Fogarty International Collaborative Trauma and Injury Research Training Program (TRAUMA)

Fogarty International Collaborative Trauma and Injury Research Training Program (TRAUMA) is sponsored by Fogarty International Center, NIH; National Institute on Alcohol Abuse and Alcoholism (NIAAA); National Institute of Neurological Disorders and Stroke (NINDS); National Center for Injury Prevention and Control (CDC/NCIPC); Department of Violence and Injury Prevention and Disability Non-communicable Diseases and Mental Health World Health Organization. This program solicits new and renewal applications for collaborative research training programs that strengthen the capacity of institutions in low- and middle-income countries (LMIC) in trauma and injury research.

Expired RFA-TW-09-002: Fogarty International Collaborative Trauma and Injury Research Training Program (TRAUMA) (D43) This notice has expired. Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Participating Organizations National Institutes of Health (NIH) ( http://www.

nih. gov ) Centers for Disease Control and Prevention (CDC) ( http://www. cdc.

gov) World Health Organization (WHO) ( http://www. who. int ) Components of Participating Organizations John E.

Fogarty International Center (FIC/NIH) ( http://www. fic. nih.

gov ) National Institute on Alcohol Abuse and Alcoholism (NIAAA) ( http://www. niaaa. nih.

gov/) National Institute of Neurological Disorders and Stroke (NINDS) ( http://www. ninds. nih.

gov ) National Center for Injury Prevention and Control ( CDC/ NCIP C ) ( http://www. cdc. gov/ncipc/ ) Department of Violence and Injury Prevention and Disability Noncommunicable Diseases and Mental Health World Health Organization ( www.

who. int/violence_injury_prevention/ ) Title : Fogarty International Collaborative Trauma and Injury Research Training Program (TRAUMA) (D43) Funding Opportunity Announcement (FOA) is a reissue of PAR-04-083 . Update: The following update relating to this announcement has been issued: December 17, 2015 - This RFA has been reissued as RFA-TW-16-001 .

August 16, 2010 - IMPORTANT NOTE! NIH has eliminated the error correction window for due dates of January 25, 2011 and beyond. As of January 25, all corrections must be complete by the due date for an application to be considered on-time.

See NOT-OD-10-123 . Applications (RFA) Number: NOTICE: Applications submitted in response to this Funding Opportunity Announcement (FOA) for Federal assistance must be submitted electronically through Grants. gov ( http://www.

grants. gov ) using the SF424 Research and Related (R&R) forms and the SF424 BE SUBMITTED IN PAPER FORMAT. in conjunction with the application guidelines included with this announcement for Grants (hereafter called Grants.

gov/Apply). is necessary before submission and applicants are highly encouraged to start the process at least eight (8) weeks prior to the grant submission date. See Section IV .

Domestic Assistance Number(s) Opening Date: May 8, 2010 (Earliest date an application may be submitted to of Intent Receipt Date(s): May 8 , 2010 NOTE: On-time submission requires that applications be successfully submitted to Grants. gov no later than 5:00 p. m.

local time (of the applicant institution/organization). Application Due Date(s): June 8 , 2010 AIDS Application Due Date(s): Not Applicable Peer Review Date(s): October/November 2010 Council Review Date(s): January 201 1 Earliest Anticipated Start Date(s): March 201 1 Additional Information --To Be Available Date (Activation Date): Not Applicable Expiration Date: June 9 , 2010 Purpose .

The Fogarty International Center (FIC), together with the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Neurological Disorders and Stroke (NINDS), the National Center for Injury Prevention and Control (CDC/NCIPC), and Department of Violence and Injury Prevention and Disability Non - communicable Diseases and Mental Health World Health Organization, solicits new and renewal applications in the Fogarty International Collaborative Trauma and Injury Research Training Program (TRAUMA).

The application must propose a collaborative research training program that will strengthen the capacity of institutions in low-and middle-income countries (LMIC), defined by the World Bank classification system , to conduct human trauma and injury research. Mechanism of Support. This FOA will utilize the National Institutes of Health (NIH) international research training D43 grant mechanism.

Funds Available and Anticipated Number of Awards. The estimated amount of funds available from all collaborating partners for support of an anticipated 9 projects awarded as a result of this announcement is $2,000,000. Budget and Project Period.

The expected amount for individual awards will be up to $ 200,000 per year (total direct costs) for up to five years. Facilities and Administrative (F&A) costs requested by consortium participants are not included in the direct cost limitation, see NOT-OD-05-004 . Facilities and administrative costs are limited to 8% for all awards and sub-awards.

