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Exploratory/Developmental Research Grant Awards (R21) is sponsored by National Library of Medicine (NLM) (NIH). The NLM R21 program encourages new, exploratory, and developmental research projects aligned with NLM's Scientific Areas of Interest.
This mechanism supports early stages of project development and may involve considerable risk, potentially leading to breakthroughs, novel techniques, or methodologies with major impact on biomedical, behavioral, or clinical research.
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Or search similar grants →According to the current listing, eligibility includes: Researchers from eligible institutions. The program intends to foster novel scientific ideas, model systems, tools, agents, targets, and technologies. Confirm the full requirements in the official notice before applying.
Exploratory/Developmental Research Grant Awards (R21) is funded by National Library of Medicine (NLM) (NIH). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
PAR-26-042 funds NLM-priority clinical informatics R01 grants up to $250,000 in direct costs per year through March 6, 2029, with standard NIH cycles on October 5, February 5, and June 5. The notice explicitly defines non-responsive applications: incremental tool improvements, projects primarily focused on social determinants of health, and projects primarily focused on ethical/legal/social issues. With NIH SBIR/STTR just reopened and the OMB Uniform Grants Regulation rewrite reshaping discretionary awards, the NLM clinical informatics line is one of the few stable, well-defined biomedical funding streams left at the agency. Here is how to read it.
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