (10/97) Promoting Safe and Effective Genetic Testing in the United States: Final Report of the Task Force on Genetic Testing (09/97) Genetic Testing for Cystic Fibrosis Consensus Development Conference Statement (04/97) NIH Workshop Statement - Reproductive Genetic Testing: Impact on Women (11/91) NIH Workshop Statement - Population Screening for the CF Gene (07/90) Genetic Discrimination and Health Insurance Genetic Information and the Workplace (01/98) NIH-DOE ELSI Working Group and National Action Plan on Breast Cancer Workshop on Genetic Discrimination and the Workplace (10/96) NIH-DOE ELSI Working Group and National Action Plan on Breast Cancer Workshop on Genetic Discrimination and Health Insurance (07/95) Insurance Task Force Report--Executive Summary (05/93) Genetic Information and Health Insurance - Report of the Task Force on Genetic Information and Insurance (05/93) Issues Related to the Conduct of Genetic Research Report of the First Community Consultation on the Responsible Collection and Use of Samples for Genetic Research (09/00) NCHGR/CDC Workshop on Informed Consent for Genetics Research Using Stored Tissue Samples (07/94) Protecting Human Research Subjects: 1993 OPRR IRB Guidebook Chapter on Human Genetic Research (1993) Report of the Working Group on Ethical, Legal, and Social Issues Related to Mapping and Sequencing the Human Genome (04/90) Underrepresented Minorities Summary of Grantees' Workshop on Strategies for Increasing the Number of Underrepresented Minorities Participating in Genomics and ELSI Research (11/01) Plan for Increasing the Number of Underrepresented Minorities Trained in Genomics and ELSI Research (2001) Studying interactions Among Social, Behavioral & Genetic Factors in Health (10/01) Cancer Genetic Studies Consortium (1998) Hereditary Hemochromatosis: Gene Discovery and Policy Meeting (03/97) Report to the National Advisory Council for Human Genome Research (02/05) The Role of ELSI Research & Policy Activities in the NHGRI Plan (10/02) A Review and Analysis of the ELSI Research Programs at NIH and DOE (ERPEG Final Report) (02/00) Report of the Joint NIH/DOE Committee to Evaluate the Ethical, Legal and Social Implications Program of the Human Genome Project (12/96) Review of the ELSI Program: 1990-1995 (03/96) Division of Genomics and Society Nicole C.

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