Grants for innovative population-based research in how work or occupation influences health outcomes and health status among health disparity populations and how work functions as a social determinant of health.

Grants for innovative population-based research in how work or occupation influences health outcomes and health status among health disparity populations and how work functions as a social determinant of health. is sponsored by National Institute on Minority Health and Health Disparities (NIMHD), National Institutes of Health (NIH).

This grant supports innovative research on the influence of work and occupation on health outcomes and status within health disparity populations, and how work acts as a social determinant of health.

Expired PAR-21-275: The Role of Work in Health Disparities in the U.S. (R01 Clinical Trials Optional) This notice has expired. Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations National Institute on Minority Health and Health Disparities ( NIMHD ) National Institute on Drug Abuse ( NIDA ) National Institute of Environmental Health Sciences ( NIEHS ) National Institute of Mental Health ( NIMH ) National Cancer Institute ( NCI ) Eunice Kennedy Shriver National Institute of Child Health and Human Development ( NICHD ) All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers.

The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Sexual and Gender Minority Research Office ( SGMRO ) Office of Research on Women's Health ( ORWH ) Funding Opportunity Title The Role of Work in Health Disparities in the U.S. (R01 Clinical Trials Optional) R01 Research Project Grant Notices of Special Interest associated with this funding opportunity November 25, 2024 - This PAR has been reissued as PAR-25-292 .

NOT-OD-23-012 Reminder: FORMS-H Grant Application Forms and Instructions Must be Used for Due Dates On or After January 25, 2023 - New Grant Application Instructions Now Available NOT-OD-22-190 - Adjustments to NIH and AHRQ Grant Application Due Dates Between September 22 and September 30, 2022 October 28, 2021 - Reminder: FORMS-G Grant Application Forms & Instructions Must be Used for Due Dates On or After January 25, 2022 - New Grant Application Instructions Now Available.

See Notice NOT-OD-22-018 . September 13, 2021 - Updates to the Non-Discrimination Legal Requirements for NIH Recipients. See Notice August 5, 2021 - New NIH "FORMS-G" Grant Application Forms and Instructions Coming for Due Dates on or after January 25, 2022.

August 5, 2021 - Update: Notification of Upcoming Change in Federal-wide Unique Entity Identifier Requirements. See Notice NOT-OD-21-170 April 20, 2021 - Expanding Requirement for eRA Commons IDs to All Senior/Key Personnel. See Notice NOT-OD-21-109 October 13, 2021 - Notice of NICHD Participation in PAR-21-275, "The Role of Work in Health Disparities in the U.S. (R01 Clinical Trials Optional)".

See Notice NOT-HD-21-044 Funding Opportunity Announcement (FOA) Number Companion Funding Opportunity See Section III. 3. Additional Information on Eligibility .

Assistance Listing Number(s) 93. 307, 93. 393, 93.

396, 93. 399, 93. 113, 93.

866, 93. 279, 93. 242, 93.

313, 93. 865 Funding Opportunity Purpose The purpose of this Funding Opportunity Announcement (FOA) is to support innovative population-based research that can contribute to identifying and characterizing pathways and mechanisms through which work or occupation influences health outcomes and health status among populations with health and/or health care disparities, and how work functions as a social determinant of health.

Open Date (Earliest Submission Date) Letter of Intent Due Date(s) The following table includes NIH standard due dates marked with an asterisk. Renewal / Resubmission / Revision (as allowed) All applications are due by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on the listed date(s).

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Required Application Instructions It is critical that applicants follow the instructions in the Research (R) Instructions in the SF424 (R&R) Application Guide , except where instructed to do otherwise (in this FOA or in a Notice from NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced.

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Part 1. Overview Information Part 2. Full Text of Announcement Section I.

Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV.

Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII.

Agency Contacts Section VIII. Other Information Part 2. Full Text of Announcement Section I.

