Global Health Discovery & Translational Sciences

Global Health Discovery & Translational Sciences is sponsored by Bill & Melinda Gates Foundation. This grant supports innovative approaches to developing new interventions for infectious diseases affecting the world's poorest populations. While not directly about governance, health and well-being are critical for a developing state.

Discovery and Translational Sciences at the Foundation Discovery & Translational Sciences To catalyze innovation for the discovery and translation of transformational solutions to global health inequity. Dr. Sène Marie-Angélique, Head of the Microbiology and Analytical Development Lab, looks through a microscope, at the Institut Pasteur in Dakar, Senegal.

We accelerate progress toward the foundation’s bold global health goals by exploiting a comparative advantage of the foundation and our team in particular: the ability to invest in initiatives with a high risk of failure but also the potential to create truly disruptive change.

We fund the discovery and translation of potentially transformative products, including vaccines, biologics, drugs, and microbiome interventions; the development of cross-cutting technology platforms that support product discovery and translation; the de-risking of novel technologies (for both products and supporting platforms); and research to fill key gaps in biological understanding.

The latest updates on discovery & translational sciences How to solve tough global health problems? Build community. The leader of Grand Challenges shares how the initiative funds 4,000 research teams to advance some of the coolest science happening today.

Deputy Director, Global Partnerships and Grand Challenges, Gates Foundation Monoclonal antibodies were effective in treating COVID-19. They can do more. Monoclonal antibodies offer promise well beyond treating COVID-19 as a potential game changer in fighting malaria, HIV, and other infectious diseases.

Senior Program Officer, Gates Foundation Our mission is to catalyze innovation for the discovery and translation of transformative solutions to global health inequity. We pursue this by accelerating the discovery and translation of products that will help achieve the foundation’s global health impact goals.

In addition to funding a pipeline of products, we provide complementary funding to develop cross-cutting technology platforms that support product discovery and translation; de-risk novel technologies (for both products and supporting platforms); and fill key gaps in biological understanding (focusing on critical gaps not filled by blue-sky science funded by others).

This work requires broad and deep technical expertise, constant surveying of the rapidly changing scientific and technological innovation landscape, and providing access to and transfer of cutting-edge technology platforms to effective partners across the discovery-translation-development ecosystem in high-, middle-, and low-income countries alike.

Our work is organized into the following domains: Two tool-focused domains (Drugs; Vaccines & Biologics) and one topic-focused domain (Reproductive Health Technologies) that focus on our core pipeline of interventional product candidates.

Three functional domains that support and accelerate the above work: Translational Sciences, which works to accelerate translation of products and technologies to maximize their potential impact; the Global Health Discovery Collaboratory , which provides foundation grantees with access to best-in-class technologies and platforms and fosters a collaborative network of centers of excellence, technology platforms, and grantees; and Global Partnerships & Grand Challenges, which focuses on global health innovation sourcing and ecosystem support, particularly for priority low- and middle-income countries.

We source, sustain, and accelerate innovations and innovative partners in diverse ways, ranging from request for proposal platforms ( the Grand Challenges family of initiatives ) to directly targeted investments in technologies, investigators, and platforms across academia, research institutes, biotechnology and pharmaceutical companies, and product development partners. We also work closely with the Gates Medical Research Institute .

We place a high value on the continued expansion of a robust, open-science, open-data ecosystem to facilitate much more rapid, data-based decision-making in global health. We work closely with academics around the globe, who are a source of much cutting-edge innovation. This often involves recruiting superb scientists from other fields to bring fresh approaches and novel technologies to global health problems.

We also work closely with the biotechnology sector, engage closely with pharmaceutical companies on both discovery and clinical applications, engage with diverse product development partners, and partner with the Gates Medical Research Institute. Where possible, we seek areas of alignment and collaboration with other major global health research and development funders.

Our Global Partnerships & Grand Challenges domain works with the global community of Grand Challenges partner organizations.

The General Hospital Corporation d/b/a Massachusetts General Hospital The Scripps Research Institute Partnership spotlight: Tuberculosis Drug Accelerator The Tuberculosis Drug Accelerator was established in 2012 to facilitate collaboration in tuberculosis drug discovery by breaking down barriers between competing labs and institutions.

The goal is to generate a new treatment for tuberculosis that works in two months or less and addresses resistance to existing drugs. Director, Discovery & Translational Sciences Chris Karp leads the team whose mission is to catalyze innovation for the discovery and translation of transformative solutions to global health and development inequity.

Deputy Director, Reproductive Health Technologies Dr. Sharon Achilles leads the foundation’s efforts in drug discovery and innovative approaches to improving reproductive and sexual health, with a focus on women in low-resource settings.

Deputy Director, Translational Sciences Fran Berlioz-Seux leads a team that focuses on accelerating the translation of scientific discoveries to practical solutions that address global health inequity across the foundation’s work. Deputy Director, Drug Discovery Ken Duncan leads the foundation’s efforts to advance drug discovery. Deputy Director, Global Health Discovery Collaboratory Karen Makar is a Ph.

D. immunologist and molecular epidemiologist who leads the Discovery & Translational Sciences team’s Global Health Discovery Collaboratory. Deputy Director, Strategy, Planning, and Management Simone Marticke oversees strategy and operations for the Discovery & Translational Sciences team.

Deputy Director, Global Partnerships and Grand Challenges Kedest Tesfagiorgis leads the Global Partnerships and Grand Challenges team within the foundation’s Discovery & Translational Sciences program. Get the Optimist newsletter Please enter a valid email address Invalid Recaptcha, Please try again