Grants to Support New Investigators in Conducting Research Related to Preventing Interpersonal Violence Impacting Children and Youth

Grants to Support New Investigators in Conducting Research Related to Preventing Interpersonal Violence Impacting Children and Youth is sponsored by Centers for Disease Control and Prevention (CDC). Provides funding for new investigators to conduct research on preventing interpersonal violence affecting children and youth.

Centers for Disease Control and Prevention NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL Grants to Support New Investigators in Conducting Research Related to Preventing Interpersonal Violence Impacting Children and Youth RFA-CE-25-029 12/02/2024 Page 1 of 54 Section I. Funding Opportunity Description ................................................................................... 6 Section II.

Award Information ....................................................................................................... 16 Section III. Eligibility Information ................................................................................................

18 Section IV. Application and Submission Information ................................................................... 23 Section V.

Application Review Information ................................................................................. 33 Section VI. Award Administration Information ............................................................................

40 Section VII. Agency Contacts ....................................................................................................... 52 Section VIII.

Other Information ....................................................................................................

53 # Participating Organization(s) Centers for Disease Control and Prevention # Components of Participating Organizations Components of Participating Organizations: National Center for Injury Prevention and Control # Notice of Funding Opportunity (NOFO) Title Grants to Support New Investigators in Conducting Research Related to Preventing Interpersonal Violence Impacting Children and Youth K01 - Mentored Research Scientist Development Awards # Notice of Funding Opportunity Type # Agency Notice of Funding Opportunity Number # Assistance Listings Number(s) # Category of Funding Activity This Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC) Mentored Research Scientist Development Award (K01) supports an intensive, supervised (mentored) career development experience in violence prevention research leading to research independence.

NCIPC supports K01 grants to help ensure the availability of Page 2 of 54 an adequate number of trained scientists to address critical public health research questions to prevent violence and injury. Applicants must propose a research project that addresses at least one NCIPC research priority related to interpersonal violence impacting children or youth (from birth through age 17). See https://www.

cdc. gov/injury-violence-prevention/programs/research- priorities. html?

CDC_AAref_Val=https://www. cdc. gov/injury/researchpriorities/index.

html .

These research priorities include: • Cross-cutting violence prevention • Adverse childhood experiences • Child abuse and neglect • Intimate partner violence (including teen dating violence) Applicants are also encouraged to address the following: • Multiple forms of interpersonal violence impacting children or youth • Firearm-related behavior, crime, injuries, and deaths among children and youth • Social or structural conditions that contribute to a greater risk for interpersonal violence and health inequities across population groups • How the proposed research study has practical relevance to inform prevention and intervention activities Applicants should explicitly state the research priorities their application addresses.

To receive notification of any changes to RFA-CE-25-029, return to the synopsis page of this announcement at www. grants. gov and click on the "Send Me Change Notification Emails" link.

An email address is needed for this service. Letter of Intent Due Date: 11/01/2024 While a letter of intent is not mandatory, nor is it binding or a factor in the review of an application, the details it provides help NCIPC staff to plan for the scientific and technical merit peer review process.

12/02/2024 On-time submission requires that electronic applications be error-free and made available to CDC for processing from the NIH eRA system on or before the deadline date. Applications must Page 3 of 54 be submitted to and validated successfully by Grants. gov no later than 11:59 PM U.S. Eastern Time.

Applicants will use a system or platform to submit their applications through Grants. gov and eRA Commons to CDC. ASSIST, an institutional system to system (S2S) solution, or Grants.

gov Workspace are options. ASSIST is a commonly used platform because it provides a validation of all requirements prior to submission and prevents errors. For more information on accessing or using ASSIST, you can refer to the ASSIST Online Help Site at: https://era.

nih. gov/erahelp/assist. Additional support is available from the NIH eRA Service desk via http://grants.

nih. gov/support/index. html .

• E-mail: commons@od. nih. gov • Phone: 301-402-7469 or (toll-free) 1-866-504-9552 • Hours: Monday - Friday, 7 a.

m. to 8 p. m.

