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The European Union funds AI research and deployment primarily through Horizon Europe, the EUR 95.5 billion research and innovation framework running from 2021 to 2027. AI-specific calls fall under Cluster 4 (Digital, Industry, and Space) with dedicated work programs for trustworthy AI, human-centric AI, and AI for the green transition. The GenAI4EU initiative and RAISE (AI for Sustainable Europe) represent the latest programmatic priorities.
U.S. researchers and institutions can participate in many Horizon Europe calls as associated partners, though funding flows primarily to EU-based entities. The EU-US Trade and Technology Council has established AI research cooperation mechanisms, and bilateral agreements allow U.S.-EU collaborative proposals in specific programs.
Beyond Horizon Europe, the European Innovation Council (EIC) funds AI startups through the Accelerator program (up to EUR 2.5 million grant plus EUR 15 million equity), and national programs in Germany (BMBF), France (ANR), and the UK (UKRI) provide substantial AI research funding with varying degrees of openness to international collaboration.
Horizon Europe AI Calls
Cluster 4 work programs funding trustworthy AI, AI for manufacturing, AI for health, and foundational AI research. Individual projects EUR 2M-20M.
GenAI4EU
EU initiative for developing and deploying European generative AI capabilities. Funding for large language models, foundation models, and generative AI applications.
EIC Accelerator (AI)
European Innovation Council grants (up to EUR 2.5M) plus equity (up to EUR 15M) for AI startups with strong market potential.
RAISE Initiative
Robotics and AI for Sustainable Europe — cross-cutting program funding AI applications addressing sustainability, climate, and societal challenges.
10 matching grants
HORIZON-CL4-2026-HUMAN-01-01: Leadership in AI based on trust is a grant from the European Commission that funds collaborative research and innovation projects to advance trustworthy, European-led artificial intelligence under the Horizon Europe program and the GenAI4EU flagship initiative. The call supports development of AI systems that are robust, transparent, and aligned with European values — contributing to Europe's strategic leadership in AI across digital, industrial, and societal domains. Individual project awards are expected to range from EUR 5,000,000 to EUR 10,000,000, with a total call budget of approximately EUR 30,000,000. Eligible applicants are consortia of at least three legal entities from three different EU Member States or associated countries. The application deadline was April 21, 2026.
Digital Europe Programme Grants is sponsored by European Commission. This call for proposals aims to establish a specialized environment for nurturing and accelerating the growth of European EdTech startups and SMEs, focusing on transforming innovative educational concepts into market-ready products that align with European values. It contributes to the Digital Education Action Plan (2021-2027) and the GENAI4EU initiative by supporting the ethical application of technologies like generative AI and extended reality in learning environments.
The Horizon Europe Cluster 4 call HORIZON-CL4-2026-05-DIGITAL-EMERGING-02 funds research and innovation on next-generation AI agents capable of operating autonomously in complex real-world environments. With a budget of approximately €20 million, this Research and Innovation Action (RIA) call supports projects developing agentic AI systems that can reason, plan, and act in dynamic settings across sectors such as manufacturing, healthcare, autonomous systems, and public services. The call is part of the broader 2026-2027 Horizon Europe Work Programme, which dedicates an estimated €2,023 million to AI-related topics across Cluster 4. Projects are expected to advance the state of the art in multi-agent coordination, robust decision-making under uncertainty, and safe deployment of autonomous AI systems. This call complements the GenAI4EU initiative and RAISE programme, collectively representing Europe's largest-ever investment in AI research.
The DIGITAL-2026-AI-PILOTING-10-SCREENING call under the EU Digital Europe Programme supports the development and piloting of scalable cloud-based AI and Generative AI systems for medical image screening in real-world healthcare settings. Projects must deploy trustworthy European algorithms trained and validated on massive patient datasets, focusing specifically on cancer and cardiovascular disease detection, prevention, and early diagnosis. The programme requires large-scale validation across multiple healthcare settings with human-in-the-loop validation by qualified medical professionals. All projects must comply with the EU AI Act, relevant cybersecurity frameworks, and data protection rules including GDPR, and must prepare Health Technology Assessment (HTA) documentation. Solutions must be interoperable with existing health IT infrastructure including EHR, PACS, and RIS systems. This call is part of the broader GenAI4EU initiative investing nearly EUR 700 million in European generative AI capabilities.
EIC Accelerator Challenge: GenAI4EU: Creating European Champions in Generative AI is sponsored by European Commission (under Horizon Europe). This challenge under the EIC Accelerator aims to support startups and SMEs committed to bringing transformative AI-driven solutions to market, safeguarding human autonomy, and enhancing human expertise to provide significant added value to decision-making processes, services, or…
EIC Accelerator Challenges: GenAI4EU: Creating European Champions in Generative AI is sponsored by European Innovation Council (EIC) under Horizon Europe. This challenge supports start-ups and SMEs committed to bringing transformative AI-driven solutions to market, safeguarding human autonomy, and enhancing human expertise to provide significant added value to decision-making processes, services, or industrial workflows.
AI and GenAI4EU Funding is a suite of grants from the European Commission under its Horizon Europe program that funds research and innovation projects applying generative AI across sectors including healthcare, energy, digital infrastructure, and industrial competitiveness. Individual calls offer between €15 million and €17 million for large-scale projects, such as leveraging multimodal data for biomedical AI and generative AI-powered digital solutions. Eligible applicants include researchers, innovators, companies, and organizations from EU member states. The program spans multiple funding calls with varying deadlines; for example, the healthcare-focused call HORIZON-HLTH-2025-01-TOOL-03 closed in September 2025.
AI Innovation Package / GenAI4EU Initiative is sponsored by European Commission. The AI innovation package aims to bolster the development and adoption of trustworthy Artificial Intelligence across the EU, supporting AI start-ups and SMEs by facilitating access to supercomputing resources, providing financial aid, and creating a supportive ecosystem for inno…
The Horizon Europe GenAI4EU Booster is a grant program from the European Commission that funds the development and deployment of generative AI technologies across Europe's strategic industrial sectors. Part of the GenAI4EU flagship initiative, the program has committed nearly €700 million through Horizon Europe, the Digital Europe Programme, and the European Innovation Council. Supported sectors include manufacturing, robotics, healthcare, energy, agrifood, mobility, and aerospace. Individual calls range from approximately €15 million to €17 million per award. Eligible applicants include researchers, innovators, companies, startups, and public organizations from EU Member States, EFTA/EEA countries, and Horizon Europe-associated nations. The initiative aims to boost EU AI adoption—currently at 13.5%—by fostering open innovation ecosystems connecting AI developers with European industrial and public sector partners.
EIC Accelerator Challenges: GenAI4EU: Creating European Champions in Generative AI is sponsored by European Innovation Council (EIC). This challenge supports start-ups and SMEs committed to bringing transformative AI-driven solutions to market. The goal is to safeguard human autonomy and enhance human expertise, providing significant added value to decision-making processes, services, or industrial workflows.
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The European Commission opened EUR 307.3M in Horizon Europe AI calls closing April 15, 2026. Here is how non-EU teams can compete for a share.
Read articleEUR 307M in Horizon Europe AI calls closed April 15, 2026. US researchers can participate — but the rules are specific. Here is how to navigate them.
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