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Hormone-Induced Resistance to GLP-1 Receptor Agonists in Diabetes is a grant from the European Research Council (ERC) that funds research into the molecular mechanisms underlying treatment resistance to GLP-1 receptor agonists (GLP-1RAs) in type 2 diabetes.
The project investigates how endogenous amidated hormones interact with GLP-1 secretion and modulate the effectiveness of GLP-1RA therapies, using in vitro and in vivo models including genetically engineered mice, with the goal of improving diabetes treatment outcomes. Machine learning approaches will also be applied to identify patient characteristics predicting GLP-1RA effectiveness.
Eligible applicants are universities and research institutions in EU member states and associated countries. The award is €1,500,000.
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Hormone-Induced Resistance to GLP-1 Receptor Agonists in Diabetes: Unraveling the Molecular Complexities Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of type 2 diabetes mellitus (T2DM). However, a subset of patients does not respond to these agents or develop treatment resistance, which poses a significant clinical challenge.
Emerging evidence from our work in humans and mice shows that endogenous amidated hormones synergize with GLP-1RAs to reduce glycated hemoglobin, and their absence promotes GLP-1RA resistance. This proposal explores the intricate mechanisms by which endogenous amidated hormones affect endogenous GLP-1 secretion, modulate its function, and influence the effectiveness of GLP-1RAs.
Furthermore, it will investigate which characteristics predict the GLP-1RA effectiveness in patients, and test potential therapeutic approaches to prevent detrimental GLP-1 resistance mechanisms with the goal of ameliorating T2DM treatment and outcomes. A plethora of approaches will be used to elucidate amidated hormone-induced GLP-1 resistance.
We will study L-cell functions and GLP-1 endogenous secretion in vitro and in vivo in the absence of amidated hormones. With tissue-specific genetically engineered mice, we will selectively deplete key amidated hormones that counteract the effects of GLP-1RAs and dissect their contribution in physiological readouts of GLP-1RA resistance.
Lastly, we will leverage machine learning approaches to clinical data analysis on large deeply phenotyped biomedical cohorts to select for patient characteristics that determine the likelihood of developing GLP-1RA resistance, and to assess the combinatorial contribution of amidated hormones on T2DM susceptibility.
By combining experimental and computational approaches, this project aims to gain a deeper understanding of the complex interplay between endogenous hormones (and their combinatorial effects) and GLP-1 signaling, to develop more effective and personalized therapies, and ultimately to improve clinical outcomes in individuals with T2DM.
Fields of science (EuroSciVoc) CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary . medical and health sciences Suggest new fields of science Project’s keywords as indicated by the project coordinator.
Not to be confused with the EuroSciVoc taxonomy (Fields of science) Multi-annual funding programmes that define the EU’s priorities for research and innovation. HORIZON. 1.
1 - European Research Council (ERC) See all projects funded under this programme Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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HORIZON-ERC - HORIZON ERC Grants See all projects funded under this funding scheme Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding. See all projects funded under this call Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party.
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This amount is a subset of the overall project budget. Sort by Net EU contribution Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party.
It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants. Higher or Secondary Education Establishments Participation in EU R&I programmes HORIZON collaboration network The total costs incurred by this organisation to participate in the project, including direct and indirect costs.
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According to the current listing, eligibility includes: Universities and research institutions in EU Member States and associated countries. Confirm the full requirements in the official notice before applying.
The current listing shows €1,500,000. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Hormone-Induced Resistance to GLP-1 Receptor Agonists in Diabetes: Unraveling the Molecular Complexities is funded by European Research Council (ERC). Verify program details on the funder's official page before applying.
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MGPV Travel Grant is sponsored by Geological Society of America (GSA), Mineralogy, Geochemistry, Petrology, Volcanology Division. MGPV Travel grants support student travel to the annual GSA meeting. Applications are restricted to active graduate or undergraduate students who are the presenting authors of an accepted abstract at the annual GSA meeting.
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