Eastern Time, excluding Federal holidays Note: HHS/CDC grant submission procedures do not provide a grace period beyond the application due date time to correct any error or warning notices of noncompliance with application instructions that are identified by Grants. gov or eRA systems (i.e., error correction window). This is an estimated date.

This is an estimated date. # Required Application Instructions It is critical that applicants follow the instructions in the How to Apply - Application Guide except where instructed to do otherwise in this NOFO. Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Note: The Research Strategy component of the Research Plan is limited to 12 pages.

Page Limitations: Pages that exceed the page limits described in this NOFO will be removed and not forwarded for peer review, potentially affecting an application's score. Applications that do not comply with these instructions may be delayed or may not be accepted for review.

Telecommunications for the Hearing Impaired: TTY 1-888-232-6348 Page 4 of 54 CDC’s NCIPC has been the nation’s leading authority on violence prevention for 30 years. NCIPC’s research priorities identify emerging or understudied violence issues that need solutions, encourage innovative research, and connect research and data to public health action.

The intent of this NCIPC extramural program is to: • Build the scientific base for preventing interpersonal violence impacting children or youth by helping to expand and advance the understanding of new and innovative strategies for the prevention of interpersonal violence.

• Encourage professionals from a wide spectrum of disciplines (including epidemiology, behavioral and social sciences, medicine, biostatistics, public health, health economics, law, and criminal justice) to conduct research that informs interpersonal violence prevention efforts. See detailed NOFO Purpose section. The funding mechanism for this NOFO will be a K01 Mentored Research Scientist Development Award.

Funds Available and Anticipated Number of Awards NCIPC intends to commit up to $600,000 (direct and indirect costs) in FY2025 to support up to four applications for this NOFO. The total funding and number of awards is contingent upon availability of funds and a sufficient number of meritorious applications. Budget and Period of Performance The maximum award amount will be $150,000 per award for the first 12-month budget period.

This includes both direct and indirect costs. Indirect costs for this award are limited to 8% of the Modified Total Direct Cost. Applicants may request a period of performance of up to 3 years.

The maximum total project funding is $450,000 (direct and indirect) per award over the 3-year period of performance, with a maximum of $150,000 per award year. The period of performance is expected to be 09/30/2025 to 09/29/2028. The total award will depend upon the project quality, duration, and cost proposed.

Application Research Strategy Length Page limits for the Research Strategy are clearly specified in Section IV. Application and Submission Information of this announcement. Eligible Institutions/Organizations Page 5 of 54 Institutions/organizations listed in Section III.

Eligibility Information 1. Eligible Applicants are eligible to apply. Eligible Project Directors/Principal Investigators CDC does not award individuals directly.

Those who possess the necessary skills, knowledge, and resources to conduct the proposed research should collaborate with their institutions to submit a support application. Underrepresented racial and ethnic groups and those with disabilities are encouraged to apply. Eligibility criteria for Project Directors (PDs)/Principal Investigators (PIs) is further described in Section I.

Funding Opportunity Description 2. Approach. Number of Project Directors/Principal Investigators Only one PD/PI can be listed in the SF-424 Senior/Key Personnel project role category.

Additional Senior/Key Personnel project roles are limited to Mentor, Co-Investigator, Consultant and Other. Multiple PDs/PIs (M-PDs/PIs) and Co-Principal Investigators (Co-PIs) project roles are not allowed for this announcement.

Awards funded under this NOFO will support the applicant contact PD/PI to conduct relevant and meaningful research in collaboration with an experienced research mentor or mentors that will lead to the applicant's research independence. Applicant contact PD/PIs should identify a primary mentor who will supervise the proposed career development and research experience funded under this NOFO.

The primary mentor must be an active investigator in the area of interpersonal violence prevention research proposed in the Research Strategy of the application and must be committed to both the career development of the contact PD/PI and to the direct supervision of the contact PD/PI’s research throughout the entire project.

The mentor should clearly document the availability of sufficient support and facilities for high-quality research. Mentor requirements are further described in Section I. Funding Opportunity Description 2.