Funding Opportunity Description Although scientific and technological discoveries have improved the health of the U.S. population overall, some populations continue to experience a disproportionate burden of disease and risk factors, unmet health care needs and other adverse health conditions.

Work activity is known to be important to health as a source of exposures and risk factors, a source of beneficial social and economic resources, and attainment of social position and status. In addition to formal work, under-employment and unpaid and informal work arrangements are also important work activities to understand.

While the contribution of work to health outcomes and substantial occupational segregation for populations that experience health disparities are known, few studies have explored to what extent and by what mechanisms work explains health disparities, especially in the contexts of racial and ethnic populations and socioeconomic status.

Because work can be modified and is amenable to intervention, the examination of the role of work as a social determinant of health (SDOH) presents an opportunity for research that may illuminate causal pathways and potential solutions for health disparities.

Vast literature demonstrates the importance of work for health outcomes, mostly through direct effects due to exposures and risk factors arising from someone’s occupation or workplace experiences. For example, 8. 4% of all cancer deaths are attributable to workplace exposures.

Workplace physical conditions such as excessive heat or cold, noise, physical exertion, and chemical hazards have been linked to multiple diseases. Workplace psychosocial hazards such as job strain (low control, high psychological demands) are consistently associated with cardiovascular disease. Job strain is also associated with depression, postpartum depression, and obesity.

Precarious employment is linked to poor mental health. Underemployment is linked to lower levels of health and wellbeing than adequate employment. Workplace discrimination is linked to poor mental health and substance use.

Work, as a source of beneficial social and economic resources, is also linked to health care outcomes and health outcomes. In the U.S., employment linked benefits constitute the primary source of health insurance coverage for about half of the population, which influences access to and use of care, and the type of insurance contributes to quality of care.

Work policies, such as paid sick leave, are linked to use of preventive health services, such as cancer screenings and immunizations. Also, increases in paid parental leave are linked with decreases in perinatal, neonatal, post-neonatal, infant, and child mortality. Profound occupational segregation in the U.S. labor force is strongly patterned by social identities that characterize populations who experience health disparities.

For example, African American/Black and Latino/Hispanic persons are the least likely to be in managerial and professional jobs and the most likely to be in service and blue-collar jobs. A national study found consistent associations between working in race-segregated occupations and poor worker health. However, the degree to which occupational segregation can be explained by education versus structural racism needs to be evaluated.

Another study found that occupational segregation accounted for disproportionate mortality rates for Latino/Hispanic and African American/Black workers during the COVID-19 pandemic.

There is also segregation within a workplace by social identities (e.g., gender, age, social class, sexual orientation, immigrant status, formerly incarcerated, marital status, head of household) that can result in large differences in exposure to workplace hazards and receipt of benefits from workplace policies, but the extent to which this explains disparities in health and health care outcomes is unknown.

Structural racism and discrimination within macro-level conditions that limit opportunities, resources, and power, shown by census tract areas with high social vulnerability, are linked to substantial health disparities.

However, what is not known is the extent that these place-based health disparities are due to regional or location specific income inequality, unfavorable labor market conditions, unequal occupational opportunities, and/or high unemployment rates.

Moreover, there are large differences in life trajectories based on someone’s work, including differences in achieving social status and position, and in access to work-related resources and social networks, but how these influence health and health care disparities is yet to be examined.

Given the unequal distribution of work among populations affected by health disparities, work is implicated in both health and health care disparities and research is needed to examine the mechanisms and pathways through which this unequal distribution influences health and health care disparities.

A few studies have demonstrated proof-of-concept that occupational segregation by race and ethnicity and the resulting unequal exposure to occupational risk factors explain a proportion of the population-level disparities seen in health outcomes. For example, disproportional employment of African American/Black persons in jobs with lower substantive complexity may explain up to 30% of the disparity seen in all-cause mortality rates.

Occupational health disparities research has mainly focused on work as a source of hazardous exposures linked with a specific health outcome. This initiative is a call for research to examine work beyond only being a source of exposures and risk factors, examining it also as a source of beneficial social and economic resources and attainment of social position and status.

