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Exploratory/Developmental Research Grant Program (R21) (Parent RFA-AG-24-006) is sponsored by National Institutes of Health (NIH). This parent R21 announcement supports exploratory or developmental research projects that may lay the groundwork for new research directions.
While not specific to adolescent substance use or social media, it could be utilized for innovative, high-risk, high-reward pilot studies in the area of social media health literacy interventions if they align with the mission of a participating NIH institute. The 'social media/online' setting is explicitly mentioned as a potential site for interventions to address social connectedness and/or loneliness to prevent or treat SUDs.
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Or search similar grants →According to the current listing, eligibility includes: Government: Public and Indian Housing Authorities, State Governments, County Governments, City or Township Governments, Special District Governments, Federally Recognized Native American Tribal Governments. Education: Independent School Districts, Public and State Controlled Institutions of Higher Education, Private Institutions of Higher Education. Nonprofit: Nonprofits with 501(c)(3) status, Nonprofits without 501(c)(3) status, Other Native American Tribal Organizations. Business: For-profit Organizations, Small Businesses. Other: U.S. Territories or Possessions, Regional Organizations, Eligible Agencies of the Federal Government, Faith-based or Community-based Organizations, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Indian/Native American Tribal Governments (Other than Federally Recognized), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Tribally Controlled Colleges and Universities (TCCUs), Non-domestic (non-U.S.) Entities (Foreign Organizations). Confirm the full requirements in the official notice before applying.
Applications for Exploratory/Developmental Research Grant Program (R21) (Parent RFA-AG-24-006) are due October 16, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Exploratory/Developmental Research Grant Program (R21) (Parent RFA-AG-24-006) is funded by National Institutes of Health (NIH). Verify program details on the funder's official page before applying.
This opportunity targets applicants in Alaska. If your organization operates elsewhere, check the official notice for location requirements.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
Past winners and funding trends for this program
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) is sponsored by National Science Foundation (NSF) & National Institutes of Health (NIH). This interagency program supports high-risk, high-reward advances in AI and data science for biomedical and public health research. Projects must cross disciplinary boundaries.
NIH R25 Summer Research Education Experience Program is a grant from the National Institutes of Health (NIH) that funds universities and institutions of higher education to provide summer research experiences in environmental health sciences to high school students, college undergraduates, and science teachers. Administered through the National Institute of Environmental Health Sciences (NIEHS), the program aims to attract young people to scientific careers and help teachers communicate about the scientific process more effectively. Eligible applicants are U.S. institutions eligible for NIH grants. The application deadline was March 17, 2026.
NCI Continuing Umbrella of Research Experiences (CURE) Academic Career Excellence (ACE) Award (K32) is a grant from the National Cancer Institute (NCI) that funds early postdoctoral fellows from diverse backgrounds, including underrepresented groups, to pursue research training in cancer-related fields. The K32 award supports fellows within 12 months prior to transitioning into, or within the first two years of, a postdoctoral position. The program, operated through NCI's Center to Reduce Cancer Health Disparities (CRCHD), aims to enhance the pool of qualified diverse cancer researchers. Beginning with the June 12, 2025 due date, the CURE ACE Award is available in both Independent Clinical Trial Required and Independent Clinical Trial Not Allowed versions. Eligible applicants must be U.S. citizens or permanent residents at time of award.
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) is sponsored by National Science Foundation (NSF) & National Institutes of Health (NIH). This interagency program supports high-risk, high-reward advances in AI and data science for biomedical and public health research. Projects must cross disciplinary boundaries.
As of October 1, 2025, NIH no longer posts Notices of Funding Opportunity in the NIH Guide — Grants.gov is now the single official source (NOT-OD-25-143). The weekly Guide table-of-contents email that thousands of investigators relied on to discover funding no longer lists opportunities. Combined with the January 25, 2026 SciENcv certified-PDF requirement, the mechanics of finding and applying for NIH money have changed underneath everyone. Here is how to rebuild your discovery workflow so nothing slips through.
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Read articleThe NIH Director's New Innovator Award (DP2, RFA-RM-27-002) closes August 17, 2026, offering roughly 30 Early Stage Investigators up to $475,000 in direct costs a year for five years — $2.375 million total — to pursue bold ideas without the preliminary data a standard R01 demands. Here is how the High-Risk, High-Reward program actually evaluates applications, who qualifies, and why the usual R01 instincts will sink you.
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