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The European Union funds AI research and deployment primarily through Horizon Europe, the EUR 95.5 billion research and innovation framework running from 2021 to 2027. AI-specific calls fall under Cluster 4 (Digital, Industry, and Space) with dedicated work programs for trustworthy AI, human-centric AI, and AI for the green transition. The GenAI4EU initiative and RAISE (AI for Sustainable Europe) represent the latest programmatic priorities.
U.S. researchers and institutions can participate in many Horizon Europe calls as associated partners, though funding flows primarily to EU-based entities. The EU-US Trade and Technology Council has established AI research cooperation mechanisms, and bilateral agreements allow U.S.-EU collaborative proposals in specific programs.
Beyond Horizon Europe, the European Innovation Council (EIC) funds AI startups through the Accelerator program (up to EUR 2.5 million grant plus EUR 15 million equity), and national programs in Germany (BMBF), France (ANR), and the UK (UKRI) provide substantial AI research funding with varying degrees of openness to international collaboration.
Horizon Europe AI Calls
Cluster 4 work programs funding trustworthy AI, AI for manufacturing, AI for health, and foundational AI research. Individual projects EUR 2M-20M.
GenAI4EU
EU initiative for developing and deploying European generative AI capabilities. Funding for large language models, foundation models, and generative AI applications.
EIC Accelerator (AI)
European Innovation Council grants (up to EUR 2.5M) plus equity (up to EUR 15M) for AI startups with strong market potential.
RAISE Initiative
Robotics and AI for Sustainable Europe — cross-cutting program funding AI applications addressing sustainability, climate, and societal challenges.
16 matching grants
The Horizon Europe Cluster 4 call HORIZON-CL4-2026-05-DIGITAL-EMERGING-02 funds research and innovation on next-generation AI agents capable of operating autonomously in complex real-world environments. With a budget of approximately €20 million, this Research and Innovation Action (RIA) call supports projects developing agentic AI systems that can reason, plan, and act in dynamic settings across sectors such as manufacturing, healthcare, autonomous systems, and public services. The call is part of the broader 2026-2027 Horizon Europe Work Programme, which dedicates an estimated €2,023 million to AI-related topics across Cluster 4. Projects are expected to advance the state of the art in multi-agent coordination, robust decision-making under uncertainty, and safe deployment of autonomous AI systems. This call complements the GenAI4EU initiative and RAISE programme, collectively representing Europe's largest-ever investment in AI research.
HORIZON-CL4-2026-05-DIGITAL-EMERGING-03 supports Research and Innovation Actions developing next-generation agile and intelligent robotics platforms with embedded AI for industrial and service applications. Funded scope includes foundation models for robotics, vision-language-action policies, sim-to-real transfer, dexterous manipulation, mobile manipulation, collaborative human-robot workflows, safe autonomy in unstructured environments, and modular AI-robotics software stacks. Aligned with the AI, Data and Robotics Partnership and the GenAI4EU strategy, projects must demonstrate clear pathway from research demonstration to industrial deployment in European value chains.
HORIZON-CL4-2026-05-DIGITAL-EMERGING-02 funds Research and Innovation Actions developing next-generation autonomous AI agents for real-world applications across the seven GenAI4EU priority sectors (healthcare, manufacturing, robotics, climate and the green deal, virtual worlds, science, and public sector). Funded work covers multi-agent orchestration, tool-using agents, memory and planning systems, trust and oversight mechanisms, evaluation methodologies, and industrial-grade deployment patterns for production AI agents. Projects must demonstrate measurable outcomes in deployed agent systems serving European industrial and public-sector use cases.
Horizon Europe HORIZON-CL4-2026-05-DIGITAL-EMERGING-02 Next-Generation AI Agents for Real-World Applications in GenAI4EU Priority Sectors is sponsored by European Commission (Horizon Europe Cluster 4 - Digital, Industry and Space). HORIZON-CL4-2026-05-DIGITAL-EMERGING-02 funds Research and Innovation Actions developing next-generation autonomous AI agents for real-world applications across the seven GenAI4EU priority sectors (healthcare, manufacturing, robotics, climate and the green deal, virtual worlds, …
The DIGITAL-2026-AI-PILOTING-10-SCREENING call under the EU Digital Europe Programme supports the development and piloting of scalable cloud-based AI and Generative AI systems for medical image screening in real-world healthcare settings. Projects must deploy trustworthy European algorithms trained and validated on massive patient datasets, focusing specifically on cancer and cardiovascular disease detection, prevention, and early diagnosis. The programme requires large-scale validation across multiple healthcare settings with human-in-the-loop validation by qualified medical professionals. All projects must comply with the EU AI Act, relevant cybersecurity frameworks, and data protection rules including GDPR, and must prepare Health Technology Assessment (HTA) documentation. Solutions must be interoperable with existing health IT infrastructure including EHR, PACS, and RIS systems. This call is part of the broader GenAI4EU initiative investing nearly EUR 700 million in European generative AI capabilities.
