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Find similar grantsHigh Impact Research and Research Infrastructure Cooperative Agreement Programs (UC2) is sponsored by National Institutes of Health (NIH). Supports high-impact ideas through cooperative agreements that may lay the foundation for new fields of investigation or accelerate breakthroughs.
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High Impact Research and Research Infrastructure Cooperative Agreement Programs (UC2) | Grants & Funding U.S. Department of Health and Human Services National Institutes of Health High Impact Research and Research Infrastructure Cooperative Agreement Programs (UC2) To support high impact ideas through cooperative agreements that that may lay the foundation for new fields of investigation; accelerate breakthroughs; stimulate early and applied research on cutting-edge technologies; foster new approaches to improve the interactions among multi- and interdisciplinary research teams; or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery.
This activity code could support either a specific research question or propose the creation of a unique infrastructure/resource designed to accelerate scientific progress in the future. This is the cooperative agreement companion to the RC2. High Impact Research and Research Infrastructure Cooperative Agreement Programs Use the Explore NIH Grant Opportunities tool to search Grants.
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AIDS and AIDS-Related Applications Beginning with applications for Advisory Council Review in January 2027 (i.e., application due dates on or after May 25, 2026), NIH will no longer accept applications submitted on dedicated AIDS application due dates. ( NOT-OD-26-029 ) Standard Application Due Dates (when applicable) Participating Funding Organizations Each funding opportunity specifies the participating organizations.
Applications must fit within the mission of at least one participating funding organization and meet all opportunity-specific requirements. The following funding organizations participate on at least one active funding opportunity.
National Center for Complementary and Integrative Health National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Dental and Craniofacial Research National Institute of General Medical Sciences National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute on Drug Abuse For technical issues E-mail OER Webmaster
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High Impact Research and Research Infrastructure Cooperative Agreement Programs (UC2) is funded by National Institutes of Health (NIH). Verify program details on the funder's official page before applying.
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PA-27-037 consolidates the Predoctoral to Postdoctoral Transition Award into a single parent announcement across 20 NIH components, with the next deadline December 8, 2026. The eligibility gate is not the science — it is a mandatory change of institution and mentor between the F99 and K00 phases.
Read articleA draft executive order would have put OMB Director Russell Vought on a commission with final say over NIH awards after peer review. Sen. Collins killed it by pointing at a provision Congress already passed. Here is what the episode teaches applicants about the December 11 cliff.
Read articlePA-27-034, PA-27-035 and PA-27-036 replace the institute-specific R25 announcements that research education programs have been built around for a decade. NCI, NIDA and NIGMS have already expired theirs early. Here is what the consolidation actually changes: an 8% indirect cost ceiling, a US-citizens-and-permanent-residents participant rule, a cooperative agreement variant that only exists on one of the three, and no clinical-trial-allowed companion anywhere.
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