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Grants for AI Initiatives (SBIR/STTR) is sponsored by National Science Foundation (NSF). This program supports startups and small businesses translating AI research into products and services, including AI systems and AI-based hardware. It emphasizes next-generation AI technologies that are safe, reliable, fair, robust, privacy-preserving, and efficient.
It funds early-stage feasibility and technical validation for novel AI technology with strong commercial potential.
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America’s Seed Fund – NSF SBIR/STTR | NSF SBIR Check recent critical alerts! (Last updated 4/16/2026) Start your grant process here A microscopic image of the metals in a plant seedling being studied for its ability to clean contaminated environments. Photo courtesy of Sigray , a small business revolutionizing x-ray research equipment through its patented innovations on x-ray source and optic technology.
View image caption and credit We fund startups to build deep technologies for commercial success. Seed capital for early stage product development We offer funding for early stage R&D and take no equity in your company — you retain full control over your team, the direction of your work, and your intellectual property. We can help fund your technology Join our regular webinars to learn more.
We fund startups across nearly all technology areas and markets like artificial intelligence, energy, medical devices, robotics, semiconductors, and many more.
Life-saving robot that keeps humans out of dangerous confinements like grain bins Grain Weevil, a startup funded by America’s Seed Fund powered by the U.S. National Science Foundation, helps farmers stay safe and improves grain quality with its life-saving robot that keeps humans out of dangerous confinements like grain bins. Designed by a father-son duo, the robot can break up crusts, level, manage, map and feed grain.
To learn more visit: https://grainweevil. com/ View featured successful NSF-funded companies New membrane filtration system for industrial processes Via Separations, a startup funded by America’s Seed Fund powered by the U.S. National Science Foundation, is creating membranes made with graphene oxide to revolutionize industrial filtration. To learn more visit: https://viaseparations.
com/ View featured successful NSF-funded companies Thermally optimized power amplifiers dramatically boost signal and broadband coverage Soctera Inc, a startup funded by America’s Seed Fund powered by the U.S. National Science Foundation, is developing thermally‑optimized gallium nitride (GaN) RF power amplifiers that boost signal range and efficiency—tackling connectivity and cooling challenges in 5G, rural broadband, telecom and radar applications.
To learn more visit: https://www. soctera.
com/ View featured successful NSF-funded companies Biomaterials startup uses enzymes to replace banned chemicals in consumer products Curie Co, a startup funded by America’s Seed Fund powered by the U.S. National Science Foundation, engineers biomaterials via precision fermentation—using enzymes inside microbial systems—to create sustainable, biodegradable ingredients for haircare, skincare, textiles, and more, replacing ingredients banned by the FDA.
To learn more visit: https://curieco. com/ . View featured successful NSF-funded companies Breast pumping bra automatically massages and compresses to increase milk output Lilu, a startup funded by America’s Seed Fund powered by the U.S. National Science Foundation, is creating a breast pumping bra that helps women produce more breast milk.
To learn more visit: https://www. wearlilu. com/ .
View featured successful NSF-funded companies New drug delivery technology for tumor treatment Tambo developed a new technology to activate drugs at specific locations within the body to treat diseases with lower doses of drugs and fewer toxic side effects. Learn more about Tambo’s technology at https://www. shasqi.
com/ . View featured successful NSF-funded companies Immersive STEM Learning Platform Prisms of Reality is using an immersive educational software in virtual reality to demonstrate how multimodal and game-driven learning can be used to enhance math proficiencies, problem solving, and the ability to transfer mathematical knowledge across contexts. To learn more visit: https://www.
prismsvr. com. View featured successful NSF-funded companies Voice biomarkers identify mental health challenges Kintsugi Mindful Wellness is using artificial intelligence to develop voice biomarker software to measure, predict, and scale access to mental healthcare.
To learn more visit: https://www. kintsugihealth. com/ .
View featured successful NSF-funded companies Blood cleansing device removes pathogens Path Ex is developing a device to remove pathogens from blood. To learn more visit: https://pathex. co/ .
View featured successful NSF-funded companies View featured successful NSF-funded companies We support research and development of deep technologies - those that are based on discoveries in fundamental science and engineering. As we review applications, we consider your technology’s innovativeness, commercial potential, and possible societal impact.