Approach. Mentor Letter(s) of Support Each proposed mentor must provide a distinct Letter of Support (LoS) in the Plans and Statements of Mentor and Co-Mentor(s) section of the application. Requirements for mentor LoSs are further described in Section I.

Funding Opportunity Description 2. Approach. Eligible applicant organizations/institutions may submit more than one application, provided that each application is scientifically distinct.

However, applicant institutions can only submit one grant application with the same contact PD/PI in response to this NOFO. Additionally, applicant institutions can submit only one grant application with the same person designated in a Mentor project role in the application in response to this NOFO. Further details regarding number of Page 6 of 54 applications are described in Section III.

Eligibility Information 10. Number of Applications A pre-application webinar call will be conducted on October 17, 2024 to address questions from prospective applicants regarding NOFO RFA-CE-25-029. See call information below.

Call may end sooner than scheduled time if all questions are addressed. Questions and answers from the discussion will be included in an amended NOFO 2–3 weeks after the call. Participant Access Information • Call Date: October 17, 2024 • Call Start Time: 2:00PM Eastern Standard Time (EST) • Call End Time: 2:50PM Eastern Standard Time (EST) • Call Leader: Tamara Crawford, DBH, MPH, Scientific Program Official https://cdc.

zoomgov. com/j/1609171236? pwd=WUw3dDBETTc4VStOb3FRcHRhKzU0d • Webinar ID: 160 917 1236 • +1 669 254 5252 US (San Jose) • +1 646 828 7666 US (New York) • +1 646 964 1167 US (US Spanish Line) • +1 415 449 4000 US (US Spanish Line) • +1 551 285 1373 US (New Jersey) • +1 669 216 1590 US (San Jose) • Dial-In Passcode: 48304634 See Section IV for application materials.

Telecommunications for the hearing impaired are available at TTY: 1-888-232-6348. # Section I. Funding Opportunity Description Section 301 (a) [42 U.S.C.

241(a)] of the Public Health Service Act, and Section 391 (a) [42 U.S.C. 280 b (a)] and Section 393(a)(3), [42 U.S.C. 280b-1a(a)(3)] of the Public Health Service Act, as amended.

Page 7 of 54 # 1. Background and Purpose Adverse childhood experiences (ACEs), child abuse and neglect, youth violence, teen dating violence, and sexual violence are major public health issues impacting children and youth. The mission of CDC’s NCIPC is to prevent injuries and violence through surveillance, research and evaluation, and prevention activities.

NCIPC uses the same scientific methods to prevent injuries and violence that have been used to prevent disease: carefully describing the problem through surveillance, studying factors that increase or decrease risk for violence or injury, designing and evaluating prevention strategies that address these risk and protective factors, and taking steps to ensure that proven strategies are implemented in communities nationwide.

Strong, innovative, and relevant research is fueled by a diverse field of qualified researchers. NCIPC values supporting new investigators to build capacity to grow the field of interpersonal violence prevention and to become experienced independent investigators.

New investigator awards support career trajectories to prepare new investigators to conduct independent research later as a principal investigator of research grants (R01) and cooperative agreements (U01). The intent of NOFO RFA-CE-25-029 is to contribute to the development of new researchers in the field of interpersonal violence prevention.

New investigators will receive resources to develop and conduct research that addresses NCIPC's interpersonal violence prevention research priorities and to acquire new skills. Exposure to interpersonal violence or other ACEs can negatively affect health and development across the lifespan.

Multiple forms of interpersonal violence including child abuse and neglect, youth violence, teen dating violence, and sexual violence affect children and youth. These forms of interpersonal violence often share risk and protective factors. Despite these links, research is often focused on a specific form of interpersonal violence in ways that limit the understanding of whether prevention strategies have cross-cutting impacts.

Applicants are encouraged to address multiple forms of interpersonal violence impacting children or youth when possible. Importantly, most children and youth aged 0–17 who are victims of homicide die from firearm-related injuries. Thus, applicants are encouraged to examine firearm-related behavior, crime, injuries, and deaths among children and youth or to include these as outcomes.

