Health and Extreme Weather Solutions-Focused Research Hubs (U54)

Health and Extreme Weather Solutions-Focused Research Hubs (U54) is sponsored by National Institute of Environmental Health Sciences (NIEHS). A program to establish research hubs focused on the health impacts of extreme weather, including wildfire smoke, extreme heat, flooding, hurricanes, drought, and other climate-related hazards.

Opportunity Listing - Health and Extreme Weather Solutions-Focused Research Hubs (U54 - Clinical Trial Optional) Health and Extreme Weather Solutions-Focused Research Hubs (U54 - Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93. 113 -- Environmental Health Last Updated: June 26, 2026 View version history on Grants.

gov The National Institute of Environmental Health Sciences (NIEHS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications that propose translational research hubs with multiple highly integrated components focused on research, capacity building, and community/public health translation for regionally relevant topics related to the health impacts of extreme weather and cumulative exposures, including but not limited to wildfire smoke, extreme heat, flooding, hurricanes, drought, and other climate-related hazards affecting populations at heightened risk across the lifespan.

Responsive applications will be led by a multidisciplinary team of investigators with non-academic partners, such as state and local public health departments, community-based organizations, Tribal entities, health care systems, and emergency preparedness agencies.

Consortia of multiple institutions are encouraged, particularly those that demonstrate meaningful community engagement and balanced, mutually beneficial partnership structures.

Research can be situated at different nodes on the translational research continuum, spanning from fundamental to implementation research with a focus on being problem-based and solutions oriented, and should clearly inform pathways to support implementation, scalability, and measurable public health impact.

Award recipients will be expected to collaborate with the HEW Research Coordination and Data Center(s) and other members of the HEW Community of Practice, including participation in data harmonization efforts, shared metrics development, and cross-site dissemination activities.

This NOFO will utilize the U54 activity code, that supports specialized centers that function as regional resources for targeted research initiatives, including support for infrastructure development, pilot projects, and partnerships with affected communities throughout the research lifecycle.

The U54 is a cooperative agreement that anticipates substantial federal programmatic staff involvement to assist investigators in the achievement of project objectives , including coordination across funded hubs, strategic alignment with NIH priorities, and facilitation of cross-institute collaboration .

Grant authorities that allow NIEHS to forecast this opportunity are as follows: 42 USC 285l (NIEHS specific); 42 USC sections 241 (NIH grant authorities).

City or township governments Federally recognized Native American tribal governments Special district governments Public and Indian housing authorities For-profit organizations other than small businesses Independent school districts Private institutions of higher education Public and state institutions of higher education Nonprofits non-higher education without 501(c)(3) Other Native American tribal organizations Nonprofits non-higher education with 501(c)(3) Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations Grantor contact information NIEHS Division of Extramural Research and Training Please contact via e-mail NOFO.

Information@niehs. nih. gov NOFO.

Information@niehs. nih. gov No documents are currently available.

Link to additional information Estimated Application Due Date : Estimated Due Date Description : Estimated Project Start Date : Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.