View featured successful NSF-funded companies National Science Foundation Photo Credit: Cyclopure | Cyclopure CP analytical chemists can measure DEXSORB@ efficiency at 1-2 part per trillion concentration We are America's Seed Fund Since 1977, America’s Seed Fund powered by NSF (also known as the NSF SBIR/STTR program) has helped startups develop their ideas and bring them to market. We funded about 400 companies each year.
Check out how NSF is making an impact We invite all tech entrepreneurs Our program fosters and encourages participation in innovation and entrepreneurship from all Americans as well as first-time entrepreneurs from all 50 states and U.S. territories. "The grants we received from NSF were instrumental in building the first version of our product and acquiring our first customers.
When we received our Phase I funding in 2010 we were two founders. As of 2022, our team within Cisco has grown to 700 employees and growing." CEO, ThousandEyes, acquired by Cisco for $1 billion, according to CNBC ( NSF-1058602 ) "Huge thanks NSF SBIR for giving us the chance to build the underlying foundational technology that is allowing us to dream big."
CEO of DataChat ( NSF-1853057 ) "NSF helped us refine our vision, figure out if our technology could be used for different applications, and helped us figure out if we can manufacture our technology in a scalable fashion — taking it from an academic project to a real-scale commercial project."
Co-founder and CEO of Via Separations ( NSF-1831203 ) "We were able to spin out from the University of Washington and get started as an independent company entirely with the support of our first NSF SBIR, and we are incredibly grateful for NSF’ continued support over the years!"
Co-Founder & CEO, A-Alpha Bio ( NSF-1950992 ) Credit: NSF-funded Electra ( NSF-2039232 ) uses chemistry and renewable energy to transform iron ore into 99% pure iron. Here, an employee examines a solution in the R&D lab. Credit: Electra
Key questions and narrative sections extracted from the solicitation.
Project description (10–15 pages addressing innovation, technical approach, and R&D plan)
Commercialization strategy
Scoring criteria used to review proposals for this grant.
Based on current listing details, eligibility includes: Small businesses (fewer than 500 employees) located in the United States, with at least 50% equity owned by U.S. citizens or permanent residents. Applicants should confirm final requirements in the official notice before submission. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates $305,000 - $1.25M (depending on project phase) Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.
Past winners and funding trends for this program
Agricultural Technologies (AG) - NSF SBIR/STTR is sponsored by National Science Foundation (NSF). The Agricultural Technologies topic supports innovations enabling farm production ecosystems that support the proper utilization of natural resources. Such technologies may encompass systems-level and multidisciplinary solutions to enable complex agricultural practices that support increased biodiversity balanced with yield production. Sub-topics include food waste mitigation, resilient supply & distribution, and other agricultural technologies.
Fire Science Innovations through Research and Education (FIRE) program is sponsored by National Science Foundation (NSF). This program invites innovative multidisciplinary and multisector investigations focused on convergent research and education activities in wildland fire. It supports research that can inform risk management and response, adaptation, and resilience across infrastructures, communities, cultures, and natural environments. Relevant topics include developing novel materials and methods for retrofitting existing buildings and remediating buildings following wildfire and smoke events.
NSF ADVANCE program is sponsored by National Science Foundation (NSF). The NSF ADVANCE program aims to broaden the implementation of evidence-based systemic change strategies that promote equity for STEM faculty in academic workplaces and the academic profession. The program provides grants to enhance systemic factors that support equity and inclusion and to mitigate systemic factors that create inequities in the academic profession and workplaces.
Research on Circular Economy, Smart Manufacturing, and Energy-Efficient Microelectronics is sponsored by U.S. Department of Energy (DOE) Advanced Materials & Manufacturing Technologies Office (AMMTO). This funding opportunity supports innovative technology R&D across the manufacturing sector with a focus on circular economy, smart manufacturing, and energy-efficient microelectronics. While the stated deadline for full applications has passed, AMMTO frequently issues similar solicitations, and this highlights a relevant area of interest for the DOE.
AWS Imagine Grant program - Momentum to Modernize Award is sponsored by Amazon Web Services (AWS). This award provides funding for transformational infrastructure projects, helping nonprofit organizations enhance their core mission operations with technology. This includes foundational technology projects, such as migrating servers to the cloud and modernizing new and existing applications.
NIST AI-Focused Manufacturing USA Institute is sponsored by National Institute of Standards and Technology (NIST). NIST announced an open competition for a new Manufacturing USA institute focused on the use of artificial intelligence (AI) to increase the resilience of U.S. manufacturers. The institute will be required to obtain cost-share funds from nonfederal sources.