Research Training Program Plan Page Length: Items 2-5 of the Research Training Program Plan (Background, Program Plan, Recruitment and Retention Plan to Enhance Diversity, and Plan for Instruction in the Responsible Conduct of Research) are limited to a combined total of 25 pages, including tables, graphs, figures, diagrams, and charts. Institutions/Organizations. Institutions/organizations listed in Section III, 1.

A. are eligible to apply. A pplications from U.S. institutions must demonstrate collaborations with institutions in the low- and middle-income countries (LMIC), defined by the World Bank classification system ) named in their application.

Directors/Principal Investigators (PDs/PIs) : An eligible Training PD/PI is any individual with the skills, knowledge, successful past training record, and available resources necessary to carry out the proposed research training program. The PD/PI should be an established researcher at the applicant institution.

The PD/PI will be responsible for the selection of eligible trainees to the training grant, the overall direction, management and administration of the research training program, program evaluation, and the submission of all required forms in a timely manner. US applicants must identify at least one scientist from each LMIC institution as the main foreign collaborator for that institution.

Women, individuals from underrepresented racial, ethnic or socially disadvantaged groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of PDs/PIs. More than one PD/PI (i.e., multiple PDs/PIs) may be designated on the application.

Number of Applications. Only one application for an award may be submitted from an institution. Only one award will be made to an institution at any given time.

Resubmissions. Resubmission applications are not permitted in response to this FOA . Renewals.

Renewal applications are allowed for this research education program. Special Date(s). This FOA uses non-standard due dates.

See Receipt, Review and Anticipated Start Dates . Materials. See Section IV.

1 for application materials. General Information: For general information on SF424 (R&R) Application and Electronic Submission, see these Web sites: (R&R) Application and Electronic Submission Information: http://grants. nih.

gov/grants/funding/424/index. htm information on Electronic Submission of Grant Applications: http://era. nih.

gov/ElectronicReceipt/ Impaired. Telecommunications for the hearing impaired are available at: TTY: (301) 451-5936 Part I Overview Information Part II Full Text of Announcement Section I. Funding Opportunity Section II.

Award Information Section III. Eligibility Information 2. Cost Sharing or Matching 3.

Other-Special Eligibility Criteria Section IV. Application and 1. Request Application Information 2.

Content and Form of Application Submission 3. Submission Dates and Times A. Receipt, Review, and Anticipated B.

Submitting an Application Electronically to the NIH C. Application Processing 4. Intergovernmental Review 6.

Other Submission Requirements Section V. Application Review Information 2. Review and Selection Process Announcement and Award Dates Section VI.

Award Administration 2. Administrative and National Policy Requirements Section VII. Agency Contacts 1.

Scientific/Research Contact(s) Financial/Grants Management Contact(s) Section VIII. Other Information - Required Federal - Full Text of Announcement Section I. Funding Opportunity Description 1.

Research Training Objectives The Fogarty International Center (FIC), together with the National Center for Injury Prevention and Control (CDC/NCIPC), Department of Violence and Injury Prevention and Disability Non-communicable Diseases and Mental Health World Health Organization, the National Institute on Alcohol Abuse and Alcoholism, and the National Institute of Neurological Disorders and Stroke, solicits renewal and new applications in the Fogarty International Collaborative Trauma and Injury Research Training Program ( TRAUMA ) .

The application must propose a collaborative research training program that will strengthen the capacity of institutions in low-and middle-income countries (LMIC), defined by the World Bank classification system , to conduct clinical, translation and implementation research on human trauma and injury research.

Trauma and injury encompass one of the leading causes of death and disability in the world, with the greater proportion of the burden falling in the developing world, where resources, both financial and medical, are sorely lacking. Six of the 15 leading causes of death in people ages 15 to 44 in the world are trauma-related. More than 5 million deaths per year are caused by trauma, intentional and unintentional.

In addition, trauma and injury are major contributors to disability. In 1998, of the estimated 5. 8 million people who died from injuries, approximately 1.

2 million died from road traffic collisions and 2. 3 million died from violence, including 948,000 by su i cide, 736,000 from homicide and 588,000 from war. The rest died from other injury-related causes, including falls, drowning, burns and poisoning.

For every person who dies of injuries, several thousand injured persons survive, but many suffer life-long health consequences. The burden of disease attributed to injuries is expected to rise in the years ahead. It is projected that, by the year 2020, injuries will be the third leading cause of death and disability worldwide.