NCIPC uses the public health approach and is committed to supporting research to eliminate inequities in risk for violence across population groups. The social and structural conditions in which people are born, grow, live, work, and age can be shaped by the distribution of resources, which is influenced in part by policies.

Social and structural determinants of health (e.g., concentrated poverty, structural racism, high rates of unemployment, limited access to high-quality education, and affordable, high-quality childcare) contribute to health inequities, including differences in health status seen across population groups.

Research related to addressing the social or structural conditions that contribute to interpersonal violence and health inequities across groups is highly encouraged. This NCIPC Mentored Research Scientist Development Award (K01) supports an intensive, supervised (mentored) career development experience in interpersonal violence prevention research leading to research independence.

NCIPC supports K01 grants to help ensure the Page 8 of 54 availability of an adequate number and trained scientists to address critical public health research questions to prevent violence and injury. See detailed NOFO Purpose section.

Applications proposing to address research focused on addressing the social and structural conditions that contribute to interpersonal violence and health inequities, including differences in health status, as evidenced by the Research Strategy section of the application's research plan, may be considered during the second level of review to broaden distribution of awards.

Applications proposing to address research focused on firearm-related behavior, crime, injuries and deaths among children and youth, as evidenced by the Research Strategy section of the application's research plan, may also be considered during the second level of review to broaden distribution of awards (see Section V. Application Review Information 4. Review and Selection Process ).

Applicants should explicitly state the research priorities their application intends to address. • Centers for Disease Control and Prevention, National Center for Injury Prevention and Control Research Priorities. Available at: https://www.

cdc. gov/injury-violence- prevention/programs/research- priorities. html?

CDC_AAref_Val=https://www. cdc. gov/injury/researchpriorities/index.

ht • Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Web-based Injury Statistics Query and Reporting System (WISQARS) Fatal Injury Data; 2024. Available at: http://www.

cdc. gov/injury/wisqars/index. html.

• Merrick MT, Ford DC, Ports KA, et al. Vital signs: Estimated proportion of adult health problems attributable to adverse childhood experiences and implications for Prevention — 25 States, 2015–2017. MMWR Morb Mortal Wkly Rep 2019;68:999-1005.

doi: https://dx. doi. org/10.

15585/mmwr. mm6844e1 . • U.S. Department of Health and Human Services, Administration for Children and Families, Administration on Children, Youth and Families, Children's Bureau, Child Maltreatment 2022 (2024).

https://www. acf. hhs.

gov/sites/default/files/documents/cb/cm2022. pdf • Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Violence Prevention at CDC.

Available at: https://www. cdc. gov/violenceprevention/index.

html . • Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Resources for Action for Violence Prevention.

Available at: https://www. cdc. gov/violence-prevention/php/resources-for- action/?

CDC_AAref_Val=https://www. cdc. gov/violenceprevention/communicationresou rces/pub/resource-for-action.

html . • Yearby R. Structural racism and health disparities: Reconfiguring the social determinants of health framework to include the root cause.

Journal of Law, Medicine & Ethics 2020; 48(3):518-526. Healthy People 2030 and other National Strategic Priorities Page 9 of 54 NCIPC at CDC within the Department of Health and Human Services (DHHS) is committed to achieving the health promotion and disease prevention objectives of “Healthy People 2030” as described at https://www. healthypeople.

gov/ . This research addresses multiple interpersonal violence-related objectives of the Healthy People 2030 violence prevention topics. The proposed research on interpersonal violence prevention will ultimately add to the existing evidence on effective strategies for preventing multiple forms of interpersonal violence.

Expanding the pool of public health researchers in the field of violence prevention will increase opportunities for developing innovative and impactful solutions. New investigators will contribute to knowledge about the best ways to prevent and address interpersonal violence impacting children or youth from birth through age 17.

These form of interpersonal violence include: child abuse and neglect, youth violence, teen dating violence, and sexual violence. NCIPC is the nation’s leading public health authority on violence and injury prevention.