The main objective of this initiative is to determine the extent and mechanisms by which work as a SDOH both contributes to, and helps ameliorate, health and health care disparities. A recent workshop on September 28-29, 2020 organized by NIMHD ( https://www. nimhd.

nih. gov/news-events/conferences-events/hd-workshop. html ) highlighted key ideas for furthering research on work as a SDOH that include conceptualizing work as a social class marker, as a source of exposures and risk factors, and as a source of beneficial social and economic resources such as income and wealth, neighborhood conditions, health care access, education, and social networks.

Some key questions include: What are the specific and modifiable mechanisms by which work explains health disparities? To what extent does work as a social class marker, source of exposures and risk factors and/or source of beneficial social and economic resources explain health disparities? Which health disparities does work as a SDOH explain?

Of particular interest are projects designed to examine pathways and mechanisms using conceptual model(s) grounded in minority health and health disparities theories that recognize that health disparities arise by multiple and overlapping contributing factors acting at multiple levels of influence (See the NIMHD Research Framework, https://www. nimhd. nih.

gov/about/overview/research-framework. html). Studies must examine NIH-designated U.S. health disparity populations, e.g. racial and ethnic minority populations, sexual and gender minority groups, underserved rural populations, and socioeconomically disadvantaged populations of any race or ethnicity ( https://www.

nimhd. nih. gov/about/overview/ ).

Studies involving primary data collection with human participants are strongly encouraged to incorporate SDOH measures from the Core and Specialty collections that are available in the Social Determinants of Health Collection of the PhenX Toolkit ( www. phenxtoolkit. org ).

Of interest are intersectional approaches that consider different social identities and the embeddedness of individuals within families, households, and communities. Life course approaches that consider the role of work in shaping cumulative processes and critical transitions including periods of unemployment, under-employment, and unpaid and informal work arrangements, are also encouraged.

Also, of interest is considering the role of work at the household level with influences on the health of partners and extended families, and the intergenerational transmission to children and their health.

In addition, exploring the role of inequity-generating mechanisms that constrain choices around work and health such as racism and discrimination by sex, age, marital status, immigration status, social class, and other power structures is also encouraged.

Additionally, of interest are projects that explore whether work can explain the health or health care disparities seen within diseases or conditions (e.g., COVID-19, opioid use disorder, mental/behavioral health, diabetes, cancer, heart disease, asthma, and maternal and infant health ) as well as disparities in co-morbidities and general indicators of health such as greater global burden of disease, quality of life, and daily functioning.

Projects that utilize a syndemics lens (i.e., multiple disease states that are interlinked because of social, environmental, and structural conditions), to examine the role of work in disparities in co-occurring health conditions, are encouraged.

Also, of interest are projects that explore how work contributes to health care disparities including but not limited to disparities in access to preventive, specialty, and emergency care, in health insurance coverage, and in quality of health care.

Moreover, given the reciprocal relationship between work and health, of interest are projects that examine how health impacts access to different work opportunities, working conditions, and work benefits, and how that varies by different social identities. Projects may involve primary data collection and/or secondary analysis of existing datasets.

Projects may utilize observational studies, natural experiments, quasi-experiments, simulation modeling, as well as use of large-scale longitudinal data sets, data mining techniques, registries, surveillance data, and linking to administrative data sets such as the Occupational Information Network (O*NET). Quantitative and mixed methods approaches are encouraged.

Investigators are encouraged as appropriate for the research questions posed, to forge research collaborations with community partners and stakeholders in the conceptualization, planning and implementation of the research to generate better-informed hypotheses and enhance the translation of the research results into practice.

Applications Not Responsive to the FOA Projects that only explore pathways and mechanisms for how hazardous exposures are linked to a specific health outcome, without exploring how they contribute to population-level minority health, health disparities or health care disparities. Projects that do not include a focus on one or more NIH-designated populations that experience health disparities in the United States.