EC Digital Europe Programme Apply AI Piloting AI-Based Image Screening in Medical Centres for Cancer and Cardiovascular Diagnostics is sponsored by European Commission (Digital Europe Programme, GenAI4EU initiative). Under the European Commission's GenAI4EU initiative and the Digital Europe Programme, this call (DIGITAL-2026-AI-PILOTING-10-SCREENING) supports the development, deployment, and large-scale clinical validation of cloud-based AI systems for medical image screening across European…
Under the European Commission's GenAI4EU initiative and the Digital Europe Programme, this call (DIGITAL-2026-AI-PILOTING-10-SCREENING) supports the development, deployment, and large-scale clinical validation of cloud-based AI systems for medical image screening across European hospital networks. Funded projects will integrate AI diagnostic tools into routine clinical workflows for cancer (mammography, lung CT, dermatology, pathology) and cardiovascular imaging, establish multi-country networks of AI-powered screening centres, demonstrate clinical performance on large patient datasets, address EU AI Act and MDR compliance, and deliver health-economic evidence to support reimbursement and scale-up. Cybersecurity, data protection under GDPR, and federated learning architectures for cross-border data governance are emphasized.
European AI Fund: Capacity Building with European Civil Society is sponsored by Network of European Foundations (supported by Mott Foundation and other private funders). This pooled fund aims to empower a diverse and resilient ecosystem of civil society organizations to participate in policy debates on artificial intelligence and related digital technologies.
AI Innovation Package / GenAI4EU Initiative is sponsored by European Commission. The AI innovation package aims to bolster the development and adoption of trustworthy Artificial Intelligence across the EU, supporting AI start-ups and SMEs by facilitating access to supercomputing resources, providing financial aid, and creating a supportive ecosystem for inno…
AI and GenAI4EU Funding is a suite of grants from the European Commission under its Horizon Europe program that funds research and innovation projects applying generative AI across sectors including healthcare, energy, digital infrastructure, and industrial competitiveness. Individual calls offer between €15 million and €17 million for large-scale projects, such as leveraging multimodal data for biomedical AI and generative AI-powered digital solutions. Eligible applicants include researchers, innovators, companies, and organizations from EU member states. The program spans multiple funding calls with varying deadlines; for example, the healthcare-focused call HORIZON-HLTH-2025-01-TOOL-03 closed in September 2025.
GenAI4EU: Creating European Champions in Generative AI (EIC Accelerator Challenge) is sponsored by European Innovation Council (EIC) under Horizon Europe. Part of the EIC Accelerator, this challenge aims to support startups and SMEs developing generative AI solutions. It provides funding to bring technologies and innovations to market and scale globally, with a focus on creating new markets or disrupting existing ones.
Horizon Europe AI in Science Pilot Networks of Laboratories for Agriculture and Environmental Pollution is sponsored by European Commission (Horizon Europe RAISE Pilot). As part of the European Commission's €100 million Horizon Europe 2026-27 AI in Science pilot, €28 million is allocated to establish pilot networks of laboratories in priority scientific domains including agriculture and environmental pollution.
EIC Accelerator Challenges 2025 is sponsored by European Innovation Council (EIC) under Horizon Europe. The EIC Accelerator Challenges calls are open to proposals in predefined topics where breakthrough technologies or game-changing innovations developed by start-ups or SMEs can have a major impact on EU objectives. The 2025 challenges include Acceleration of advanced materials development and upscaling, Biotechnology driven low emission food and feed production systems, GenAI4EU: Creating European Champions in Generative AI, Innovative in-space servicing, operations, robotics and technologies for resilient EU space infrastructure, and Breakthrough innovations for future mobility.
As part of the European Commission's €100 million Horizon Europe 2026-27 AI in Science pilot, €28 million is allocated to establish pilot networks of laboratories in priority scientific domains including agriculture and environmental pollution. These networks will use shared AI infrastructure, federated experimental datasets, and coordinated machine-learning workflows to accelerate discovery in agricultural productivity, soil health, water quality, air pollution monitoring, and ecosystem modeling. Funded networks will pilot the operational model for the Resource for AI Science in Europe (RAISE) — a virtual institute described as a 'CERN for AI' — through cross-laboratory data sharing, AI model exchange, jointly supervised doctoral training, exchange schemes, matchmaking events with industry, and federated compute access. The pilot networks are expected to demonstrate scalable AI-for-science governance models, FAIR data and model sharing standards, and reusable benchmarks for AI applied to agricultural and environmental challenges.
The Horizon Europe GenAI4EU Booster is a grant program from the European Commission that funds the development and deployment of generative AI technologies across Europe's strategic industrial sectors. Part of the GenAI4EU flagship initiative, the program has committed nearly €700 million through Horizon Europe, the Digital Europe Programme, and the European Innovation Council. Supported sectors include manufacturing, robotics, healthcare, energy, agrifood, mobility, and aerospace. Individual calls range from approximately €15 million to €17 million per award. Eligible applicants include researchers, innovators, companies, startups, and public organizations from EU Member States, EFTA/EEA countries, and Horizon Europe-associated nations. The initiative aims to boost EU AI adoption—currently at 13.5%—by fostering open innovation ecosystems connecting AI developers with European industrial and public sector partners.
EIC Accelerator Challenges: GenAI4EU: Creating European Champions in Generative AI is sponsored by European Innovation Council (EIC). This challenge supports start-ups and SMEs committed to bringing transformative AI-driven solutions to market. The goal is to safeguard human autonomy and enhance human expertise, providing significant added value to decision-making processes, services, or industrial workflows.
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The European Commission opened EUR 307.3M in Horizon Europe AI calls closing April 15, 2026. Here is how non-EU teams can compete for a share.
Read articleEUR 307M in Horizon Europe AI calls closed April 15, 2026. US researchers can participate — but the rules are specific. Here is how to navigate them.
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