NCIPC’s approach involves three elements: a focus on prevention, a science-driven approach to identify risk and protective factors, and multidisciplinary collaboration to address the problem and keep people safe, healthy, and productive. NCIPC’s Division of Violence Prevention has developed and published resources for action to help states and communities take advantage of the best available evidence to prevent violence (https://www.

cdc. gov/violence-prevention/php/resources-for- action/? CDC_AAref_Val=https://www.

cdc. gov/violenceprevention/communicationresources/pu b/resource-for-action. html ).

The strategies and approaches in the resources for action represent different levels of the social ecology with efforts intended to impact individual behaviors as well as the relationship, family, school, community, and societal factors that influence risk and protective factors for violence.

CDC has also released an ACEs prevention resource that highlights six ACEs prevention strategies drawn from CDC resources for action documents (https://www. cdc. gov/violenceprevention/pdf/ACEs-Prevention-Resource_508.

pdf NCIPC’s research priorities ( https://www. cdc. gov/injury-violence- prevention/programs/research- priorities.

html? CDC_AAref_Val=https://www. cdc.

gov/injury/researchpriorities/index. html ) support the need for prevention strategies that address multiple forms of violence and advance economic, gender, and racial equity. A key goal of CDC’s research is to enhance the effects of violence prevention activities by focusing on the interconnections across the different forms of violence.

Cross-cutting violence prevention activities can use resources more effectively and help achieve health equity by focusing on the underlying conditions that contribute to increased risk. Examples of previously-funded research and descriptions of violence prevention initiatives are available on NCIPC’s website: https://www. cdc.

gov/violenceprevention/fundinghub/fundedprograms/research-awards. html . NCIPC’s overall goal is to increase the number and diversity of experienced violence prevention research professionals conducting independent violence prevention research.

This research grant program supports the development of new researchers who have not yet served as a contact Page 10 of 54 project director (PD)/principal investigator (PI) on a specified major CDC or NIH research award.

Applicant contact PD/PIs must have a qualifying degree, less than 5 years of experience as a post-graduate researcher in the violence prevention field, full time employment at the applicant organization at the time of the NOFO application due date, and no current or former funding as a contact PD/PI on specified excluded research project mechanisms (see below) are eligible to apply.

The contact PD/PI must meet all of the following criteria: • A qualifying (relevant to the field of study) research or health-professional doctoral or medical degree (such as PhD, ScD, DO, DrPH, MD, DVM, PharmD, DDS, DMD, PsyD, DPT) from an accredited institution of higher learning.

• Less than 5 years of post-graduate research experience as a researcher in the violence prevention field, as documented on the contact PD/PI’s SF-424 Biographical Sketch at the time of the NOFO application due date.

The 5-years will be calculated from the completion of the qualifying degree (e.g., a research or health-professional doctoral or medical degree [such as PhD, ScD, DO, DrPH, MD, DVM, PharmD, DDS, DMD, PsyD, DPT] from an accredited institution of higher learning). The Positions and Employment section of SF-424 Biographical Sketch should clearly document all of the contact PD/PI’s relevant research experience.

• Significant breaks in employment, or employment in areas unrelated to violence prevention, should be clearly documented. Only the years where any violence prevention research was conducted after completing the qualifying degree will count towards the limit of 5 years of research experience.

Research conducted during undergraduate or pre-graduate training does not count towards this research time even if the applicant contact PD/PI authored or co-authored a paper relevant to the research prior to completing the qualifying degree.

• This funding opportunity may support persons who propose to train in a new field or have had a hiatus in their research career due to circumstances such as, but not limited to, illness or pressing family circumstances.

Applicant contact PD/PIs who are changing their career trajectory to violence prevention must clearly document the start date of their post-graduate emphasis in the field in their SF-424 Biographical Sketch and must clearly demonstrate that they have less than 5 years of post-graduate experience as a researcher in the violence prevention field.

• Specified excluded research project mechanisms: Persons identified as the contact PD/PI on a current and/or former CDC or National Institutes of Health (NIH) grant or cooperative agreement award from any of the following independent research assistance mechanisms defined below, as documented by their eRA Commons PD/PI Grant History profile, are NOT eligible for funding under this NOFO.