Projects conducting research outside of the U.S. or its territories and possessions, the Commonwealth of Puerto Rico, or the Trust Territory of the Pacific Islands, or requesting foreign components. Projects that do not utilize a clear conceptual framework and theoretical model to guide the analyses.

Projects that only describe the existence of health disparities related to work without examining the mechanisms through which work contributes to these disparities. Non-responsive applications will not be reviewed. Applicants are strongly encouraged to reach out to the relevant scientific contacts to discuss whether their applications are responsive.

Areas of Research Interest Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD's mission is to lead research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all.

The NICHD's broad and diverse research portfolio includes research related to conception and pregnancy; typical and atypical development in childhood; childhood trauma and critical illness; the transition from adolescence to adulthood; reproductive health; rehabilitation; intellectual, developmental, and physical disabilities; and population dynamics across the lifespan.

For this PAR, NICHD encourages research that integrates cross-cutting topics: health disparities, disease prevention, infectious disease, and nutrition.

In response to PAR-21-275 , topics of interest to NICHD include, but are not limited to research on: Work and educational, occupational, and/or life course pathways contributing to health disparities, The impact of employment on health outcomes for persons with intellectual, developmental, learning, physical and psychological disabilities, Variation in state employment policies on health outcomes, The physical location of work and ease of getting to service providers, whether of direct health care or facilitators of healthy behaviors (e.g., grocery stores and gyms), Labor market change (e.g., growth/dissolution of occupations/industries, changes in certification/education requirements) and associated occupational exposures with health, fertility, and pregnancy outcomes, Consequences of bias and discrimination in workplace policies (e.g., differential hiring, salary and promotion practices) on health, fertility, and pregnancy outcomes, Job-related exposures (e.g., essential and frontline workers during the COVID19 pandemic, high risk/stress occupations, shift work, etc.) and their impact on child health, reproductive health, and pregnancy outcomes.

National Institute on Minority Health and Health Disparities (NIMHD): NIMHD is interested in studies that evaluate: The role of work as a SDOH, teasing apart work as a social class marker, as a source of exposures and risk factors , and/or source of beneficial social and economic resources.

The extent to which work as a SDOH explains health and health care disparities, in the context of socioeconomic status (years of education and/or household income) and racial or ethnic minority populations. The mechanisms and causal pathways by which work contributes to health and health care disparities.

This includes mechanisms influenced by structural racism, such as occupational segregation and workplace segregation as well as other inequity-generating mechanisms such as climates of racism, perceived societal discrimination by other factors such as sex, age, marital status, immigration status, social class, and other power structures that constrain choices around work and health.

The mechanisms and causal pathways by which work as a SDOH contributes to health disparities for specific diseases or clusters of diseases (e.g., syndemics), health conditions, and general indicators of health such as greater global burden of disease, quality of life, and daily functioning.

The mechanisms and causal pathways by which work as a SDOH contributes to health care disparities in access to and quality of primary care, preventive services, and specialty consultations, after accounting for type of health insurance coverage.

The role of work as a SDOH for household units, and the mechanisms and pathways by which work influences health disparities for household members, such as primary employee, partners, children, grandparents, dependents, and extended families.

The extent to which work as a SDOH influenced by structural racism within macro-level conditions (e.g., decline in unions, globalization and workplace restructuring, entrepreneurism, rise of self-employment occupations, rise of the gig economy, increases in precarious jobs, percent of immigrants in labor force, natural disasters such as COVID-19, recessions) can explain, exacerbate, or mitigate national, regional or location specific health disparities.

The extent to which work as a SDOH is influenced by system-level trends, shifts in labor, and sector disruptions (e.g., issues of social justice versus individualism, distributive justice versus free market, economics and the tradeoff between efficiency and equity) and their role in exacerbating or mitigating the contribution of work to health and health care disparities.