For people ages 5 to 44, trauma and injury account for at least 5 of the 15 most common causes of disability adjusted life years lost. The 1999 CDC report of Traumatic Brain Injury in the United States: A Report to Congress identifies traumatic brain injury as the leading cause of death and disability among children and young adults.

CDC also notes that worldwide, of all types of injury, those to the brain are among the most likely to result in death or permanent disability. The technical definition of an injury is "a bodily lesion at the organic level, resulting from acute exposure to energy (mechanical, thermal, electrical, chemical or radiant) in amounts that exceed the threshold of physiologic tolerance.

In some cases, for example, drowning, strangulation or freezing, the injury results from an insufficiency of a vital element."

Professionals in the injury field divide the causes of injuries into two categories: "unintentional," which includes most injuries resulting from traffic accidents, burns, falls, and poisonings; and "intentional," which include injuries resulting from deliberate acts of violence against Although injuries affect everyone regardless of age, sex, income or geographic region, some populations are more vulnerable than others.

Data indicate that, for most types of injuries, people die at a higher rate in LMICs and in the poorest sections of LMICs than in HICs. The poor are at higher risk for injury because they are faced with hazardous situations on a daily basis. For example, pedestrians on unsafe, overcrowded, and poorly maintained roads are vulnerable to being hit by cars, buses, or other vehicles.

People living in homes lacking safety devices and precautions are more vulnerable to the risk of fires and burns. While residents in resource-poor settings are at greater risk for trauma and injury than those in wealthier regions, it is not possible to simply transfer technologies from developed nations to developing nations because the context in which injuries occur is different.

For example, road traffic injuries (RTI) are the leading cause of injuries across the globe. In HICs, changes in automobile engineering have contributed to a reduction in RTI morbidity and mortality. In contrast, in LMICs, most of the injured do not own an automobile, making such technological changes of significantly less importance as protective factors.

Instead, other approaches such as road safety education become more important.

Among the reasons why trauma and injury are so devastating in LMICs are inadequate systems of emergency care at both the community and hospital levels and inadequate infrastructure, such as paved roads, inequities in access to emergency response systems, as well as inequities in access to pre-hospital and hospital emergency services between urban and rural areas.

Other factors include constrained resources, need for enhanced administrative leadership in ministries of health due to poor recognition of the impact of trauma on national health, inadequate public education and public communication around injury prevention issues.

Compounding the problem is the fact that responsibility for injury prevention cuts across many administrative domains including public health, criminal justice, and road safety, among others. The burden imposed by trauma and injury is not confined to the physical consequences of a single, acute event.

There is risk of significant mental health consequences associated with trauma and injury stemming from experiences such as child and elder abuse, criminal victimization, domestic violence, rape, torture, war, terrorism, natural and technological disaster.

In addition to psychiatric disorders such as post-traumatic stress disorder and depression, that can last for years, increased risk for severe functional impairment and disability creates a need for interdisciplinary researchers (e.g., public health, psychiatry, psychology, nursing, neuroscientists, biologists, prevention researchers, etc) to identify risk and protective factors for the development and dissemination of innovative models for the prevention and treatment of trauma related disorders and adverse functioning among children, adolescents and adults there is a need for interdisciplinary researchers to address the broad spectrum of disorders associated with trauma and injury.

Occupational injury and trauma are also of great importance. Of particular interest are industrial accidents as LMICs progress toward industrialization, as well as farm injuries, and violent acts. This program solicits renewal and new applications to conduct research training on the diagnosis, prevention, and/or treatment related to injury and trauma in the LMICs.

For this F O A, research training can include programs such as those related to prevention, treatment at the scene, emergency medical facilities and services, diagnostic imaging, post-acute care, and long-term care including rehabilitation. Diagnostic procedures especially low-cost techniques could be evaluated.

Training may include topics such as low-cost surrogate technologies for CT and MRI Scan, ventilators, optimal resuscitation fluids, blood substitutes, and materials to cover wounds in burn victims and integration of psychosocial services with other systems providing assistance to victims. Special Program Objectives and Considerations: The objectives of this research training program include, but are not limited to: 1.

Substantially increase the expertise of trainees from LMICs in human trauma and injury-related research including the scientific, clinical, legal, ethical and social requirements of trauma and injury research and to strengthen sustainable research within the LMIC institutions with a n emphasis on interdisciplinary research. 2 .

Expand collaborative human trauma and injury research between HIC and LMIC scientists, nurses, bioengineers and imaging researchers . 3. Provide a foundation for evidence-based and best-practice based guidelines in health care in LMICs.