The excluded assistance mechanisms are (R01 or U01), program project (P01), center grant (R49, P50), sub-project of program project (P01), sub-project of center grant (R49, P50), or other major individual career development award (e.g., K01, K07, K08, K22, K23, K25, K76, K99/R00).

Page 11 of 54 • Persons with current or former funding from the following CDC or NIH training award assistance mechanisms ARE eligible to apply as contact PD/PIs for this NOFO: CDC or NIH Small Grant (R03), Exploratory/Developmental Grant (R21), Dissertation Award (R36 or R49), Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) (R41, R42, R43, or R44), Transition Scholar (K38) awards, National Research Service Awards (F30, F31, F32), and appointment to institutional K (K12, KL2), T (T32) programs.

• The contact PD/PI must be a citizen, a non-citizen national of the United States, or have been lawfully admitted for permanent residence (i.e., possess a currently valid Permanent Resident Card USCIS Form I-551, or other legal verification of such status) at the time of award. • The contact PD/PI must have a full-time position at the eligible applicant institution at the time of the NOFO application due date.

The application must include a Candidate Eligibility Statement (e.g., an institutional letter of attestation) that is signed by the eligible applicant institution’s Authorized Representative or proxy that explicitly verifies the contact PD/PI’s full-time employment status. This should be included in the Institutional Commitment to Candidate’s Research Career Development section of the application.

The contact PD/PI is not required to have a tenure track appointment at the eligible applicant institution to be eligible for this NOFO. • Applicant contact PD/PIs are required to commit a minimum of 60% of full-time professional effort (i.e., a minimum of 7. 2 person-months/year) to their research project and career development for the entire period of performance.

The budget, budget justification and PHS 398 Career Development Award sections of the application must clearly describe the contact PD/PI’s commitment. Awards funded under NOFO RFA-CE-25-029 will support the applicant contact PD/PI to conduct relevant and meaningful research in collaboration with an experienced research mentor or mentors that will lead to the applicant's research independence.

Applicant contact PD/PIs must identify a primary mentor who will supervise the proposed career development and research experience funded under this NOFO.

The primary mentor must be an active investigator in the area of the interpersonal violence prevention research proposed in the Research Strategy of the application and must be committed to both the career development of the contact PD/PI and to the direct supervision of the contact PD/PI's research throughout the entire period of performance.

The mentor should clearly document the availability of sufficient research support and facilities for high-quality research. Applicant contact PD/PIs are encouraged to identify more than one mentor, i.e., a mentoring team (or advisory committee), if this is deemed advantageous for providing expert advice in all aspects of the research career development program and research proposal.

However, only one person can be identified as the primary mentor who will coordinate the contact PD/PI's research . The contact PD/PI must work with the selected mentor(s) to prepare the application. The primary mentor and all members of the mentoring team should have a successful track record of mentoring persons at the contact PD/PI's career stage.

The mentor(s) must demonstrate appropriate expertise, experience, and ability to guide the contact PD/PI in organizing, Page 12 of 54 managing, and implementing the proposed interpersonal violence prevention research impacting children or youth from birth through age 17.

The application must also include evidence that each member of the mentoring team has the commitment, experience, and institutional resources to provide both career development and research support to the candidate. The primary mentor and each co-mentor must be clearly identified in the Mentor project role category in the SF-424 Senior/Key Personnel section of the application.

The Plans and Statements of Mentor and Co-Mentor(s) section of the application should provide: • Detailed information about each mentor's research qualifications and previous experience as a research supervisor • A plan that describes the nature of the supervision and mentoring that will occur during the proposed award period • A plan for career progression for the contact PD/PI to move from the mentored stage of his/her career to independent research investigator status during the award period • A plan for monitoring the contact PD/PI's research, publications, and progression towards independence • A plan to provide annual evaluations of the contact PD/PI's progress as required in the annual progress report The application must describe the relationship between the proposed research and each mentor's current research and research expertise.

The mentor should be recognized as an accomplished investigator in the proposed interpersonal violence prevention research area and should have sufficient research support to cover the costs of the proposed research project in excess of the allowable costs of this award. This award does not include funds for mentor support on the award.