The implementation of laws and regulations at the municipal, state or national levels (e.g., paid family and medical leave, paid sick leave, workers compensation, medical benefits, minimum wage, and diversity, equity and inclusion policies) and their differential effects for populations with health disparities.

The reciprocal relationship between work and health, and how health for populations, such as increased burden of disease and co-morbidities impacts work as a SDOH, including access to different work opportunities, working conditions, and work benefits, and how that varies by different social identities.

National Institute on Aging (NIA): The NIA mission is to support and conduct genetic, biological, clinical, behavioral, social, and economic research on aging; foster the development of research and scientists in aging; provide research resources to facilitate innovative aging research; and disseminate information about aging and advances in research to the public, health care professionals, and the scientific community, among a variety of audiences.

NIA’s interest in this FOA includes research to understand the influences employment, occupational factors, and voluntary/involuntary job loss on life course health and aging, including Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD).

Specific areas of interest include, but are not limited to, research elucidating life course pathways via occupational circumstances leading to disparities in mid and later-life cognitive and health outcomes; the relationships between labor market change (e.g., growth/dissolution of occupations/industries, changes in certification/education requirements, etc.) and associated occupational exposures with health and disability at older age; the consequences of occupational and workplace policies (e.g. shift work, high-risk jobs, etc.) on health outcomes at older ages; experimental or quasi-experimental approaches using changes in workplace/labor policies from the national to the firm level (e.g., Fair Labor Standards Act, Minimum Wages, shift work regulations, unions, paid childcare/eldercare, etc.) to conduct causal analyses of work-related factors on health and cognition in mid- and later life; how hazardous job-related exposures across the work life (e.g., front-line or essential workers during the COVID19 pandemic, high risk/stress occupations, etc.) are related to later life health and cognition; how timing and duration of job loss and retirement (e.g., disruption or completion of work history) influence health and cognition in later life; how occupation and occupation change over the life course influence health, well-being, and cognition (e.g., job qualities and benefits); how differences in social isolation or integration caused by occupational experiences serve as risk or protective for cognitive and health outcomes; how workplace accommodation influences disability and/or decline among persons with cognitive, sensory, or motor disabilities as they continue to age.

Applicants are encouraged to consult summaries of two recent NIA-sponsored activities, including a series of teleconferences on Work, the Workplace, and Aging and a recent National Academies Planning Meeting on how workplace policies and qualities promote health and support work into older ages, for recent discussions of scientific challenges and opportunities related to these topics.

Note where appropriate in FOA: NIA requires all applicants planning to collect data provide plans to document and share all research data (see https://www. nia. nih.

gov/research/data-sharing-resources-researchers ). All projects should strive to employ common data elements/constructs and those developing new/innovative measures should employ approaches supporting crosswalks to common data elements/constructs.

National Institute on Drug Abuse (NIDA): NIDA is interested in research that explicates the mechanisms by which employment and drug use are related, in order to inform the future development and testing of interventions to directly address those mechanisms. NIDA encourages stakeholders and end users to be active partners in all stages of research so that findings have greater potential to directly influence practice.

Examples of NIDA interest areas include, but are not limited to: Studies to understand the structural (e.g., loss of venues or sectors) and individual level (e.g., occupational injuries) aspects of employment and their influence on drug use (including opioids and stimulants) and related health problems including infectious disease (e.g., HIV, HCV) and mental illness.

Studies of the effects of drug involvement on employment opportunities, job seeking behaviors, job training/job readiness, and job retention to identify the mechanisms by which use impacts employment and vice versa. Studies that examine structural or social aspects work environments that might facilitate or hinder recovery, e.g., peer recovery groups in restaurant or entertainment industry.

Studies that examine how structural aspects of engaging in treatment (e.g., residential treatment, daily visits to an Opioid Treatment Program, timing of appointments, transportation) influence occupational opportunities and outcomes.