4. Increase the capacity of LMICs to plan for, adapt to and prevent the potential trauma-related consequences of climate change. 5 .

Consider potential sex and race differences in the design and analysis, when possible.

Examples of research and training areas include, but are not limited to : Patterns and trends in morbidity and mortality from different sources of trauma by demographic and demographic characteristics; Long-term impact related to rehabilitation needs, disability and loss of productivity; Treatment of injury and trauma in the acute phase at the scene or at the first healthcare institution; Broad spectrum of disorders associated with trauma and injury, including neurologic and psychiatric disorders; Post trauma physical and psychological rehabilitation including low-cost prosthetics; Development and testing of preventive interventions to shorten the course of psychological problems by early identification and rapid intervention; Post-trauma psychological interventions to reduce prolonged emotional problems, and prevent complications such as health, work or family problems; Development and testing of tools, models and algorithms that could facilitate assessment, utility and priority for injury services in LMICs and be used in trauma or injury research studies; Formation of interdisciplinary disaster research teams and protocols for rapid data collection efforts after trauma and injury in conjunction with national, state, and local authorities and researchers: Measurement of alcohol involvement in injury deaths, preventable years of life lost, and Disability Adjusted Life Years (DALYs); Identification of genetic factors that will maximize cerebral perfusion in the trauma or injury patient with brain injury; Research on acute complications after trauma or injury and to identify the influencing factors; Research on the ethical, legal and social implications of performing human injury research (as an adjunct to the other research training); Research related to the creation of low-cost diagnostic and treatment methods that might facilitate the recognition of specific sequelae to trauma and injury, and the development of preventive or ameliorative treatment options.

Alcohol and drug policy research examining effects of policies on injury morbidity and mortality. Research on comprehensive community interventions to reduce alcohol-related and non-alcohol-related injuries and deaths; and Similarities and differences between blast injuries and other types of traumatic injuries. 6.

Enhance the implementation of internationally validated interventions in specific LMIC contexts, and provide general lessons regarding the science of Dissemination and Implementation related to trauma and injury. The program is not an individual training fellowship program. The trainees are expected to contribute to the research capacity in the LMIC upon completion of their training.

Applicants This FOA responds to all five goals. Applicants should design a training plan to fill specific gaps in human trauma and injury research expertise at the collaborating LMIC institution. The end result should be a critical mass of scientists, nurses, and health professionals who will be able to conduct and sustain injury research at their institution .

Proposals may incorporate a wide range of long- or short-term research training opportunities. A proposed training plan should include : A combination of training at the high Income Countries (HIC) grantee institution and the LMIC trainee institution. Over the years of the award at least 80 percent of the funding should be spent in the LMIC or directly for the training of the LMIC scientists.

Applicants are also strongly encouraged to include women and LMIC ethnic minorities as trainees. Applicants must address the ability of the trainee recruiting and selection process to capture the most qualified individuals and to include an adequate representation of men, women and ethnic minorities or socially disadvantaged population groups among the LMIC trainees.

program application should incorporate an appropriate mix of long-, medium- and short-term training opportunities to address the research training needs identified for the LMIC. The proposed training is expected to strengthen sustainable research capacity at the LMIC institution. Training can take place in the U.S. or a foreign country, but training-related research should be carried out mainly in the LMIC.

While a range of short-, medium- and long-term training is allowed, emphasis will be on medium- to long-term training, including mid-career training and advanced following types of training are included: (master’s or doctoral degree and other training that is six months or longer) training for the full range of skills necessary to support research with the understanding that the focus of thesis and training-related research will be in their country.

Part time long term training is permitted but should be described and justified in the application. (three- to up to six-months) training or mentoring, including specialized clinical, laboratory, research or administrative/business skills necessary to support research that is planned or ongoing.

(less than three months) training or mentoring that focuses on research methodology, laboratory skills necessary to support research ethics and compliance issues, program and grants administration, accounting, financial management, grant writing, peer review, preparation of scientific manuscripts, data management, Internet connectivity, technology transfer, medical informatics, and other relevant areas.

institutional capacity-building efforts are encouraged.

These may include, but are not limited to, in-country training workshops in advanced techniques; distance learning; and interaction with other national and regional efforts to strengthen the ability of institutions to support research and research All training-related research projects in which trainees are involved under this award must be independently peer-reviewed through scientific review procedures established by the applicant institution, and have written evidence of documentation of education in the protection of human subjects for the trainee, compliance with the required federal citations, and approval from an institutional (or ethical) review board or committee at the applicant institution and, if different, at the LMIC institution in which the research is being conducted.

Please see: Procedures for Registering Institutional Review Boards and Filing Federal-Wide Assurances of Protection for Human Subjects (FWAs) at http://www. hhs. gov/ohrp/assurances/assurances_index.

html . program strongly encourages principal investigator/program directors (PIs/PDs) to include women and individuals from underrepresented racial, ethnic or socially disadvantaged groups in the country as faculty at all sites. See Section VIII, Other Information - Required Federal Citations , for policies related to this announcement.

This FOA will use the D43 award mechanism. The Project Director/Principal Investigator (PD/PI) will be solely responsible for planning, directing, and executing the proposed project.

FOA uses the non-modular budget format and Just-in-Time information concepts (see SF424 (R&R) Application detailed categorical budget for the "Initial Budget Period" and the "Entire Proposed Period of Support" is to be submitted with the application, following the Instructions for preparing a D43 institutional research training application described in Section IV 6A.

the nature and scope of the proposed research training will vary from application to application, it is anticipated that the size and duration of each award will also vary. Although the financial plans of the IC(s) provide support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds.

The expected amount for individual awards will be up to $ 200,000 per year (total direct costs) for up to five years. Facilities and Administrative (F&A) costs requested by consortium participants are not included in the direct cost limitation, see NOT-OD-05-004 . Facilities and administrative costs are limited to 8% for all awards and sub-awards.

estimated amount of funds available from all collaborative partners for support of an anticipated 9 projects awarded as a result of this announcement is $2,000,000 for fiscal year 2011 .

Future year amounts will depend on annual grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in Stipends : Stipends are provided as a subsistence allowance for trainees to help defray living expenses during the research training experience. Trainees may be paid a stipend comparable to their professional experience.

Applicants should use an appropriate stipend level and can use the NRSA levels (see Kirschstein-NRSA stipend schedule ,) or grantee institutional policies for trainees involved in medium- or long-term training.

Partial stipends for part time long-term trainees should reflect the amount of time they need to be supported for training in the budget and described in the Tuition and Fees : Funds for tuition and academic fees at the U.S. or foreign institution may be requested. Programs are encouraged to seek cost-sharing arrangements with the grantee institutions in order to provide reduced tuition for trainees.

Note that health insurance is not included as part of this budget category, and is now included under Training Related Expenses category. Tuition and fees are excluded from the F&A base. Health insurance is included in the F&A Trainee Travel: Funds may be requested for round-trip economy class airfare on U.S. carriers (to the maximum extent possible).

Funds may be requested for lodging and per diem for short-term trainees. Funds may be requested to support participation in meetings in which current or former trainees will be presenting training-related research Training-related Expenses : Applicants are encouraged to budget adequate professional development opportunities for trainees, including international scientific conference attendance.

Training-related expenses (e.g., books, computers, and courses for software, English language proficiency, etc.) may be included but must be described in the budget justification. Funds for self-only or family medical insurance may be requested. Include costs for logistics for short- term courses and describe in budget justification.

Salary for Senior/Key Personnel : The salary for the PD, other training faculty and administrative staff must be commensurate with the salary structure and benefits at the institution where they are employed and within the limits described at http://grants. nih. gov/grants/policy/salcap_summary.

htm . Collaborators may receive appropriate compensation for their significant activities on the program, such as recruitment and selection activities, as well as other program-related roles. The administrative, training or teaching responsibilities and time commitment for personnel receiving salary should be thoroughly described.

The salary and fringe benefits for the faculty and staff should not exceed 25 percent of total direct costs. may be requested for round-trip economy airfare on U.S. carriers (to the maximum extent possible) and lodging and per diem for the applicant to attend the annual program network meeting, normally in the U.S. Principal Investigators are expected to attend.

Funds may be requested for round-trip economy airfare on U.S. carriers (to the maximum extent possible) and lodging and per diem for faculty providing training at the foreign site.

and Administrative (F&A) Costs: F&A costs for the applicant organization and consortium participants will be reimbursed at 8 percent of modified total direct costs, exclusive of tuition, fees, equipment , and consortia costs in excess of $25,000, per NIH Grants policy for institutional research training grants http://grants. nih. gov/grants/policy/nihgps_2003/NIHGPS_Part11.

htm#_Toc54600212 grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA. Section III. Eligibility Information 1.

A.

Eligible Institutions following organizations/institutions are eligible to apply: Controlled Institutions of Higher Education Institutions of Higher Education with 501(c)(3) IRS Status (Other than Institutions of Higher Education) without 501(c)(3) IRS Status (Other than Institutions of Higher Education) (non-U.S.) Entities (Foreign Organizations) submitted by foreign institutions in LMIC or by eligible domestic (U.S.) institutions that demonstrate collaborations with institutions in the low- and middle-income countries ((LMIC), defined by the World Bank classification system ) named in their application.

Taiwan is not listed in the World Bank income classification list but is considered high-income and therefore is not eligible. Hong Kong is listed as high-income in the World Bank income classification list, so is not considered a LMIC. research activities are ongoing at the foreign site at the onset of the grant they must be developed within 2 years.

In this case t here must be an active, U.S. government-funded research in the high-income country institution from the onset of the grant that can be used in the first years for the research training activities. But it is expected that the research training activities will be developed within these 2 years and then will continuously increase at the foreign site.

In the last two years of the award it is expected that almost all of the research will be done in the foreign institution. Applicants from U.S. institutions must propose collaborations with two foreign institutions in low- and middle-income countries and must name an individual at each foreign institution as the major foreign collaborator for that country.

Individuals chosen as major foreign collaborators should be scientists with whom the Principal Investigator or key personnel named in the application have had prior successful research Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research training as the PD/PI is invited to work with his/her organization to develop an application for support.

Women and individuals from underrepresented racial, ethnic and socially disadvantaged groups as well as individuals with disabilities are always encouraged to apply for NIH support.

applicant PD/PI must have strong research and research-training program experience, should include the requisite faculty in the application, and have access to the requisite facilities to carry out the proposed research training applicant PD/PI must name at least one individual at each collaborating institution as the major collaborator for that institution.

Individuals chosen as major collaborators should be scientists with whom the Principal Investigator or key personnel named in the application have had prior successful collaborations. These collaborations should be described in the application. PI and collaborators will be responsible for the overall conduct of the grant.

The role of the collaborators in setting the research agenda and in conceptualizing and mentoring research projects should be described in the applicants should explain in detail how their relevant research grant support and activities are related to the proposed research training plan.

than one Training PD/PI (or multiple PD/PIs), may be designated on the application for research training programs that require a team approach and therefore clearly do not fit the single PD/PI model, e.g., interdisciplinary or multidisciplinary training.

The decision to apply with a single PD/PI or a multiple PD/PIs is the responsibility of the investigators and applicant organizations, and should be determined and justified by the goals of the training program. Applications for grants with multiple PD/PIs require additional information.

When considering multiple PD/PIs, please be aware that the structure and governance of the PD/PI leadership team as well as the knowledge, skills and experience of the individual PD/PI will be factored into the assessment of the overall scientific merit of the application. Multiple PD/PIs on a program share the authority and responsibility for leading and directing the research training program, intellectually and logistically.

Each PD/PI is responsible and accountable to the grantee organization for the proper conduct of the program, including the submission of required reports. with multiple Training PD/PIs must provide a Leadership Plan that emphasizes how leadership by multiple PD/PIs will benefit the research training program and the trainees.

A single Contact PD/PI must be designated for the purpose of communicating with the NIH, although other individuals may contact the NIH on behalf of the Contact PD/PI when necessary. Because training programs are intended to be coherent a single award will be made. NIH will not allocate the budget or training positions between multiple PD/PIs.

Multiple PD/PI applications should include reasonable numbers of PD/PIs and each should be included for a specific purpose. Multiple PD/PI applications should not include all mentors of the training grant as PD/PIs, except Additional information on the implementation plans, policies and procedures to formally allow more than one PD/PI is available at http://grants. nih.

gov/grants/multi_pi . All PDs/PIs must be registered in the NIH electronic Research Administration (eRA) Commons prior to the submission of the application (see http://era. nih.

gov/ElectronicReceipt/preparing. htm for instructions). The PD/PI and/or at least one key personnel listed in the application must be designated as the PD or key personnel of at least one active (with at least 18 months of support remaining at the time of submission of the application) research award that is directly relevant to the research training proposed.

The research grants may be funded by the NIH, other U.S. government funding, or by other national or international organizations with pre-approval.

If 18 months will not remain in the parent grant award period at the time of application submission, an applicant must provide documentation that a renewal of a research grant to meet the eligibility requirement is expected, that a no-cost extension has been/will be requested for the research grant to meet the eligibility requirement and it will have sufficient remaining resources to continue the research project, or that other research support will be available to meet the eligibility This program does not require cost sharing as defined in the current NIH of Applications.

Only one