Mentor Letter(s) of Support Each proposed mentor must provide a distinct Letter of Support (LoS) in the Plans and Statements of Mentor and Co-Mentor(s) section of the application. Each mentor's LoS must describe in detail the partnership, i.e., specific roles and responsibilities between the contact PD/PI and mentor and the nature and extent of the relationship.

If more than one mentor is proposed, the respective areas of expertise and responsibility of each one must be described in the mentor's respective LoS. Co-mentors should clearly describe how they will coordinate the mentoring of the applicant among all mentors.

If the primary or co-mentor does not have an appointment at the applicant institution, a statement must be provided describing the mechanism(s) and frequency of communication with the contact PD/PI, including the frequency of face-to-face meetings. An LoS from other participating collaborators or consultants, if applicable, should be included in the LoS from the Collaborators, Contributors, and Consultants section of the application.

Each LoS should clearly document the role and responsibilities of the collaborator/consultant. Page 13 of 54 The application should describe the institutional support of the applicant's career development plan and proposed research in the Description of Institutional Environment and Institutional Commitment to Candidate's Research Career Development.

Research Strategy Requirements The application must clearly state the NCIPC interpersonal violence research priority or priorities to be addressed by the proposed research in the Specific Aims section of the application.

The application should clearly describe the proposed research approach including: 1) Data source(s) and data access plans 2) Planned analyses and how the analytic approach is well suited to the data source including estimated sample size and a power analysis for outcomes of interest clearly specified) 3) A research plan that describes the research question(s) of interest, the proposed hypothesis for the study, the proposed aims and objectives, the research study design used to test the hypothesis, and the expected outcomes to be evaluated Analytic plans should anticipate and evaluate the effects of threats to the internal and external validity of the specified research design.

Rigorous research designs using quantitative, qualitative, or mixed methods that are appropriate to address the research questions are expected. Applicants must propose studies that can feasibly be completed within the requested budget and period of performance. Proposed research projects could include an expansion of a current investigation in which the researcher is involved or analyses of secondary data.

Applications must be responsive to NOFO RFA-CE-25-029 Section III. Eligibility Information 5. Responsiveness of this NOFO.

It is the applicant's responsibility to ensure that the submitted research proposal meets all responsiveness criteria listed in Section III. Eligibility Information 5. Responsiveness .

Applications must assess interpersonal violence outcomes (e.g., victimization or perpetration) or key risk or protective factors for one or more forms of interpersonal violence impacting children or youth from birth through age 17. The research project must address at least one of NCIPC research priority related to interpersonal violence impacting children or youth (from birth through age 17). See: ( https://www.

cdc. gov/injury-violence-prevention/programs/research- priorities. html?

CDC_AAref_Val=https://www. cdc. gov/injury/researchpriorities/index.

html ).

These research priorities include: • Cross-cutting violence prevention • Adverse Childhood Experiences • Child abuse and neglect • Intimate partner violence (including teen dating violence) Page 14 of 54 Applicants are encouraged to address the following: • Multiple forms of interpersonal violence impacting children or youth • Firearm-related behavior, crime, injuries and deaths among children and youth • Social or structural conditions that contribute to a greater risk for interpersonal violence and health inequities across population groups • How the proposed research study has practical relevance to inform prevention and intervention activities This NOFO is focused on addressing interpersonal violence impacting children or youth from birth through age 17.

Applicants may propose research that focuses on a subset of ages between 0 and 17. Applicants may also include participants outside this age range, but the application should describe how the research question and results are relevant to those ages 0-17.

Applicants are encouraged to focus on children or youth who are experiencing high risk for interpersonal violence, including but not limited to, racial/ethnic minorities, people with disabilities, tribal populations, and sexual and gender minorities. Applicants are also encouraged to examine the underlying social and structural conditions that are contributing to this high risk.

This NOFO, including funding and eligibility, is not limited based on, and does not discriminate on the basis of race, color, national origin, disability, age, sex (including gender identity, sexual orientation, and pregnancy) or other constitutionally protected statuses.

Data collection, acquisition, and analysis Applicants must identify and describe appropriate data sources and provide evidence of their ability to acquire and/or collect