Studies that examine the influence of structural aspects of work environments and/or employment outcomes for family members or supportive others (e.g., parents, spouses) and how those factors influence substance use, treatment and recovery outcomes for individuals who have a substance use disorder.

Studies that examine how working in a peer recovery support role influences the worker’s own substance use, mental health, and recovery. National Institute of Environmental Health Sciences (NIEHS): The mission of the NIEHS is to discover how the environment affects people to promote healthier lives. NIEHS has long recognized the harmful impacts of the physical work environment and other occupational exposures on human health.

These workplace exposures disproportionately affect health disparity populations and are often an issue of environmental justice.

National Institute on Mental Health (NIMH): NIMH is interested in studies that examine: The mechanisms and potential causal pathways by which work as a SDOH affects mental health symptoms/disorders, either by contributing to, or ameliorating mental health care disparities in individuals and among household members.

Establishing causal pathways could be examined through randomized controlled trials where appropriate, or through analytic methods such as instrumental variables, propensity score matching, or other appropriate analytic methods.

The extent to which work as a SDOH differentially impacts the presence and severity of mental health symptoms in individuals who have histories of job loss and/or periods of underemployment, and/or the mechanisms and potential causal pathways that contribute to the impact of such job loss/underemployment on the mental health symptoms among members of their family, neighborhood, and community.

The extent to which work as a SDOH impacts interpersonal relationships that may affect mental health status, for example, by creating differences in quality of interpersonal relationships within the work environment (e.g., perceptions of interpersonal disconnectedness, bullying, verbal abuse) that contribute to worsening mental health status, including feelings of hopelessness, isolation, burdensomeness, emotion dysregulation, and presence of suicide ideation and behaviors.

The extent to which work as a SDOH promotes positive experiences at the individual (e.g., improved self-efficacy, improved belongingness), familial (e.g., positive familial relationship, reduced family conflict, improved family functioning), neighborhood (e.g., neighborhood cohesion, support), and community-level (e.g., improved community investment, reduced community violence) to reduce presence and severity of mental health symptoms.

For research on the effectiveness of interventions or services, NIMH requires a study design using an experimental therapeutics approach, in which clinical trials test intervention effects on mental health outcomes as well as elucidate the intervention’s mechanism(s) of action. Clinical trials applications that do not adhere to the experimental therapeutics framework will be considered non-responsive to this FOA.

Therefore, applications must specify intervention target/mechanism and assess whether intervention-induced changes in the target account for the hypothesized outcome. In the case of services interventions, targets/mechanisms might involve change in service-user, family and/or provider behavior, or in organizational/system-level factors to improve access, engagement, continuity, quality, equity, and/or value of services.

Studies adapting interventions for racial and ethnic minority populations (e.g., American Indians/Alaska Natives, Asian Americans, Blacks/African Americans, Hispanics/Latinos, and Native Hawaiians and other Pacific Islanders), sexual and gender minorities, socioeconomically disadvantaged populations, and underserved rural populations should provide an empirical rationale for the adaptation/augmentation target and a clear hypothesis and plan to address the target mechanism by which the adapted intervention will enhance outcomes.

See the Support for Clinical Trials at NIMH web page for additional information. NIMH also encourages researchers to provide a data analytic plan that specifies how multi-level factors, effects and interactions, or outcomes will be conducted. See Section VIII.

Other Information for award authorities and regulations. Section II. Award Information Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed for this FOA. Optional: Accepting applications that either propose or do not propose clinical trial(s).

Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Application budgets are not limited but need to reflect the actual needs of the proposed project.

The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this FOA.

Section III.

Eligibility Information Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education: Hispanic-serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISIs) Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are not allowed. Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

Dun and Bradstreet Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number. After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application.

System for Award Management (SAM) Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.

NATO Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. eRA Commons - Applicants must have an active DUNS number to register in eRA Commons. Organizations can register with the eRA Commons as they are working through their SAM or Grants.

gov registration, but all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants.

gov Applicants must have an active DUNS number and SAM registration in order to complete the Grants. gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA